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1. 发明公开

EP2323774A4 FLUID CONCENTRATOR 有权转让
标题翻译： FLUIDKONZENTRATOR
公开(公告)号：EP2323774A4
公开(公告)日：2014-08-20
申请号：EP05858823
申请日：2005-04-20
申请人： CIRCLE BIOLOG INC
发明人： COULL THOMAS , KYLE MATTHEW , KIDDER LOUIS S
IPC分类号： B04B1/00 , A61M1/26 , A61M1/34 , A61M1/36 , B04B5/04
CPC分类号： B04B1/00 , A61M1/262 , A61M1/3496 , A61M1/3693 , B04B5/04 , B04B2005/0478
摘要： A concentrator (10) is used for concentrating a fluid, particularly a plasma component out of blood, for treatment of a patient. The concentrator apparatus (10) includes a main housing (12) defining a centrifuge chamber ( 14), that also holds the filter (38). The concentrator (10) allows viewing of the fluid after centrifuging, with an outlet port (32) positionable at a height corresponding to the level of the fraction of the fluid to be further concentrated. Once the fluid is centrifuged, a portion of the fluid is drawn through the outlet (32), and then pressured past the filter (38) to further concentrate the fluid using the same vessel (10) as used for centrifuging. The same plunger (68) is preferably used to draw centrifuged fluid from the centrifuge chamber (14) as to pressure the centrifuged fluid past the filter (38).

2. 发明公开

EP2705903A1 Rotoreinrichtung, Zentrifugenkessel und Zentrifuge, und deren Herstellungsverfahren 审中-公开
标题翻译： Rotoreinrichtung，Zentrifugenkessel und Zentrifuge，und deren Herstellungsverfahren
公开(公告)号：EP2705903A1
公开(公告)日：2014-03-12
申请号：EP12006283.1
申请日：2012-09-06
申请人： Eppendorf AG
发明人： Lurz, Werner, Dr.
IPC分类号： B04B5/04 , B04B7/02 , B04B7/08
CPC分类号： B04B5/04 , B04B5/0414 , B04B7/02 , B04B7/08
摘要： Die Erfindung bezieht sich auf eine Rotoreinrichtung einer Zentrifuge, insbesondere Laborzentrifuge, ausgebildet zur Rotation um eine Rotationsachse A in einem Fluid, aufweisend einen Innenbereich zur Aufnahme einer zu zentrifugierenden Probe, eine Außenwand mit einer Außenfläche, die bei Rotation der Rotoreinrichtung von dem Fluid umströmt wird, wobei zumindest ein Flächenabschnitt der Außenfläche eine Mikrorillenstruktur aufweist, deren Rillen in einem Abstand d benachbarter Rillen mit insbesondere d
摘要翻译：转子装置（20）具有用于接收要离心的样品的内部区域。设置有外表面（21）的外壁围绕流体的转子组件的旋转布置。外表面的表面部分设置有微通道结构。凹槽以相邻凹槽的2mm以下的距离延伸。包括以下独立权利要求：（1）用于接收转子的离心机碗; （2）离心机; 和（3）制造转子组件的方法。

3. 发明公开

EP2670840A2 METHODS AND DEVICES FOR IMMUNODIAGNOSTIC APPLICATIONS 审中-公开
标题翻译：方法和设备免疫诊断应用
公开(公告)号：EP2670840A2
公开(公告)日：2013-12-11
申请号：EP12741469.6
申请日：2012-02-01
申请人： Arryx, Inc.
发明人： KNUTSON, Christopher, R , GRANT, Christopher, F. , KLINE, Timothy, R. , DOORNEWEERD, Derek, D. , KURELLA, Sridevi , MUETH, Daniel, M. , RUNYON, Matthew, K. , FU, Haojun , GUEVARA, Sergio, O.
IPC分类号： C12N5/07 , G01N33/555 , C07K16/18
CPC分类号： G01N33/80 , B04B5/04 , G01N21/07
摘要： A rotor is provided for use in a centrifuge system configured to spin the rotor for separating complex fluids. The rotor includes a housing configured to be secured by the centrifuge system and several chambers formed in the housing. Each chamber includes a first chamber portion having a port formed therein and a second chamber portion in fluid communication with the port of the first chamber portion. The second chamber portion may be disposed generally below the port of the first chamber portion. Other rotor designs and methods for separating complex fluids are further disclosed.

4. 发明公开

EP2227334A2 A CENTRIFUGE FOR SEPARATING A SAMPLE INTO AT LEAST TWO COMPONENTS 有权转让
标题翻译：样品的至少两个组成部分离心机的分离
公开(公告)号：EP2227334A2
公开(公告)日：2010-09-15
申请号：EP08858277.0
申请日：2008-12-08
申请人： Miltenyi Biotec GmbH
发明人： MILTENYI, Stefan , SCHIMMELPFENNIG, Winfried , LANTOW, Holger , NEUSCHÄFER, Elmar, Niklas , BIEHL, Martin , KABAHA, Eiad , SCHULZ, Jürgen
IPC分类号： B04B5/04 , B04B13/00 , G01N15/04
CPC分类号： G01N33/58 , A61M1/0209 , A61M1/3618 , A61M1/3633 , A61M1/3679 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M2202/0071 , A61M2202/0413 , A61M2202/0427 , A61M2202/10 , B01D15/3809 , B01D15/3885 , B01D21/26 , B03C1/002 , B03C1/027 , B03C1/032 , B03C1/0332 , B03C1/0335 , B03C1/034 , B03C1/288 , B03C2201/18 , B03C2201/26 , B04B1/12 , B04B5/00 , B04B5/04 , B04B5/0442 , B04B5/10 , B04B7/08 , B04B13/00 , B04B2005/0464 , B04B2013/006 , C12M23/28 , C12M33/10 , C12M41/48 , C12M47/04 , C12N5/0636 , C12N5/0646 , C12N5/0647 , C12N5/0669 , G01N35/0098 , G01N2333/70596
摘要： The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder, a pump and a plurality of valves configured to at least partially control fluid flow through a fluid circuitry and a separation column positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

5. 发明授权

EP1711268B1 USER-CONFIGURABLE ANALYTICAL ROTOR SYSTEM 有权
标题翻译：用户可配置的分析转头系统
公开(公告)号：EP1711268B1
公开(公告)日：2007-05-02
申请号：EP05722615.1
申请日：2005-02-02
申请人： Hach Company
发明人： MOORE, Leon, E.
IPC分类号： B04B5/04 , G01N21/07
CPC分类号： B04B5/04 , G01N21/07
摘要： An analytical rotor system (120) is configured to perform a plurality of tests selected by a user. The analytical rotor comprises a plurality of rotor blocks (101-104) and a rotor base (100). The rotor blocks (101-104) are each configured to perform at least one of the tests on at least one sample in response to centrifugal force. The rotor blocks (101-104) are physically separate units from one another. The rotor base (100) is a physically separate unit from the rotor blocks (101-104) and is configured to allow the user to manually install the rotor blocks (101-104) on the base. The rotor base (100) is configured to hold the installed rotor blocks (101-104) in place during the centrifugal force and to connect to an analytical device (110) that provides the centrifugal force.

6. 发明公开

EP0420153A1 Centrifugal separator, method of separating animal cells from animal cell-containing suspension using said centrifugal separator, and method of culturing animal cells in suspension using said centrifugal separator 失效
标题翻译：的离心分离器，通过该分离器和处理由该分离器中的悬浮液中培养动物细胞的装置从动物含细胞悬浮液中分离动物细胞的方法。
公开(公告)号：EP0420153A1
公开(公告)日：1991-04-03
申请号：EP90118402.8
申请日：1990-09-25
申请人： TEIJIN LIMITED
发明人： Tokashiki, Michiyuki , Hamamoto, Kimihiko , Ishimaru, Kenji
IPC分类号： B04B5/04 , C12M3/02 , C12N5/02
CPC分类号： C12M47/02 , B04B5/04 , B04B2005/0457
摘要： A centrifugal separator characterized in that

(i) a centrifugal space consists of a peripheral slot having an outside peripheral wall inclining toward a central axis of a rotor at an inclination angle of 30 to 80° in a direction perpendicular to the central axis of the rotor,
(ii) the peripheral slot exists with a length of an outside wall corresponding to an angular range of not less than 360° around the central axis of the rotor,
(iii) the peripheral slot has such a space that the liquid fluid forms a continuous flow,
(iv) the peripheral slot has a feed opening or a discharge opening of the liquid fluid at, or near, the farthest position from the central axis of the rotor, and
(v) the peripheral slot has a feed opening or a discharge opening of the liquid fluid at, or near, the nearest position from the central axis of the rotor, as well as a method of separating animal cells from an animal cell-containing suspension using the centrifugal separator, and a method of culturing animal cells in suspension using the centrifugal separator.
摘要翻译：的离心分离器为特征的DASS（I）的具有外周壁的周向槽的转子的中心轴在以30〜80°的倾斜角度在一个方向倾斜垂直于转子的中心轴线的离心空间besteht （ii）所述外围狭槽与外部壁以围绕转子的中心轴线不小于360°的角度范围内对应于的长度存在，（iii）所述外围狭槽审查的空间那样的液体流体形成一连续流动，（ⅳ）所述外围狭槽具有一个进料口，或在液体流体的排出口，或附近，从转子的中心轴线最远的位置，和（v）所述外围狭槽具有一个进料口或在排出液体流体的开口，或附近，从转子的中心轴线最近的位置，以及使用该离心分离器从含细胞的动物悬浮液中分离动物细胞的方法，和在培养的方法进制细胞悬浮液中使用离心分离器。

7. 发明公开

EP0035397A3 Rotor for sedimentation field flow fractionation 有权
$Rotor for sedimentation field flow fractionation$
标题翻译：用于定位的转子场流分解
公开(公告)号：EP0035397A3
公开(公告)日：1983-03-16
申请号：EP81300842
申请日：1981-02-27
申请人： E.I. DU PONT DE NEMOURS AND COMPANY
发明人： Grant, John Wallace
IPC分类号： B01D21/00 , B04B07/08 , G01N33/00 , B03B05/00 , B04B05/04
CPC分类号： B03B5/00 , B04B5/04 , B04B5/0442 , B04B2005/045
摘要： A long, thin annular belt-like channel is designed for use in sedimentation field flow fractionation. This channel defined by inner and outer rings 104,102, which may be the rotor of a centrifuge, is designed to mainteain its thickness dimension constant by forming the radially inner wall with a radial thickness t such that the distorting effects of centrifugal force on the inner ring are substantially balanced by the centrifugal pressure of fluid in the flow channel.

8. 发明授权

EP2227271B1 SAMPLE PROCESSING SYSTEM AND METHODS 有权转让
标题翻译：样品处理系统和方法
公开(公告)号：EP2227271B1
公开(公告)日：2018-01-24
申请号：EP08857318.3
申请日：2008-12-08
申请人： Miltenyi Biotec GmbH
发明人： MILTENYI, Stefan , SCHIMMELPFENNIG, Winfried , LANTOW, Holger , NEUSCHÄFER, Elmar, Niklas , BIEHL, Martin , KABAHA, Eiad , SCHULZ, Jürgen
IPC分类号： A61M1/02 , A61M1/36 , B04B13/00 , B03C1/032 , B03C1/033 , B03C1/034
CPC分类号： G01N33/58 , A61M1/0209 , A61M1/3618 , A61M1/3633 , A61M1/3679 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M2202/0071 , A61M2202/0413 , A61M2202/0427 , A61M2202/10 , B01D15/3809 , B01D15/3885 , B01D21/26 , B03C1/002 , B03C1/027 , B03C1/032 , B03C1/0332 , B03C1/0335 , B03C1/034 , B03C1/288 , B03C2201/18 , B03C2201/26 , B04B1/12 , B04B5/00 , B04B5/04 , B04B5/0442 , B04B5/10 , B04B7/08 , B04B13/00 , B04B2005/0464 , B04B2013/006 , C12M23/28 , C12M33/10 , C12M41/48 , C12M47/04 , C12N5/0636 , C12N5/0646 , C12N5/0647 , C12N5/0669 , G01N35/0098 , G01N2333/70596
摘要： The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder, a pump and a plurality of valves configured to at least partially control fluid flow through a fluid circuitry and a separation column positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

9. 发明公开

EP2670840A4 METHODS AND DEVICES FOR IMMUNODIAGNOSTIC APPLICATIONS 审中-公开
标题翻译：方法和设备免疫诊断应用
公开(公告)号：EP2670840A4
公开(公告)日：2015-08-19
申请号：EP12741469
申请日：2012-02-01
申请人： ARRYX INC
发明人： KNUTSON CHRISTOPHER R , GRANT CHRISTOPHER F , KLINE TIMOTHY R , DOORNEWEERD DEREK D , KURELLA SRIDEVI , MUETH DANIEL M , RUNYON MATTHEW K , FU HAOJUN , GUEVARA SERGIO O
IPC分类号： C12N5/07 , C07K16/18 , G01N33/555 , G01N33/80
CPC分类号： G01N33/80 , B04B5/04 , G01N21/07

10. 发明公开

EP2691182A1 METHOD AND DEVICE FOR CENTRIFUGATION AND FILTRATION 有权转让
标题翻译：离心和过滤的方法和装置
公开(公告)号：EP2691182A1
公开(公告)日：2014-02-05
申请号：EP12764963.0
申请日：2012-03-28
申请人： EMD Millipore Corporation , Jouette, Sebastian
发明人： JOUETTE, Sebastian , FELDEN, Luc
IPC分类号： B04B7/16 , B04B1/00 , B01D17/038 , B01D61/00
CPC分类号： B01D21/262 , B01D17/0217 , B01D17/085 , B01D61/18 , B01D63/16 , B01D71/34 , B01D2315/02 , B04B5/04 , B04B5/0407 , B04B2005/0435 , B04B2005/0478 , B04B2005/0485
摘要： The invention provides a filtering and centrifugation device, comprising a barrel, a volume in the barrel for receiving a fluid sample to be processed, a filter medium, at least one piston movable in the barrel to force fluid in the volume through the filter medium to produce a filtrate, and a space for pelleting particulate material. The device is centrifugeable, and said space is located in or communicates with the volume and is located preferably away from the filter medium such that the particulate material does not or at least not completely clog the filter medium during such centrifugation of the device. The invention also provides a method for the sterile filtration of a sample, comprising the steps of introducing the sample into the volume of such a device, subjecting the device to centrifugation to pellet particulate material contained in the sample at the space away from the filter medium, and applying force to the piston(s) to force fluid of the sample in the volume through the filter medium to produce a filtrate. By providing the space for pelleting the particulate material under the influence of the centrifugation force, the clogging of the filter medium can be avoided or considerably delayed. Further, the entire process can be performed in the same device without having to remove the sample for any intermediate clarification steps.
摘要翻译：本发明提供了一种过滤和离心分离装置，其包括桶体，桶体中的用于接收待处理的流体样本的体积，过滤介质，至少一个活塞，所述活塞在桶体中可移动以迫使体积中的流体通过过滤介质到达产生滤液，以及用于造粒颗粒材料的空间。所述装置是可离心的，并且所述空间位于所述容积中或与所述容积连通，并且优选地远离所述过滤介质定位，使得在所述装置的这种离心过程中，所述颗粒材料不会或至少不完全堵塞所述过滤介质。本发明还提供了一种用于无菌过滤样品的方法，该方法包括以下步骤：将样品引入这种装置的容积中，使该装置离心以使样品中包含的颗粒物质在远离过滤介质的空间并且向活塞施加力以迫使体积中的样品流体通过过滤介质以产生滤液。通过在离心力的作用下提供用于造粒颗粒材料的空间，可以避免或显着延迟过滤介质的堵塞。此外，整个过程可以在相同的装置中进行，而不必为了任何中间澄清步骤而移除样品。

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