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31. 发明公开

EP2794584A1 BENZYL SULFONAMIDE DERIVATIVES AS RORc MODULATORS 审中-公开
标题翻译：苄基磺酰脲衍生物
公开(公告)号：EP2794584A1
公开(公告)日：2014-10-29
申请号：EP12810285.2
申请日：2012-12-21
申请人： F.Hoffmann-La Roche AG
发明人： FAUBER, Benjamin , RENE, Olivier
IPC分类号： C07D309/14 , C07C311/11 , C07C311/13 , C07D405/04 , C07D241/08 , C07D471/10 , C07D487/10 , C07D491/107 , C07D207/12 , C07D207/14 , C07D211/46 , C07D211/58 , C07D305/06 , C07D305/08 , A61K31/435 , A61K31/18
CPC分类号： C07D491/107 , C07C311/13 , C07C2601/08 , C07C2601/14 , C07D207/12 , C07D207/14 , C07D211/46 , C07D211/58 , C07D241/04 , C07D241/08 , C07D265/30 , C07D267/14 , C07D295/135 , C07D295/185 , C07D295/26 , C07D305/06 , C07D305/08 , C07D309/14 , C07D405/04 , C07D471/08 , C07D471/10 , C07D487/08 , C07D487/10
摘要： Compounds of the formula (I) or pharmaceutically acceptable salts thereof, wherein m, n, A, X
1 , X
2 , X
3 , X
4 , R
1 , R
2 , R
3a , R
3b , R
4a and R
4b are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.
摘要翻译：式I化合物或其药学上可接受的盐，其中m，n，A，X1，X2，X3，X4，R1，R2，R3a，R3b，R4a和R4b如本文所定义。还公开了制备化合物和使用该化合物治疗炎性疾病如关节炎的方法。

32. 发明公开

EP2542232A4 FATTY ACID INHIBITORS 审中-公开
标题翻译： FETTSÄUREHEMMER
公开(公告)号：EP2542232A4
公开(公告)日：2013-08-28
申请号：EP10859382
申请日：2010-11-02
申请人： LIFE TECHNOLOGIES CORP
发明人： BRANCHAUD BRUCE
IPC分类号： A61K31/185 , A61K31/336 , A61K31/337 , A61K31/70 , C07C57/03 , C07D303/38 , C07D303/48 , C07D305/06 , C07D305/08 , C07D331/04
CPC分类号： C07D303/48 , C07C57/03 , C07C205/55 , C07C2601/02 , C07D203/08 , C07D205/04 , C07D303/38 , C07D305/04 , C07D305/06 , C07D305/08 , C07D331/02 , C07D331/04

33. 发明公开

EP2402328A1 METHOD FOR PRODUCING OPTICALLY ACTIVE FLUORINATED OXETANE 有权
标题翻译：生产光学活性氟化壬烷的方法
公开(公告)号：EP2402328A1
公开(公告)日：2012-01-04
申请号：EP10746169.1
申请日：2010-02-22
申请人： Tokyo Institute of Technology , Central Glass Company, Limited
发明人： MIKAMI,Koichi , AIKAWA,Kohsuke , AIDA,Junpei , ISHII,Akihiro , KATO,Misugi , MASUDA,Takashi
IPC分类号： C07D305/08 , B01J31/22 , C07B53/00 , C07B61/00
CPC分类号： C07D305/04 , B01J31/223 , B01J31/2409 , B01J2231/32 , B01J2531/0266 , B01J2531/46 , B01J2531/824 , C07B53/00 , C07D305/08
摘要： Disclosed is a method of producing an optically active fluorinated oxetane, which can be an important pharmaceutical or agricultural intermediate, by reaction of a fluorinated α-keto ester with an acyl alkenyl ether in the presence of a transition metal complex with an optically active ligand. This method utilizes a catalytic asymmetric synthesis process and does not require a stoichiometric amount of chiral source. It is thus possible to dramatically reduce the amount of use of the asymmetric catalyst especially when the reaction is performed at a high concentration of substrate (with the use of a small amount of reaction solvent) or in the absence of a reaction solvent (under neat conditions). Further, the target optically active fluorinated oxetane can be obtained with high yield and with very high optical purity. The product contains almost no difficult-to-separate impurity and shows high chemical purity.
摘要翻译：本发明公开了一种通过氟化α-酮酯与酰基烯基醚在过渡金属配合物与光学活性配体的存在下反应而制备光学活性氟化氧杂环丁烷的方法，其可以是重要的药物或农业中间体。该方法采用催化不对称合成方法，不需要化学计量的手性源。因此可以大大减少不对称催化剂的使用量，特别是当反应在高浓度的底物（使用少量反应溶剂）或不使用反应溶剂时（纯净条件）。此外，目标光学活性的氟化氧杂环丁烷可以以高收率和非常高的光学纯度获得。该产品几乎不含难以分离的杂质，并显示出高化学纯度。

34. 发明公开

EP2396296A1 AMINOTETRALINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY 有权
标题翻译： AMINOTETRALINDERIVATE，PHARMAZEUTISCHE ZUSAMMENSETZUNGEN DAMIT UND IHRE THERAPEUTISCHE VERWENDUNG
公开(公告)号：EP2396296A1
公开(公告)日：2011-12-21
申请号：EP10706575.7
申请日：2010-02-16
申请人： Abbott GmbH & Co. KG , Abbott Laboratories
发明人： AMBERG, Wilhelm , OCHSE, Michael , LANGE, Udo , KLING, Andreas , BEHL, Berthold , HORNBERGER, Wilfried , MEZLER, Mario , HUTCHINS, Charles
IPC分类号： C07C215/70 , C07C311/00 , C07C317/00 , C07C233/00 , C07D213/71 , C07D231/18 , C07D233/84 , C07D249/12 , C07D261/08 , C07D275/02 , C07D305/08 , C07D333/04 , C07F7/10 , A61K31/16 , A61P25/00
CPC分类号： C07C311/05 , C07C215/64 , C07C217/74 , C07C233/18 , C07C233/19 , C07C233/69 , C07C255/58 , C07C271/24 , C07C307/06 , C07C309/65 , C07C311/07 , C07C311/09 , C07C311/10 , C07C311/13 , C07C311/14 , C07C311/17 , C07C311/18 , C07C311/20 , C07C311/24 , C07C317/18 , C07C317/28 , C07C2601/02 , C07C2601/04 , C07C2602/10 , C07D205/04 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/27 , C07D207/36 , C07D207/48 , C07D213/71 , C07D231/18 , C07D233/84 , C07D249/12 , C07D261/08 , C07D265/30 , C07D275/02 , C07D295/096 , C07D295/135 , C07D305/08 , C07D333/34 , C07D401/12 , C07D403/12 , C07D409/12 , C07F7/0818
摘要： The present invention relates to aminotetraline derivatives of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such aminotetraline derivatives, and the use of such aminotetraline derivatives for therapeutic purposes. The aminotetraline derivatives are GlyT1 inhibitors.
摘要翻译：本发明涉及式（I）的氨基四氢化萘衍生物或其生理上耐受的盐。本发明涉及包含这种氨基四氢化萘衍生物的药物组合物以及这种氨基四氢化萘衍生物用于治疗目的的用途。氨基四氢叶酸衍生物是GlyT1抑制剂。

35. 发明公开

EP2101577A1 OXOOXETANE ALS FUNGIZIDE MITTEL 审中-公开
标题翻译： OXOOXETANE作为杀真菌剂MEDIUM
公开(公告)号：EP2101577A1
公开(公告)日：2009-09-23
申请号：EP07856256.8
申请日：2007-11-24
申请人： Bayer CropScience AG
发明人： ES-SAYED, Mazen , HILLEBRAND, Stefan , WIESE, Welf-Burkhard , ULLMANN-KOPPOLD, Astrid , KUNZ, Klaus , SCHREIER, Peter , VAUPEL, Martin , KUCK, Karl-Heinz , WACHENDORFF-NEUMANN, Ulrike , ILG, Kerstin , DE MEIJERE, Armin , LARIONOV, Oleg , MATTES, Amos , DAHMEN, Peter
IPC分类号： A01N43/20 , C07D305/08 , A01P3/00
CPC分类号： A01N43/20 , C07D305/12 , C07D307/62 , C07D403/12
摘要： The invention relates to compounds of formula (1), to the agrochemically active salts thereof, and to the use of the same either individually or mixed with other active ingredients and/or auxiliary agents and/or additives for controlling phytopathogenic fungi and other micro-organisms in or on plants. The invention also relates to methods for producing said compounds and mixtures, intermediate products in said method, and seeds treated with said compounds, salts or mixtures.

36. 发明公开

EP1950190A1 FLUORINE-CONTAINING ADAMANTANE DERIVATIVE, FLUORINE-CONTAINING ADAMANTANE DERIVATIVE HAVING POLYMERIZABLE GROUP, AND RESIN COMPOSITION CONTAINING SAME 审中-公开
标题翻译：荧光素酶ADAMANTANDERIVAT，FLUORINHALTIGES ADAMANTANDERIVAT MIT POLYMERISIERBARER GRUPPE UND HARZZUSAMMENSETZUNG，DIE DEESESENTHÄLT
公开(公告)号：EP1950190A1
公开(公告)日：2008-07-30
申请号：EP06782702.2
申请日：2006-08-11
申请人： IDEMITSU KOSAN CO., LTD.
发明人： OKADA, Yasunari , YAMANE, Hideki , MATSUMOTO, Nobuaki
IPC分类号： C07C31/44 , C07C67/14 , C07C69/653 , C07D303/22 , C07D305/08 , C08F20/28 , G03F7/11 , H01L21/027
CPC分类号： C07D407/12 , C07C43/196 , C07C69/653 , C07C2603/74 , C07D303/28 , C08F222/1006 , G03F7/0007 , G03F7/091
摘要： Provided are a polymerizable group-containing and fluorine-containing adamantane derivative capable of affording a cured product having good heat resistance, good mechanical properties such as surface hardness and a low refractive index, a resin composition containing such a polymerizable group-containing adamantane derivative, and a fluorine-containing adamantane derivative which is useful as a reaction intermediate used for the production of the polymerizable group-containing and fluorine-containing adamantane derivative. Specifically provided are a fluorine-containing adamantane derivative represented by the general formula (I) below, a polymerizable group-containing and fluorine-containing adamantane derivative represented by the general formula (II) below, and a resin composition containing such a polymerizable group-containing and fluorine-containing adamantane derivative. In the formulas, X 1 and X 2 each represent OH or NH 2 , a, b and c each represent an integer of 0 or more and a + b + c ≥ 1, for example a = b = 0 and c = 1, Z 3 represents, for example, -C 2 H 4 -, s and t each represent an integer of 1 to 15, u represents an integer of 0 to 14, s + t + u = 16, for example s = 2, t = 14, u = 0, and X 3 represents, for example, -O-CO-CH=CH 2 .
摘要翻译：提供能够提供具有良好耐热性，良好机械性能如表面硬度和低折射率的固化产物的含可聚合基团的含氟金刚烷衍生物，含有这种含聚合基团的金刚烷衍生物的树脂组合物，和可用作制备含聚合基团的含氟金刚烷衍生物的反应中间体的含氟金刚烷衍生物。具体地提供由以下通式（I）表示的含氟金刚烷衍生物，下述通式（II）表示的可聚合基团的含氟金刚烷衍生物和含有这样的可聚合基团的含氟金刚烷衍生物，含氟和金属金刚烷衍生物。在该式中，X 1和X 2分别表示OH或NH 2，a，b和c各自表示0以上的整数，a + b + c‰×1，例如a = b = 0，c = 1 Z 3表示例如-C 2 H 4 - ，s和t各自表示1〜15的整数，u表示0〜14的整数，s + t + u = 16，例如s = 2， t = 14，u = 0，X 3表示例如-O-CO-CH = CH 2。

37. 发明公开

EP1114704A3 Waterproofing/preservative compositions 失效
标题翻译：一种用于防水和防腐剂的组合物
公开(公告)号：EP1114704A3
公开(公告)日：2001-08-08
申请号：EP01100855.4
申请日：1994-06-09
申请人： LONZA INC.
发明人： Walker,Leigh
IPC分类号： B27K3/50 , B27K3/34 , C07D313/04 , C07D309/10 , C07D307/20 , C07D305/08 , C07C69/527 , C07C69/33 , C07C69/30 , A01N33/12 , C07C69/52
CPC分类号： C07C211/63 , A01N33/12 , A01N37/02 , A01N37/04 , A01N37/06 , A01N37/36 , A01N59/00 , A01N59/14 , B27K3/20 , B27K3/34 , B27K3/50 , B27K3/52 , B27K2240/70 , C07C51/412 , C07C209/62 , C07C209/68 , C07C211/62 , A01N25/30 , A01N2300/00
摘要： Waterproofing compositions for wood preservative systems are provided comprising compounds of the formula wherein X is hydrogen or Y is substituted or unsubstituted -CH 2 -(CHOH-CH 2 -O-) w , substituted or unsubstituted or an enantiomer thereof, or substituted or unsubstituted or an enantiomer thereof; R 3 , R 4 and R 5 independently are a saturated or unsaturated, substituted or unsubstituted, interrupted or uninterrupted C 9 -C 50 group, w is an integer from 1 to 10 and x and y independently are 0, 1 or 2. The composition optionally contains a biocidal effective amount of at least one C 1 -C 20 alkyl- or aryl-substituted alkyl, C 8 -C 20 alkyl quaternary ammonium composition, a solvent or a combination thereof.

38. 发明公开

EP0983255A1 SUBSTITUIERTE 2-BENZOYL-CYCLOHEXAN-1,3-DIONE 失效
标题翻译：取代的2-苯甲酰基环己烷-1,3-二酮
公开(公告)号：EP0983255A1
公开(公告)日：2000-03-08
申请号：EP98922776.4
申请日：1998-04-24
申请人： BASF AKTIENGESELLSCHAFT
发明人： ENGEL, Stefan , BAUMANN, Ernst , VON DEYN, Wolfgang , HILL, Regina, Luise , KARDORFF, Uwe , MAYER, Guido , OTTEN, Martina , RHEINHEIMER, Joachim , WAGNER, Oliver , WITSCHEL, Matthias , MISSLITZ, Ulf , WALTER, Helmut , WESTPHALEN, Karl-Otto
IPC分类号： C07D305/12 , C07D305/10 , C07D305/08 , C07D303/32 , C07F9/655 , C07D493/10 , C07F7/08 , A01N43/04
CPC分类号： C07D493/10 , A01N43/20 , C07D303/32 , C07D305/08 , C07D305/10 , C07D305/12 , C07F9/6551
摘要： The invention relates to 2-benzoyl-cyclohexane-1,3 diones of formula (I) wherein the substituents have the following meanings: R1, R2 stands for hydrogen, mercapto, nitro, halogen, cyano, rhodano, C¿1?-C6 alkyl, C1-C6 alkyl halide, C1-C6 alkoxy, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkinyl, -OR?10, -OCOR10¿, -OSO¿2R?10, -S(O)¿n?R?10, -SO¿2OR10, -SO2NR?3R10, -NR10SO¿2R?10 or -NR10¿COR; Q represents an optionally substituted cyclohexane-1,3-dione-ring bonded in position 2; and A means a group of formula (IIa), (IIb) or (III) wherein the substituents have the meaning cited in Claim 1. The invention also relates to the salts of said compounds which can be used in agriculture.

39. 发明公开

EP0702517A4 QUATERNARY AMMONIUM AND WATERPROOFING/PRESERVATIVE COMPOSITIONS 失效
标题翻译：季铵和WASSERDICHTUNG- /保存组合物
公开(公告)号：EP0702517A4
公开(公告)日：1999-02-03
申请号：EP94920194
申请日：1994-06-09
申请人： LONZA AG
发明人： WALKER LEIGH
IPC分类号： B27K3/20 , A01N20060101 , A01N33/02 , A01N33/12 , A01N37/00 , A01N37/02 , A01N37/04 , A01N37/06 , A01N37/10 , A01N37/36 , A01N47/06 , A01N59/00 , A01N59/14 , B27K3/34 , B27K3/36 , B27K3/38 , B27K3/50 , B27K7/00 , C07C20060101 , C07C51/41 , C07C53/10 , C07C53/122 , C07C53/126 , C07C57/12 , C07C59/105 , C07C69/34 , C07C69/527 , C07C69/675 , C07C209/62 , C07C209/68 , C07C211/62 , C07C211/63 , C07C211/64 , C07D305/08 , C07D307/20 , C09K3/18 , A01N31/14 , A01N43/16 , B27K3/00
CPC分类号： C07C211/63 , A01N33/12 , A01N37/02 , A01N37/04 , A01N37/06 , A01N37/36 , A01N59/00 , A01N59/14 , B27K3/20 , B27K3/34 , B27K3/50 , B27K3/52 , B27K2240/70 , C07C51/412 , C07C209/62 , C07C209/68 , C07C211/62 , A01N25/30 , A01N2300/00
摘要： Waterproofing compositions for wood preservative systems are provided comprising compounds of the formula wherein X is hydrogen or Y is substituted or unsubstituted -CH2-(CHOH-CH2-O-)w, substituted or unsubstituted or an enantiomer thereof, or substituted or unsubstituted or an enantiomer thereof; R , R and R independently are a saturated or unsaturated, substituted or unsubstituted, interrupted or uninterrupted C9-C50 group, w is an integer from 1 to 10 and x and y independently are 0, 1 or 2. The composition optionally contains a biocidal effective amount of at least one C1-C20alkyl- or aryl-substituted alkyl, C8-C20alkyl quaternary ammonium composition, a solvent or a combination thereof.

40. 发明授权

EP0748318B1 PROCESS FOR PREPARING POLYFLUOROOXETANES 失效
标题翻译：的生产方法POLYFLOUROXETANEN的
公开(公告)号：EP0748318B1
公开(公告)日：1998-09-02
申请号：EP95912030.4
申请日：1995-03-01
申请人： E.I. DU PONT DE NEMOURS AND COMPANY
发明人： PETROV, Viacheslav Alexandrovich , SMART, Bruce, Edmund
IPC分类号： C07D305/08
CPC分类号： C07D305/08
摘要： This invention concerns a process for the preparation of polyfluorooxetanes by the reaction of fluoroketones of fluoroepoxides with haloethylenes in the presence of a Lewis acid catalyst. Polyfluorooxetanes are useful as solvents and plasticizers having high thermal stability.

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