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    • 95. 发明授权
    • CONTROLLED ALIGNMENT OF NANOBARCODES ENCODING SPECIFIC INFORMATION FOR SCANNING PROBE MICROSCOPY (SPM) READING
    • 纳米条形码的排列受控对探针显微分析具体所包含的信息GRID
    • EP1543152B1
    • 2011-03-09
    • EP03752088.9
    • 2003-09-05
    • Intel Corporation
    • CHAN, SelenaSU, XingYAMAKAWA, Mineo
    • C12Q1/68G01N33/543
    • C12Q1/6816B82Y5/00B82Y10/00B82Y30/00Y10S977/702Y10S977/704Y10S977/705Y10S977/728Y10S977/729Y10S977/734Y10S977/742Y10S977/773Y10S977/774Y10S977/924C12Q2565/601C12Q2563/185
    • The methods, apparatus and compositions disclosed herein concern the detection, identification and/or sequencing of biomolecules, such as nucleic acids or proteins. In certain embodiments of the invention, coded probes comprising a probe molecule attached to one or more nanobarcodes may be allowed to bind to one or more target molecules. After binding and separation from unbound coded probes, the bound coded probes may be aligned on a surface and analyzed by scanning probe microscopy. The nanobarcodes may be any molecule or complex that is distinguishable by SPM, such as carbon nanotubes, fullerenes, submicrometer metallic barcodes, nanoparticles or quantum dots. Where the probes are oligonucleotides, adjacent coded probes hybridized to a target nucleic acid may be ligated together before alignment and SPM analysis. Compositions comprising coded probes are also disclosed herein. Systems for biomolecule analysis may comprise an SPM instrument and at least one coded probe attached to a surface.
    • 所述方法,装置和组合物在光盘游离缺失关注的生物分子如,:核酸或蛋白质等的检测,鉴定和/或测序。 在本发明的某些实施方案中,包括连接到一个或多个纳米条形码探针分子编码探针可以结合至一个或多个目标分子。 与未结合的编码探针的结合和分离后,将结合的编码探针可以在表面上对齐,并且通过扫描探针显微镜分析。 纳米条形码可以是任何分子或复合物确实是由SPM区分:例如碳纳米管,富勒烯,亚微米金属条形码,纳米颗粒或量子点。 其中探针是寡核苷酸,相邻的编码探针杂交到靶核酸之前对准和扫描探针显微镜(SPM)分析可以连接在一起。 组合物,包含编码探针因此光盘游离缺失。 用于生物分子分析系统可以包括SPM仪器和附着于表面的至少一个已编码探针的。