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1. 发明公开

EP1623762A3 Cartridge for processing a nucleic acid sample 审中-公开
标题翻译：盒用于处理核酸样品
公开(公告)号：EP1623762A3
公开(公告)日：2014-05-21
申请号：EP05022568.9
申请日：2000-12-28
申请人： F.Hoffmann-La Roche AG , Roche Diagnostics GmbH
发明人： Vischer, Peter
IPC分类号： B01L3/00 , G01N35/00 , B01F11/00 , B01L9/00
CPC分类号： B01L3/502 , B01F11/0002 , B01F11/0008 , B01L3/5027 , B01L9/527 , B01L2300/0636 , B01L2300/0816 , B01L2400/0457 , G01N2035/00158 , G01N2035/00524 , Y10S977/924
摘要： A cartridge for processing a nucleic acid sample contained in a liquid. The cartridge comprises a chip shaped carrier (14) having an active surface (15) which carries an array of oligonucleotides. The active surface (15) faces an inner surface (24) of a part (21) of the cartridge (12). The cartridge also comprises a chamber (11) which has a narrow interior and includes a curved channel (13). A portion of the channel (13) lies between the active surface (15) and the inner surface (24).

2. 发明公开

EP2360271A1 Decoding of array sensors with microspheres 审中-公开
标题翻译：米克罗斯菲尔德（Dekodierung von Arraysensoren mitMikrosphären）
公开(公告)号：EP2360271A1
公开(公告)日：2011-08-24
申请号：EP10010302.7
申请日：1999-06-24
申请人： Illumina, Inc.
发明人： Chee, Mark S. , Stuelpnagel, John R. , Czarnik, Anthony W.
IPC分类号： C12Q1/68 , B01J19/00 , G01N33/543
CPC分类号： C12Q1/6837 , B01J19/0046 , B01J2219/00317 , B01J2219/00459 , B01J2219/00466 , B01J2219/005 , B01J2219/00572 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00648 , B01J2219/00659 , B01J2219/00677 , B01J2219/00702 , B01J2219/00722 , B01L3/5085 , B82Y30/00 , C12Q1/6816 , C12Q1/6825 , C12Q1/6834 , C40B40/06 , C40B60/14 , C40B70/00 , G01N33/54313 , G06K9/6202 , Y10S977/924 , C12Q2563/155 , C12Q2563/179 , C12Q2563/107 , C12Q2527/137 , C12Q2521/313 , C12Q2537/143
摘要： The invention relates to compositions and methods for decoding microsphere array sensors based on beads which comprise nucleic acids and identifier probes for decoding the arroy.
摘要翻译：本发明涉及用于解码基于珠的微球阵列传感器的组合物和方法，所述珠包含用于解码所述arroy的核酸和标识符探针。

3. 发明公开

EP2356431A2 A METHOD FOR FORMING A NANOSTRUCTURE PENETRATING A LAYER 审中-公开
标题翻译：法形成SCHICHTPENETRIERENDEN纳米结构的
公开(公告)号：EP2356431A2
公开(公告)日：2011-08-17
申请号：EP09804260.9
申请日：2009-12-09
申请人： IMEC , Katholieke Universiteit Leuven, K.U. Leuven R&D
发明人： CHENG, Kai , VAN DORPE, Pol , LAGAE, Liesbet , BORGHS, Gustaaf , CHEN, Chang
IPC分类号： G01N21/64 , G01N21/65 , H01L21/28
CPC分类号： B82Y15/00 , B82Y20/00 , B82Y40/00 , G01N21/554 , G01N21/648 , G01N21/658 , G01N33/48721 , G01N2021/653 , Y10S977/724 , Y10S977/924
摘要： The device comprises a substrate, a layer present thereon and a nanostructure penetrating said layer, which nanostructure defines a nanoscale passageway through which a molecule to be analyzed can pass through the passageway, wherein the nanostructure has, in cross-sectional view, a substantially triangular shape. This shape is particularly achieved by growth of an epitaxial layer having crystal facets defining tilted sidewalls of the nanostructure. It is highly suitably for use for optical characterisation of molecular structure, particularly with surface plasmon enhanced transmission spectroscopy.

4. 发明公开

EP2280083A1 Nucleid acid ligand diagnostic biochip 有权
标题翻译： Diagnosebiochip mitNukleinsäureliganden
公开(公告)号：EP2280083A1
公开(公告)日：2011-02-02
申请号：EP10176907.3
申请日：1998-12-14
申请人： Somalogic, Inc.
发明人： Gold, Larry , Drolet, Daniel , Zichi, Dominic, A. , Jayasena, Sumedha , Creighton, Steve , Gill, Stanley
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04 , G01N33/543
CPC分类号： C12Q1/6839 , C07B2200/11 , C12Q1/6834 , C12Q1/6837 , C40B40/00 , Y10S977/924 , C12Q2565/514 , C12Q2565/101 , C12Q2541/101 , C12Q2525/205
摘要： A nucleic acid ligand "biochip" is disclosed, consisting of a solid support to which one or more specific nucleic acid ligands is attached in a spatially defined manner. Each nucleic acid ligand binds specifically and avidly to a particular target molecule contained within a test mixture, such as a bodily fluid. The target molecules include, but are not limited to, proteins (cellular, viral, bacterial, etc.) hormones, sugars, metabolic byproducts, cofactor, and intermediates, drugs, and toxins. Contacting the test mixture with the biochip leads to the binding of a target molecule to its cognate nucleic acid ligand. Binding of target to the nucleic acid ligand results in a detectable change at each specific location on the biochip. The detectable change can include, but is not limited to, a change in fluorescence, or a change in a physical parameter, such as electrical conductance or refractive index, at each location on the biochip. The biochip will then be read by a device, such as a fluorescence scanner or a surface plasmon resonance detector, that can measure the magnitude of the change at each location on the biochip. The location of the change reveals what target molecule has been detected, and the magnitude of the change indicates how much of it is present. The combination of these two pieces of information will yield diagnostic and prognostic medical information when signal patterns are compared with those obtained from bodily fluids of individuals with diagnosed disorders. In principle, the biochip could be used to test any chemically complex mixture provided that nucleic acid ligands to components suspected of being present in the mixture are attached to the biochip. Thus, the nucleic acid ligand biochip will have a wider use in environmental testing, etc.
摘要翻译：公开了一种核酸配体“生物芯片”，其由以空间限定的方式连接一个或多个特定核酸配体的固体支持物组成。每个核酸配体特异性地并且亲和地结合到测试混合物（例如体液）中所含的特定靶分子。靶分子包括但不限于蛋白质（细胞，病毒，细菌等）激素，糖，代谢副产物，辅因子和中间体，药物和毒素。将测试混合物与生物芯片接触导致靶分子与其同源核酸配体的结合。靶向核酸配体的结合导致生物芯片上每个特定位置的可检测变化。可检测的变化可以包括但不限于在生物芯片上的每个位置的荧光的变化或物理参数的变化，例如电导率或折射率。然后生物芯片将被诸如荧光扫描仪或表面等离子体共振检测器的装置读取，该装置可以测量生物芯片上每个位置处的变化幅度。变化的位置揭示了目标分子被检测到的，而变化的大小表明它有多少存在。当将信号模式与从具有诊断的病症的个体的体液获得的信号模式进行比较时，这两个信息的组合将产生诊断和预后的医学信息。原则上，如果怀疑存在于混合物中的组分的核酸配体连接到生物芯片上，则生物芯片可用于测试任何化学复合物混合物。因此，核酸配体生物芯片将在环境测试等方面有更广泛的应用。

5. 发明公开

EP1818417A3 Nanoparticles having oligonucleotides attached thereto and uses therefor 失效
标题翻译：附带寡核苷酸及其用途的纳米粒子
公开(公告)号：EP1818417A3
公开(公告)日：2010-01-20
申请号：EP07105334.2
申请日：1997-07-21
申请人： Nanosphere, Inc.
发明人： Mirkin, Chad A. , Letsinger, Robert L. , Mucic, Robert C. , Storhoff, James J. , Elghanian, Robert
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6837 , B01J2219/005 , B01J2219/00585 , B01J2219/00596 , B01J2219/00603 , B01J2219/00648 , B01J2219/00653 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , B82B1/00 , B82Y5/00 , B82Y15/00 , B82Y30/00 , C07H21/00 , C12Q1/6816 , C12Q1/6834 , C40B40/06 , Y10S977/924 , C12Q2565/113 , C12Q2563/155 , C12Q2565/101 , C12Q2563/137 , C12Q2565/543 , C12Q2537/125 , C12Q2537/119
摘要： A method of detecting a nucleic acid having at least two portions comprises providing nanoparticles having oligonucleotides attached thereto; providing one or more types of binding oligonucleotides, each of the binding oligonucleotides having two portions, the sequence of one portion being complementary to the sequence of one of the portions of the nucleic acid and the sequence of the other portion being complementary to the sequence of the oligonucleotides on the nanoparticles; contacting the nanoparticles and the binding oligonucleotides under conditions effective to allow hybridization of the oligonucleotides on the nanoparticles with the binding oligonucleotides; contacting the nucleic acid and the binding oligonucleotides under conditions effective to allow hybridization of the binding oligonucleotides with the nucleic acid; and observing a detectable change.

6. 发明公开

EP2109685A1 SYSTEMS AND METHODS FOR POLYMER CHARACTERIZATION 有权
标题翻译：系统和聚合物表征方法
公开(公告)号：EP2109685A1
公开(公告)日：2009-10-21
申请号：EP08701574.9
申请日：2008-01-18
申请人： International Business Machines Corporation
发明人： POLONSKY, Stanislav , ROSSNAGEL, Stephen , STOLOVITZKY, Gustavo, Alejandro
IPC分类号： C12Q1/68 , G01N15/12
CPC分类号： G01N33/48721 , B82Y15/00 , B82Y30/00 , C12Q1/6825 , C12Q1/6869 , G01N2015/0038 , Y10S977/924 , C12Q2565/631 , C12Q2565/607 , C12Q2563/155
摘要： Techniques for controlling the position of a charged polymer (112) inside a nanopore (105) are provided. For example, one technique includes using electrostatic control to position a linear charged polymer inside a nanopore, and creating an electrostatic potential well (114) inside the nanopore, whereby the electrostatic potential well controls the position of the linear charged polymer inside the nanopore. By sequentially locking each monomer unit in the potential well (114), nanopore sequencing of DNA with single base resolution can be achieved.

7. 发明公开

EP1956367A1 Characterization of individual polymer molecules based on monomer-interface interactions 失效
标题翻译： on ung ung ung ung ung ung ung ung ung ung ung ung ung ung ung ung ung ung ung ung ung ung ung ung ung
公开(公告)号：EP1956367A1
公开(公告)日：2008-08-13
申请号：EP08010129.8
申请日：1996-03-01
申请人： President and Fellows of Harvard College , The Regents of the University of California
发明人： Church, George , Deamer, David W.
IPC分类号： G01N27/04 , G01N15/10 , G01N15/12
CPC分类号： G01N33/68 , B82Y30/00 , C07K14/705 , C12N9/1241 , C12Q1/6869 , G01N33/48721 , Y10S977/781 , Y10S977/788 , Y10S977/84 , Y10S977/88 , Y10S977/924 , Y10S977/953 , C12Q2523/307
摘要： The invention provides 1 method for determining the duration of interaction of a polymer with a nanopore or ion permeable passage, the method comprising the steps of:
(a) providing a structure comprising a nanopore connecting a first pool and a second pool, wherein a polymer to be analyzed is placed in the first pool; ,
(b) causing the polymer to traverse the ion permeable passage; and
(c) measuring the duration of step (b).
摘要翻译：本发明提供了一种用于确定聚合物与纳米孔或离子可渗透通道的相互作用持续时间的方法，所述方法包括以下步骤：（a）提供包含连接第一池和第二池的纳米孔的结构，其中聚合物被分析放置在第一个池中; ，（b）使聚合物穿过离子可渗透通道; 和（c）测量步骤（b）的持续时间。

8. 发明授权

EP1108035B1 TREATMENT OF CERVICAL CANCER 有权
标题翻译：治疗宫颈癌
公开(公告)号：EP1108035B1
公开(公告)日：2007-08-08
申请号：EP99942661.2
申请日：1999-09-03
申请人： Sanofi Pasteur Limited
发明人： GAJEWCZYK, Diane, M. , PERSSON, Roy , YAO, Fei-Long , CAO, Shi-Xian , KLEIN, Michel, H. , TARTAGLIA, James , MOINGEON, Phillipe , ROVINSKI, Benjamin
IPC分类号： C12N15/37 , C12N15/86 , C07K14/025 , A61K48/00
CPC分类号： A61B5/055 , A61B5/0263 , A61B5/029 , A61B5/41 , A61K48/00 , A61K2039/51 , A61K2039/53 , C07K14/005 , C12N2710/20022 , C12N2710/20043 , Y10S977/804 , Y10S977/904 , Y10S977/916 , Y10S977/924
摘要： Vectors for DNA immunization against cervical cancer comprise a nucleic acid molecule encoding at least one none-toxic T-cell epitope of the E6 and/or E7 antigens of a strain of human papilloma virus (HPV) associated with cervical cancer, such as HPV-16, and a promoter operatively coupled to the nucleic acid molecule for expression of the nucleic acid molecule in a host to which the vector is administered.

9. 发明授权

EP1360318B1 METHOD OF DETECTION BY ENHANCEMENT OF SILVER STAINING 有权
标题翻译：检测方法由增加的银色
公开(公告)号：EP1360318B1
公开(公告)日：2006-04-26
申请号：EP01954641.5
申请日：2001-07-11
申请人： Northwestern University
发明人： LETSINGER, Robert, L. , GARIMELLA, Viswanadham
IPC分类号： C12Q1/68
CPC分类号： B82Y15/00 , C12Q2563/137 , G01N27/44721 , G01N27/44726 , Y10S977/924
摘要： The present invention relates to a method for amplifying a detection signal by enhancing or promoting the deposition of additional silver in assay detection systems where the formation of a silver spot serves as a reporter for the presence of a target molecule, including biological polymers (e.g., proteins and nucleic acids) and small molecules.

10. 发明公开

EP1271154A3 Biological applications of semiconductor nanocrystals 审中-公开
标题翻译：生物利用半导体纳米晶体
公开(公告)号：EP1271154A3
公开(公告)日：2005-08-17
申请号：EP02078313.0
申请日：1999-09-17
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： Bawendi,Moungi G. , Sundar, Vikram C. , Mikulec, Frederick V.
IPC分类号： G01N33/58 , G06K19/06 , G01N21/64 , H01L33/00
CPC分类号： G01N33/588 , B82Y15/00 , C12Q1/6844 , C12Q1/6869 , G01N33/532 , G01N33/533 , G01N33/54373 , G01N33/582 , G06K19/06046 , Y10S977/924 , Y10T428/2982 , Y10T428/2989 , Y10T428/2991 , Y10T428/2993 , Y10T428/2995 , Y10T428/2996 , Y10T436/24 , C12Q2563/155 , C12Q2563/113
摘要： The present invention provides a composition comprising fluorescent semiconductor nanocrystals associated to a compound, wherein the nanocrystals have a characteristic spectral emission, wherein said spectral emission is tunable to a desired wavelength by controlling the size of the nanocrystal, and wherein said emission provides information about a biological state or event.

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