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101. 发明公开

EP0289969A2 Apparatus for processing fluids 失效
标题翻译： Gerätzur Behandlung vonFlüssigkeiten。
公开(公告)号：EP0289969A2
公开(公告)日：1988-11-09
申请号：EP88106972.8
申请日：1988-04-30
申请人： E.I. DU PONT DE NEMOURS AND COMPANY
发明人： Kuhl, Ernest B. , Long, George Robinson , Mitchell, Juleen Alivia , Jenkins, Richard S. , Wolfe Jr.,Henry R. , Malone, Gerard F.
IPC分类号： B01L3/00
CPC分类号： C07K1/045 , B01J19/0046 , B01J2219/00286 , B01J2219/00288 , B01J2219/00308 , B01J2219/0031 , B01J2219/00416 , B01J2219/00484 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00725 , C40B40/10 , C40B60/14
摘要： A cartridge is formed of two parts which form an outlet valve at the lower end. The valve is opened or closed by relative rotation of the parts.
摘要翻译：墨盒由两部分组成，在下端形成出口阀。通过部件的相对旋转来打开或关闭阀门。

102. 发明公开

EP0245945A2 Automated nucleic acid extractor 失效
标题翻译： AutomatischesGerätzum Extrahieren vonNukleinsäuren。
公开(公告)号：EP0245945A2
公开(公告)日：1987-11-19
申请号：EP87303040.7
申请日：1987-04-08
申请人： APPLIED BIOSYSTEMS, INC.
发明人： Cathcart, Guy Richard , Mayrand, P. Eric , Nordman, Eric S.
IPC分类号： C12P19/34 , C12N15/00 , C12M1/00 , B01L11/00
CPC分类号： C12N9/0012 , B01J19/0046 , B01J2219/00286 , B01J2219/00308 , B01J2219/00331 , B01J2219/00389 , B01J2219/00488 , B01J2219/00689 , B01J2219/00695 , C12M47/06 , C12N15/1003 , C40B60/14
摘要： An automated apparatus is provided which implements a new method of extracting and purifying nucleic acids from cells without the use of centrifugation. In the method, a lysate is created by treating the cells with proteinase K in the presence of a lysis buffer having a high concentration of a salt. The lysate is mixed with a phenol-based solvent system, thereby creating an emulsion. The emulsion is heated to promote phase separation. Similarly, the rate of phase separation is also enhanced by increasing the surface area of the emulson. Once the phase separation is complete, the lower organic phase is removed and the upper aqueous phase is repeatedly extracted with the phenol-based solvent a preselected number of times, and is finally extracted using chloroform. The remaining aqueous phase is then dialyzed to further purify and concentrate the nucleic acid solution. Two preferred embodiments of apparatus are presented to accomplish this extraction.
摘要翻译：提供了一种自动化装置，其实现了从细胞中提取和纯化核酸而不使用离心的新方法。在该方法中，通过在具有高浓度盐的裂解缓冲液的存在下用蛋白酶K处理细胞产生裂解物。将裂解物与苯酚系溶剂体系混合，从而产生乳液。将乳液加热以促进相分离。类似地，通过增加乳化剂的表面积也增加了相分离速率。一旦相分离完成，除去较低的有机相，并用苯酚类溶剂反复提取上部水相预选次数，最后用氯仿萃取。然后将剩余的水相透析以进一步纯化并浓缩核酸溶液。呈现装置的两个优选实施例以完成该提取。

103. 发明公开

EP3116641A1 AUTOMATIC GAS VALVE CONTAINER HOLDER FOR CHEMICAL SYNTHESIS 有权转让
标题翻译：自动化学气相色谱法合成
公开(公告)号：EP3116641A1
公开(公告)日：2017-01-18
申请号：EP15710474.6
申请日：2015-03-12
申请人： GE Healthcare Bio-Sciences AB
发明人： OLOVSSON, Bjorn, Markus , OSMARK, Mathias , GAMBERG, Magnus , CARLSSON, Daniel
IPC分类号： B01J19/00 , B65B31/04 , B67C3/26
CPC分类号： C07K1/045 , B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/00337 , B01J2219/00346 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00585 , B01J2219/00725 , B65B31/04 , C07K1/063 , C07K1/08
摘要： The invention relates to a container holder 10, comprising a main body 12 which in turn comprises a gas inlet 16; a solution liquid outlet 18; a gas control valve 20 through which a gas enters the container 100 from the gas inlet; and a sealing means 22 for the container, which sealing means includes a passageway 24 for the input of gas and output of a solution in the container via an egress tube 19; wherein when the container is connected to the container holder through the sealing means, the gas control valve opens automatically, and when the container is disconnected the gas control valve is closed automatically. The invention further relates to a container panel 50 which includes two or more container holders. Also disclosed are methods of using these containers and container panels for synthesizing a polypeptide.
摘要翻译：本发明涉及容器保持器10，其包括主体12，主体12又包括气体入口16; 溶液出口18; 气体控制阀20，气体从气体入口进入容器100; 和用于容器的密封装置22，该密封装置包括用于输入气体的通道24和通过出口管19输出容器中的溶液; 其中当容器通过密封装置连接到容器支架时，气体控制阀自动打开，当容器断开时，气体控制阀自动关闭。本发明还涉及包括两个或更多个容器保持器的容器面板50。还公开了使用这些容器和容器面板合成多肽的方法。

104. 发明授权

EP1374991B1 Mischen und Reaktion von Feststoffen, Suspensionen oder Emulsionen in einem Mikrowellenfeld 有权
标题翻译：混合和在微波场中的固体，悬浮液，或乳液的反应
公开(公告)号：EP1374991B1
公开(公告)日：2011-08-17
申请号：EP03013729.3
申请日：2003-06-17
申请人： Mikrowellen-Systeme MWS GmbH
发明人： Lautenschläger, Werner
IPC分类号： B01J19/12 , B01F15/06 , B01F9/02 , B01F11/00 , B01F9/00 , H05B6/80 , B01J37/34
CPC分类号： H05B6/806 , B01F9/0018 , B01F9/04 , B01F13/06 , B01F15/067 , B01F2009/0063 , B01J19/126 , B01J37/346 , B01J2219/00308 , B01J2219/00326 , B01J2219/00488 , B01J2219/00716 , B01J2219/00745 , B01J2219/00747 , B01J2219/187 , C40B30/08 , C40B40/18 , C40B60/14

105. 发明公开

EP2263790A2 Reactor assembly 有权
标题翻译： Reaktoranordnung
公开(公告)号：EP2263790A2
公开(公告)日：2010-12-22
申请号：EP10182340.9
申请日：2002-05-13
申请人： Avantium International B.V.
发明人： Van den Brink, Peter John , Bracht, Maarten , Gruter, Gerardus Johannes Maria , De Ruiter, René , Harji, Bashir Husein
IPC分类号： B01J19/00 , G01N31/10
CPC分类号： B01L3/5025 , B01J19/0046 , B01J2219/00286 , B01J2219/00306 , B01J2219/00308 , B01J2219/00313 , B01J2219/00331 , B01J2219/00333 , B01J2219/00351 , B01J2219/00423 , B01J2219/00495 , B01J2219/00585 , B01J2219/00702 , B01J2219/0072 , B01J2219/00745 , B01J2219/00747 , B01L2300/04 , B01L2300/0867 , C40B30/08 , C40B40/18 , C40B60/12 , C40B60/14 , G01N1/405 , G01N31/10
摘要： The invention relates to a reactor assembly for analyzing the effluent streams from a plurality of flow-through reactors, comprising:
- a plurality of flow-through reactors for performing chemical reactions, each reactor comprising:
- a reaction chamber (1), comprising a reaction zone (2), the reaction chamber being connected to
- at least one reactor inlet (3) for at least one reactant, upstream of the reaction zone,
- at least one reactor outlet (4) for the effluent stream from the reaction zone, downstream of the reaction zone,

- a housing comprising a base block and a cover element,
wherein the base block (5) comprises a plurality of first channels (6), each first channel accommodating a flow-through reactor and a second sealing element (12), arranged between the outside of the reactor and the inner wall of the fist channel,

wherein the reactor assembly further comprises:
- at least one analyzer for subjecting the effluent stream to an analyzing procedure, each reactor outlet being connected to at least one analyzer by an effluent conduit, and
- at least one dilution gas supply means (16), for adding at least one dilution gas to the effluent stream, downstream of the reaction zone,

characterized in that,
a space (14) is present in each first channel between the outer wall of the reactor and the inner wall of the first channel and below the second sealing element (12),
and in that the base block comprises fourth channels, each fourth channel being connected to a first channel and opening in said space (14) in that first channel below the second sealing element and above the reactor outlet for adding a dilution gas to the effluent stream of the reactor arranged in said first channel.
摘要翻译：本发明涉及一种用于分析来自多个流通反应器的流出物流的反应器组件，包括： - 用于进行化学反应的多个流通反应器，每个反应器包括： - 反应室（1），包括反应区（2），所述反应室连接至至少一个用于至少一个反应物的反应器入口（3），所述反应器入口（3）在所述反应区的上游， - 至少一个反应器出口（4），在所述反应区的下游， - 包括基块和盖元件的壳体，其中所述基块（5）包括多个第一通道（6），每个第一通道容纳流过反应器和第二密封元件（12），其布置在所述反应器的外部和所述第一通道的内壁之间，其中所述反应器组件还包括： - 至少一个用于使所述流出物流进行分析程序的分析器，每个反应器出口是通过流出物导管连接到至少一个分析器，和 - 至少一个稀释气体供应装置（16），用于在反应区的下游向流出物流中加入至少一种稀释气体，其特征在于，空间（14 ）存在于反应器的外壁和第一通道的内壁和第二密封元件（12）下方的每个第一通道中，并且基部块包括第四通道，每个第四通道连接到第一通道通道和在第二密封元件下方的第一通道的所述空间（14）中并在反应器出口的上方开口，用于将稀释气体添加到布置在所述第一通道中的反应器的流出物流中。

106. 发明公开

EP2252849A1 MEHRZONENOFEN 有权转让
公开(公告)号：EP2252849A1
公开(公告)日：2010-11-24
申请号：EP09710657.9
申请日：2009-02-13
申请人： hte Aktiengesellschaft
发明人： DEJMEK, Michael , MAZZONCINI, Luca , HAAS, Andreas , FRIESS, Markus , KOECHEL, Oliver , VASSILIADIS, Georg
IPC分类号： F27B17/02
CPC分类号： F27B17/02 , B01J19/0046 , B01J2219/00286 , B01J2219/00308 , B01J2219/00337 , B01J2219/00389 , B01J2219/00418 , B01J2219/00495 , B01J2219/00585 , B01J2219/00698 , B01J2219/00747 , B01L7/00 , B01L2300/1827 , B01L2300/1844 , B01L2300/185 , B01L2300/1883
摘要： The present invention relates to a multi-zone oven for heating and controlling the temperature of reactors and lines in apparatuses. The multi-zone oven according to the invention has a modular design, thus enabling the heating and/or cooling of the oven, or also of individual zones of the oven, in an efficient manner. Exchangeable heating cartridges further provide the advantage that the reactors and the components connected to the reactors can be accessed particularly well, thus facilitating modifications.

107. 发明公开

EP2170500A1 SYSTEM, HEATING BLOCK AND METHOD 审中-公开
标题翻译：系统，加热块和方法
公开(公告)号：EP2170500A1
公开(公告)日：2010-04-07
申请号：EP07747344.5
申请日：2007-06-27
申请人： Avantium International B.V.
发明人： BODENSTAFF, Emilio, René , de KEIJZER, Adrianus, Hendricus,Joseph,Franciscus , NIJBACKER, Tom
IPC分类号： B01J19/00 , B01L7/00
CPC分类号： B01J19/0046 , B01J2219/00283 , B01J2219/00286 , B01J2219/00308 , B01J2219/00389 , B01J2219/00423 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/00596 , B01J2219/00599 , B01J2219/00747
摘要： The present invention provides a system, comprising at least one reactor array, comprising at least two reactor vessels (2) a connecting member for fixating the at least two reactor vessels relative to each other (4, 5) at least one reactor block (18) comprising a heating block (20) for heating the reactor vessels (2) the heating block (20) comprising at least two reactor channels for receiving the at least two reactor vessels (2) wherein the heating block (20) is constructed of a material having a thermal expansion coefficient
摘要翻译：本发明提供了一种包括至少一个反应器阵列的系统，所述反应器阵列包括至少两个反应器容器（2），用于将所述至少两个反应器容器相对于彼此固定的连接构件（4,5），至少一个反应器块（18 ）包括用于加热反应器容器（2）的加热块（20），加热块（20）包括用于接收至少两个反应器容器（2）的至少两个反应器通道，其中加热块（20）由材料具有热膨胀系数≤1×10 -5 KI（在293K）。在一个实施例中，加热块基本上完全由石墨构成。

108. 发明公开

EP2160237A2 PARALLEL BATCH REACTOR 审中-公开
标题翻译：不连续的工作并联电抗器
公开(公告)号：EP2160237A2
公开(公告)日：2010-03-10
申请号：EP08727236.5
申请日：2008-03-31
申请人： Symyx Solutions Inc.
发明人： DIAMOND, Gary, M. , HALL, Keith, A. , McWAID, Thomas, Harding , MURPHY, Vince , MYSLOVATY, Michael , SHOEMAKER, James, A., W. , SIDHU, Robbie, Singh , TURNER, Howard , DIAS, Eric , SPITKOVSKY, Mikhail
IPC分类号： B01J19/00 , C40B60/14
CPC分类号： C40B60/14 , B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/00389 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/00599 , B01J2219/00601 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/0072 , B01J2219/00736 , F16K27/003
摘要： In one embodiment, a parallel batch reactor for effecting chemical reactions includes a vessel block (24) comprising reactor vessels (32) for receiving components of a reaction and a valve block (23) removably attached to the vessel block. The valve block (22) includes a first plurality of valves (72) in fluid communication with an inlet port for supplying pressurized fluid to the reactor vessels. (32) and configured to fluidically isolate one or more of the reactor vessels from (32) at least one of the other reactor vessels (32) The valve block (22) further includes a second plurality of valves (76) in fluid communication with the reactor vessels for injecting chemical components into the pressurized reactor vessels (32) or sampling chemical components from the pressurized reactor vessels (32) The vessel block (26) and valve block (22) are configured to sustain an operating pressure of at least 15 psig. A stirring assembly (26) may also be present.

110. 发明授权

EP1525049B1 AN ASSEMBLY AND METHOD FOR PERFORMING PARALLEL CHEMICAL EXPERIMENTS, IN PARTICULAR CRYSTALLISATION EXPERIMENTS 有权
标题翻译： DEVICE AND METHOD FOR化学实验特别是结晶实验并行行为
公开(公告)号：EP1525049B1
公开(公告)日：2007-07-04
申请号：EP02749451.7
申请日：2002-08-02
申请人： Avantium International B.V.
发明人： BLOMSMA, Erwin , VAN LANGEVELDE, Adriaan, Jan , STAM, Danny, Dirk, Pieter, Willem
IPC分类号： B01J19/00
CPC分类号： B01J19/0046 , B01D9/0031 , B01D9/0072 , B01D9/0077 , B01J2219/00286 , B01J2219/00308 , B01J2219/00333 , B01J2219/00335 , B01J2219/00373 , B01J2219/00376 , B01J2219/00423 , B01J2219/00495 , B01J2219/00585 , B01J2219/00599 , B01J2219/00756 , B01L3/06 , B01L3/50255 , B01L3/5085 , B01L7/52 , B01L2200/026 , B01L2200/0684 , B01L2300/044 , B01L2300/0681 , B01L2300/0829 , B01L2300/10
摘要： An assembly and method for performing parallel chemical experiments, in particular crystallisation experiments. The assembly has a main body having a first and a second face on opposite sides thereof. Multiple bores extend through said main body between said first and second face. Tubular liners are provided having openings at opposite ends thereof, each liner removably fitting in a bore in the main body. First closure means close the openings of the liners at the first face of the main body. Second closure means close the openings of the liners at the second face of the main body. The first and second closure means are fastenable to said main body, so that an experimentation chamber is defined within each liner.

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