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1. 发明授权

EP3078379B1 DRUG FOR THE TREATMENT OF CHOLESTEROL ACCUMULATION DISORDERS, AND SCREENING METHOD FOR SAME 有权
公开(公告)号：EP3078379B1
公开(公告)日：2018-11-28
申请号：EP14866984.9
申请日：2014-12-03
申请人： National University Corporation Kumamoto University , Nihon Shokuhin Kako Co., Ltd.
发明人： ERA Takumi , IRIE Tetsumi
IPC分类号： A61K31/724 , A61P1/16 , A61P19/00 , A61P25/00 , A61P25/28 , A61P27/02 , C12N5/07 , C12Q1/02
CPC分类号： A61K31/724 , A61K9/0019 , C12N5/0696 , G01N33/5073 , G01N33/92 , G01N2500/04 , G01N2500/10 , G01N2800/04
摘要： Provided is a pharmaceutical composition for the treatment of disorders such as Niemann-Pick disease and GM1 gangliosidosis which are caused by the storage of cholesterol, such as lysosomal storage disease. Also provided is a method for screening for said pharmaceutical compositions that uses iPS cell strains that phenocopy phentotypes of these disorders. Provided is a pharmaceutical composition for the treatment and/or prevention of lysosomal storage disease, characterized by containing hydroxypropyl-³-cyclodextrin as an active ingredient. Also provided are an iPS cell strain derived from patients suffering from intractable disorders and prepared using a new temperature-sensitive Sendai virus vector, and a screening method for pharmaceuticals using said iPS cell strain.

2. 发明公开

EP2949221A1 FAT-PROCESSED STARCH AND PROCESS FOR PRODUCING SAME 有权
标题翻译： MIT FETT VERARBEITETESTÄRKEUND VERFAHREN ZUR HERSTELLUNG DAVON
公开(公告)号：EP2949221A1
公开(公告)日：2015-12-02
申请号：EP13873031.2
申请日：2013-04-23
申请人： Nihon Shokuhin Kako Co., Ltd.
发明人： ANDO, Ryuichi , TAKAGUCHI, Hitoshi , OKUDA, Akane , TAKADA, Masayasu
IPC分类号： A23L1/0522 , A23L1/176
CPC分类号： A23L1/0522 , A23D7/0053 , A23D7/011 , A23L5/11 , A23L13/03 , A23L17/75 , A23L29/10 , A23L29/212 , A23L29/219 , A23P20/105 , A23P20/11 , A23V2002/00 , A23V2250/5118
摘要： The present invention addresses the problem of developing a fat-processed starch which is excellent in terms of all of three properties, i.e., "workability during the preparation of a coating material for fries," "function required of coating materials for fries (adhesion to ingredients)" and "moderate slurry viscosity." The fat-processed starch of the present invention is produced by a process comprising the steps: adding a fat with which an emulsifying agent has been mixed to a starch having a water content adjusted to 25 to 45 mass%, in an amount of 0.02 to 0.4 mass% in terms of the weight of the fat excluding the emulsifying agent relative to the weight of dry matter of the starch, and mixing the fat and the starch; adjusting the water content of the mixture is 0.2 to 0.5 time that of the starch before the addition of the fat; and aging the starch having the adjusted water content.
摘要翻译：本发明涉及开发脂肪加工淀粉的问题，所述脂肪加工淀粉在三种性质方面都是优异的，即“油炸用涂料的制备过程中的可加工性”，“油炸用涂料所需的功能（粘附于成分）“和”中等浆液粘度“。本发明的脂肪加工淀粉是通过以下工序制造的，其特征在于，包括以下步骤：将已经混合有乳化剂的脂肪添加到水分含量为25〜45质量％的淀粉中，添加量为0.02〜相对于淀粉的干物质的重量，除了乳化剂以外的脂肪重量为0.4质量％，并混合脂肪和淀粉; 在添加脂肪之前，调整混合物的含水量为淀粉的0.2〜0.5倍; 并使具有调节水含量的淀粉老化。

3. 发明公开

EP2031066A1 MUTANT AND GENE ENCODING THE SAME 审中-公开
标题翻译： DAFÜRKODIERENDES GEN
公开(公告)号：EP2031066A1
公开(公告)日：2009-03-04
申请号：EP07767052.9
申请日：2007-06-05
申请人： Nihon Shokuhin Kako Co., Ltd. , Japan Agency for Marine-Earth Science and Technology
发明人： NAKAGAWA, Yoshinori , TAKADA, Masayasu , OGAWA, Koichi , HATADA, Yuji , HORIKOSHI, Hiroki
IPC分类号： C12N15/54 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12P21/02
CPC分类号： C12Y204/01019 , C12N9/1074 , C12P19/10
摘要： A mutant CGTase, having greater specific activity in the synthesis of gamma- cyclodextrin than the parent gamma -CGTase, in which at least one of the amino acid residues in the parent gamma -CGTase has been replaced with an amino acid residue differing from that particular amino acid residue in the parent gamma -CGTase. A gene encoding the amino acid sequence of the mutant. A method for manufacturing the mutant CGTase comprising: culturing the transformant that has been transformed or modified by chromosomal homologous recombination with the recombinant vector comprising the gene, and collecting the mutant CGTase produced by the transformant. Provided is an improved mutant CGTase that is imparted with greater specific activity than the parent gamma -CGTase by the addition of a mutation to gamma -CGTase, reducing the quantity of enzyme required to obtain a targeted CD composition. Provided is a gene encoding this mutant CGTase and a method for manufacturing the mutant CGTase employing this gene.
摘要翻译：一种突变体CGT酶，其在γ-环糊精的合成中具有比母体-GGTase更高的比活性，其中母体γ-GTase中的至少一个氨基酸残基被替换为与该特定的氨基酸残基不同的氨基酸残基母体γ-GTase中的氨基酸残基。编码突变体的氨基酸序列的基因。一种用于制备突变型CGT酶的方法，包括：通过与包含该基因的重组载体进行染色体同源重组而转化或修饰的转化体，并收集由转化体产生的突变型CGT酶。提供了一种改进的突变体CGTase，其通过向γ-GTTase添加突变赋予比母体γ-GTase更大的比活性，从而减少获得靶向CD组合物所需的酶的量。提供了编码该突变型CGT酶的基因和使用该基因的突变型CGTase的制造方法。

4. 发明授权

EP0956856B1 BETA-GLUCOOLIGOSACCHARIDE FOR ACCELERATING CALCIUM ASSIMILATION 有权
标题翻译： BETA-低聚葡萄糖，加快钙记录
公开(公告)号：EP0956856B1
公开(公告)日：2006-11-22
申请号：EP99303116.0
申请日：1999-04-22
申请人： Nihon Shokuhin Kako Co., Ltd.
发明人： Takase, Sachiko , Goda, Toshinao , Unno, Takehiro , Nakakuki, Teruo
IPC分类号： A61K31/702 , A61P3/14
CPC分类号： A61K31/70

5. 发明公开

EP1308508A1 NOVEL CYCLODEXTRIN GLUCANOTRANSFERASE, PROCESS FOR PRODUCING THE SAME AND PROCESS FOR PRODUCING CYCLODEXTRIN BY USING THIS ENZYME 有权
标题翻译：环糊精GLUCANTRANSFERASE，方法及其及其制备方法环糊精中使用该酶
公开(公告)号：EP1308508A1
公开(公告)日：2003-05-07
申请号：EP01932221.3
申请日：2001-05-23
申请人： Nihon Shokuhin Kako Co., Ltd.
发明人： TAKADA, Masayasu , IDE, Takahiro , YAMAMOTO, Takeshi , UNNO, Takehiro , WATANABE, Yoshimi , SONE, Hironobu , YAMAMOTO, Mikio
IPC分类号： C12N9/10 , C12P19/18 , C12N1/20
CPC分类号： C12N9/1074 , C12P19/18
摘要： CGTase having the following enzymatic chemical properties: (1) Function and substrate specificity: funtioning on starch, dextrin, amylopectin, and amylose to produce primarily γ -CD, with the quantities of β- and α-CD produced being smaller than the quantity of γ -CD produced; (2) Optimum pH: 10.5-11.0; (3) Optimum temperature: About 60°C; (4) Stable pH: 6-11; and (5) Temperature stability: With a 15 minute-treatment at 50°C, residual activity of not less than 90 percent is exhibited. A method of manufacturing cyclodextrin glucanotransferase in which a microorganism belonging to the species Bacillus clarkii (for example, FERM BP-7156) and having the ability to produce cyclodextrin glucanotransferase is cultured, cyclodextrin glucanotransferase is produced in the cultured product, and the cyclodextrin glucanotransferase that has been produced is collected. A method of manufacturing CD in which CGTase produced by the species Bacillus clarkii is reacted with a solution comprising starch or the like to produce principally γ -cyclodextrin. γ -Cyclodextrin glucanotransferase (CGTase) capable of predominantly producing γ -CD, a microorganism having the ability to produce γ -CGTase, and a method of manufacturing γ -CD using γ -CGTase are provided.
摘要翻译： CGT酶具有下列酶学化学性质：（1）功能和底物特异性：funtioning上淀粉，糊精，支链淀粉，直链淀粉和以产生主要伽马CD，与β-的量 - 和α-CD制备比的量小伽马-CD产生; （2）最适pH：10.5-11.0; （3）最适温度：约60℃; （4）稳定的pH：6-11; 和（5）温度稳定性：在50℃C，不低于90％的残余活性在15分钟处理展出。制造的环糊精葡聚糖转移酶的一种方法，其中属于虾种芽孢杆菌的微生物（例如，FERM BP-7156）和具有产生的环糊精葡聚糖转移酶的能力进行培养时，环糊精葡聚糖转移酶在培养产物产生，和环糊精葡聚糖转移酶没有已经产生被收集。其中CGT酶由虾种芽孢杆菌产生的制造CD的方法进行反应用溶液包含淀粉或类似物以产生主要地γ-环糊精。 γ-环糊精葡聚糖转移酶（CGT酶），其能够生产主要伽马CD，具有产生伽马-CGTase的能力的微生物，并且使用制造提供-CGTase伽马伽马CD的方法。

6. 发明公开

EP1287827A1 IMMUNOPOTENTIATOR 有权
标题翻译：免疫增强剂
公开(公告)号：EP1287827A1
公开(公告)日：2003-03-05
申请号：EP01930134.0
申请日：2001-05-15
申请人： Nihon Shokuhin Kako Co., Ltd.
发明人： TAKEUCHI, Masayasu , NAKAMURA, Nobuyuki
IPC分类号： A61K31/715 , A61K35/78 , A61P37/04 , C08B37/14
CPC分类号： C08B37/006 , A61K31/715 , A61K36/899 , A61K39/39 , C08B37/0057
摘要： The present invention relates to an immuno-active agent showing an action of activating the immunity of organisms by orally ingesting it. This immuno-active agent contains hemicellulose obtained from cornhusk and/or its partially hydrolyzed product. The hemicellulose is preferably the one obtained by removing starch and protein from cornhusk and subjecting the residue to extraction with an alkali. Further, the partially hydrolyzed product of hemicellulose is preferably the one obtained by removing starch and protein from cornhusk and subjecting the residue to extraction with an alkali, and further treating the hemicellulose with a xylanase, and its mass average molecular weight is preferably from 20,000 to 200,000.
摘要翻译：本发明涉及通过口服摄取而显示激活机体免疫力的作用的免疫活性剂。该免疫活性剂含有从玉米穗叶螨和/或其部分水解产物获得的半纤维素。半纤维素优选是通过从玉米穗中除去淀粉和蛋白质并将残余物用碱提取而获得的。此外，半纤维素的部分水解产物优选为通过从玉米穗上除去淀粉和蛋白质并用碱提取残余物并进一步用木聚糖酶处理半纤维素而获得的产物，其质均分子量优选为20,000至 200000。

7. 发明公开

EP0956856A3 Calcium assimilation accelerator, calcium supplementing diet and method for accelerating calcium assimilation 有权
标题翻译：钙的摄入，钙类膳食补充剂和方法的加速器钙摄取的加速
公开(公告)号：EP0956856A3
公开(公告)日：2002-05-02
申请号：EP99303116.0
申请日：1999-04-22
申请人： Nihon Shokuhin Kako Co., Ltd.
发明人： Takase, Sachiko , Goda, Toshinao , Unno, Takehiro , Nakakuki, Teruo
IPC分类号： A61K31/702 , A61K33/06 , A23L1/236 , A61P3/02
CPC分类号： A61K31/70
摘要： Disclosed is a calcium assimilation accelerator which contains a β-glucooligosaccharide as an active ingredient, a calcium-supplementing diet which contains a β-glucooligosaccharide and a calcium material, and a method for accelerating calcium assimilation using the calcium assimilation accelerator.
摘要翻译：本发明提供一种钙吸收促进剂其中含有的β-glucooligosaccharide作为活性成分，钙补充饮食其中含有的β-glucooligosaccharide和钙的材料，以及使用该钙同化加速器加速钙同化的方法。

8. 发明公开

EP1120046A1 PET FOODS 审中-公开
标题翻译： TIERFUTTER
公开(公告)号：EP1120046A1
公开(公告)日：2001-08-01
申请号：EP99970299.6
申请日：1999-10-08
申请人： Nihon Shokuhin Kako Co., Ltd.
发明人： FURUSE, Mitsuhiro , SAKO, Toshinori
IPC分类号： A23K1/16 , A23K1/18
CPC分类号： A23K50/40 , A23K20/163 , Y10S426/805
摘要： A pet food containing a cyclodextrin such as β -cyclodextrin, such as a dog food and a cat food. For example, a pet food in which a content of fat is equal to or higher than 5 % by weight per solid part and a content of β -cyclodextrin ranges from 1 to 15 % by weight per solid part. A method of suppressing an increase of a body weight of a pet or reducing the body weight, characterized by feeding the aforementioned pet food to a pet to the extent that an ingested amount of β -cyclodextrin ranges from 0.1 to 5 g per 1 kg of body weight for one day. It is possible to provide a novel pet food which is suited to a liking of a pet because of having the same taste and mouth-feeling as conventional pet foods, and which can suppress an increase of a body weight of a pet or reduce the body weight with the same feeding amount as conventional, and a method which can suppress an increase of a body weight of a pet or reduce the body weight without impairing health of pets.
摘要翻译：含有环糊精如β-环糊精的宠物食品，如狗食和猫食。例如，其中脂肪含量等于或高于每个固体部分的5重量％和β-环糊精的含量的宠物食品的范围为每个固体部分的1至15重量％。一种抑制宠物体重增加或降低体重的方法，其特征在于将上述宠物食品喂给宠物，其摄取量的β-环糊精的量为0.1至5g / 1kg 体重一天。由于具有与传统宠物食品相同的味道和口感，可以提供适合于宠物喜好的新型宠物食品，并且能够抑制宠物体重的增加或减少身体重量与常规相同的饲喂量，以及能够抑制宠物体重增加或减轻体重而不损害宠物健康的方法。

9. 发明授权

EP0618236B1 Method for recovering cyclodextrin 失效
标题翻译：一种用于环糊精的取得处理
公开(公告)号：EP0618236B1
公开(公告)日：1998-10-21
申请号：EP94302305.1
申请日：1994-03-30
申请人： Nihon Shokuhin Kako Co., Ltd.
发明人： Nakamura, Nobuyuki , Yamamoto, Mikio , Sumiyoshi, Hideyuki
IPC分类号： C08B37/16
CPC分类号： C08B37/0012

10. 发明公开

EP0704495A3 Biodegradable compositions 失效
标题翻译：可生物降解成分
公开(公告)号：EP0704495A3
公开(公告)日：1997-01-15
申请号：EP95114621.6
申请日：1995-09-18
申请人： Nihon Shokuhin Kako Co., Ltd.
发明人： Shitaohzono, Tetsuya , Muramatsu, Akira , Hino, Jiro
IPC分类号： C08L101/00 , C08L3/02 , C08L67/04
CPC分类号： C08L3/00 , C08L67/04 , C08L101/00 , C08L2201/06 , C08L2666/02 , C08L2666/26
摘要： Disclosed is biodegradable compositions comprising a biodegradable resin and starch, wherein fat or oil treated starch or its gelatinized product is utilized as the starch and thereby its production cost and biodegradability is improved without losing its mechanical properties. Biodegradable compositions comprising a gelatinized product of fat or oil treated starch and a biodegradable resin. A process for the production of the biodegradable composition comprising a gelatinized fat or oil treated starch and a biodegradable resin described above, which comprises heating and kneading fat or oil treated starch and a biodegradable resin in the presence of water or water and a plasticizer.

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