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1. 发明授权

EP2336772B1 METHODS FOR PREDICTING PREGNANCY OUTCOME IN A SUBJECT BY HCG ASSAY 有权
标题翻译： HCG分析预测受试者妊娠结局的方法
公开(公告)号：EP2336772B1
公开(公告)日：2017-06-28
申请号：EP10184567.5
申请日：1999-02-03
申请人： The Trustees of Columbia University in the City of New York
发明人： O'Connor, John F. , Kovalevskaya, Galina I. , Birken, Steven
IPC分类号： G01N33/53
CPC分类号： G01N33/76 , C07K14/59 , C07K16/26 , G01N33/57434 , G01N33/57449 , G01N2333/59 , Y10S435/971 , Y10S436/811 , Y10S436/814 , Y10S436/818

2. 发明授权

EP1183390B1 METHODS FOR PREDICTING PREGNANCY OUTCOME IN A SUBJECT BY hCG ASSAY 有权
标题翻译：通过hCG测定法预测受试者妊娠结局的方法
公开(公告)号：EP1183390B1
公开(公告)日：2006-01-04
申请号：EP00935949.8
申请日：2000-05-12
申请人： The Trustees of Columbia University in the City of New York
发明人： O'CONNOR, John , BIRKEN, Steven , KOVALEVSKAYA, Galina
IPC分类号： C12Q1/68 , C12Q1/70 , G01N21/64 , G01N33/00 , G01N33/53 , G01N33/531 , G01N33/533 , G01N33/543 , C07H21/02 , C07H21/04 , C12N15/00 , B05D1/18 , B01J13/00
CPC分类号： G01N33/76 , C07K16/26 , G01N33/57434 , G01N33/57449 , G01N2333/59 , G01N2800/368 , Y10S436/814 , Y10S436/818
摘要： The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample.
摘要翻译：本发明提供了通过确定样品中hCG的早孕相关分子同种型的量来预测受试者的妊娠结果的方法。本发明进一步提供了用于确定样品中人绒毛膜促性腺激素（hCG）的早孕相关分子同种型的量的方法。本发明还提供了用于确定样品中早期妊娠相关hCG量的诊断试剂盒。本发明另外提供了特异性结合人早孕相关的人绒毛膜促性腺激素分子同种型的抗体。最后，本发明提供了检测样品中滋养层或非滋养层恶性肿瘤的方法。

3. 发明公开

EP1057000A4 METHODS FOR PREDICTING PREGNANCY OUTCOME IN A SUBJECT BY hCG ASSAY 审中-公开
标题翻译： FOR VOHERSAGE妊娠结果的方式等在实验中使用的人一HCG试验
公开(公告)号：EP1057000A4
公开(公告)日：2003-06-11
申请号：EP99925541
申请日：1999-02-03
申请人： UNIV COLUMBIA
发明人： O'CONNOR JOHN F , KOVALEVSKAYA GALINA I , BIRKEN STEVEN
IPC分类号： G01N33/53 , C12N15/02 , G01N33/577 , G01N33/76
CPC分类号： G01N33/76 , C07K14/59 , C07K16/26 , G01N33/57434 , G01N33/57449 , G01N2333/59 , Y10S435/971 , Y10S436/811 , Y10S436/814 , Y10S436/818
摘要： The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample.

4. 发明公开

EP1307134A1 DIAGNOSTIC DEVICE FOR DISTINGUISHING BETWEEN NORMAL AND ECTOPIC PREGNANCY AND METHOD FOR PREPARING THE SAME 有权
标题翻译：诊断仪之间的正常妊娠和异位DISTINCTION
公开(公告)号：EP1307134A1
公开(公告)日：2003-05-07
申请号：EP01957025.8
申请日：2001-08-10
申请人： Humasis Co.,Ltd.
发明人： CHANG, Jin-Dong , CHA, Jung-Hak , NAM, Jung-Hyun
IPC分类号： A61B5/00 , G01N33/53
CPC分类号： G01N33/76 , A61B8/0866 , A61B10/0012 , G01N33/558 , G01N33/689 , G01N2800/368 , Y10S436/818
摘要： The present invention provides one-step pregnancy diagnosis devices which can simultaneously detect and distinguish between normal pregnancy and ectopic pregnancy and methods of preparing the devices. According to the present invention, normal pregnancy and ectopic pregnancy can be rapidly and accurately determined at an early stage by immunologically detecting the morphological differences between human chorionic gonadotropin (hCG) and modified forms thereof which are secreted into the body fluid of a pregnant female.

5. 发明公开

EP1183390A1 METHODS FOR PREDICTING PREGNANCY OUTCOME IN A SUBJECT BY hCG ASSAY 有权
标题翻译： FOR VOHERSAGE妊娠结果的方式等在实验中使用的人一HCG试验
公开(公告)号：EP1183390A1
公开(公告)日：2002-03-06
申请号：EP00935949.8
申请日：2000-05-12
申请人： The Trustees of Columbia University in the City of New York
发明人： O'CONNOR, John , BIRKEN, Steven , KOVALEVSKAYA, Galina
IPC分类号： C12Q1/68 , C12Q1/70 , G01N21/64 , G01N33/00 , G01N33/53 , G01N33/531 , G01N33/533 , G01N33/543 , C07H21/02 , C07H21/04 , C12N15/00 , B05D1/18 , B01J13/00
CPC分类号： G01N33/76 , C07K16/26 , G01N33/57434 , G01N33/57449 , G01N2333/59 , G01N2800/368 , Y10S436/814 , Y10S436/818
摘要： The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample.

6. 发明公开

EP1141703A1 METHODS OF DETERMINING AN INCREASED RISK OF A WOMAN CARRYING A DOWNS SYNDROME 有权
标题翻译：一种用于确定女性的甲风险增加，随着“唐氏综合征” A胎儿WEAR
公开(公告)号：EP1141703A1
公开(公告)日：2001-10-10
申请号：EP00904286.2
申请日：2000-01-10
申请人： Quest Diagnostics Investments Incorporated
发明人： PANDIAN, M., R.
IPC分类号： G01N33/48 , G01N33/00 , G01N33/53 , G01N33/573 , C12Q1/00
CPC分类号： G01N33/74 , Y10S436/814 , Y10S436/817 , Y10S436/818
摘要： There are provided methods for assaying biological specimens for one or more of leptin, prorenin or renin in order to provide predictive information about the likelihood of a woman carrying a Downs Syndrome affected fetus.

7. 发明授权

EP0627082B1 ANTENATAL SCREENING FOR CHROMOSOMAL ABNORMALITIES 失效
标题翻译：测试之前出生染色体异常
公开(公告)号：EP0627082B1
公开(公告)日：2000-03-22
申请号：EP94901864.2
申请日：1993-11-24
申请人： KODAK LIMITED , Johnson & Johnson Clinical Diagnostics, Inc.
发明人： DAVIES, Christopher John
IPC分类号： G01N33/76 , G01N33/68 , G01N33/74
CPC分类号： G01N33/74 , G01N33/689 , G01N33/743 , G01N33/76 , G01N2800/368 , G01N2800/387 , G06F19/00 , G06Q50/22 , Y10S436/811 , Y10S436/817 , Y10S436/818
摘要： A method for antenatal screening for chromosomal abnormalities in which maternal blood from a pregnant woman is measured for levels of free beta hCG and at least a second serum marker and/or precursors and metabolites of these markers and the measured levels of these markers together with the gestational age of the pregnant woman are compared to reference values at various gestational ages of the levels for free beta hCG and the second serum marker in (a) pregnant women carrying foetuses having the abnormalitie(s) subject to the screen and (b) pregnant women carrying normal foetuses, the comparison being indicative of the risk of the pregnant woman carrying a foetus with an abnormality subject to the screen characterised in that the second serum marker is pregnancy associated plasma protein A (PAPPA) and the screen is carried out by the end of the thirteenth (13th) completed week of pregnancy.

8. 发明公开

EP0923730A1 PRENATAL SCREENING FOR DOWN'S SYNDROME USING HYPERGLYCOSYLATED GONADOTROPIN 失效
标题翻译：产前唐氏综合症测试程序下的使用HYPERGLYKOSYLIERTEM促性腺激素
公开(公告)号：EP0923730A1
公开(公告)日：1999-06-23
申请号：EP97943383.0
申请日：1997-09-05
申请人： Yale University
发明人： COLE, Laurence, A.
IPC分类号： G01N33
CPC分类号： G01N33/76 , Y10S435/806 , Y10S436/808 , Y10S436/813 , Y10S436/814 , Y10S436/817 , Y10S436/818
摘要： A prenatal screening method for Down's syndrome involves assaying for hyperglycosylated gonadotropin in biological test samples such as urine, plasma or serum obtained from pregnant women. Hyperglycosylated gonadotropin comprises a variant population of chorionic gonadotropin, chorionic gonadotropin-free β-subunit, β-core fragment, and/or free α-subunit exhibiting differences in the carbohydrate content from what is observed in samples obtained from pregnant women carrying normal fetuses. Qualitative or quantitative observation of differences in the carbohydrate content of the hyperglycosylated gonadotropin population from corresponding control samples containing a normal gonadotropin population, or direct observation of the variant species seen in Down's syndrome, indicates that the woman's fetus has Down's syndrome. Typical screens involve carbohydrate analyses, immunoassays, or combinations of these methods. Some embodiments employ a lectin such as concanavalin A reactive to the carbohydrate moiety; others employ antibodies to at least one hyperglycosylated gonadotropin species.

9. 发明公开

EP0560410A2 A test device for performing specific binding assays 失效
标题翻译：用于进行特异性结合测定的测试设备
公开(公告)号：EP0560410A2
公开(公告)日：1993-09-15
申请号：EP93108763.9
申请日：1988-04-26
申请人： UNILEVER N.V.
发明人： May, keith , Prior, Michael Evans , Richards, Ianl Evans
IPC分类号： G01N33/52 , G01N33/558 , G01N33/76 , B01L3/00 , G01N33/58
CPC分类号： G01N33/54366 , G01N30/90 , G01N33/54386 , G01N33/548 , G01N33/549 , G01N33/558 , G01N33/58 , G01N33/689 , G01N33/76 , G01N2800/368 , Y10S435/805 , Y10S435/81 , Y10S435/962 , Y10S435/969 , Y10S435/97 , Y10S435/975 , Y10S436/805 , Y10S436/81 , Y10S436/814 , Y10S436/817 , Y10S436/818 , Y10S436/906
摘要： An analytical test device useful for example in pregnancy testing, comprises a hollow casing (500) constructed of moisture-impervious solid material, such as plastics materials, containing a dry porous carrier (510) which communicates indirectly with the exterior of the casing via a bibulous sample receiving member (506) which protrudes from the casing such that a liquid test sample can be applied to the receiving member and permeate therefrom to the porous carrier, the carrier containing in a first zone a labelled specific binding reagent is freely mobile within the porous carrier when in the moist state, and in a second zone spatially distinct from the first zone unlabelled specific binding reagent for the same analyte which unlabelled reagent is permanently immobilised on the carrier material and is therefore not mobile in the moist state, the two zones being arranged such that liquid sample applied to the porous carrier can permeate via the first zone into the second zone, and the device incorporating means, such as an aperture (508) in the casing, enabling the extent (if any) to which the labelled reagent becomes bound in the second zone to be observed. Preferably the device includes a removable cap for the protruding bibulous member.
摘要翻译：用于例如妊娠试验的分析测试装置包括由不透湿的固体材料（例如塑料材料）构成的中空壳体（500），其包含干多孔载体（510），该载体通过吸水样品接收构件（506），其从壳体突出，使得液体测试样品可以施加到接收构件并从其渗透到多孔载体，载体在第一区域中包含标记的特异性结合试剂，多孔载体处于潮湿状态时，以及在与第一区域空间上不同的第二区域中，未标记试剂永久固定在载体材料上并因此在潮湿状态下不能移动的相同分析物的未标记特异性结合试剂，两个区域被布置成使得施加到多孔载体的液体样品可以经由第一区域渗透到第二区域中，装置包含诸如壳体中的孔（508）的装置，使得能够观察到标记试剂在第二区域中结合的程度（如果有的话）。优选地，该装置包括用于突出的吸水部件的可移除的帽。

10. 发明授权

EP0249357B1 Methods of immunoassay 失效
标题翻译：免疫方法
公开(公告)号：EP0249357B1
公开(公告)日：1993-08-18
申请号：EP87304644.5
申请日：1987-05-26
申请人： ARS Holding 89 N.V.
发明人： Philo, Roger David
IPC分类号： G01N33/53 , G01N33/78 , G01N33/577 , G01N33/537 , G01N33/76
CPC分类号： G01N33/581 , G01N33/535 , Y10S435/962 , Y10S435/973 , Y10S436/818

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