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1. 发明授权

EP2808399B1 Soluble analyte detection and amplification 有权
标题翻译：检测和可溶性分析物的扩增
公开(公告)号：EP2808399B1
公开(公告)日：2016-11-02
申请号：EP14171566.4
申请日：2004-08-31
申请人： Restalyst Pte Ltd
发明人： Lawton, Robert L.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6804 , Y10S435/971 , Y10S435/973 , C12Q2563/173 , C12Q2563/179

2. 发明公开

EP2808399A1 Soluble analyte detection and amplification 有权
标题翻译： Nachweis undVerstärkunglöslicher分析
公开(公告)号：EP2808399A1
公开(公告)日：2014-12-03
申请号：EP14171566.4
申请日：2004-08-31
申请人： Restalyst Pte Ltd
发明人： Lawton, Robert L
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6804 , Y10S435/971 , Y10S435/973 , C12Q2563/173 , C12Q2563/179
摘要： The present invention relates to a method of detection of a compound of interest that is present at low levels in a sample. In particular, the present invention relates to a method of detection of a compound of interest in solution by a nucleic acid-labelled binding construct, separation of the unbound nucleic acid-labelled binding construct, and the detection of the bound nucleic acid-labelled binding construct in the solution phase. The present invention is particularly adaptable to be used in conjunction with a nucleic acid amplification reaction for detecting the presence or absence of the nucleic acid portion of binding construct in a sample indicating the presence or absence of the compound of interest.
摘要翻译：本发明涉及在样本中以低水平存在的目标化合物的检测方法。特别地，本发明涉及通过核酸标记的结合构建体检测溶液中感兴趣的化合物的方法，分离未结合的核酸标记的结合构建体以及检测结合的核酸标记的结合在溶液相中构建。本发明特别适合与核酸扩增反应结合使用，用于检测在表明存在或不存在感兴趣化合物的样品中结合构建体的核酸部分的存在或不存在。

3. 发明授权

EP0935140B1 Novel methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays 失效
标题翻译：一种用于肌钙蛋白的测定方法I和T和肌钙蛋白I的复合物和T和抗体的选择用于在免疫测定中使用
公开(公告)号：EP0935140B1
公开(公告)日：2013-10-02
申请号：EP99106629.1
申请日：1996-04-18
申请人： Alere San Diego, Inc.
发明人： Buechler, Kenneth F. , McPherson, Paul H.
IPC分类号： G01N33/68 , G01N33/53 , C07K16/18
CPC分类号： G01N33/6887 , G01N2800/32 , Y10S435/96 , Y10S435/961 , Y10S435/962 , Y10S435/971 , Y10S435/973 , Y10S436/811 , Y10S436/819

4. 发明授权

EP0821794B2 NOVEL METHODS FOR THE ASSAY OF TROPONIN I AND T AND COMPLEXES OF TROPONIN I AND T AND SELECTION OF ANTIBODIES FOR USE IN IMMUNOASSAYS 失效
标题翻译：方法用于分析肌钙蛋白I和T和肌钙蛋白I的复和T和抗体的FOR USE免疫测定法选择
公开(公告)号：EP0821794B2
公开(公告)日：2010-08-11
申请号：EP96913812.2
申请日：1996-04-18
申请人： Biosite Incorporated
发明人： BUECHLER, Kenneth, F. , McPHERSON, Paul, H.
IPC分类号： G01N33/68 , G01N33/543 , G01N33/58 , C07K14/47
CPC分类号： G01N33/6887 , G01N2800/32 , Y10S435/96 , Y10S435/961 , Y10S435/962 , Y10S435/971 , Y10S435/973 , Y10S436/811 , Y10S436/819

5. 发明公开

EP1950564A1 Mutiple immunochemistry assays on an element 审中-公开
标题翻译： Mehrfache Immunochemie-Assays auf einem Element
公开(公告)号：EP1950564A1
公开(公告)日：2008-07-30
申请号：EP08250101.6
申请日：2008-01-09
申请人： ORTHO-CLINICAL DIAGNOSTICS, INC.
发明人： Jacobs, Merrit N.
IPC分类号： G01N33/53 , G01N33/543
CPC分类号： G01N33/54386 , Y10S435/96 , Y10S435/969 , Y10S435/971 , Y10S435/973
摘要： A method of analyzing a sample for one or more analytes of interest includes: providing an element having a base layer; a layer containing streptavidin; a spreading layer, wherein the streptavidin may or may not be in the spreading layer; providing immunocomponents and labeled immunoreactants which may be in the spreading layer or may be combined with the sample; dispensing the sample, and optionally the immunocomponents and a labeled immunoreactant onto the spreading layer at three or more areas, wherein each center of the three or more areas is substantially equidistance to the center formed by the three or more areas, and wherein each area contacts an adjacent area such that wash fluid flow in any direction will contact sample; washing the sample and label by directing the wash fluid at the center formed by the three or more areas, whereby the wash fluid equally flows over each of the three or more areas; and taking a measurement at each three or more areas to determine the presence or concentration of the one or more analyte. In a preferred embodiment, the element is a dry slide used on a diagnostic analyzer.
摘要翻译：分析一种或多种感兴趣分析物的样品的方法包括：提供具有基础层的元件; 含有链霉亲和素的层; 扩散层，其中所述链霉抗生物素蛋白可以或不在扩散层中; 提供可以在扩散层中或可以与样品组合的免疫组分和标记的免疫反应物; 将样品和任选地将免疫组分和标记的免疫反应物分配到三个或更多个区域的扩散层上，其中三个或更多个区域的每个中心与由三个或更多个区域形成的中心基本上等距，并且其中每个区域接触相邻区域使得洗涤流体沿任何方向流动将接触样品; 通过将清洗流体引导到由三个或更多个区域形成的中心处洗涤样品和标签，由此洗涤流体均匀地流过三个或更多个区域中的每一个; 并且在每个三个或更多个区域进行测量以确定一种或多种分析物的存在或浓度。在优选实施例中，该元件是用于诊断分析器的干滑片。

6. 发明授权

EP1042675B1 Methods for the stabilisation and measurement of troponin complexes 有权
标题翻译：一种用于肌钙蛋白的稳定化和测量过程
公开(公告)号：EP1042675B1
公开(公告)日：2007-01-31
申请号：EP98964095.8
申请日：1998-12-18
申请人： Biosite Incorporated
发明人： BUECHLER, Kenneth, F. , MCPHERSON, Paul, H.
IPC分类号： G01N33/68
CPC分类号： G01N33/6887 , G01N2333/4712 , Y10S435/96 , Y10S435/962 , Y10S435/971 , Y10S435/973 , Y10S436/811 , Y10S436/819
摘要： The invention relates in part to methods and compositions for identifying the presence, measuring the amount, stabilizing, and facilitating recovery of troponin complexes or individual troponin isoforms in a sample.

7. 发明公开

EP1699934A2 SOLUBLE ANALYTE DETECTION AND AMPLIFICATION 审中-公开
标题翻译：检测与放大可溶性分析物
公开(公告)号：EP1699934A2
公开(公告)日：2006-09-13
申请号：EP04782696.1
申请日：2004-08-31
申请人： Lawton, Robert L.
发明人： Lawton, Robert L.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6804 , Y10S435/971 , Y10S435/973 , C12Q2563/173 , C12Q2563/179
摘要： The present invention relates to a method of detection of a compound of interest that is present at low levels in a sample. In particular, the present invention relates to a method of detection of a compound of interest in solution by a nucleic acid-labelled binding construct, separation of the unbound nucleic acid-labelled binding construct, and the detection of the bound nucleic acid-labelled binding construct in the solution phase. The present invention is particularly adaptable to be used in conjunction with a nucleic acid amplification reaction for detecting the presence or absence of the nucleic acid portion of binding construct in a sample indicating the presence or absence of the compound of interest.

8. 发明授权

EP1111389B1 Utilisation d'un anticorps spécifique des fibroblastes papillaires comme marqueur de qualité d'une peau 有权
标题翻译： Papillarfibroblast使用特异性抗体作为皮肤质量的标志物
公开(公告)号：EP1111389B1
公开(公告)日：2006-03-01
申请号：EP00403310.6
申请日：2000-12-04
申请人： L'OREAL
发明人： Asselineau, Daniel , Caplan, Arnold
IPC分类号： G01N33/68 , G01N33/53
CPC分类号： G01N33/6881 , G01N2400/40 , G01N2800/20 , Y10S435/971

9. 发明公开

EP1409713A4 ASSAY FOR MEASURING FACTOR VIIa-ANTITHROMBIN COMPLEXES 有权
标题翻译：比色法检测凝血因子Ⅶa/抗凝血酶复合物
公开(公告)号：EP1409713A4
公开(公告)日：2004-09-22
申请号：EP02763220
申请日：2002-07-02
申请人： OKLAHOMA MED RES FOUND
发明人： MORRISSEY JAMES H
IPC分类号： G01N33/53 , C07K16/36 , C07K16/40 , C12N5/10 , C12N15/02 , C12P21/08 , C12Q1/56 , G01N33/543 , G01N33/577 , G01N33/86 , C12Q1/37
CPC分类号： G01N33/54306 , C07K16/40 , C12Q1/56 , G01N33/86 , G01N2800/52 , Y10S435/971 , Y10S435/973 , Y10T436/106664
摘要： A method for determining the concentration of factor VIIa-antithrombin complexes is disclosed which has application to estimating the level of intravascular exposure of tissue factor, assessing patient risk for hypercoagulation or other coagulopathies, and monitoring patients for factor VIIa-antithrombin complexes over time which can reveal changes in risk for hypercoagulation or other coagulopathies and/or effectiveness of anticoagulant therapy. Antibodies suitable for use in an in vitro assay for determining the concentration of factor VIIa-antithrombin complexes and methods for making the same are also disclosed.

10. 发明公开

EP1456661A1 BINDING ASSAY DEVICE WITH NON-ABSORBENT CARRIER MATERIAL 有权
标题翻译：具有不吸水打底结合分析DEVICE
公开(公告)号：EP1456661A1
公开(公告)日：2004-09-15
申请号：EP02791407.6
申请日：2002-12-12
申请人： Varian, Inc.
发明人： BACHAND, Steven, S.
IPC分类号： G01N33/558
CPC分类号： G01N33/558 , Y10S435/97 , Y10S435/971 , Y10S436/81
摘要： A binding assay device includes a porous membrane comprising a material enabling capillary movement of a liquid sample from a first area on the membrane on a second area on the membrane. A detection site is disposed on the membrane between the first and second areas in a non-absorbent medium disposed on the membrane between the detection site and the membrane first area is attached by an adhesion with a dry reagent disposed between the medium and the membrane in order to enable mobilization of the reagent by passage of a liquid sample therepast.

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