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21. 发明授权

EP1772159B1 Methods for preparing autologous fibrin glue 有权
标题翻译： Verfahren zur Herstellung von autologen Fibrinklebern
公开(公告)号：EP1772159B1
公开(公告)日：2010-03-24
申请号：EP06027028.7
申请日：2003-01-15
申请人： Beretta, Roberto , Grippi, Nicholas A.
发明人： Beretta, Roberto , Grippi, Nicholas A.
IPC分类号： A61L24/10
CPC分类号： A61L24/106 , A61B17/00491 , A61B2017/00495 , A61C5/64 , A61J1/062 , A61J1/201 , A61J1/2013 , A61J1/2065 , A61J1/2086 , A61J1/2089 , A61L24/00 , B01D21/262 , B01D33/15

22. 发明公开

EP2090277A1 CHEMICAL LIQUID CONTAINER 有权转让
标题翻译：罐车化学流体
公开(公告)号：EP2090277A1
公开(公告)日：2009-08-19
申请号：EP07831712.0
申请日：2007-11-13
申请人： Nipro Corporation , Wakamoto Pharmaceutical Co., Ltd.
发明人： KUBO, Tomohiko , KISHIMOTO, Kazuya
IPC分类号： A61J1/10 , A61J1/05 , B65D47/18 , B65D51/16
CPC分类号： A61J1/1418 , A61J1/145 , A61J1/1456 , A61J1/1468 , A61J1/2075 , A61J1/2082 , A61J1/2086 , B65D47/18 , B65D51/1633
摘要： In accordance with the present invention, a liquid agent container includes the container's main unit (1), a cap (2), an intermediate member (3), and an internal stopper (4). The cap (2) is provided with a liquid agent discharging path (25) and an air introducing path (28). The intermediate member (3) has a tube (35) projecting toward the interior of the main unit (1). Between a liquid agent introducing path (34) and the liquid agent discharging path (25) a hydrophilic filter (29) is provided, and between an air supplying path (36) communicating with the air introducing path (28) and an air delivering path (43) a filter (37) is provided. The air delivering path (43) communicates with the interior of the main unit (1) via a check valve, with an annular valve (42) having an inner circumferential surface in contact with an outer circumferential surface of the tube (35), to pass air only in a direction toward the interior of the main unit (1). The present invention can provide a liquid agent container including a check valve readily fabricated and ensuring preventing a liquid agent from flowing back.

23. 发明授权

EP1192927B1 Entnahmespike 有权
标题翻译：抽吸针
公开(公告)号：EP1192927B1
公开(公告)日：2009-02-25
申请号：EP01123022.4
申请日：2001-09-26
申请人： B. BRAUN MELSUNGEN AG
发明人： Heil, Norbert , Siemon, Bernd , Siemon, Klaus
IPC分类号： A61J1/20
CPC分类号： A61J1/2096 , A61J1/145 , A61J1/1456 , A61J1/201 , A61J1/2075 , A61J1/2082 , A61J1/2086 , A61M5/162 , A61M5/165 , A61M39/20 , A61M39/26 , A61M2039/266

24. 发明公开

EP1595532A3 Sustained release of peptides from pharmaceutical compositions 失效
标题翻译：从药物组合物中的肽的延迟释放
公开(公告)号：EP1595532A3
公开(公告)日：2007-05-30
申请号：EP05016415.1
申请日：1995-08-31
申请人： SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES S.A.S.
发明人： Cherif-Cheikh, Roland
IPC分类号： A61K9/20 , A61K9/06 , A61K38/31
CPC分类号： A61K9/1629 , A61J1/201 , A61J1/2013 , A61J1/2086 , A61J1/2089 , A61J1/2096 , A61K9/0019 , A61K9/0024 , A61K9/06 , A61K9/19 , A61K9/2018 , A61K9/70 , A61K38/09 , A61K38/23 , A61K38/25 , A61K38/29 , A61K38/31 , A61K47/26 , A61M5/14244 , A61M5/14248 , A61M5/31505 , A61M5/31531 , A61M31/002 , A61M37/0069
摘要： The invention features a solid, non-particulate, sustained-release pharmaceutical composition for parenteral administration to a patient. The composition consists essentially of (1) a soluble, gelable peptide salt, and (2) up to 30 percent, by weight, of a pharmaceutically acceptable, monomeric, soluble carrier, compounded into a solid cylindrical form, wherein the solid composition automatically forms a gel after interaction with the patient's bodily fluids, the gel releasing the peptide continuously within the patient over an extended period of at least three days.

25. 发明授权

EP1465675B1 SYSTEMS AND METHODS FOR PREPARING AUTOLOGOUS FIBRIN GLUE 有权
标题翻译：圣彼得堡VERFAHREN ZUR HERSTELLUNG VON AUTOLOGEM FIBRINKLEBER
公开(公告)号：EP1465675B1
公开(公告)日：2007-03-21
申请号：EP03703826.2
申请日：2003-01-15
申请人： Beretta, Roberto , Grippi, Nicholas A.
发明人： Beretta, Roberto , Grippi, Nicholas A.
IPC分类号： A61L24/10
CPC分类号： A61L24/106 , A61B17/00491 , A61B2017/00495 , A61C5/64 , A61J1/062 , A61J1/201 , A61J1/2013 , A61J1/2065 , A61J1/2086 , A61J1/2089 , A61L24/00 , B01D21/262 , B01D33/15
摘要： The invention provides a system for preparing an autologous solid-fibrin web suitable for regenerating tissue in a living organism. The system includes a sealed primary container containing a separation medium and a low-density high-viscosity liquid. The separation medium is capable of separating red blood cells from plasma when the container contains blood and is centrifuged, and the primary container has a first pressure. The system further includes a sealed secondary container containing a calcium-coagulation activator. The secondary container has a second pressure that is less than the first pressure. The system also comprises a transfer device including a cannula having a first end and a second end. The first and second ends are capable of puncturing the sealed primary and secondary containers in order to provide fluid communication between the first and second containers. The low-density high-viscosity liquid of the primary container is capable of blocking flow through the cannula upon entering therein.
摘要翻译：本发明提供了一种用于制备适于再生生物体中的组织的自体固体纤维蛋白网的系统。该系统包括含有分离介质和低密度高粘度液体的密封的初级容器。当容器含有血液并离心时，分离介质能够将红细胞与血浆分离，并且主容器具有第一压力。该系统还包括含有钙凝固活化剂的密封次级容器。次级容器具有小于第一压力的第二压力。所述系统还包括具有第一端和第二端的插管的转移装置。第一和第二端能够刺穿密封的初级和次级容器，以便在第一和第二容器之间提供流体连通。主要容器的低密度高粘度液体能够在进入其中时阻止穿过套管的流动。

26. 发明公开

EP1558194A1 PHARMACEUTICAL DELIVERY SYSTEMS AND METHODS FOR USING SAME 审中-公开
标题翻译：中医药管理局的系统和方法使用
公开(公告)号：EP1558194A1
公开(公告)日：2005-08-03
申请号：EP03773389.6
申请日：2003-11-07
申请人： DUOJECT MEDICAL SYSTEMS INC
发明人： REYNOLDS, David L.
IPC分类号： A61J1/00
CPC分类号： A61J1/2096 , A61J1/201 , A61J1/2013 , A61J1/2051 , A61J1/2075 , A61J1/2086 , A61M5/1626 , A61M5/1782
摘要： The present invention provides an assembly (10) for transferring a liquid between a vial (56) and a syringe (66). The assembly includes a housing (12) having a central portion (15), the housing being open at one end (19) and having a vial socket (16) at the other opposite end (17) adapted to receive and retain a vial having a penetrable closure (62). The housing further includes a sleeve (26) located within the central portion of the housing. The sleeve has a first portion (28a), a second portion (30) adjacent the first portion, and a shoulder (32) between the first portion and the second portion. The assembly also includes a protractible luer adaptor (14) with a central hub (44) having a first axial end and a second opposite axial end. The first axial end has a hollow piercing member (48) with a tip having an opening mounted thereon and the second axial end has an engaging member (38) for releasably engaging a syringe, the hollow piercing member, the central hub, and the engaging member being in fluid communication with one another. The protractible luer adaptor is longitudinally slidable within the sleeve between a retracted position where the hollow piercing member is substantially contained within the central portion of the housing and an advanced position where the tip of the hollow piercing member extends into the vial socket.

27. 发明公开

EP1465675A2 SYSTEMS AND METHODS FOR PREPARING AUTOLOGOUS FIBRIN GLUE 有权
标题翻译：系统及其制造方法自体纤维蛋白胶
公开(公告)号：EP1465675A2
公开(公告)日：2004-10-13
申请号：EP03703826.2
申请日：2003-01-15
申请人： Beretta, Roberto , Grippi, Nicholas A.
发明人： Beretta, Roberto , Grippi, Nicholas A.
IPC分类号： A61L24/10
CPC分类号： A61L24/106 , A61B17/00491 , A61B2017/00495 , A61C5/64 , A61J1/062 , A61J1/201 , A61J1/2013 , A61J1/2065 , A61J1/2086 , A61J1/2089 , A61L24/00 , B01D21/262 , B01D33/15
摘要： The invention provides a system for preparing an autologous solid-fibrin web suitable for regenerating tissue in a living organism. The system includes a sealed primary container containing a separation medium and a low-density high-viscosity liquid. The separation medium is capable of separating red blood cells from plasma when the container contains blood and is centrifuged, and the primary container has a first pressure. The system further includes a sealed secondary container containing a calcium-coagulation activator. The secondary container has a second pressure that is less than the first pressure. The system also comprises a transfer device including a cannula having a first end and a second end. The first and second ends are capable of puncturing the sealed primary and secondary containers in order to provide fluid communication between the first and second containers. The low-density high-viscosity liquid of the primary container is capable of blocking flow through the cannula upon entering therein.

28. 发明授权

EP0928182B1 DELIVERY SYSTEM FOR PHARMACEUTICALS PACKED IN PHARMACEUTICAL VIALS 失效
标题翻译：供应系统营销小瓶包装在一起药物
公开(公告)号：EP0928182B1
公开(公告)日：2002-05-08
申请号：EP97900167.4
申请日：1997-01-10
申请人： DUOJECT MEDICAL SYSTEMS INC
发明人： REYNOLDS, David, L.
IPC分类号： A61J1/00
CPC分类号： A61J1/2096 , A61F13/0203 , A61J1/10 , A61J1/1475 , A61J1/201 , A61J1/2013 , A61J1/2051 , A61J1/2058 , A61J1/2065 , A61J1/2086 , A61J1/2089 , A61L15/225 , C08L89/06
摘要： A system is provided for providing syringes filled with pharmaceuticals whose components must be stored separately, using an active ingredient in a pharmaceutical vial (2), a diluent in a protosyringe such as a bottomless vial (4) or a cartridge, and a combiner assembly which enables the content of the pharmaceutical vial to be transferred into the protosyringe and converts it into a ready-to-use syringe on activation. The combined assembly included a tubular body (22, 24) having recesses (30, 31) at opposite ends for receiving capped ends of the vial (2) and the protosyringe (4), and a hub (34) and needle (40, 44) assembly between penetrable sheaths or shields (46, 64) which acts on activation of the assembly to enable the transfer and conversion referred to above. Components of the system may also be used to convert protosyringes and pharmaceutical vials containing pharmaceuticals into delivery systems.

29. 发明公开

EP1061868A1 VIAL PACKAGE FOR A BONE CEMENT MIXER AND DISPENSER 有权
标题翻译：瓶子包装，用于骨水泥搅拌车和分配器
公开(公告)号：EP1061868A1
公开(公告)日：2000-12-27
申请号：EP99905600.5
申请日：1999-02-01
申请人： Immedica, Inc.
发明人： SEATON, James, P. , BARKER, Donald
IPC分类号： A61F2/46 , B01F13/00 , B01F15/02 , A61J1/00
CPC分类号： B01F15/0205 , A61B17/8822 , A61B17/8825 , A61B17/8827 , A61B2017/8838 , A61B2050/002 , A61B2050/0064 , A61B2050/0066 , A61F2002/30065 , A61F2002/30289 , A61F2002/30561 , A61F2002/4685 , A61F2210/0071 , A61F2230/0091 , A61F2250/0071 , A61J1/2027 , A61J1/2086 , A61J1/2093 , B01F7/00433 , B01F7/24 , B01F13/002 , B01F15/0206 , B01F15/0234 , B01F15/0266 , B01F15/0289 , B01F2003/1257 , B01F2215/0029
摘要： Lower (24) and upper (22) covers permanently secured together form a vial (10) enclosing chamber (52) in a cap assembly (12) which encloses the top of a bone cement mixing apparatus (6) mixing chamber (5) having prepackaged premeasured bone cement powder (7). The vial (10) contains a monomer bone cemnt liquid (8) and may be glass. The vial (10) has two valve seats in corresponding ports (74, 76) on opposing vial side walls sealed by a releaseably secured preferably glass valve member (40) threaded (64, 41) to a nozzle (36) attached to the cap assembly (12). The vial ports (74, 76) are aligned with a mixing chamber (5) liquid inlet port (88) to permit the cement liquid (8) to flow into the mixing chamber (5) from the opened valves. The vial (10) may be supplied enclosed in a separate package and includes valves on a valve stem (54) attached to the package for opening and sealing the vial (10). In the alternative, the vial (10) is frangible glass and may be opened by fracturing it and retaining the fragments in the vial receiving chamber (52) to release the liquid (8) to the mixing chamber (5).

30. 发明公开

EP1006981A1 DISPOSITIF DE CONNEXION, EN PARTICULIER ENTRE UN RECIPIENT AVEC BOUCHON PERFORABLE ET UNE SERINGUE 失效
标题翻译：连接器件，尤其之间，闭幕容器和注射器DURCHSTOSSBAREM
公开(公告)号：EP1006981A1
公开(公告)日：2000-06-14
申请号：EP97942082.5
申请日：1997-09-24
申请人： Biodome
发明人： ANEAS, Antoine
IPC分类号： A61J1/20
CPC分类号： A61J1/2096 , A61J1/1412 , A61J1/201 , A61J1/2075 , A61J1/2082 , A61J1/2086
摘要： The invention concerns a connecting device (1) between a first receptacle (2), and a second receptacle (4) comprising a muff joint (4a), said device comprising means (5) for perforating a stopper, including a faucet (6) and a filtering chamber (7) isolated from outside by a filter (8), two independent channels (9, 10) being provided in the perforating means (5) for communicating the inside of the first receptacle (2) with the faucet (6) and the filtering chamber (7) respectively, said device further comprising means (11) for displacing with guidance the perforating means (5), means for fastening (13) the skirt (12) on the neck (2a), a plunger (15) mounted in the internal bore (12a) on which the perforating means (5) are fixed, for sliding by simple pressure, and means (16) for definitively stopping the plunger (15).

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