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91. 发明公开

EP1766051A4 METHODS FOR IDENTIFYING RISK OF BREAST CANCER AND TREATMENTS THEREOF 审中-公开
标题翻译：鉴定乳腺癌风险的方法及其治疗方法
公开(公告)号：EP1766051A4
公开(公告)日：2007-10-10
申请号：EP04753723
申请日：2004-05-27
申请人： SEQUENOM INC
发明人： ROTH RICHARD B , NELSON MATTHEW ROBERTS , BRAUN ANDREAS , KAMMERER STEFAN M , DENISSENKO MIKHAIL F , RENELAND RIKARD , ROSETTE CARIDAD , HOYAL-WRIGHTSON CAROLYN R
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172

92. 发明公开

EP1501863A4 KINASE ANCHOR PROTEIN MUTEINS, PEPTIDES THEREOF, AND RELATED METHODS 审中-公开
标题翻译：金鱼肝油蛋白，肽DAVON UND DAMIT IM ZUSAMMENHANG STEHENDE VERFAHREN
公开(公告)号：EP1501863A4
公开(公告)日：2007-01-24
申请号：EP03726581
申请日：2003-05-01
申请人： SEQUENOM INC , UNIV CALIFORNIA
发明人： BRAUN ANDREAS , CANTOR CHARLES R , KAMMERER STEFAN M , TAYLOR SUSAN , HAMURO LORA BURNS , COOK CHARLES , OLSON GARY , SELF CHRISTOPHER
IPC分类号： A01K67/027 , C07K14/47 , C12N15/12 , C07K14/00 , A61K38/16 , A61K38/17 , C12N15/11
CPC分类号： C07K14/47 , A01K67/0275 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2227/105 , A01K2267/03
摘要： A-kinase anchor protein (AKAPs) muteins, peptides thereof, and nucleic acids encoding the peptides are provided herein. Also provided are transgenic animals, cells comprising transgenes and various methods employing such peptides.
摘要翻译：本文提供了A-激酶锚定蛋白（AKAP）突变蛋白，其肽和编码该肽的核酸。还提供了转基因动物，包含转基因的细胞和使用这些肽的各种方法。

93. 发明公开

EP1601972A2 ASSOCIATION OF POLYMORPHIC KINASE ANCHOR PROTEINS WITH CARDIAC PHENOTYPES AND RELATED METHODS 审中-公开
标题翻译：与KARDIOPHÄNOTYPEN及相关手续协会多态性激酶蛋白质锚定
公开(公告)号：EP1601972A2
公开(公告)日：2005-12-07
申请号：EP04718045.0
申请日：2004-03-05
申请人： SEQUENOM, INC.
发明人： BRAUN, Andreas , KAMMERER, Stefan, M.
IPC分类号： G01N33/68 , G06F17/00 , C12Q1/68
CPC分类号： G01N33/6872
摘要： Polymorphic A-kinase anchor proteins (AKAPs) and nucleic acids encoding the proteins are provided herein. Methods of detecting polymorphic AKAPs and nucleic acids encoding the AKAPs, and kits for use in the detection methods are also provided. Further provided herein are methods of identifying subjects having or at risk of developing diseases or disorders, such as those related to signal transduction and/or cardiovascular disease. Methods of determining susceptibility to morbidity and/or increased or early mortality are also provided.

94. 发明公开

EP1565579A2 METHODS FOR IDENTIFYING RISK OF BREAST CANCER AND TREATMENTS THEREOF 有权
标题翻译：方法识别乳腺癌风险的
公开(公告)号：EP1565579A2
公开(公告)日：2005-08-24
申请号：EP03787201.7
申请日：2003-11-25
申请人： SEQUENOM, INC.
发明人： ROTH, Richard, B. , NELSON, Matthew, Roberts , BRAUN, Andreas , KAMMERER, Stefan, M. , RENELAND, Rikard
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172 , G01N33/57415 , G01N2800/52
摘要： Provided herein are methods for identifying risk of breast cancer in a subject and/or a subject at risk of breast cancer, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating breast cancer, and therapeutic methods for treating breast cancer in a subject. These embodiments are based upon an analysis of polymorphic variations in nucleotide sequences within the human genome.

95. 发明公开

EP1501863A2 KINASE ANCHOR PROTEIN MUTEINS, PEPTIDES THEREOF, AND RELATED METHODS 审中-公开
标题翻译：激酶锚定蛋白突变蛋白，其肽，及相关方法
公开(公告)号：EP1501863A2
公开(公告)日：2005-02-02
申请号：EP03726581.6
申请日：2003-05-01
申请人： SEQUENOM, INC. , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： BRAUN, Andreas , CANTOR, Charles, R. , KAMMERER, Stefan, M. , TAYLOR, Susan , HAMURO, Lora, Burns , COOK, Charles , OLSON, Gary , SELF, Christopher
IPC分类号： C07K14/00 , C07K14/47 , C12N15/11 , C12N15/12 , A61K38/16 , A61K38/17
CPC分类号： C07K14/47 , A01K67/0275 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2227/105 , A01K2267/03
摘要： A-kinase anchor protein (AKAPs) muteins, peptides thereof, and nucleic acids encoding the peptides are provided herein. Also provided are transgenic animals, cells comprising transgenes and various methods employing such peptides.
摘要翻译：本文提供了A-激酶锚定蛋白（AKAP）突变蛋白，其肽和编码该肽的核酸。还提供了转基因动物，包含转基因的细胞和使用这些肽的各种方法。

96. 发明公开

EP1460083A1 High density immobilization of nucleic acids 失效
标题翻译： Verfahren zur Analyze und Vorrichtung
公开(公告)号：EP1460083A1
公开(公告)日：2004-09-22
申请号：EP04075084.6
申请日：1997-11-06
申请人： SEQUENOM, INC.
发明人： O'Donnell, Maryanne J. , Little, Daniel P. , Cantor, Charles R. , Köster, Hubert
IPC分类号： C07H21/00 , C12Q1/68
CPC分类号： B01L3/0244 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00387 , B01J2219/00468 , B01J2219/00497 , B01J2219/005 , B01J2219/00504 , B01J2219/00511 , B01J2219/0052 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/0262 , B01L3/0268 , B01L2200/025 , B01L2300/0838 , B01L2400/0439 , B01L2400/0487 , C07B2200/11 , C07F9/2408 , C07F9/2429 , C07H21/00 , C12Q1/6816 , C12Q1/6827 , C12Q1/6834 , C12Q1/6837 , C12Q1/6858 , C12Q1/6872 , C12Q1/6883 , C12Q1/6886 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/1067 , G01N35/1074 , G01N2035/00237 , G01N2035/1037 , G01N2035/1069 , C12Q2525/197 , C12Q2523/10 , C12Q2531/113 , C12Q2565/537 , C12Q2565/627 , C12Q2565/507 , C12Q2565/518 , C12Q2535/101
摘要： The invention provides a method for analyzing a material, comprising:

providing a vesicle suitable for carrying a fluid having said material therein,
disposing said vesicle adjacent a first location of a surface of a substrate,
controlling said vesicle to deliver a nanoliter volume of the fluid to provide a defined and controlled volume of said fluid at said first location of said surface of the substrate,
moving said vesicle to a second position adjacent a second location on said surface of the substrate to dispense a defined and controlled volume of said material along an array of locations on said substrate surface, and
performing mass spectrometry analysis for said material at each location of said array.
摘要翻译：本发明提供了一种用于分析材料的方法，包括：提供适于携带其中具有所述材料的流体的囊泡，将所述囊泡设置在基底表面的第一位置附近，控制所述囊泡以输送纳升体积的流体以在衬底的所述表面的所述第一位置处提供限定和受控的体积的所述流体，将所述泡囊移动到邻近所述衬底的所述表面上的第二位置的第二位置，以沿着所述衬底的所述表面分配限定和受控体积的所述材料在所述衬底表面上的位置阵列，并且在所述阵列的每个位置对所述材料进行质谱分析。

97. 发明公开

EP1352971A2 DNA diagnostics based on mass spectrometry 失效
标题翻译： DNA诊断通过质谱
公开(公告)号：EP1352971A2
公开(公告)日：2003-10-15
申请号：EP03002612.4
申请日：1996-03-18
申请人： SEQUENOM, INC.
发明人： Köster, Hubert
IPC分类号： C12Q1/68 , C07H21/00 , C07F9/24
CPC分类号： C12Q1/6872 , C12Q1/6816 , C12Q1/6827 , C12Q1/6837 , C12Q1/6858 , C12Q1/686 , C12Q1/6862 , C12Q1/6883 , C12Q1/706 , G01N35/1067 , H01J49/00 , Y10T436/143333 , Y10T436/24 , C12Q2565/627 , C12Q2537/113 , C12Q2535/113 , C12Q2521/325 , C12Q2535/131 , C12Q2525/107 , C12Q2523/107 , C12Q2523/319 , C12Q2565/625 , C12Q2535/125
摘要： The invention provides fast and highly accurate mass spectrometer based processes for detecting a particular nucleic acid sequence in a biological sample. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromosomal abnormality; a predisposition to a disease or condition, infection by a pathogenic organism, or for determining identity or heredity.

98. 发明授权

EP0868740B1 METHOD AND APPARATUS FOR MALDI ANALYSIS 失效
标题翻译：方法和装置MALDI分析
公开(公告)号：EP0868740B1
公开(公告)日：2003-01-15
申请号：EP97941535.3
申请日：1997-09-19
申请人： SEQUENOM, INC.
发明人： HILLENKAMP, Franz
IPC分类号： H01J49/16
CPC分类号： H01J49/164 , B01J2219/00387 , C40B60/14 , H01J49/0418
摘要： Matrix assisted laser desorption/ionization is performed in a manner to thermalize large analyte ions in a plume of desorbed material for spectroscopic analysis. The thermalized ions have a low or zero mean velocity and are presented at a well-defined instant in time, reducing artifacts and sharpening the spectral peaks. In one embodiment the light is delivered to a matrix or sample holder having a cover, baffle or compartment. The baffle or compartment impedes or contains a plume of desorbed material and the analyte undergoes collisions to lower its mean velocity and directionality. Thus "thermalized", the analyte ions are passed to a mass analysis instrument. In a preferred embodiment, an optical fiber butts up against a thin transparent plate on which the specimen resides, with the matrix side in a vacuum acceleration chamber. A mechanical stage moves the specimen in both the x- and y-directions to select a point on the specimen which is to receive the radiation. The use of a fiber optic illuminator allows the entire stage assembly to be subsumed essentially within the dimensions of a conventional stage.

99. 发明公开

EP1175620A2 AUTOMATED ANALYZERS 审中-公开
标题翻译：自动分析系统
公开(公告)号：EP1175620A2
公开(公告)日：2002-01-30
申请号：EP00918447.4
申请日：2000-03-27
申请人： SEQUENOM, INC.
发明人： KÖSTER, Hubert , YIP, Ping , STEADMAN, Jhobe , REUTER, Dirk , MACDONALD, Richard
IPC分类号： G01N35/00
CPC分类号： G01N35/0099 , Y10T436/11 , Y10T436/113332 , Y10T436/203332 , Y10T436/24 , Y10T436/25875
摘要： A fully automated modular analytical system integrates instrumentation to permit analysis of biopolymer samples, such as nucleic acids, proteins, peptides and carbohydrates. The system integrates analytical methods of detection and analysis, such as mass spectrometry, radiolabeling, mass tags, chemical tags, fluorescence and chemiluminescence, with robotic technology and automated chemical reaction systems to provide a high-throughput, accurate automated system for high throughput analyses.

100. 发明公开

EP0937096A2 HIGH DENSITY IMMOBILIZATION OF NUCLEIC ACIDS 失效
标题翻译： NUCLEIC的固定化高密度
公开(公告)号：EP0937096A2
公开(公告)日：1999-08-25
申请号：EP97946893.0
申请日：1997-11-06
申请人： SEQUENOM, INC.
发明人： O'DONNELL, Maryanne, J. , CANTOR, Charles, R. , LITTLE, Daniel, P. , KOSTER, Hubert
IPC分类号： G01N27 , B01J19 , B01L3 , C07B61 , C07F9 , C07H21 , C12M1 , C12N15 , C12Q1 , G01N33 , G01N35 , G01N37 , C40B40 , C40B60
CPC分类号： B01L3/0244 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00387 , B01J2219/00468 , B01J2219/00497 , B01J2219/005 , B01J2219/00504 , B01J2219/00511 , B01J2219/0052 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/0262 , B01L3/0268 , B01L2200/025 , B01L2300/0838 , B01L2400/0439 , B01L2400/0487 , C07B2200/11 , C07F9/2408 , C07F9/2429 , C07H21/00 , C12Q1/6816 , C12Q1/6827 , C12Q1/6834 , C12Q1/6837 , C12Q1/6858 , C12Q1/6872 , C12Q1/6883 , C12Q1/6886 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/1067 , G01N35/1074 , G01N2035/00237 , G01N2035/1037 , G01N2035/1069 , C12Q2525/197 , C12Q2523/10 , C12Q2531/113 , C12Q2565/537 , C12Q2565/627 , C12Q2565/507 , C12Q2565/518 , C12Q2535/101
摘要： Processes and kits for immobilizing a high density of nucleic acids on an insoluble surface, which are particularly useful for mass spectrometric detection of nucleic acids, are disclosed. Arrays containing the immobilized nucleic acids and use of the immobilized nucleic acids in a variety of solid phase nucleic acid chemistry applications, including nucleic acid synthesis (chemical and enzymatic), hybridization and/or extension, and sequencing, are provided. Serial and parallel dispensing tools that can deliver defined volumes of fluid to generate multi-element arrays of sample material on a substrate surface are further provided. Tools provided herein can include an assembly of vesicle elements, or pins, wherein each of the pins can include a narrow interior chamber suitable for holding nanoliter volumes of fluid. Methods for dispensing tools that can be employed to generate multi-element arrays of sample material on a substrate surface are also provided. The tool can dispense a spot of fluid to a substrate surface by spraying the fluid from the pin, contacting the substrate surface or forming a drop that touches against the substrate surface. The tool can form an array of sample material by dispensing sample material in a series of steps, while moving the pin to different locations above the substrate surface to form the sample array. The prepared sample arrays may be passed to a plate assembly that disposes the sample arrays for analysis by mass spectrometry.

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