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1. 发明公开

EP4371143A1 A TARGET FOR USE IN A LASER DESORPTION MASS SPECTROMETER 审中-公开
公开(公告)号：EP4371143A1
公开(公告)日：2024-05-22
申请号：EP22751015.3
申请日：2022-07-12
申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
发明人： REMPT, Martin , SEITZ, Manuel Josef , ZUTH, Christoph
IPC分类号： H01J49/04
CPC分类号： H01J49/0418

2. 发明公开

EP3336877A1 SAMPLE PLATE, METHOD OF FABRICATING THE SAME AND MASS SPECTROMETER ANALYSIS BY USING THE SAME 有权
公开(公告)号：EP3336877A1
公开(公告)日：2018-06-20
申请号：EP17207067.4
申请日：2017-12-13
申请人： University-Industry Foundation(UIF), Yonsei University
发明人： PYUN, Jae-Chul
IPC分类号： H01J49/04
CPC分类号： H01J49/0418 , G01N33/6851 , G01N2560/00 , H01J49/049
摘要： Embodiments of the present invention relate to a sample plate for mass analysis of a sample to be analyzed, a sample plate of manufacturing the same, and a mass spectrometry sample plate using the same. According to an embodiment of the present invention, the present invention includes a substrate and a photoreaction catalyst layer comprising a metal oxide formed on the substrate. There is provided a sample plate for laser desorption/ionization mass spectrometric analysis in which a sample to be analyzed is arranged on a photoreaction catalyst layer.

3. 发明授权

EP2792471B1 Polymer parts 有权转让
标题翻译：聚合物部件
公开(公告)号：EP2792471B1
公开(公告)日：2018-01-31
申请号：EP14164799.0
申请日：2014-04-15
申请人： Stratec Consumables GmbH
发明人： Naisby, Andrew , Balika, Werner , Hofer, Johann , Bauer, Georg
IPC分类号： B29C71/02 , H01J49/04
CPC分类号： C08J7/06 , B05D3/007 , B05D3/145 , B05D5/00 , B05D7/02 , C08F110/06 , C08F132/00 , C08J7/08 , C08J2323/12 , C08J2345/00 , C08L23/12 , C08L45/00 , H01J49/0418
摘要： A method of producing a polymer part comprising the following steps: (a) incorporating a hydrophobic small molecule into the polymer before, during or after manufacture of the polymer part, the hydrophobic small molecule and the polymer being essentially inert to one another; and (b) annealing the polymer part to induce migration of the hydrophobic small molecules to a surface of the polymer part to provide that surface with a specified degree of hydrophobicity defined by the combination of the polymer and the hydrophobic small molecule; is described. Polymer parts made according to the method are also described.

4. 发明授权

EP2752659B1 MALDI MASS ANALYSIS METHOD 有权
标题翻译： MALDI质量分析方法
公开(公告)号：EP2752659B1
公开(公告)日：2017-10-18
申请号：EP12827009.7
申请日：2012-08-29
申请人： The Noguchi Institute
发明人： AMANO Junko , OKUMURA Hisako
IPC分类号： G01N27/62 , G01N27/64
CPC分类号： H01J49/0031 , G01N33/6851 , H01J49/0418 , Y10T436/143333

5. 发明公开

EP3214437A1 SAMPLE SUPPORTING BODY AND METHOD OF MANUFACTURING SAMPLE SUPPORTING BODY 有权
标题翻译：样品支撑体和制造样品支撑体的方法
公开(公告)号：EP3214437A1
公开(公告)日：2017-09-06
申请号：EP16841742.6
申请日：2016-08-26
申请人： Hamamatsu Photonics K.K.
发明人： NAITO Yasuhide , KOTANI Masahiro , OHMURA Takayuki
IPC分类号： G01N27/62
CPC分类号： H01J49/0418 , B01L3/5027 , B01L2300/0819 , G01N27/62
摘要： A sample support (2) according to an aspect is a sample support for a surface-assisted laser desorption/ionization method, and includes: a substrate (21) in which a plurality of through-holes (S) passing from one surface (21a) thereof to the other surface (21b) thereof are provided; and a conductive layer (23) that is formed of a conductive material and covers at least the one surface (21a). The through-holes (S) have a width (d3) of 1 to 700 nm, and the substrate (21) has a thickness (d1) of 1 to 50 µm.
摘要翻译：根据一个方面的样品架（2）是用于表面辅助激光解吸/电离方法的样品架，并且包括：基板（21），其中从一个表面（21a）通过的多个通孔（S））被提供到其另一表面（21b）; 以及由导电材料形成并至少覆盖所述一个表面（21a）的导电层（23）。通孔（S）的宽度（d3）为1〜700nm，基板（21）的厚度（d1）为1〜50μm。

6. 发明公开

EP2466290A3 Sample preparation for ionisation with matrix-assisted laser desorption 审中-公开
标题翻译：利用基质辅助激光解吸进行电离的样品制备
公开(公告)号：EP2466290A3
公开(公告)日：2017-07-26
申请号：EP11009640.1
申请日：2011-12-07
申请人： Bruker Daltonik GmbH
发明人： Maier, Thomas
IPC分类号： G01N1/40 , G01N1/04 , H01J49/04
CPC分类号： G01N1/4055 , G01N2001/045 , H01J49/0418
摘要： A simplified sample preparation on a sample support for ionisation with laser desorption (MALDI or LDCI, for example) is proposed, whereby a homogeneous crystallisation of the matrix material is possible, even if a large quantity of analyte material is deposited, serving as the source of the analyte molecules. The method includes depositing the analyte material onto a deposition site, providing a sample site which is intended as the substrate for a matrix crystal layer at a distance from the deposition site, and establishing a liquid communication between the deposition site and the sample site. The invention also relates to a device for the preparation of samples for ionisation with matrix-assisted laser desorption, and to a sample support.
摘要翻译：在激光解吸电离（例如MALDI或LDCI）的样品载体上提供简化的样品制备，由此即使大量的分析物材料沉积，基质材料的均匀结晶也是可能的，用作源的分析物分子。该方法包括将分析物材料沉积到沉积位置上，在离沉积位置一定距离处提供旨在作为基质晶体层的基底的样品位点，并在沉积位点和样品位点之间建立液体连通。本发明还涉及用于利用基质辅助激光解吸来制备用于离子化的样品的装置以及样品支架。

7. 发明公开

EP3183553A1 METHOD OF SAMPLE PREPARATION FOR MALDI AND AUTOMATED SYSTEM THEREFOR 有权
标题翻译：用于MALDI的样品制备方法及其自动系统
公开(公告)号：EP3183553A1
公开(公告)日：2017-06-28
申请号：EP15833985.3
申请日：2015-08-17
申请人： Becton, Dickinson and Company
发明人： WILES, Timothy , MANTLO, John, D.
IPC分类号： G01N1/28 , G01N1/38 , G01N27/62 , H01J49/40
CPC分类号： G01N1/38 , G01N1/2813 , G01N1/4022 , G01N1/44 , G01N35/00722 , G01N35/1016 , G01N2001/4027 , G01N2015/0693 , H01J49/0413 , H01J49/0418 , H01J49/0468 , H01J49/40
摘要： Methods for preparing a biological sample for testing by Maldi where such methods are selected based on sample parameters. Maldi scores are obtained for a range of sample parameters (e.g. McFarland, dispense volume and number of dispenses). From the data, sample preparation parameters can be selected for a biological sample being prepared for Maldi testing. One sample preparation strategy uses multiple dispenses of sample with an intervening drying step, which yields more accurate Maldi scores, particularly for samples at the low range of McFarland values (e.g. below about 2).
摘要翻译：用于制备供Maldi测试的生物样品的方法，其中根据样品参数选择这些方法。对于一系列样品参数（例如McFarland，分配体积和分配次数）获得马尔迪分数。从数据中，可以为正准备用于马尔迪测试的生物样品选择样品制备参数。一种样品制备策略使用多次样品分配和干预干燥步骤，这产生更准确的Maldi分数，特别是对于低范围McFarland值（例如低于约2）的样品。

8. 发明授权

EP2848306B1 Dispenser system for mass spectrometric sample preparations 有权
标题翻译：用于质谱样品制剂分配系统
公开(公告)号：EP2848306B1
公开(公告)日：2016-04-06
申请号：EP13004465.4
申请日：2013-09-13
申请人： Bruker Daltonik GmbH
发明人： Schürenberg, Martin , Vossgröne, Alexander
IPC分类号： H01J49/04 , H01J49/26 , B01L3/02 , G01N35/10
CPC分类号： H01J49/0431 , B01L3/021 , B01L3/0241 , B01L2200/0615 , B01L2300/0654 , G01N35/1004 , H01J49/0418 , H01J49/26

9. 发明公开

EP2899745A3 Sample plate usable by MALDI-TOF mass spectrometer and method of fabricating the same sample plate 有权
标题翻译：通过MALDI-TOF质谱仪及其制造样品板的方法中使用的样品板
公开(公告)号：EP2899745A3
公开(公告)日：2015-08-12
申请号：EP14191929.0
申请日：2014-11-05
申请人： Industry-Academic Cooperation Foundation Yonsei University
发明人： Kim, Jo Il , Pyun, Jaechul
IPC分类号： H01J49/04 , H01J49/16
CPC分类号： H01J49/0418 , C08G61/025 , C08G2261/3424 , H01J49/164
摘要： A sample plate in use with a MALDI-TOF (matrix-assisted laser desorption ionization time-of-flight) mass spectrometer. The sample plate is usable for the mass spectrometry of a polymeric material on the order of several hundreds of Da and a method of manufacturing the same sample plate. The sample plate including a target plate, an organic matrix formed on one surface of the target plate, and a Parylene thin film formed on the target plate on which the organic matrix is formed, the Parylene thin film entirely covering the organic matrix.

10. 发明公开

EP2848306A1 Dispenser system for mass spectrometric sample preparations 有权
标题翻译： Proponubereitungen的Spendersystemfürmassenspektrometrische
公开(公告)号：EP2848306A1
公开(公告)日：2015-03-18
申请号：EP13004465.4
申请日：2013-09-13
申请人： Bruker Daltonik GmbH
发明人： Schürenberg, Martin , Vossgröne, Alexander
IPC分类号： B01L3/02 , G01N35/10
CPC分类号： H01J49/0431 , B01L3/021 , B01L3/0241 , B01L2200/0615 , B01L2300/0654 , G01N35/1004 , H01J49/0418 , H01J49/26
摘要： The invention relates to the preparation of samples on mass spectrometric sample supports with dispensing of liquids, and particularly to devices and methods to clean the dispenser. During dispensing of hundreds of samples, solved material may crystallize over time as deposit at the capillary tip of the dispenser, which impedes the vertical detachment of the drop in the medium and long run. Therefore, frequently cleaning the capillary tip is essential for a robust operation of the preparation device. The invention proposes to automatically clean the dispenser tip by creating a drop of washing fluid, such as pure solvent, fully enclosing the dispenser tip. The washing fluid is fed through a channel outside the central dispenser capillary to a location slightly above the capillary tip. The size of the hanging drop of washing fluid is photometrically regulated and monitored to prevent it from falling off prematurely.
摘要翻译：本发明涉及在分配液体的质谱样品支架上制备样品，特别涉及清洁分配器的装置和方法。在分配数百个样品期间，溶解的材料随着时间的推移可能随着分配器的毛细管尖端沉积而结晶，这阻碍了介质中的液滴的垂直分离并长期运行。因此，经常清洁毛细管尖端对于制备装置的鲁棒操作是必需的。本发明提出通过产生完全包围分配器尖端的一滴洗涤液（例如纯溶剂）来自动清洁分配器尖端。洗涤液通过中央分配器毛细管外部的通道进入到毛细管尖端稍微上方的位置。清洗液悬挂液滴的尺寸被光度调节和监测，以防过早脱落。

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