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11. 发明公开

EP2227334A2 A CENTRIFUGE FOR SEPARATING A SAMPLE INTO AT LEAST TWO COMPONENTS 有权
标题翻译：样品的至少两个组成部分离心机的分离
公开(公告)号：EP2227334A2
公开(公告)日：2010-09-15
申请号：EP08858277.0
申请日：2008-12-08
申请人： Miltenyi Biotec GmbH
发明人： MILTENYI, Stefan , SCHIMMELPFENNIG, Winfried , LANTOW, Holger , NEUSCHÄFER, Elmar, Niklas , BIEHL, Martin , KABAHA, Eiad , SCHULZ, Jürgen
IPC分类号： B04B5/04 , B04B13/00 , G01N15/04
CPC分类号： G01N33/58 , A61M1/0209 , A61M1/3618 , A61M1/3633 , A61M1/3679 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M2202/0071 , A61M2202/0413 , A61M2202/0427 , A61M2202/10 , B01D15/3809 , B01D15/3885 , B01D21/26 , B03C1/002 , B03C1/027 , B03C1/032 , B03C1/0332 , B03C1/0335 , B03C1/034 , B03C1/288 , B03C2201/18 , B03C2201/26 , B04B1/12 , B04B5/00 , B04B5/04 , B04B5/0442 , B04B5/10 , B04B7/08 , B04B13/00 , B04B2005/0464 , B04B2013/006 , C12M23/28 , C12M33/10 , C12M41/48 , C12M47/04 , C12N5/0636 , C12N5/0646 , C12N5/0647 , C12N5/0669 , G01N35/0098 , G01N2333/70596
摘要： The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder, a pump and a plurality of valves configured to at least partially control fluid flow through a fluid circuitry and a separation column positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

12. 发明授权

EP1711268B1 USER-CONFIGURABLE ANALYTICAL ROTOR SYSTEM 有权
标题翻译：用户可配置的分析转头系统
公开(公告)号：EP1711268B1
公开(公告)日：2007-05-02
申请号：EP05722615.1
申请日：2005-02-02
申请人： Hach Company
发明人： MOORE, Leon, E.
IPC分类号： B04B5/04 , G01N21/07
CPC分类号： B04B5/04 , G01N21/07
摘要： An analytical rotor system (120) is configured to perform a plurality of tests selected by a user. The analytical rotor comprises a plurality of rotor blocks (101-104) and a rotor base (100). The rotor blocks (101-104) are each configured to perform at least one of the tests on at least one sample in response to centrifugal force. The rotor blocks (101-104) are physically separate units from one another. The rotor base (100) is a physically separate unit from the rotor blocks (101-104) and is configured to allow the user to manually install the rotor blocks (101-104) on the base. The rotor base (100) is configured to hold the installed rotor blocks (101-104) in place during the centrifugal force and to connect to an analytical device (110) that provides the centrifugal force.

13. 发明公开

EP0420153A1 Centrifugal separator, method of separating animal cells from animal cell-containing suspension using said centrifugal separator, and method of culturing animal cells in suspension using said centrifugal separator 失效
标题翻译：的离心分离器，通过该分离器和处理由该分离器中的悬浮液中培养动物细胞的装置从动物含细胞悬浮液中分离动物细胞的方法。
公开(公告)号：EP0420153A1
公开(公告)日：1991-04-03
申请号：EP90118402.8
申请日：1990-09-25
申请人： TEIJIN LIMITED
发明人： Tokashiki, Michiyuki , Hamamoto, Kimihiko , Ishimaru, Kenji
IPC分类号： B04B5/04 , C12M3/02 , C12N5/02
CPC分类号： C12M47/02 , B04B5/04 , B04B2005/0457
摘要： A centrifugal separator characterized in that

(i) a centrifugal space consists of a peripheral slot having an outside peripheral wall inclining toward a central axis of a rotor at an inclination angle of 30 to 80° in a direction perpendicular to the central axis of the rotor,
(ii) the peripheral slot exists with a length of an outside wall corresponding to an angular range of not less than 360° around the central axis of the rotor,
(iii) the peripheral slot has such a space that the liquid fluid forms a continuous flow,
(iv) the peripheral slot has a feed opening or a discharge opening of the liquid fluid at, or near, the farthest position from the central axis of the rotor, and
(v) the peripheral slot has a feed opening or a discharge opening of the liquid fluid at, or near, the nearest position from the central axis of the rotor, as well as a method of separating animal cells from an animal cell-containing suspension using the centrifugal separator, and a method of culturing animal cells in suspension using the centrifugal separator.
摘要翻译：的离心分离器为特征的DASS（I）的具有外周壁的周向槽的转子的中心轴在以30〜80°的倾斜角度在一个方向倾斜垂直于转子的中心轴线的离心空间besteht （ii）所述外围狭槽与外部壁以围绕转子的中心轴线不小于360°的角度范围内对应于的长度存在，（iii）所述外围狭槽审查的空间那样的液体流体形成一连续流动，（ⅳ）所述外围狭槽具有一个进料口，或在液体流体的排出口，或附近，从转子的中心轴线最远的位置，和（v）所述外围狭槽具有一个进料口或在排出液体流体的开口，或附近，从转子的中心轴线最近的位置，以及使用该离心分离器从含细胞的动物悬浮液中分离动物细胞的方法，和在培养的方法进制细胞悬浮液中使用离心分离器。

14. 发明公开

EP0035397A3 Rotor for sedimentation field flow fractionation 失效
$Rotor for sedimentation field flow fractionation$
标题翻译：用于定位的转子场流分解
公开(公告)号：EP0035397A3
公开(公告)日：1983-03-16
申请号：EP81300842
申请日：1981-02-27
申请人： E.I. DU PONT DE NEMOURS AND COMPANY
发明人： Grant, John Wallace
IPC分类号： B01D21/00 , B04B07/08 , G01N33/00 , B03B05/00 , B04B05/04
CPC分类号： B03B5/00 , B04B5/04 , B04B5/0442 , B04B2005/045
摘要： A long, thin annular belt-like channel is designed for use in sedimentation field flow fractionation. This channel defined by inner and outer rings 104,102, which may be the rotor of a centrifuge, is designed to mainteain its thickness dimension constant by forming the radially inner wall with a radial thickness t such that the distorting effects of centrifugal force on the inner ring are substantially balanced by the centrifugal pressure of fluid in the flow channel.

15. 发明公开

EP4360672A1 SYSTEM FOR TREATING BIOLOGICAL MATERIAL 审中-公开
公开(公告)号：EP4360672A1
公开(公告)日：2024-05-01
申请号：EP22826647.4
申请日：2022-05-18
申请人： Cantero Burgaz, José
发明人： CANTERO BURGAZ, José
IPC分类号： A61M5/178 , A61M5/315 , B01L3/00 , A61B5/15 , B04B5/04 , B04B11/04
CPC分类号： B01L3/00 , A61M5/315 , A61M5/178 , A61B5/15 , B04B11/04 , B04B5/04
摘要： The invention relates to a medical veterinary device for extracting and containing biological material to be processed, wherein the medical veterinary device (100) comprises interchangeable pieces for forming a syringe (110a) for extracting biological material, a container (100b) for the extracted biological material to be processed, and a syringe or system for applying the biological material contained in the container (100b). The invention also relates to equipment for processing a biological material contained in the medical veterinary device.

16. 发明公开

EP2691182A4 METHOD AND DEVICE FOR CENTRIFUGATION AND FILTRATION 有权转让
标题翻译：方法和装置离心和过滤
公开(公告)号：EP2691182A4
公开(公告)日：2014-09-17
申请号：EP12764963
申请日：2012-03-28
申请人： EMD MILLIPORE CORP , JOUETTE SEBASTIAN
发明人： JOUETTE SEBASTIAN , FELDEN LUC
IPC分类号： B04B7/16 , B01D17/038 , B01D61/00 , B04B1/00
CPC分类号： B01D21/262 , B01D17/0217 , B01D17/085 , B01D61/18 , B01D63/16 , B01D71/34 , B01D2315/02 , B04B5/04 , B04B5/0407 , B04B2005/0435 , B04B2005/0478 , B04B2005/0485
摘要： The invention provides a filtering and centrifugation device, comprising a barrel, a volume in the barrel for receiving a fluid sample to be processed, a filter medium, at least one piston movable in the barrel to force fluid in the volume through the filter medium to produce a filtrate, and a space for pelleting particulate material. The device is centrifugeable, and said space is located in or communicates with the volume and is located preferably away from the filter medium such that the particulate material does not or at least not completely clog the filter medium during such centrifugation of the device. The invention also provides a method for the sterile filtration of a sample, comprising the steps of introducing the sample into the volume of such a device, subjecting the device to centrifugation to pellet particulate material contained in the sample at the space away from the filter medium, and applying force to the piston(s) to force fluid of the sample in the volume through the filter medium to produce a filtrate. By providing the space for pelleting the particulate material under the influence of the centrifugation force, the clogging of the filter medium can be avoided or considerably delayed. Further, the entire process can be performed in the same device without having to remove the sample for any intermediate clarification steps.

17. 发明公开

EP2670534A1 CENTRIFUGE ROTOR FOR SEPARATION AND PROCESSING OF COMPLEX FLUIDS 审中-公开
标题翻译：离心机转子分离和处理复杂液体的
公开(公告)号：EP2670534A1
公开(公告)日：2013-12-11
申请号：EP12742453.9
申请日：2012-02-01
申请人： Arryx, Inc.
发明人： RUNYON, Matthew, K. , MUETH, Daniel, M. , GUEVARA, Sergio, O. , FU, Haojun
IPC分类号： B04B5/02
CPC分类号： G01N33/80 , B04B5/04 , G01N21/07
摘要： A rotor is provided for use in a centrifuge system configured to spin the rotor for separating complex fluids. The rotor includes a housing configured to be secured by the centrifuge system and several chambers formed in the housing. Each chamber includes a first chamber portion having a port formed therein and a second chamber portion in fluid communication with the port of the first chamber portion. The second chamber portion may be disposed generally below the port of the first chamber portion. Other rotor designs and methods for separating complex fluids are further disclosed.

18. 发明公开

EP2433713A2 Cell processing systems and methods 有权
标题翻译：方法和系统处理的细胞
公开(公告)号：EP2433713A2
公开(公告)日：2012-03-28
申请号：EP11193362.8
申请日：2008-12-08
申请人： Miltenyi Biotec GmbH
发明人： Miltenyi, Stefan , Schimmelpfennig, Winfried , Lantow, Holger , Neuschäfer, Elmar Niklas , Biehl, Martin , Schulz, Jürgen , Kabaha, Eiad
IPC分类号： B04B5/04 , B04B13/00 , G01N15/04 , A61M1/36
CPC分类号： G01N33/58 , A61M1/0209 , A61M1/3618 , A61M1/3633 , A61M1/3679 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M2202/0071 , A61M2202/0413 , A61M2202/0427 , A61M2202/10 , B01D15/3809 , B01D15/3885 , B01D21/26 , B03C1/002 , B03C1/027 , B03C1/032 , B03C1/0332 , B03C1/0335 , B03C1/034 , B03C1/288 , B03C2201/18 , B03C2201/26 , B04B1/12 , B04B5/00 , B04B5/04 , B04B5/0442 , B04B5/10 , B04B7/08 , B04B13/00 , B04B2005/0464 , B04B2013/006 , C12M23/28 , C12M33/10 , C12M41/48 , C12M47/04 , C12N5/0636 , C12N5/0646 , C12N5/0647 , C12N5/0669 , G01N35/0098 , G01N2333/70596
摘要： The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder, a pump and a plurality of valves configured to at least partially control fluid flow through a fluid circuitry and a separation column positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

19. 发明授权

EP2227334B1 A CENTRIFUGE FOR SEPARATING A SAMPLE INTO AT LEAST TWO COMPONENTS 有权
标题翻译： ZENTRIFUGE ZUR TRENNUNG EINER MINIESTENS探索ZWEI KOMPONENTEN
公开(公告)号：EP2227334B1
公开(公告)日：2011-10-12
申请号：EP08858277.0
申请日：2008-12-08
申请人： Miltenyi Biotec GmbH
发明人： MILTENYI, Stefan , SCHIMMELPFENNIG, Winfried , LANTOW, Holger , NEUSCHÄFER, Elmar, Niklas , BIEHL, Martin , KABAHA, Eiad , SCHULZ, Jürgen
IPC分类号： B04B5/04 , B04B13/00 , G01N15/04
CPC分类号： G01N33/58 , A61M1/0209 , A61M1/3618 , A61M1/3633 , A61M1/3679 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M2202/0071 , A61M2202/0413 , A61M2202/0427 , A61M2202/10 , B01D15/3809 , B01D15/3885 , B01D21/26 , B03C1/002 , B03C1/027 , B03C1/032 , B03C1/0332 , B03C1/0335 , B03C1/034 , B03C1/288 , B03C2201/18 , B03C2201/26 , B04B1/12 , B04B5/00 , B04B5/04 , B04B5/0442 , B04B5/10 , B04B7/08 , B04B13/00 , B04B2005/0464 , B04B2013/006 , C12M23/28 , C12M33/10 , C12M41/48 , C12M47/04 , C12N5/0636 , C12N5/0646 , C12N5/0647 , C12N5/0669 , G01N35/0098 , G01N2333/70596
摘要： The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder, a pump and a plurality of valves configured to at least partially control fluid flow through a fluid circuitry and a separation column positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.
摘要翻译：本发明涉及一种系统，包括：a）样品处理单元，包括输入端口和耦合到具有至少一个样品室的旋转容器的输出端口，所述样品处理单元配置为样品提供第一处理步骤，使容器旋转以对沉积在室中的样品施加离心力，并分离沉积样品的至少第一组分和第二组分; 以及b）样品分离单元，其耦合到所述样品处理单元的输出端口，所述细胞分离单元包括分离柱保持器，泵和多个阀，所述多个阀构造成至少部分地控制通过流体回路的流体流和分离柱定位在保持器中，分离柱构造成分离流过柱的样品的标记和未标记组分。

20. 发明公开

EP2323774A1 FLUID CONCENTRATOR 有权转让
标题翻译：流体浓缩器
公开(公告)号：EP2323774A1
公开(公告)日：2011-05-25
申请号：EP05858823.7
申请日：2005-04-20
申请人： Millennium Medical Technologies, Inc.
发明人： COULL, Thomas , KYLE, Matthew , KIDDER, Louis, S.
IPC分类号： B04B7/16 , B04B7/18
CPC分类号： B04B1/00 , A61M1/262 , A61M1/3496 , A61M1/3693 , B04B5/04 , B04B2005/0478
摘要： A concentrator (10) is used for concentrating a fluid, particularly a plasma component out of blood, for treatment of a patient. The concentrator apparatus (10) includes a main housing (12) defining a centrifuge chamber ( 14), that also holds the filter (38). The concentrator (10) allows viewing of the fluid after centrifuging, with an outlet port (32) positionable at a height corresponding to the level of the fraction of the fluid to be further concentrated. Once the fluid is centrifuged, a portion of the fluid is drawn through the outlet (32), and then pressured past the filter (38) to further concentrate the fluid using the same vessel (10) as used for centrifuging. The same plunger (68) is preferably used to draw centrifuged fluid from the centrifuge chamber (14) as to pressure the centrifuged fluid past the filter (38).
摘要翻译：浓缩器（10）用于浓缩流体，尤其是血液外的血浆成分，用于患者的治疗。浓缩器装置（10）包括限定离心室（14）的主壳体（12），该主壳体还保持过滤器（38）。浓缩器（10）允许在离心之后观察流体，其中出口端口（32）可定位在与待进一步浓缩的流体部分的水平相对应的高度处。一旦流体被离心分离，一部分流体通过出口（32）被抽出，然后被压过过滤器（38）以使用用于离心的相同容器（10）进一步浓缩流体。优选使用相同的柱塞（68）从离心室（14）抽取离心流体，以便将离心流体加压通过过滤器（38）。

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