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    • 50. 发明公开
    • FINE PARTICLE PRODUCTION METHOD
    • FEINPARTIKELHERSTELLUNGSVERFAHREN
    • EP3112017A1
    • 2017-01-04
    • EP15752000.8
    • 2015-02-18
    • M Technique Co., Ltd.
    • ENOMURA Masakazu
    • B01J19/00C09B48/00C09B67/14C09B67/20A61K31/405
    • B01F1/0011A61K31/405B01F3/0807B01F7/00775B01F7/164B01F7/166B01F7/1675B01F7/247B01F15/00175B01F15/00376B01F2001/0072B01F2215/005B01J4/002B01J19/0066B01J19/18B01J19/1887B01J2219/00772B01J2219/00779C09B67/0036C09B67/009C09B67/0095C09B67/0097
    • This fine particle production method involves a dissolving step in which a stirrer having a rotating stirring blade is used to dissolve at least one type of fine particle raw material in a solvent to obtain a fine particle raw material solution, and a precipitation step in which the fine particle raw material solution and at least one type of precipitation solvent for precipitating the fine particle raw material from the fine particle raw material solution are introduced between at least two treatment surfaces which are arranged oppositely one another, can move closer to and farther apart from one another, and at least one of which can rotate relative to the other, and the fine particle raw material solution and the at least one type of precipitation solvent are mixed in a thin film fluid formed between the at least two treatment surfaces, and the fine particles are precipitated. The stirring energy is determined by the stirring time conditions of the stirrer, the circumferential velocity conditions of the stirring blade, and the temperature conditions of the fine particle raw material solution, and in the dissolving step, the stirring energy is varied by changing at least one of the aforementioned conditions, and by changing the stirring energy, the degree of crystallization and the crystal form of the fine particles obtained in the precipitation step are controlled.
    • 这种微粒生产方法包括一种溶解步骤,其中使用具有旋转搅拌叶片的搅拌器将至少一种类型的细颗粒原料溶解在溶剂中以获得细颗粒原料溶液,并且沉淀步骤,其中 微粒原料溶液和至少一种用于使细粒原料溶液中的微粒原料沉淀的沉淀溶剂引入到彼此相对布置的至少两个处理表面之间,可以更靠近并远离 并且其中至少一个可以相对于另一个旋转,并且将细颗粒原料溶液和至少一种沉淀溶剂混合在形成在至少两个处理表面之间的薄膜流体中,并且 细颗粒沉淀。 通过搅拌器的搅拌时间条件,搅拌叶片的圆周速度条件和微粒原料溶液的温度条件来确定搅拌能量,并且在溶解步骤中,搅拌能量通过至少改变 上述条件之一,并且通过改变在沉淀步骤中获得的微粒的搅拌能量,结晶度和晶体形状来控制。