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1. 发明公开

EP2365081A2 13 Transmembrane protein expressed in prostate cancer 审中-公开
标题翻译： 13-跨膜蛋白质在Prostatakrebs exprimiert wird
公开(公告)号：EP2365081A2
公开(公告)日：2011-09-14
申请号：EP10185550.0
申请日：2000-04-12
申请人： Agensys, Inc.
发明人： Afar, Daniel E. , Hubert, Rene S. , Leong, Kahan , Raitano, Arthur B. , Saffran, Douglas C.
IPC分类号： C12N15/12 , C07K14/705 , C07K16/28 , C12Q1/68 , G01N33/68 , A61P13/08 , A61K38/17 , A61K39/395 , A01K67/027
CPC分类号： C07K14/705 , A01K2217/05 , C07K16/3069 , C12N2799/026 , C12N2799/027
摘要： A prostate tumor associated gene (designated 24P4C12) and its encoded protein is described. 24P4C12 is highly expressed in prostate tissue xenografts, providing evidence that it is turned on in at least some prostate cancers. 24P4C12 provides a diagnostic and/or therapeutic target for prostate and other cancers
摘要翻译：描述了前列腺肿瘤相关基因（称为24P4C12）及其编码的蛋白质。 24P4C12在前列腺组织异种移植物中高度表达，提供证据表明它在至少一些前列腺癌中开启。 24P4C12提供前列腺癌和其他癌症的诊断和/或治疗靶点

2. 发明公开

EP2080802A3 Novel serpentine transmembrane antigens expressed in human cancers and uses thereof 有权
标题翻译：新蛇纹石跨膜抗原由人类癌症中表达，及其用途
公开(公告)号：EP2080802A3
公开(公告)日：2009-08-05
申请号：EP09002996.8
申请日：1999-06-01
申请人： Agensys, Inc.
发明人： Afar, Daniel E. , Hubert, Rene S. , Leong, Kahan , Raitano, Arthur B. , Saffran, Douglas C. , Mitchell, Stephen Chappell
IPC分类号： C12N15/12 , C07K14/47 , C12N15/63 , C12N5/10 , C12P21/00 , C07K16/18 , G01N33/574 , C12Q1/68 , A61K39/395
CPC分类号： C07K14/4748 , C07K14/705 , C07K14/723 , C07K16/28 , C07K16/3069 , C07K2317/34 , C07K2319/00 , Y10T436/143333
摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed "STRAP" (Serpentine TRansmembrane Antigens of the Prostate). Four particular human STRAPs are described and characterized herein. The human STRAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STRAP family, STRAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues.; Structurally, STRAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a "serpentine" manner into three extracellular and two intracellular loops. STRAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STRAP-1 is highly over-expressed in certain other human cancers.
摘要翻译：描述了一种新的细胞表面跨膜蛇形抗原的家族。在该家族中的蛋白质中的两个被完全或主要过度表达在前列腺，以及在前列腺癌，和该家族的因此，成员已被称为“绳”（前列腺的蛇形跨膜抗原）。四条特别是人类带的描述和刻画。人类带表现出高度其中结构保守的，但没有显示出显著结构同源性的任何已知的人类蛋白质。家庭STRAP的原型成员，STRAP-1，看来是在正常人组织中的前列腺细胞主要过表达的类型IIIa的膜蛋白。在结构上，STRAP-1是由六个跨膜结构域的分子拓扑结构和细胞内N-和C-末端为特征的一个339个氨基酸的蛋白质，这表明确实它折叠在一个“蛇形”方式为三个胞外和两个胞内环。 STRAP-1蛋白的表达被保持在横跨前列腺癌的不同阶段的高水平。更过，背带-1是高度在某些其他人类癌症过度表达。

3. 发明授权

EP2182064B1 GENE EXPRESSED IN PROSTATE CANCER 有权
标题翻译：在前列腺癌基因表达
公开(公告)号：EP2182064B1
公开(公告)日：2012-08-29
申请号：EP10000495.1
申请日：1999-09-30
申请人： Agensys, Inc.
发明人： Afar, Daniel E. , Hubert, Rene S. , Mitchell, Stephen Chappell
IPC分类号： C12N15/12 , C07K14/47 , C07K16/18 , C12Q1/68 , A01K67/027 , A61K38/17 , G01N33/53 , G01N33/574
CPC分类号： C07K14/47 , A01K2217/05 , A61K39/00 , Y02A50/466 , Y10S977/91 , Y10S977/916 , Y10S977/924
摘要： A novel testis-specific gene expressed in human prostate cancer, designated 22P4F11, is described. Analysis of 22P4F11 mRNA expression in normal prostate, prostate tumor xenografts, and a variety of normal tissues indicates that the expression of this gene is testis specific in normal tissues. The 22P4F11 gene is also expressed in human prostate tumors, in some cases at high levels. A full length cDNA encoding 22P4F11 is provided. The 22P4F11 transcript and/or protein may represent a useful diagnostic marker and/or therapeutic target for prostate cancer.

4. 发明公开

EP2365081A3 13 Transmembrane protein expressed in prostate cancer 审中-公开
标题翻译：其在前列腺癌中表达的13次跨膜蛋白
公开(公告)号：EP2365081A3
公开(公告)日：2012-07-18
申请号：EP10185550.0
申请日：2000-04-12
申请人： Agensys, Inc.
发明人： Afar, Daniel E. , Hubert, Rene S. , Leong, Kahan , Raitano, Arthur B. , Saffran, Douglas C.
IPC分类号： C12N15/12 , C07K14/705 , C07K16/28 , C12Q1/68 , G01N33/68 , A61P13/08 , A61K38/17 , A61K39/395 , A01K67/027 , C07K16/30
CPC分类号： C07K14/705 , A01K2217/05 , C07K16/3069 , C12N2799/026 , C12N2799/027
摘要： A prostate tumor associated gene (designated 24P4C12) and its encoded protein is described. 24P4C12 is highly expressed in prostate tissue xenografts, providing evidence that it is turned on in at least some prostate cancers. 24P4C12 provides a diagnostic and/or therapeutic target for prostate and other cancers

5. 发明授权

EP2080802B1 NOVEL SERPENTINE TRANSMEMBRANE ANTIGENS EXPRESSED IN HUMAN CANCERS AND USES THEREOF 有权
标题翻译：新型蛇形TRANS细胞膜抗原癌症的人表达，及其用途
公开(公告)号：EP2080802B1
公开(公告)日：2017-03-29
申请号：EP09002996.8
申请日：1999-06-01
申请人： Agensys, Inc.
发明人： Afar, Daniel E. , Hubert, Rene S. , Leong, Kahan , Raitano, Arthur B. , Saffran, Douglas C. , Mitchell, Stephen Chappell
IPC分类号： C12N15/12 , C07K14/47 , C12N15/63 , C12N5/10 , C12P21/00 , C07K16/18 , G01N33/574 , C12Q1/68 , A61K39/395
CPC分类号： C07K14/4748 , C07K14/705 , C07K14/723 , C07K16/28 , C07K16/3069 , C07K2317/34 , C07K2319/00 , Y10T436/143333

6. 发明公开

EP2182064A1 GENE EXPRESSED IN PROSTATE CANCER 有权
标题翻译：基因表达在前列腺癌
公开(公告)号：EP2182064A1
公开(公告)日：2010-05-05
申请号：EP10000495.1
申请日：1999-09-30
申请人： Agensys, Inc.
发明人： Afar, Daniel E. , Hubert, Rene S. , Mitchell, Stephen Chappell
IPC分类号： C12N15/12 , C07K14/47 , C07K16/18 , C12Q1/68 , A01K67/027 , A61K38/17 , G01N33/53 , G01N33/574
CPC分类号： C07K14/47 , A01K2217/05 , A61K39/00 , Y02A50/466 , Y10S977/91 , Y10S977/916 , Y10S977/924
摘要： A novel testis-specific gene expressed in human prostate cancer, designated 22P4F11, is described. Analysis of 22P4F11 mRNA expression in normal prostate, prostate tumor xenografts, and a variety of normal tissues indicates that the expression of this gene is testis specific in normal tissues. The 22P4F11 gene is also expressed in human prostate tumors, in some cases at high levels. A full length cDNA encoding 22P4F11 is provided. The 22P4F11 transcript and/or protein may represent a useful diagnostic marker and/or therapeutic target for prostate cancer.
摘要翻译：描述了在人前列腺癌中表达的新型睾丸特异性基因，称为22P4F11。在正常前列腺，前列腺肿瘤异种移植物和多种正常组织中分析22P4F11mRNA表达表明该基因的表达在正常组织中是睾丸特异性的。 22P4F11基因也在人类前列腺肿瘤中表达，在某些情况下以高水平表达。提供了编码22P4F11的全长cDNA。 22P4F11转录物和/或蛋白质可以代表前列腺癌的有用的诊断标记和/或治疗靶标。

7. 发明公开

EP2080802A2 Novel serpentine transmembrane antigens expressed in human cancers and uses thereof 有权
标题翻译：新型蛇形TRANS细胞膜抗原癌症的人表达，及其用途
公开(公告)号：EP2080802A2
公开(公告)日：2009-07-22
申请号：EP09002996.8
申请日：1999-06-01
申请人： Agensys, Inc.
发明人： Afar, Daniel E. , Hubert, Rene S. , Leong, Kahan , Raitano, Arthur B. , Saffran, Douglas C. , Mitchell, Stephen Chappell
IPC分类号： C12N15/12 , C07K14/47 , C12N15/63 , C12N5/10 , C12P21/00 , C07K16/18 , G01N33/574 , C12Q1/68 , A61K39/395
CPC分类号： C07K14/4748 , C07K14/705 , C07K14/723 , C07K16/28 , C07K16/3069 , C07K2317/34 , C07K2319/00 , Y10T436/143333
摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed "STRAP" (Serpentine TRansmembrane Antigens of the Prostate). Four particular human STRAPs are described and characterized herein. The human STRAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STRAP family, STRAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues.; Structurally, STRAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a "serpentine" manner into three extracellular and two intracellular loops. STRAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STRAP-1 is highly over-expressed in certain other human cancers.

8. 发明公开

EP1792989A1 13 Transmembrane protein expressed in prostate cancer 审中-公开
标题翻译： 13-跨膜蛋白质在Prostatakrebs exprimiert wird
公开(公告)号：EP1792989A1
公开(公告)日：2007-06-06
申请号：EP06120391.5
申请日：2000-04-12
申请人： Agensys, Inc.
发明人： Afar, Daniel E. , Hubert, Rene S. , Leong, Kahan , Raitano, Arthur B. , Saffran, Douglas C.
IPC分类号： C12N15/12 , C07K14/705 , C07K16/28 , C12Q1/68 , G01N33/68 , A61P13/08 , A61K38/17 , A61K39/395 , A01K67/027
CPC分类号： C07K14/705 , A01K2217/05 , C12N2799/026 , C12N2799/027
摘要： A prostate tumour associated gene (designated 24P4C12) and its encoded protein is described. 24P4C12 is highly expressed in prostate tissue xenografts, providing evidence that it is turned on in at least some prostate cancers. 24P4C12 provides a diagnostic and/or therapeutic target for prostate and other cancers,
摘要翻译：描述了前列腺肿瘤相关基因（称为24P4C12）及其编码的蛋白质。 24P4C12在前列腺组织异种移植物中高度表达，提供证据表明它在至少一些前列腺癌中开启。 24P4C12提供了前列腺和其他癌症的诊断和/或治疗靶点，

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