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91. 发明公开

EP2539707A2 ARTIFICIAL MYCOLIC ACID MEMBRANES 有权
标题翻译：人造粘弹性酸膜
公开(公告)号：EP2539707A2
公开(公告)日：2013-01-02
申请号：EP11748021.0
申请日：2011-02-23
申请人： University of Washington
发明人： GUNDLACH, Jens, H. , DERRINGTON, Ian, M. , LANGFORD, Kyle, W.
IPC分类号： G01N33/15 , G01N33/48 , C12Q1/68 , C07H21/04
CPC分类号： G01N27/447 , B01D69/06 , B01D2325/02 , B01D2325/24 , B82Y5/00 , B82Y15/00 , C07K14/35 , G01N27/44704 , G01N33/48721 , Y10S977/712 , Y10S977/714 , Y10S977/781 , Y10S977/924
摘要： Provided herein are artificial membranes of mycolic acids. The membranes may be unsupported or tethered. These membranes are long lived and highly resistant to electroporation, demonstrating their general strength. The mycolic acid membranes are suitable for controlled studies of the mycobacterial outer membrane and can be used in other experiments, such as nanopore analyte translocation experiments.
摘要翻译：本文提供霉菌酸的人造膜。这些膜可以是无支撑或束缚的。这些膜寿命长，对电穿孔高度耐受，表明它们的一般强度。分枝菌酸膜适用于分枝杆菌外膜的对照研究，可用于其他实验，如纳米孔分析物易位实验。

92. 发明授权

EP2182064B1 GENE EXPRESSED IN PROSTATE CANCER 有权
标题翻译：在前列腺癌基因表达
公开(公告)号：EP2182064B1
公开(公告)日：2012-08-29
申请号：EP10000495.1
申请日：1999-09-30
申请人： Agensys, Inc.
发明人： Afar, Daniel E. , Hubert, Rene S. , Mitchell, Stephen Chappell
IPC分类号： C12N15/12 , C07K14/47 , C07K16/18 , C12Q1/68 , A01K67/027 , A61K38/17 , G01N33/53 , G01N33/574
CPC分类号： C07K14/47 , A01K2217/05 , A61K39/00 , Y02A50/466 , Y10S977/91 , Y10S977/916 , Y10S977/924
摘要： A novel testis-specific gene expressed in human prostate cancer, designated 22P4F11, is described. Analysis of 22P4F11 mRNA expression in normal prostate, prostate tumor xenografts, and a variety of normal tissues indicates that the expression of this gene is testis specific in normal tissues. The 22P4F11 gene is also expressed in human prostate tumors, in some cases at high levels. A full length cDNA encoding 22P4F11 is provided. The 22P4F11 transcript and/or protein may represent a useful diagnostic marker and/or therapeutic target for prostate cancer.

93. 发明授权

EP1040203B1 NUCLEIC ACID LIGAND DIAGNOSTIC BIOCHIP 有权
标题翻译：与核配体诊断生物芯片
公开(公告)号：EP1040203B1
公开(公告)日：2011-10-26
申请号：EP98963150
申请日：1998-12-14
申请人： SOMALOGIC INC
发明人： GOLD LARRY , DROLET DANIEL , ZICHI DOMINIC A , JAYASENA SUMEDHA , CREIGHTON STEVE , GILL STANLEY
IPC分类号： C12Q1/68 , G01N33/53 , C07B61/00 , C07H21/04 , C12M1/00 , C12N15/09 , C12P19/34 , G01N33/543 , G01N33/566 , G01N37/00
CPC分类号： C12Q1/6839 , C07B2200/11 , C12Q1/6834 , C12Q1/6837 , C40B40/00 , Y10S977/924 , C12Q2565/514 , C12Q2565/101 , C12Q2541/101 , C12Q2525/205
摘要： A nucleic acid ligand 'biochip' is disclosed, consisting of a solid support to which one or more specific nucleic acid ligands is attached in a spatially defined manner. Each nucleic acid ligand binds specifically and avidly to a particular target molecule contained within a test mixture, such as a bodily fluid. The target molecules include, but are not limited to, proteins (cellular, viral, bacterial, etc.) hormones, sugars, metabolic byproducts, cofactor, and intermediates, drugs, and toxins. Contacting the test mixture with the biochip leads to the binding of a target molecule to its cognate nucleic acid ligand. Binding of target to the nucleic acid ligand results in a detectable change at each specific location on the biochip. The detectable change can include, but is not limited to, a change in fluorescence, or a change in a physical parameter, such as electrical conductance or refractive index, at each location on the biochip. The biochip will then be read by a device, such as a fluorescence scanner or a surface plasmon resonance detector, that can measure the magnitude of the change at each location on the biochip. The location of the change reveals what target molecule has been detected, and the magnitude of the change indicates how much of it is present. The combination of these two pieces of information will yield diagnostic and prognostic medical information when signal patterns are compared with those obtained from bodily fluids of individuals with diagnosed disorders. In principle, the biochip could be used to test any chemically complex mixture provided that nucleic acid ligands to components suspected of being present in the mixture are attached to the biochip. Thus, the nucleic acid ligand biochip will have a wider use in environmental testing, etc.

94. 发明授权

EP1294930B1 NANOPARTICLES HAVING OLIGONUCLEOTIDES ATTACHED THERETO AND USES THEREFOR 有权
标题翻译：纳米粒子当使用寡核苷酸的约束，它们的用途
公开(公告)号：EP1294930B1
公开(公告)日：2011-03-30
申请号：EP01904855.2
申请日：2001-01-12
申请人： Nanosphere, Inc.
发明人： MIRKIN, Chad, A. , LETSINGER, Robert, L. , MUCIC, Robert, C. , STORHOFF, James, J. , ELGHANIAN, Robert , TATON, Thomas, Andrew , LI, Zhi , GARIMELLA, Viswanadham
IPC分类号： C12Q1/68 , C07H21/00
CPC分类号： B82Y30/00 , B01J2219/00274 , B01J2219/005 , B01J2219/00585 , B01J2219/00596 , B01J2219/00603 , B01J2219/00648 , B01J2219/00653 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , B82B1/00 , B82Y15/00 , C07B2200/11 , C07H21/00 , C12Q1/6816 , C12Q1/6818 , C12Q1/6825 , C12Q1/6827 , C12Q1/6834 , C12Q1/6837 , C12Q1/6839 , C40B40/00 , C40B40/06 , Y10S977/924 , C12Q2563/155 , C12Q2563/143 , C12Q2537/143 , C12Q2525/197 , C12Q2525/161 , C12Q2565/625 , C12Q2537/125
摘要： The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one embodiment of the method, the oligonucleotides are attached to nanoparticles and have sequences complementary to portions of the sequence of the nucleic acid. A detectable change (preferably a color change) is brought about as a result of the hybridization of the oligonucleotides on the nanoparticles to the nucleic acid. The invention also provides compositions and kits comprising particles. The invention further provides methods of synthesizing unique nanoparticle-oligonucleotide conjugates, the conjugates produced by the methods, and methods of using the conjugates. In addition, the invention provides nanomaterials and nanostructures comprising nanoparticles and methods of nanofabrication utilizing nanoparticles. Finally, the invention provides a method of separating a selected nucleic acid from other nucleic acids.

95. 发明授权

EP1543152B1 CONTROLLED ALIGNMENT OF NANOBARCODES ENCODING SPECIFIC INFORMATION FOR SCANNING PROBE MICROSCOPY (SPM) READING 有权
标题翻译：纳米条形码的排列受控对探针显微分析具体所包含的信息GRID
公开(公告)号：EP1543152B1
公开(公告)日：2011-03-09
申请号：EP03752088.9
申请日：2003-09-05
申请人： Intel Corporation
发明人： CHAN, Selena , SU, Xing , YAMAKAWA, Mineo
IPC分类号： C12Q1/68 , G01N33/543
CPC分类号： C12Q1/6816 , B82Y5/00 , B82Y10/00 , B82Y30/00 , Y10S977/702 , Y10S977/704 , Y10S977/705 , Y10S977/728 , Y10S977/729 , Y10S977/734 , Y10S977/742 , Y10S977/773 , Y10S977/774 , Y10S977/924 , C12Q2565/601 , C12Q2563/185
摘要： The methods, apparatus and compositions disclosed herein concern the detection, identification and/or sequencing of biomolecules, such as nucleic acids or proteins. In certain embodiments of the invention, coded probes comprising a probe molecule attached to one or more nanobarcodes may be allowed to bind to one or more target molecules. After binding and separation from unbound coded probes, the bound coded probes may be aligned on a surface and analyzed by scanning probe microscopy. The nanobarcodes may be any molecule or complex that is distinguishable by SPM, such as carbon nanotubes, fullerenes, submicrometer metallic barcodes, nanoparticles or quantum dots. Where the probes are oligonucleotides, adjacent coded probes hybridized to a target nucleic acid may be ligated together before alignment and SPM analysis. Compositions comprising coded probes are also disclosed herein. Systems for biomolecule analysis may comprise an SPM instrument and at least one coded probe attached to a surface.
摘要翻译：所述方法，装置和组合物在光盘游离缺失关注的生物分子如，：核酸或蛋白质等的检测，鉴定和/或测序。在本发明的某些实施方案中，包括连接到一个或多个纳米条形码探针分子编码探针可以结合至一个或多个目标分子。与未结合的编码探针的结合和分离后，将结合的编码探针可以在表面上对齐，并且通过扫描探针显微镜分析。纳米条形码可以是任何分子或复合物确实是由SPM区分：例如碳纳米管，富勒烯，亚微米金属条形码，纳米颗粒或量子点。其中探针是寡核苷酸，相邻的编码探针杂交到靶核酸之前对准和扫描探针显微镜（SPM）分析可以连接在一起。组合物，包含编码探针因此光盘游离缺失。用于生物分子分析系统可以包括SPM仪器和附着于表面的至少一个已编码探针的。

96. 发明授权

EP1179185B1 A METHOD OF DETECTING AN ANALYTE USING SEMICONDUCTOR NANOCRYSTALS 有权
标题翻译：方法检测分析物使用HALBLEITERNANOKRYSTALLEN
公开(公告)号：EP1179185B1
公开(公告)日：2009-08-12
申请号：EP00928836
申请日：2000-05-05
申请人： LIFE TECHNOLOGIES CORP
发明人： BRUCHEZ MARCEL P , DANIELS R HUGH , EMPEDOCLES STEPHEN A , PHILLIPS VINCE E , WONG EDITH Y , ZEHNDER DONALD A
IPC分类号： C12Q1/68 , G01N21/64 , G01N33/50 , G01N33/53 , G01N33/533 , G01N33/542 , G01N33/543 , G01N33/566 , G01N33/58 , G01Q70/00
CPC分类号： G01N33/54346 , B82Y15/00 , G01N33/533 , G01N33/588 , G01N2458/00 , Y10S977/924
摘要： The use of semiconductor nanocrystals as detectable labels in various chemical and biological applications is disclosed. The methods find use for detecting a single analyte, as well as multiple analytes by using more than one semiconductor nanocrystal as a detectable label, each of which emits at a distinct wavelength.

97. 发明授权

EP1593967B1 Composite arrays 无效
标题翻译： Kompositmatrix
公开(公告)号：EP1593967B1
公开(公告)日：2009-07-01
申请号：EP05010428.0
申请日：1999-12-28
申请人： Illumina, Inc.
发明人： Chee, Mark S. , Auger, Steven R. , Steulpnagel, John R.
IPC分类号： G01N33/543
CPC分类号： G01N33/543 , B01J2219/00315 , B01J2219/00317 , B01J2219/00382 , B01J2219/005 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , C40B60/14 , G01N33/54313 , G01N33/54393 , Y10S977/924

98. 发明公开

EP1848986A2 ELECTROKINETIC CONCENTRATION DEVICE AND METHODS OF USE THEREOF 审中-公开
标题翻译： DEVICE FOR电动力学浓度及其使用方法
公开(公告)号：EP1848986A2
公开(公告)日：2007-10-31
申请号：EP06733869.9
申请日：2006-01-25
申请人： THE MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： HAN, Jogyoon , WANG, Ying-Chih
IPC分类号： G01N27/00
CPC分类号： G01N27/44791 , B01L3/502753 , Y10S977/904 , Y10S977/924
摘要： The present invention provides a device and methods of use thereof in concentrating a species of interest and/or controlling liquid flow in a device. The methods, inter-alia, make use of a device comprising microchannels, which are linked to nanochannels, whereby induction of an electric field in the nanochannel results in ion depletion in the linkage region between the microchannel and nanochannel, and a space charge layer is formed within the microchannel, which provides an energy barrier for said species of interest which enables its concentration in a region in the microchannel.

99. 发明公开

EP1552017A4 APPARATUS AND METHODS FOR DETECTING DNA IN BIOLOGICAL SAMPLES 有权
标题翻译： DEVICE AND METHOD FOR DNA的生物样品中检测
公开(公告)号：EP1552017A4
公开(公告)日：2007-08-29
申请号：EP03783907
申请日：2003-08-12
申请人： HONG KONG DNA CHIPS LTD
发明人： YU CHEUNG HOI , LAU LOK-TING , LIN SELMA SAU WAH , CHAN DUNCAN KA-YUN
IPC分类号： G01N33/53 , C12M1/00 , C12M1/34 , C12Q1/68 , G01N33/543 , G01N33/553 , G01N37/00
CPC分类号： C12Q1/6825 , C12Q1/6837 , Y10S435/975 , Y10S977/924 , C12Q2537/137 , C12Q2563/155 , C12Q2565/607 , C12Q2565/501
摘要： Apparatus and methods are described for detecting target DNA in a biological sample using capture probes and electrically-assisted hybridization. The reaction cell is formed with an attachment surface of aluminum oxide for better thermal and physical properties, and the aluminum oxide surface is coated with anti-DIG antibody to provide a convenient attachment layer for the capture probes allowing their correct orientation, while the capture probes are formed with a DIG-label so that they attach to the surface of the cell through an anti-DIG/DIG linkage.

100. 发明公开

EP1728865A1 Treatment of cervical cancer 审中-公开
标题翻译： Behandlung vonGebärmutterhalskrebs
公开(公告)号：EP1728865A1
公开(公告)日：2006-12-06
申请号：EP06015673.4
申请日：1999-09-03
申请人： Aventis Pasteur Limited
发明人： Gajewczyk, Diane M. , Persson, Roy , Yao, Fei-Long , Cao, Shi-Xian , Klein, Michel H. , Tartaglia, James , Moingeon, Philippe , Rovinski, Benjamin
IPC分类号： C12N15/37 , C12N15/86 , C07K14/025 , A61K48/00
CPC分类号： A61B5/055 , A61B5/0263 , A61B5/029 , A61B5/41 , A61K48/00 , A61K2039/51 , A61K2039/53 , C07K14/005 , C12N2710/20022 , C12N2710/20043 , Y10S977/804 , Y10S977/904 , Y10S977/916 , Y10S977/924
摘要： Vectors for DNA immunization against cervical cancer comprise a nucleic acid molecule encoding at least one none-toxic T-cell epitope of the E6 and/or E7 antigens of a strain of human papilloma virus (HPV) associated with cervical cancer, such as HPV-16, and a promoter operatively coupled to the nucleic acid molecule for expression of the nucleic acid molecule in a host to which the vector is administered.
摘要翻译：用于针对子宫颈癌的DNA免疫的载体包含编码与子宫颈癌相关的人乳头状瘤病毒（HPV）的菌株的E6和/或E7抗原的至少一种无毒T细胞表位的核酸分子，例如HPV- 16和可操作地偶联于核酸分子的启动子，用于在施用载体的宿主中表达核酸分子。

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