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91. 发明公开

EP0864002A1 METHODS AND COMPOSITIONS FOR DETECTION OF SPECIFIC NUCLEOTIDE SEQUENCES 失效
标题翻译：方法和组合物为检测针对特定核苷酸
公开(公告)号：EP0864002A1
公开(公告)日：1998-09-16
申请号：EP96942723.0
申请日：1996-10-25
申请人： Ramberg, Elliot R.
发明人： Ramberg, Elliot R.
IPC分类号： C12N15 , C07H21 , C12Q1
CPC分类号： C12Q1/6816 , C07H21/00 , C12Q1/6813 , C12Q1/6839 , C12Q1/689 , C12Q2525/107 , C12Q2537/119 , C12Q2521/319 , C12Q2525/125 , C12Q2521/301 , C12Q2561/108 , C12Q2563/149 , C12Q2563/143
摘要： Methods and compositions are provided for the detection of specific nucleic acid sequences purified from cellular or tissue sources. More particularly, the present invention includes methods, as illustrated in the figure, and compositions for the detection of nucleic acid sequences using a protection molecule that forms a protected nucleic acid sequence (PNAS) such as a triplex or duplex nucleic acid structure that includes the target nucleic acid sequence. An assay using the methods of the present invention may include one, two or three levels of specificity to minimize false positive signals. An assay using the methods or compositions of the present invention can be performed on large amounts of purified DNA in a single test, with high levels of sensitivity, thus eliminating the need for DNA amplification procedures.

92. 发明授权

EP0733062B1 PROTECTING NUCLEIC ACIDS AND METHODS OF ANALYSIS 有权
标题翻译： NUCLEIC进行分析保护和方法
公开(公告)号：EP0733062B1
公开(公告)日：1998-05-13
申请号：EP95903782.1
申请日：1994-11-30
申请人： PNA Diagnostics A/S
发明人： STANLEY, Christopher, John , ORUM, Henrik , JORGENSEN, Mikkel , BASBOLL, Ole
IPC分类号： C07K14/00 , C12Q1/68 , C07H21/00
CPC分类号： C07K14/003 , C07H21/00 , C12Q1/6816 , C12Q2525/107 , C12Q2521/319 , C12Q2521/301
摘要： A selected region of a nucleic acid is protected from attack by nuclease by complexing to the nucleic acid a nucleic acid analogue of the PNA type. The surviving sequence may be detected in an assay, optionally after amplification. A PCR reaction may be sterilised and its product assayed by protecting a characterising region of the product by PNA hybridisation followed by nuclease degradation of unprotected nucleic acid.

93. 发明公开

EP0829542A1 Verfahren zur Amplifikation von Nukleinsäuren 失效
标题翻译： Verfahren zur Amplifikation vonNukleinsäuren
公开(公告)号：EP0829542A1
公开(公告)日：1998-03-18
申请号：EP97115521.3
申请日：1997-09-08
申请人： HOECHST AKTIENGESELLSCHAFT
发明人： Uhlmann, Eugen, Dr. , Breipohl, Gerhard, Dr. , Benner, Steven, Prof,-Dr. , Lutz, Michael, DCh.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6844 , C12Q2525/107 , C12Q2527/101 , C12Q2565/501
摘要： Die vorliegende Erfindung betrifft ein neues vorteilhaftes Verfahren zur Amplifikation von Nukleinsäuren unter Verwendung von DNA/PNA-Primern und eines temperaturstabilen Polymeraseenzyms.
摘要翻译：核酸扩增包括：（a）在一端使用≥1个具有3'-羟基的核苷单位的PNA / DNA引物，和（b）热稳定聚合酶。

94. 发明公开

EP0383803A4 OLIGONUCLEOTIDE-POLYAMIDE CONJUGATES 有权
标题翻译：寡核苷酸 - 聚酰胺结合物
公开(公告)号：EP0383803A4
公开(公告)日：1991-03-20
申请号：EP88909271
申请日：1988-10-25
申请人： HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE
发明人： HARALAMBIDIS, JIM , TREGEAR, GEOFFREY, WILLIAM
IPC分类号： G01N33/53 , A61K38/00 , A61K47/48 , A61K48/00 , A61P31/04 , A61P31/12 , C07H21/00 , C07K1/113 , C07K5/10 , C07K7/02 , C07K7/06 , C07K14/00 , C07K17/08 , C07K19/00 , C08G69/08 , C08G69/42 , C08G69/48 , C12Q1/68 , G01N33/566 , G01N33/569 , C07H21/04 , G01N33/532 , G01N33/533 , G01N33/571
CPC分类号： C07H21/00 , A61K47/645 , C07B2200/11 , C07K7/02 , C08G69/48 , C12Q1/6834 , C12Q1/6841 , C12Q1/6876 , C12Q2525/107

95. 发明授权

EP3071707B1 DETECTION OF NUCLEIC ACIDS BY STRAND INVASION BASED AMPLIFICATION 有权转让
公开(公告)号：EP3071707B1
公开(公告)日：2018-10-31
申请号：EP14800105.0
申请日：2014-11-21
申请人： Orion Diagnostica Oy
发明人： EBOIGBODIN, Kevin , BRUMMER, Mirko
IPC分类号： C12Q1/6844 , C12Q1/6818
CPC分类号： C12Q1/689 , C12Q1/6818 , C12Q1/6844 , C12Q2600/16 , C12Q2521/507 , C12Q2525/113 , C12Q2537/1373 , C12Q2561/113 , C12Q2565/1015 , C12Q2525/107 , C12Q2525/125
摘要： A method for detecting a target nucleic acid sequence in a sample in the presence of at least protein capable of binding to single-stranded DNA is provided, comprising contacting said sample with at least one oligonucleotide probe comprising a fluorophore, a quencher and a region complementary to said target nucleic acid sequence. The sequence of the oligonucleotide probe comprises at least 20% RNA nucleotides, modified RNA nucleotides and/or PNA nucleotides.

96. 发明公开

EP3216879A1 PNA PROBE, KIT AND METHOD FOR DETECTING HUMAN PAPILLOMAVIRUS GENOTYPE 无效
标题翻译： PNA探针，试剂盒和检测人类乳头状瘤病毒基因型的方法
公开(公告)号：EP3216879A1
公开(公告)日：2017-09-13
申请号：EP15857492.1
申请日：2015-10-29
申请人： Panagene Inc.
发明人： CHOI, Bo Ra , KANG, Jae Hyun , CHOI, Jae Jin , KIM, Sung Kee , PARK, Doo San
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： C12Q1/68 , C12N2310/3181 , C12Q1/6816 , C12Q1/6818 , C12Q1/6851 , C12Q1/6888 , C12Q1/708 , C12Q2525/107 , C12Q2565/1015
摘要： The present invention relates to methods for detecting HPV using PNA detection probes. More specifically, it relates to detection probes capable of genotype specifically binding to Human Papillomavirus (hereinafter referred to as "HPV") DNA, detection kits comprising them, methods for detecting HPV genotypes using them. The present invention is capable of accurately detecting 22 HPV genotypes found in cervix, diagnosing coinfection with one or more HPV genotypes, detecting the presence or absence of other HPV genotypes than the 22 genotypes, and detecting HPV genotypes with high sensitivity and specificity.
摘要翻译：本发明涉及使用PNA检测探针检测HPV的方法。更具体地，涉及能够特异性结合人乳头瘤病毒（以下称为“HPV”）DNA的基因型检测探针，包含它们的检测试剂盒，使用它们检测HPV基因型的方法。本发明能够准确检测在宫颈中发现的22种HPV基因型，诊断与一种或多种HPV基因型的共感染，检测除22种基因型之外是否存在其他HPV基因型，并以高灵敏度和特异性检测HPV基因型。

97. 发明授权

EP2744912B1 COMPOSITIONS AND METHODS FOR DETECTING ALLELIC VARIANTS 有权
标题翻译：组合物和方法等位基因变异的检测
公开(公告)号：EP2744912B1
公开(公告)日：2016-11-02
申请号：EP12753322.2
申请日：2012-08-17
申请人： Nestec S.A.
发明人： PRINCEN, Fred , SELVARAJ, Fabiyola , SINGH, Sharat
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6851 , C12Q2525/107 , C12Q2525/186 , C12Q2535/125 , C12Q2537/163

98. 发明公开

EP3039155A1 MOLECULE DETECTION USING BORONIC ACID SUBSTITUTED PROBES 有权转让
标题翻译： ON EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN
公开(公告)号：EP3039155A1
公开(公告)日：2016-07-06
申请号：EP14838934.9
申请日：2014-08-26
申请人： Two Pore Guys, Inc.
发明人： MORIN, Trevor
IPC分类号： C12P21/00 , C12N9/00
CPC分类号： C07K14/003 , C12Q1/68 , C12Q1/6813 , G01N33/533 , C12Q2525/107 , C12Q2525/113 , C12Q2563/137 , C12Q2565/631
摘要： Provided are polymeric scaffold compositions and methods for detecting or quantitating diols such as carbohydrates or carbohydrate containing molecules (e.g., glycosylated protein). Provided herein are capture probes configured to bind to a scaffold. Also provided herein are capture probes linked to one or more reactive organoboronic moiety for binding diol-containing compounds in a solution. Methods of detecting complexes comprising diol-containing compounds for detecting or quantifying the presence of diol-containing compounds in solution using a nanopore device are also provided herein.
摘要翻译：提供了聚合物支架组合物和用于检测或定量二醇如碳水化合物或含碳水化合物的分子（例如，糖基化蛋白质）的方法。本文提供了构造成结合到支架的捕获探针。本文还提供了与一种或多种反应性有机物部分连接的捕获探针，用于在溶液中结合含二醇的化合物。本文还提供了检测包含含二醇化合物的复合物的方法，用于使用纳米孔装置检测或定量溶液中含二醇化合物的存在。

99. 发明授权

EP2494065B1 MEANS AND METHODS FOR NON-INVASIVE DIAGNOSIS OF CHROMOSOMAL ANEUPLOIDY 有权
标题翻译： MITTEL UND VERFAHRENFÜRNICHT-INVASIVE DIAGNOSE VON CHROMOSOMALER ANEUPLOIDIE
公开(公告)号：EP2494065B1
公开(公告)日：2015-12-23
申请号：EP10768959.8
申请日：2010-10-26
申请人： Lifecodexx AG
发明人： BENZ, Marcus , HOFMANN, Wera , POHL, Thomas , VON KALLE, Christoph
IPC分类号： C12Q1/68
CPC分类号： G01N33/574 , C12Q1/6806 , C12Q1/6851 , G01N2800/368 , G01N2800/385 , G06F19/22 , C12Q2525/107 , C12Q2525/121 , C12Q2537/157 , C12Q2545/101
摘要： The invention relates to a prenatal diagnostic method for the determination of a chromosomal aberration in a biological sample obtained from an individual, the method comprising: a) selecting for and isolating from said biological sample of an individual one or more target sequences of DNA molecules contained in the biological sample, wherein said target sequences comprise DNA sequences having consensus nucleosome binding regions; b)amplifying said selected target sequences; c) sequencing said amplified selected target sequences and allotting them to the chromosomes of the genome and identifying the unique allotted target sequences; d) determining a first amount for each of one or more first chromosomes identified on the basis of said unique allotted target sequences originating from said one or more first chromosomes; e) determining a second amount for each of one or more second chromosomes identified on the basis of said unique allotted target sequences originating from said one or more second chromosomes; and f) determining based on the said first and second amount a chromosomal abberation.
摘要翻译：本发明涉及一种用于确定从个体获得的生物样品中的染色体畸变的产前诊断方法，所述方法包括：a）从所述生物样品中选择和分离一个或多个包含的DNA分子的一个或多个靶序列在所述生物样品中，其中所述靶序列包含具有共有核小体结合区域的DNA序列; b）扩增所选择的靶序列; c）对所述扩增的选定靶序列进行测序并将其分配给基因组的染色体并鉴定唯一分配的靶序列; d）确定基于源自所述一个或多个第一染色体的所述唯一分配的靶序列鉴定的一个或多个第一染色体中的每一个的第一量; e）确定基于源自所述一个或多个第二染色体的所述唯一分配的靶序列鉴定的一个或多个第二染色体中的每一个的第二量; 以及f）基于所述第一和第二量确定染色体异常。

100. 发明公开

EP2780480A4 GAMMA-PNA MINIPROBES FOR FLUORESCENT LABELING 失效转让
标题翻译： GAMMA-PNA MINISONDEN ZUR FLUORESZENZMARKIERUNG
公开(公告)号：EP2780480A4
公开(公告)日：2015-06-10
申请号：EP12849889
申请日：2012-11-14
申请人： UNIV CARNEGIE MELLON , UNIV PITTSBURGH
发明人： ARMITAGE BRUCE A , OPRESKO PATRICIA L , LY DANITH , SHANK NATHANIEL
IPC分类号： C12Q1/68 , C12N15/11 , G01N33/533
CPC分类号： C12Q1/6825 , C12N15/113 , C12N2310/3181 , C12N2320/10 , C12Q1/6816 , G01N33/533 , C12Q2525/107 , C12Q2565/101
摘要： A category of γPNA miniprobes and chimeric γPNA probes is especially useful for detecting RNA and telomeric DNA in a cell sample. In particular, the probes can be used to deliver fluorescent dyes to the telomeres, allowing direct visualization of telomeres in cells.
摘要翻译：一类γPNA小分子和嵌合γPNA探针特别适用于检测细胞样品中的RNA和端粒DNA。特别地，探针可以用于将荧光染料递送到端粒，允许在细胞中直接观察端粒。

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