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41. 发明授权

EP2455077B1 PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR DYSMENORRHEA 有权转让
标题翻译：预防和/或处理剂痛经
公开(公告)号：EP2455077B1
公开(公告)日：2014-06-11
申请号：EP10789558.3
申请日：2010-06-17
申请人： National University Corporation Kumamoto University , Keio University , Link Genomics, Inc.
发明人： KATABUCHI Hidetaka , HONDA Ritsuo , SAYA Hideyuki , ARIMA Yoshimi , NIWA Shinichiro , MAKINO Yasutaka
IPC分类号： A61K31/196 , A61P1/10 , A61P1/12 , A61P7/06 , A61P15/00 , A61P25/04 , A61P25/18 , A61P29/00
CPC分类号： A61K31/196

42. 发明公开

EP2733204A1 METHOD FOR PRODUCING PLURIPOTENT CELL USING BACTERIUM HAVING FERMENTATION ABILITY 审中-公开
标题翻译：方法用于生产具有FERMENTATIONSFÄHIGEM细菌多能细胞
公开(公告)号：EP2733204A1
公开(公告)日：2014-05-21
申请号：EP12811861.9
申请日：2012-07-10
申请人： National University Corporation Kumamoto University
发明人： OHTA Kunimasa
IPC分类号： C12N5/074 , A61K35/74 , A61P35/00 , C12N5/071 , C12N5/0775 , C12N5/09 , C12N1/20
CPC分类号： C12N5/0696 , A61K35/744 , A61K35/747 , C12N1/38 , C12N2500/72 , C12N2502/70 , C12P39/00 , G01N33/5011
摘要： It is an object of the present invention to provide a method for producing pluripotent cells that are free of the risk of cellular canceration and that can be applied to regenerative medicine with a high degree of safety. The present invention provides a method for producing pluripotent cells from somatic cells comprising a step of bringing bacteria having fermentation ability or a component or secretory product thereof into contact with somatic cells.

43. 发明公开

EP2636731A1 METHOD OF PRODUCING INTESTINAL CELLS 有权转让
标题翻译： VERFAHREN ZUR HERSTELLUNG VON DARMZELLEN
公开(公告)号：EP2636731A1
公开(公告)日：2013-09-11
申请号：EP11837965.0
申请日：2011-10-31
申请人： National University Corporation Kumamoto University
发明人： KUME Shoen , OGAKI Soichiro , SHIRAKI Nobuaki , KUME Kazuhiko
IPC分类号： C12N5/073 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50
CPC分类号： C12N5/0679 , C12N2501/115 , C12N2501/117 , C12N2501/119 , C12N2501/16 , C12N2501/415 , C12N2501/42 , C12N2501/999 , C12N2502/13 , C12N2506/02 , C12Q1/6881 , C12Q2600/158 , G01N33/5064 , G01N33/5073 , G01N2500/00
摘要： An object of the present invention is to provide a method of producing intestinal cells by use of pluripotent stem cells as a starting material. According to the present invention, provided is a method of producing intestinal cells, comprising the steps of: (A) inducing differentiation of pluripotent stem cells into definitive endoderm cells; and (B) culturing the definitive endoderm cells in the presence of (2'Z, 3'E)-6-bromoindirubin-3-oxime (BIO) and N-[(3,5-difluorophenyl)acetyl]-L-Ala-2-phenyl-L-Gly-tert-butyl-OH (DAPT) to thereby induce differentiation of the definitive endoderm cells into intestinal cells.
摘要翻译：本发明的目的是提供通过使用多能干细胞作为起始材料来生产肠细胞的方法。根据本发明，提供了一种生产肠细胞的方法，包括以下步骤：（A）诱导多能干细胞分化为定形内胚层细胞; 和（B）在（2'Z，3'E）-6-溴靛玉红-3-肟（BIO）和N - [（3,5-二氟苯基）乙酰基] -L-丙氨酸存在下培养定形内胚层细胞 -2-苯基-L-Gly-叔丁基-OH（DAPT），从而诱导将定形内胚层细胞分化成肠细胞。

44. 发明公开

EP2623594A1 ANTIBODY AGAINST HUMAN PROSTAGLANDIN E2 RECEPTOR EP4 有权
标题翻译：抗生素GEGEN DEN人类PROSTAGLANDIN-E2-REZEPTOR EP4
公开(公告)号：EP2623594A1
公开(公告)日：2013-08-07
申请号：EP11829187.1
申请日：2011-09-28
申请人： NB Health Laboratory Co. Ltd. , National University Corporation Kumamoto University
发明人： TAKAYAMA, Kiyoshi , SHIMIZU, Tomoko , URUSHIBATA, Yuji , SUGIMOTO, Yukihiko
IPC分类号： C12N15/09 , A61K39/395 , A61P29/00 , A61P35/00 , A61P37/02 , C07K16/28 , C07K17/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , G01N33/53 , C12P21/08
CPC分类号： C07K16/28 , C07K16/2869 , C07K17/00 , C07K2317/24 , C07K2317/76 , G01N33/88
摘要： It is an object of the present invention to provide an antibody that binds to a human PGE 2 receptor subtype EP4 and inhibits the function of EP4, or a functional fragment thereof. It is another object of the present invention to provide a medicament comprising the aforementioned antibody or a functional fragment thereof. Mice were immunized with the human PGE 2 receptor subtype EP4, and a monoclonal antibody that suppresses the intracellular cAMP level increase induced by EP4 was screened. In addition, the CDR sequences of the obtained monoclonal antibody were determined.
摘要翻译：本发明的目的是提供结合人PGE 2受体亚型EP4并抑制EP4的功能的抗体或其功能片段。本发明的另一个目的是提供一种包含上述抗体或其功能片段的药物。用人PGE 2受体亚型EP4免疫小鼠，并筛选抑制EP4诱导的细胞内cAMP水平升高的单克隆抗体。另外，测定得到的单克隆抗体的CDR序列。

45. 发明公开

EP2402305A1 LOXOPROFEN DERIVATIVE AND PHARMACEUTICAL CONTAINING SAME 有权
标题翻译：洛索洛芬衍生物和含有它的药物
公开(公告)号：EP2402305A1
公开(公告)日：2012-01-04
申请号：EP10746132.9
申请日：2010-02-18
申请人： National University Corporation Kumamoto University , LTT Bio-Pharma Co., Ltd.
发明人： MIZUSHIMA, Toru , OHTSUKA, Masami , OKAMOTO, Yoshinari , YAMAKAWA, Naoki
IPC分类号： C07C59/88 , A61K31/192 , A61K31/194 , A61K31/235 , A61P29/00 , C07C59/54 , C07C59/56 , C07C59/86 , C07C59/90 , C07C205/56 , C07C229/42 , C07C323/62
CPC分类号： C07C205/56 , C07B2200/07 , C07C59/54 , C07C59/56 , C07C59/88 , C07C59/90 , C07C65/36 , C07C69/757 , C07C69/76 , C07C229/42 , C07C323/62 , C07C2601/08
摘要： There is provided a novel loxoprofen derivative that has no side effect such as a gastrointestinal disorder and also has excellent anti-inflammatory and analgesic effects and is represented by the following formula (I) or (II):

(wherein R 1 and R 2 each represent a halogen atom or a substituted or unsubstituted phenyl group)
or a pharmacologically acceptable salt thereof. In the derivative, the halogen atom is selected from a chlorine atom, a bromine atom, a fluorine atom, and an iodine atom, and a substituent of the substituted phenyl group is a halogen atom, a hydroxyl group, a substituted or unsubstituted lower alkyl group, a lower alkylthio group, a lower alkoxy group, a nitro group, an amino group, or a carboxyl group.
摘要翻译：本发明提供一种新型的洛索洛芬衍生物，其不具有胃肠疾病等副作用，并且还具有优异的抗炎镇痛作用，并且由下式（I）或（II）表示：（其中R 1和R 2各自表示卤素原子或取代或未取代的苯基）或其药理学上可接受的盐。在衍生物中，卤素原子选自氯原子，溴原子，氟原子和碘原子，取代苯基的取代基为卤原子，羟基，取代或未取代的低级烷基基团，低级烷硫基，低级烷氧基，硝基，氨基或羧基。

46. 发明公开

EP2380492A1 PHASE DIFFERENCE ENHANCED IMAGING METHOD (PADRE), FUNCTIONAL IMAGE CREATING METHOD, PHASE DIFFERENCE ENHANCED IMAGING PROGRAM, PHASE DIFFERENCE ENHANCED IMAGING APPARATUS, FUNCTIONAL IMAGE CREATING APPARATUS, AND MAGNETIC RESONANCE IMAGING (MRI) APPARATUS 审中-公开
标题翻译：相移钢筋成像方法（PADRE），用于产生功能性的图像处理，移相IMAGING加强方案的相移钢筋成像装置中，制造装置功能图像及摄像装置磁
公开(公告)号：EP2380492A1
公开(公告)日：2011-10-26
申请号：EP09834726.3
申请日：2009-12-11
申请人： National University Corporation Kumamoto University
发明人： YONEDA, Tetsuya , HIAI, Yasuhiro
IPC分类号： A61B5/055 , G01R33/54
CPC分类号： G01R33/56 , G01R33/4806 , G01R33/5608
摘要： A functional image creating method and a functional image creating apparatus, each enabling rendering of an activated region, are provided. A phase difference image PDr(x) is created using a complex image σr(x) created from an MR signal in an inactive state and a complex image σ'r(x) obtained by filtering the complex image σr(x). A phase difference image PDa(x) is created using a complex image σa(x) created from an MR signal in an active state and a complex image σ'a(x) obtained by filtering the complex image σa(x). Function signal images diff1(x) and diff2(x) are created using the phase difference images PDr(x) and PDa(x), respectively. A magnitude image Mr(x), a magnitude image Ma(x), a standard image, or a morphological image I(x) is masked with the function signal image diff1(x) or diff2(x), thereby a function image I'(x) with an activated region rendered is created.

47. 发明公开

EP1925684A3 Magnesium alloy material and production thereof 有权
标题翻译：镁合金材料及其制造方法
公开(公告)号：EP1925684A3
公开(公告)日：2010-08-04
申请号：EP07022572.7
申请日：2007-11-21
申请人： KABUSHIKI KAISHA KOBE SEIKO SHO , Nissan Motor Company Limited , National University Corporation Kumamoto University
发明人： Nakata, Mamoru , Yamada, Yuuichi , Itakura, Koji , Okada, Yoshio , Kawamura, Yoshihito , Yamasaki, Michiaki
IPC分类号： C22C23/06 , C22F1/06 , C22C23/04
CPC分类号： C22C23/06 , C22C23/04 , C22F1/06
摘要： The present invention provides a magnesium alloy material, having superior mechanical properties without using special production equipment or processes, and a production process thereof. The magnesium alloy material of the present invention composed of an Mg-Zn-RE alloy comprises essential components in the form of 0.5 to 3 atomic percent of Zn and 1 to 5 atomic percent of RE, with the remainder comprising Mg and unavoidable impurities. The Mg-Zn-RE alloy has a lamellar phase formed from a long period stacking ordered structure and α-Mg in the alloy structure thereof. The long period stacking ordered structure has at least one of a curved portion and a bent portion and has a divided portion in at least a portion thereof. Finely granulated α-Mg having a mean particle diameter of 2 µm or less is formed in the divided portion.

48. 发明公开

EP2155365A1 OXYGEN STORAGE/RELEASE MATERIAL AND EXHAUST GAS PURIFYING CATALYST COMPRISING THE SAME 有权
标题翻译：材料是氧气储存/分布与该材料含催化剂排放
公开(公告)号：EP2155365A1
公开(公告)日：2010-02-24
申请号：EP08764548.7
申请日：2008-05-16
申请人： National University Corporation Kumamoto University , Toyota Jidosha Kabushiki Kaisha
发明人： MACHIDA, Masato , IKEUE, Keita , MIURA, Masahide
IPC分类号： B01D53/94 , B01J23/10 , B01J23/63 , B01J27/02 , B01J27/053
CPC分类号： B01J23/10 , B01D53/945 , B01D2255/206 , B01D2255/908 , B01J23/63 , B01J27/053 , B01J37/03 , C01B13/0262 , C01B13/0281 , C01F17/0081 , C01F17/0093 , C01P2002/50 , Y02T10/22
摘要： There is provided an oxygen storage/release material using a rare earth oxysulfate or oxysulfide, which has a high oxygen storage/release capacity even at lower temperatures. The oxygen storage/release material of the present invention comprises a compound consisting of Pr2O2SO4 and/or Pr2O2S in which at least a part of Pr is replaced with Ce.
摘要翻译：本发明提供关于使用的稀土类含氧硫酸盐或氧硫化物氧储存/释放材料，其甚至在较低温度下具有高的氧储存/释放能力。本发明的氧储存/释放材料包括由Pr2O2SO4和/或Pr2O2S的化合物，其中至少镨的一部分被Ce取代。

49. 发明公开

EP2011560A1 METHOD FOR SEPARATING AND ENRICHING ISOTOPE MATERIAL, MULTISTAGE ROTOR, AND APPARATUS FOR SEPARATING AND ENRICHING ISOTOPE MATERIAL 审中-公开
标题翻译：方法一种用于切割和丰富ISOTOP材料的切割和丰富ISOTOP材料，多级转子和设备
公开(公告)号：EP2011560A1
公开(公告)日：2009-01-07
申请号：EP07741008.2
申请日：2007-04-04
申请人： National University Corporation Kumamoto University , Maruwa Electronic Inc.
发明人： MASHIMO, Tsutomu , ONO, Masao , HUANG, Xinsheng , IGUCHI, Yusuke , OKAYASU, Satoru , YASUOKA, Hiroshi , SHIBASAKI, Koji , SUEYOSHI, Masanori
IPC分类号： B01D59/20 , B01J19/00 , B04B5/02 , B04B15/02 , C22F3/00 , C23C10/28
CPC分类号： C23C26/00 , B01D59/20 , C22F3/00 , C23C10/18 , C23C10/28 , Y10S494/90
摘要： This invention provides a method for separating and enriching isotopes in an efficient and low-cost manner from a condensation-system (liquid or/and solid) material comprising two or more different isotopes by taking advantage of the sedimentation of atoms through an acceleration field by ultra-high speed rotation. A condensation-system (liquid or/and solid) material (5) comprising the two or more isotopes is placed in a sedimentation tank (for example, 2) which is then housed in a supercentrifuge. The supercentrifuge in its rotor is rotation driven by an ultra-high speed rotation power source, and an acceleration field of energy of 100000 G to 1500000 G, i.e., about 100 to 800 m/s in terms of peripheral velocity, is applied to the above condensed (liquid or/and solid) material under such a temperature that is specified by an isotope material to be enriched. In this case, a difference in centrifugal force applied is provided between the isotopes in the condensed (liquid or/and solid) material comprising the at least two isotopes. By virtue of sedimentation by taking advantage of this difference, isotope atoms within the condensed material interact, and, consequently, separation and enrichment of the isotopes can be realized in a higher efficiency than the case where gas is used, by conducting the separation and enrichment of the isotopes within the liquid material, using an effective material, and using a multistaged rotor system.
摘要翻译：本发明提供一种方法，用于从冷凝系统中分离和富集同位素高效和低成本的方式（液体或/和固体）材料由通过利用原子的沉降的通过加速度字段，其包括两种或更多种不同的同位素超高速旋转。缩合系统（液体或/和固体）材料（5）包括所述两个或更多个同位素在沉降槽被设置（例如，2）的所有其然后在supercentrifuge饲养。在其转子的supercentrifuge旋转通过在超高速旋转动力源在圆周速度方面驱动，并且在100,000克的能量的加速场至1,500,000 G，即，约100〜800米/秒，施加到上述冷凝（液体或/和固体）在调查通过在同位素材料规定的温度没有材料被富集。在这种情况下，在同位素之间的冷凝提供了离心力应用的差（液体或/和固体），其包括至少两个同位素的材料。借助于沉降的通过利用这种差异，同位素原子的稠合材料相互作用之内，并且，因此，同位素分离和富集可以在比情况下的更高的效率，在使用气体来实现，通过进行分离和富集的液体材料中的同位素的，使用有效的材料制成，并且使用多降期旋翼系统。

50. 发明公开

EP4299521A1 DISPERSION OF EXFOLIATED PARTICLES OF LAYERED POLYSILICATE COMPOUND, AND METHOD FOR PRODUCING SAME 审中-公开
公开(公告)号：EP4299521A1
公开(公告)日：2024-01-03
申请号：EP22759663.2
申请日：2022-02-22
申请人： National University Corporation Kumamoto University , Nissan Chemical Corporation
发明人： IDA, Shintaro , AWAYA, Keisuke , SEKIGUCHI, Kazutoshi , KITAGAWA, Hirotake , YAMADA, Shuhei
IPC分类号： C01B33/38 , H01B1/06 , H01M8/10 , H01M8/1016
摘要： To provide a dispersion of exfoliated particles in which a layered polysilicate compound is interlayer-exfoliated. A dispersion of exfoliated particles which includes at least one nitrogen-containing basic compound (A) which is a tertiary amine or a quaternary ammonium hydroxide having at least one alkyl group having 3 or 4 carbon atoms, and in which exfoliated particles (C) produced by interlayer-exfoliating a proton-type layered polysilicate compound (B) are dispersed in an aqueous solution (D) having 10 vol% to 90 vol% of an alcohol having 1 to 3 carbon atoms; and a film-forming composition, a porous body-forming composition, an LB film, a coating film, a free-standing membrane, a proton conductor, an electrolyte membrane for fuel cells, and a porous body each containing exfoliated particles.

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