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2. 发明公开

EP2691182A1 METHOD AND DEVICE FOR CENTRIFUGATION AND FILTRATION 有权转让
标题翻译：离心和过滤的方法和装置
公开(公告)号：EP2691182A1
公开(公告)日：2014-02-05
申请号：EP12764963.0
申请日：2012-03-28
申请人： EMD Millipore Corporation , Jouette, Sebastian
发明人： JOUETTE, Sebastian , FELDEN, Luc
IPC分类号： B04B7/16 , B04B1/00 , B01D17/038 , B01D61/00
CPC分类号： B01D21/262 , B01D17/0217 , B01D17/085 , B01D61/18 , B01D63/16 , B01D71/34 , B01D2315/02 , B04B5/04 , B04B5/0407 , B04B2005/0435 , B04B2005/0478 , B04B2005/0485
摘要： The invention provides a filtering and centrifugation device, comprising a barrel, a volume in the barrel for receiving a fluid sample to be processed, a filter medium, at least one piston movable in the barrel to force fluid in the volume through the filter medium to produce a filtrate, and a space for pelleting particulate material. The device is centrifugeable, and said space is located in or communicates with the volume and is located preferably away from the filter medium such that the particulate material does not or at least not completely clog the filter medium during such centrifugation of the device. The invention also provides a method for the sterile filtration of a sample, comprising the steps of introducing the sample into the volume of such a device, subjecting the device to centrifugation to pellet particulate material contained in the sample at the space away from the filter medium, and applying force to the piston(s) to force fluid of the sample in the volume through the filter medium to produce a filtrate. By providing the space for pelleting the particulate material under the influence of the centrifugation force, the clogging of the filter medium can be avoided or considerably delayed. Further, the entire process can be performed in the same device without having to remove the sample for any intermediate clarification steps.
摘要翻译：本发明提供了一种过滤和离心分离装置，其包括桶体，桶体中的用于接收待处理的流体样本的体积，过滤介质，至少一个活塞，所述活塞在桶体中可移动以迫使体积中的流体通过过滤介质到达产生滤液，以及用于造粒颗粒材料的空间。所述装置是可离心的，并且所述空间位于所述容积中或与所述容积连通，并且优选地远离所述过滤介质定位，使得在所述装置的这种离心过程中，所述颗粒材料不会或至少不完全堵塞所述过滤介质。本发明还提供了一种用于无菌过滤样品的方法，该方法包括以下步骤：将样品引入这种装置的容积中，使该装置离心以使样品中包含的颗粒物质在远离过滤介质的空间并且向活塞施加力以迫使体积中的样品流体通过过滤介质以产生滤液。通过在离心力的作用下提供用于造粒颗粒材料的空间，可以避免或显着延迟过滤介质的堵塞。此外，整个过程可以在相同的装置中进行，而不必为了任何中间澄清步骤而移除样品。

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