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1. 发明公开

EP4299521A1 DISPERSION OF EXFOLIATED PARTICLES OF LAYERED POLYSILICATE COMPOUND, AND METHOD FOR PRODUCING SAME 审中-公开
公开(公告)号：EP4299521A1
公开(公告)日：2024-01-03
申请号：EP22759663.2
申请日：2022-02-22
申请人： National University Corporation Kumamoto University , Nissan Chemical Corporation
发明人： IDA, Shintaro , AWAYA, Keisuke , SEKIGUCHI, Kazutoshi , KITAGAWA, Hirotake , YAMADA, Shuhei
IPC分类号： C01B33/38 , H01B1/06 , H01M8/10 , H01M8/1016
摘要： To provide a dispersion of exfoliated particles in which a layered polysilicate compound is interlayer-exfoliated. A dispersion of exfoliated particles which includes at least one nitrogen-containing basic compound (A) which is a tertiary amine or a quaternary ammonium hydroxide having at least one alkyl group having 3 or 4 carbon atoms, and in which exfoliated particles (C) produced by interlayer-exfoliating a proton-type layered polysilicate compound (B) are dispersed in an aqueous solution (D) having 10 vol% to 90 vol% of an alcohol having 1 to 3 carbon atoms; and a film-forming composition, a porous body-forming composition, an LB film, a coating film, a free-standing membrane, a proton conductor, an electrolyte membrane for fuel cells, and a porous body each containing exfoliated particles.

2. 发明公开

EP4147697A1 NOVEL THERAPEUTIC AGENT FOR VASCULAR DISORDER 审中-公开
公开(公告)号：EP4147697A1
公开(公告)日：2023-03-15
申请号：EP21799741.0
申请日：2021-05-07
申请人： National University Corporation Kumamoto University
发明人： ERA, Takumi , WATANABE, Sayaka , KUSAYANAGI, Tomoe
IPC分类号： A61K31/439 , A61P1/00 , A61P9/00 , A61P9/12 , A61P9/14 , A61P11/00 , A61P13/12 , A61P43/00
摘要： An object is to provide a drug that effectively treats a vascular disorder caused by excessive synthesis and secretion of a type IV collagen protein from a vascular endothelial cell.
Provided are [1] a therapeutic agent for a vascular disorder associated with excessive synthesis and secretion of a type IV collagen protein; [2] a therapeutic agent for a disease caused by excessive synthesis and secretion of a type IV collagen protein; [3] a pharmaceutical composition for treatment of a vascular disorder associated with excessive synthesis and secretion of a type IV collagen protein; [4] a pharmaceutical composition for treatment of a disease caused by excessive synthesis and secretion of a type IV collagen protein from a vascular endothelial cell; and [5] an agent that inhibits excessive synthesis and secretion of a type IV collagen protein from a vascular endothelial cell, each of [1] to [5] containing sirolimus as an active ingredient.

3. 发明公开

EP3858382A1 MUCOSAL ADJUVANT 审中-公开
公开(公告)号：EP3858382A1
公开(公告)日：2021-08-04
申请号：EP19865238.0
申请日：2019-09-26
申请人： Denka Company Limited , National University Corporation Kumamoto University
发明人： MISUMI, Shogo , KISHIMOTO, Naoki , MITSUMATA, Ryotaro , NAKATA, Nagisa , GOTANDA, Takuma
IPC分类号： A61K39/39 , A61K38/06 , A61K39/145 , A61P31/16 , A61P37/04 , A61P43/00 , C07K5/033
摘要： Provided is a mucosal adjuvant which has high mucosal immunogenicity and high safety and is useful in the preparation of mucosal vaccines, and a mucosal vaccine composition comprising the same. The present invention provides a mucosal adjuvant comprising TGDK.

4. 发明授权

EP3101131B1 ANTI-TRANSTHYRETIN HUMANIZED ANTIBODY 有权转让
公开(公告)号：EP3101131B1
公开(公告)日：2020-08-19
申请号：EP15743230.3
申请日：2015-01-23
申请人： KM Biologics Co., Ltd. , National University Corporation Kumamoto University
发明人： HOSOI, Akihiko , TORIKAI, Masaharu , TAKEO, Tomoyo , UENO, Masayo , HIGUCHI, Hirofumi , SOEJIMA, Kenji , NAKASHIMA, Toshihiro , ANDO, Yukio , JONO, Hirofumi , SU, Yu
IPC分类号： C12N15/09 , A61K39/395 , A61P25/28 , C07K16/18 , C12M1/34 , C12N15/02 , C12P21/08 , G01N33/53

5. 发明公开

EP3637037A1 EXPLOSIVE BODY FOR NANODIAMOND SYNTHESIS 审中-公开
公开(公告)号：EP3637037A1
公开(公告)日：2020-04-15
申请号：EP18814226.9
申请日：2018-05-07
申请人： Daicel Corporation , National University Corporation Kumamoto University
发明人： MAHIKO, Tomoaki , INA, Tomohide , ISHIMOTO, Daisuke , HOKAMOTO, Kazuyuki , TANAKA, Shigeru
IPC分类号： F42B1/02 , B01J3/08 , C01B32/26 , C06B25/08
摘要： Provided is an explosive body X, i.e., an explosive body for nanodiamond synthesis, includes at least an explosive main body (10) that includes a frustum part (11) and a columnar part (12). The frustum part (11) includes an upper bottom surface (11a) including an open end of a hole (H), in which a triggering unit is received, and an angled side surface (11b) forming an imaginary apex angle θ on the upper bottom surface (11a) side. The columnar part (12) is formed contiguous with the frustum part (11) on an opposite side of the frustum part (11) to the upper bottom surface (11a) of the frustum part (11) and extends in a direction away from the upper bottom surface (11a). The explosive body for nanodiamond synthesis is suitable for improving the yield in nanodiamond synthesis by a detonation method.

6. 发明授权

EP2894127B1 COMPOSITE MATERIAL, AND METHOD FOR PRODUCING SAME 有权
公开(公告)号：EP2894127B1
公开(公告)日：2020-03-04
申请号：EP13833721.7
申请日：2013-08-30
申请人： Sekisui Chemical Co., Ltd. , National University Corporation Kumamoto University
发明人： NOZATO, Shoji , NAKASUGA, Akira , IHARA, Hirotaka , TAKAFUJI, Makoto , GANAPATHY, Hullathy Subban , FUKUDA, Rika
IPC分类号： B32B9/00 , C08J7/06 , B82Y30/00 , B82Y40/00 , C04B35/524 , C01B32/182

7. 发明授权

EP2987875B1 FIRE-RESISTANT MAGNESIUM ALLOY AND PRODUCTION METHOD THEREFOR 有权
公开(公告)号：EP2987875B1
公开(公告)日：2018-10-10
申请号：EP14785713.0
申请日：2014-04-14
申请人： National University Corporation Kumamoto University
发明人： KAWAMURA, Yoshihito , KIM, Jonghyun
IPC分类号： C22C1/02 , B22D21/04 , B22D27/04 , C22C23/04 , C22C23/06
CPC分类号： C22C23/06 , B22D21/007 , B22D21/04 , B22D27/04 , C22C1/02 , C22C23/04
摘要： A method of manufacturing a flame-retardant magnesium alloy having mechanical properties of a long period stacking ordered magnesium alloy and having an ignition temperature of 800°C or more is provided. The method of manufacturing a flame-retardant magnesium alloy comprises a step of melting a flame-retardant magnesium alloy which contains a atomic% of Zn, b atomic% of Y, x atomic% of Ca and a residue of Mg, and a, b and x satisfy formulae 1 to 4 below. 0.5 ‰¤ a

8. 发明公开

EP3363494A1 DEVICE FOR SUPPRESSING INFLAMMATION AND HYPERIMMUNITY, AND METHOD FOR SUPPRESSING INFLAMMATION AND HYPERIMMUNITY 审中-公开
公开(公告)号：EP3363494A1
公开(公告)日：2018-08-22
申请号：EP16855492.1
申请日：2016-10-13
申请人： National University Corporation Kumamoto University
发明人： KAI, Hirofumi , SHUTO, Tsuyoshi , SUICO Mary ann soten , ARAKI, Eiichi , KONDO, Tatsuya
IPC分类号： A61N1/32
CPC分类号： A61N1/32
摘要： Provided is a new means for suppressing inflammation or suppressing inflammatory cytokine production. Provided is a device in which a weak pulse current is passed through a living body or living tissue to suppress inflammation in the living body or the living tissue. This device is provided with a power supply means, and a current control means for receiving a supply of power to intermittently apply a direct current at prescribed intervals, and is configured such that the current control means includes a pulse width modulation control means, and the pulse width modulation control means generates a pulse wave that is a rectangular wave, and in which the time indicating a peak value for rising in one cycle of the pulse wave ("pulse duration") is at least 0.1 millisecond, the peak value is 1.0-20 V, inclusive, and the duty ratio of the pulse wave is at least 5.5%.

9. 发明授权

EP2644694B1 METHOD AND CULTURE MEDIUM FOR IMPROVING PLURIPOTENT STEM CELL DIFFERENTIATION INDUCING EFFICIENCY 有权
公开(公告)号：EP2644694B1
公开(公告)日：2018-07-11
申请号：EP11836133.6
申请日：2011-10-20
申请人： National University Corporation Kumamoto University
发明人： KUME, Shoen , ENDO, Fumio , SHIRAKI, Nobuaki , SHIRAKI, Yasuko , KUME, Kazuhiko
IPC分类号： C12N5/00 , C12N5/071 , C12N5/0735 , C12N5/10
CPC分类号： C12N5/067 , C12N5/0602 , C12N2500/32 , C12N2506/02 , C12N2506/45 , C12N2533/52
摘要： The purpose of the present invention is to provide a method and a culture medium which are capable of efficiently inducing the differentiation of pluripotent stem cells such as ES cells and iPS cells into desired cells by a simple means. The differentiation of pluripotent stem cells can be induced by culturing mammal-derived pluripotent stem cells in a differentiation culture medium that does not contain at least one amino acid selected from the group consisting of methionine, leucine, cysteine, tyrosine and arginine. Also provided is a differentiation-inducing culture medium which does not contain at least one amino acid selected from the group consisting of methionine, leucine, cysteine, tyrosine and arginine.

10. 发明公开

EP3315136A1 CANCER THERAPEUTIC DRUG AND CANCER TREATMENT METHOD 审中-公开
标题翻译：癌症治疗药物和癌症治疗方法
公开(公告)号：EP3315136A1
公开(公告)日：2018-05-02
申请号：EP16814119.0
申请日：2016-06-02
申请人： National University Corporation Kumamoto University , Tokyo Institute of Technology
发明人： NIIMORI Kanako
IPC分类号： A61K45/00 , A61K31/713 , A61K48/00 , A61P35/00 , A61P35/02 , A61P43/00
CPC分类号： C12N15/1135 , A61K31/713 , A61K45/00 , A61K48/00 , A61K2039/505 , A61P35/00 , C07K16/30 , C12N2310/14
摘要： An object of the present invention is to reveal a role of a stem cell control factor including Matrin-3 in cancer exhibiting neural differentiation including small cell lung cancer, and develop a medicine useful for treating cancer and the like based on the role. Among cancers having the cancer stem cell controlling mechanism, in cancer exhibiting the differentiation potency, the peculiar balance where both of expression of a stem cell maintenance factor and expression of a differentiation promoting factor are higher as compared with normal cells is retained. Additionally, in undifferentiated cancer, the peculiar balance where expression of a stem cell maintenance factor is higher as compared with normal cells is retained. In cancer in which the cancer stem cell controlling mechanism exists, these peculiar balances of a stem cell control factor different from the balance of normal cells exist. In the medicine for treating cancer and the method for treating cancer of the present invention, proliferativeness of cancer is suppressed by breaking down this balance of a stem cell control factor.
摘要翻译：本发明的目的在于揭示含有Matrin-3的干细胞调控因子在表现包括小细胞肺癌在内的神经分化的癌症中的作用，并基于其作用开发用于治疗癌症等的药物。在具有癌症干细胞调控机制的癌症中，在表现出分化潜能的癌症中，与正常细胞相比，保留了干细胞维持因子的表达和分化促进因子的表达均高的特异性平衡。此外，在未分化癌症中，与正常细胞相比，干细胞维持因子的表达更高的特异性平衡被保留。在存在癌症干细胞调控机制的癌症中，存在这些与正常细胞的平衡不同的干细胞调控因子的特有平衡。在本发明的用于治疗癌症的药物和用于治疗癌症的方法中，通过分解干细胞控制因子的这种平衡来抑制癌症的增殖。

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