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1. 发明授权

EP3260556B1 METHODS FOR THE EXTRACTION OF NUCLEIC ACID FROM A SAMPLE 有权
公开(公告)号：EP3260556B1
公开(公告)日：2019-07-31
申请号：EP17180962.7
申请日：2007-05-30
申请人： Sequenom, Inc.
发明人： HOYAL-WRIGHTSON, Carolyn R. , BRAUN, Andreas , SCHMIDT, Karsten E.
IPC分类号： C12Q1/686 , C12Q1/6806 , C12N15/10

2. 发明公开

EP1353945A2 POLYMORPHIC KINASE ANCHOR PROTEINS AND NUCLEIC ACIDS ENCODING THE SAME 审中-公开
标题翻译：多晶型激酶锚蛋白和编码它们的核酸
公开(公告)号：EP1353945A2
公开(公告)日：2003-10-22
申请号：EP01952445.3
申请日：2001-07-05
申请人： SEQUENOM, INC.
发明人： BRAUN, Andreas
IPC分类号： C07K14/47
CPC分类号： C07K14/003
摘要： Polymorphic A-Kinase anchor proteins (AKAPs) and nucleic acids encoding the proteins are provided herein. Methods of detecting polymorphic AKAPs and nucleic acids encoding the AKAPs, and kits for use in the detection methods are also provided. Further provided herein are methods of identifying subjects having or at risk of developing disorders of signal transduction. Methods of determining susceptibility to morbidity and/or increased or early mortality are also provided.

3. 发明授权

EP0815261B1 DNA DIAGNOSTICS BASED ON MASS SPECTROMETRY 失效
标题翻译： DNA诊断，以通过MASS
公开(公告)号：EP0815261B1
公开(公告)日：2003-02-12
申请号：EP96910464.5
申请日：1996-03-18
申请人： SEQUENOM, INC.
发明人： KÖSTER, Hubert , TANG, Kai , FU, Dong-Jing , SIEGIRT, Carsten W. , LITTLE, Daniel P. , HIGGINGS, G.Scott , BRAUN, Andreas , DARNHOFER-DEMAR, Brigitte , JURINKE, Christian
IPC分类号： C12Q1/68 , G01N30/72
CPC分类号： C12Q1/6872 , C12Q1/6816 , C12Q1/6827 , C12Q1/6837 , C12Q1/6858 , C12Q1/686 , C12Q1/6862 , C12Q1/6883 , C12Q1/706 , G01N35/1067 , H01J49/00 , Y10T436/143333 , Y10T436/24 , C12Q2565/627 , C12Q2537/113 , C12Q2535/113 , C12Q2521/325 , C12Q2535/131 , C12Q2525/107 , C12Q2523/107 , C12Q2523/319 , C12Q2565/625 , C12Q2535/125
摘要： The invention provides fast and highly accurate mass spectrometer based processes for detecting a particular nucleic acid sequence in a biological sample. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromosomal abnormality; a predisposition to a disease or condition, infection by a pathogenic organism, or for determining identity or heredity.

4. 发明公开

EP3260556A1 METHODS AND COMPOSITIONS FOR THE EXTRACTION AND AMPLIFICATION OF NUCLEIC ACID FROM A SAMPLE 有权
标题翻译：从样品中提取和扩增核酸的方法和组合物
公开(公告)号：EP3260556A1
公开(公告)日：2017-12-27
申请号：EP17180962.7
申请日：2007-05-30
申请人： Sequenom, Inc.
发明人： HOYAL-WRIGHTSON, Carolyn R. , BRAUN, Andreas , SCHMIDT, Karsten E.
IPC分类号： C12Q1/68 , C12P19/34 , C12N15/10
CPC分类号： C12N15/1006 , C12N15/1003 , C12N15/1013 , C12Q1/6806 , C12Q1/686
摘要： The present invention relates to a method for extracting low molecular weight nucleic acid from a sample comprising a mixture of low molecular weight nucleic acid and high molecular weight nucleic acid, which comprises:
(a) mixing the sample, a salt and a solid support capable of reversibly binding nucleic acid, thereby forming a first binding solution, wherein the salt is present at a concentration at which the high molecular weight nucleic acid selectively adsorbs to the solid support;
(b) separating the solid support from the first binding solution, thereby yielding a fraction separated from the solid support;
(c) mixing the fraction separated from the solid support in (b) with additional salt, whereby the salt is present at a higher concentration than that of the first binding solution in (a);
(d) introducing additional solid support to the mixture in (c), thereby forming a second binding solution, wherein the low molecular weight nucleic selectively adsorbs to the additional solid support; and
(e) separating the additional solid support from the second binding solution, thereby extracting low molecular weight nucleic acid from the sample, wherein the low molecular weight nucleic acid comprises less than 1200 base pairs and the high molecular weight nucleic acid comprises 1200 or more base pairs.
摘要翻译：本发明涉及从包含低分子量核酸和高分子量核酸的混合物的样品中提取低分子量核酸的方法，其包括：（a）将样品，盐和固体载体从而形成第一结合溶液，其中所述盐以所述高分子量核酸选择性吸附至所述固体支持物的浓度存在; （b）从第一结合溶液中分离固体载体，由此产生与固体载体分离的部分; （c）将（b）中与固体载体分离的部分与另外的盐混合，由此所述盐以比（a）中的第一结合溶液更高的浓度存在; （d）将额外的固体载体引入（c）中的混合物中，由此形成第二结合溶液，其中低分子量核酸选择性吸附到另外的固体载体上; 和（e）从第二种结合溶液中分离另外的固体支持物，从而从样品中提取低分子量核酸，其中低分子量核酸包含少于1200个碱基对，高分子量核酸包含1200个或更多个碱基对。

5. 发明授权

EP0815261B3 DNA DIAGNOSTICS BASED ON MASS SPECTROMETRY 失效
标题翻译： DNA诊断，以通过MASS
公开(公告)号：EP0815261B3
公开(公告)日：2010-08-25
申请号：EP96910464.5
申请日：1996-03-18
申请人： SEQUENOM, INC.
发明人： KÖSTER, Hubert , TANG, Kai , FU, Dong-Jing , SIEGIRT, Carsten W. , LITTLE, Daniel P. , HIGGINGS, G.Scott , BRAUN, Andreas , DARNHOFER-DEMAR, Brigitte , JURINKE, Christian
IPC分类号： C12Q1/68 , G01N30/72 , H01J49/00
CPC分类号： C12Q1/6872 , C12Q1/6816 , C12Q1/6827 , C12Q1/6837 , C12Q1/6858 , C12Q1/686 , C12Q1/6862 , C12Q1/6883 , C12Q1/706 , G01N35/1067 , H01J49/00 , Y10T436/143333 , Y10T436/24 , C12Q2565/627 , C12Q2537/113 , C12Q2535/113 , C12Q2521/325 , C12Q2535/131 , C12Q2525/107 , C12Q2523/107 , C12Q2523/319 , C12Q2565/625 , C12Q2535/125
摘要： The invention provides fast and highly accurate mass spectrometer based processes for detecting a particular nucleic acid sequence in a biological sample. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromosomal abnormality; a predisposition to a disease or condition, infection by a pathogenic organism, or for determining identity or heredity.

6. 发明公开

EP2029777A2 METHODS AND COMPOSITIONS FOR THE EXTRACTION AND AMPLIFICATION OF NUCLEIC ACID FROM A SAMPLE 有权
标题翻译： VERFAHREN UND ZUSAMMENSETZUNGEN ZURNUKLEINSÄUREEXTRAKTIONAUS EINER PROBE
公开(公告)号：EP2029777A2
公开(公告)日：2009-03-04
申请号：EP07797885.6
申请日：2007-05-30
申请人： SEQUENOM, INC.
发明人： HOYAL-WRIGHTSON, Carolyn, R. , BRAUN, Andreas , SCHMIDT, Karsten, E.
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12N15/1006 , C12N15/1003 , C12N15/1013 , C12Q1/6806 , C12Q1/686
摘要： Provided herein are methods, compositions and kits to extract and relatively enrich by physical separation or amplification short base pair nucleic acid in the presence of a high background of genomic material (e.g., host or maternal nucleic acids).
摘要翻译：本发明涉及从含有目标核酸和非靶核酸的混合物的生物样品中选择性扩增靶核酸的方法，其中靶核酸是具有5'末端的双链，平坦化的核酸片段，磷酸化末端，靶核酸小于非靶核酸的大小，包括以下步骤：a）将所述生物样品，5'衔接子和3'衔接子混合，其中3'衔接子与 3'端的5'接头，从而产生双链接头复合体; b）向步骤a）的混合物中引入连接酶并将双链衔接复合物的5'衔接子与靶核酸和非靶核酸连接，由此产生连接的复合物; c）加热步骤b）的产品以释放3'适配器; d）加入聚合酶以填充连接到靶核酸的5'衔接子的单链5'突出端和非目标核酸; 和e）加入与步骤d）的产物杂交的5'衔接子并在有利于扩增靶核酸核酸的条件下进行扩增，从而靶核酸被选择性扩增。

7. 发明公开

EP0954612A2 DNA DIAGNOSTICS BASED ON MASS SPECTROMETRY 失效
标题翻译： DNA诊断，以通过MASS
公开(公告)号：EP0954612A2
公开(公告)日：1999-11-10
申请号：EP97945641.0
申请日：1997-11-06
申请人： SEQUENOM, INC.
发明人： KOSTER, Hubert , TANG, Kai , FU, Dong-Jing , SIEGERT, Carston, W. , LITTLE, Daniel, P. , HIGGINS, G., Scott , BRAUN, Andreas , DAMHOFFER-DEMAR, Brigitte , JURINKE, Christian , VAN DEN BOOM, Dirk , XIANG, Guobing , LOUGH, David, M. , Ruppert, Andreas
IPC分类号： B01J19 , B01L3 , C07B61 , C07F9 , C07H21 , C12Q1 , G01N35 , C40B40 , C40B60
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00387 , B01J2219/00468 , B01J2219/00497 , B01J2219/005 , B01J2219/00504 , B01J2219/00511 , B01J2219/0052 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00648 , B01J2219/00659 , B01J2219/00707 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C07F9/2408 , C07F9/2429 , C07H21/00 , C12Q1/6837 , C12Q1/6858 , C12Q1/6865 , C12Q1/6872 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/1067 , G01N35/1074 , G01N2035/00237 , G01N2035/1037 , G01N2035/1069 , H01J49/00 , C12Q2565/507 , C12Q2565/537 , C12Q2523/10 , C12Q2565/627 , C12Q2525/197 , C12Q2531/113 , C12Q2565/518 , C12Q2535/101
摘要： Fast and highly accurate mass spectrometry-based processes for detecting a particular nucleic acid sequence in a biological sample are provided. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromosomal abnormality; a predisposition to a disease or condition, infection by a pathogenic organism, or for determining identity or heredity.

8. 发明公开

EP0815261A2 DNA DIAGNOSTICS BASED ON MASS SPECTROMETRY 失效
标题翻译： DNA诊断工具质量
公开(公告)号：EP0815261A2
公开(公告)日：1998-01-07
申请号：EP96910464.0
申请日：1996-03-18
申请人： SEQUENOM, INC.
发明人： KÖSTER, Hubert , TANG, Kai , FU, Dong-Jing , SIEGIRT, Carsten W. , LITTLE, Daniel P. , HIGGINGS, G.Scott , BRAUN, Andreas , DARNHOFER-DEMAR, Brigitte , JURINKE, Christian
IPC分类号： G01N27 , C12N15 , C12Q1 , G01N33 , G01N35
CPC分类号： C12Q1/6872 , C12Q1/6816 , C12Q1/6827 , C12Q1/6837 , C12Q1/6858 , C12Q1/686 , C12Q1/6862 , C12Q1/6883 , C12Q1/706 , G01N35/1067 , H01J49/00 , Y10T436/143333 , Y10T436/24 , C12Q2565/627 , C12Q2537/113 , C12Q2535/113 , C12Q2521/325 , C12Q2535/131 , C12Q2525/107 , C12Q2523/107 , C12Q2523/319 , C12Q2565/625 , C12Q2535/125
摘要： The invention provides fast and highly accurate mass spectrometer based processes for detecting a particular nucleic acid sequence in a biological sample. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromosomal abnormality; a predisposition to a disease or condition, infection by a pathogenic organism, or for determining identity or heredity.

9. 发明公开

EP3617321A2 METHODS AND COMPOSITIONS FOR THE EXTRACTION AND AMPLIFICATION OF NUCLEIC ACID FROM A SAMPLE 有权
公开(公告)号：EP3617321A2
公开(公告)日：2020-03-04
申请号：EP19183631.1
申请日：2007-05-30
申请人： Sequenom, Inc.
发明人： HOYAL-WRIGHTSON, Carolyn R. , BRAUN, Andreas , SCHMIDT, Karsten E.
IPC分类号： C12Q1/68 , C12P19/34 , C12N15/10
摘要： Provided herein are methods, compositions and kits to extract and relatively enrich by physical separation or amplification short base pair nucleic acid in the presence of a high background of genomic material (e.g., host or maternal nucleic acids).

10. 发明授权

EP1261932B1 METHODS FOR IDENTIFYING POLYMORPHIC GENETIC MARKERS 有权
标题翻译：一种用于识别遗传标记的PolyMorph
公开(公告)号：EP1261932B1
公开(公告)日：2009-09-30
申请号：EP00972148.1
申请日：2000-10-13
申请人： SEQUENOM, INC.
发明人： BRAUN, Andreas , KÖSTER, Hubert , VAN DEN BOOM, Dirk , PING, Yip , RODI, Charlie , HE, Liyan , CHIU, Norman , JURINKE, Christian
IPC分类号： G06F19/00
CPC分类号： G06F19/28 , C12Q1/6827 , G06F19/18 , G06F19/22 , C12Q2563/167 , C12Q2523/125
摘要： Process and methods for creating a database of genomic samples from healthy human donors, methods that use the database to identify and correlate polymorphic genetic markers and other markers with diseases and conditions are provided.

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