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1. 发明授权

US07338781B2 Organic anion transporting (oat)-like protein UST3-LIKE1 and uses thereof 失效
标题翻译：有机阴离子输送（燕麦）样蛋白质UST3-LIKE1及其用途
公开(公告)号：US07338781B2
公开(公告)日：2008-03-04
申请号：US10548420
申请日：2004-03-04
申请人： Stefan Golz , Ulf Brüggemeier , Andreas Geerts
发明人： Stefan Golz , Ulf Brüggemeier , Andreas Geerts
IPC分类号： C21P21/06 , C07K14/00
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention is directed to a polynucleotide sequence of a novel organic anion transporting (OAT)-like protein UST3-likel. More particularly, the present invention provides a polynucleotide sequence comprising the nucleic acid sequence SEQ ID NO: 1 or nucleic acid sequences that hybridize to SEQ ID NO: 1 or its complimentary strand. The invention also provides the human UST3-LIKE1 associated with the gastrointestinal and liver diseases, metabolic diseases, hematological disorders, respiratory diseases, neurological disorders, urological disorders and cardiovascular diseases as a result of relative quantification of the mRNA distribution in different human tissues by expression profiling. The invention also provides assays for the identification of compounds useful for the modulation of said diseases. The methods of the invention involve cell-free and cell-based assays that identify compounds which bind to and/or activate or inhibit the activity of UST3-LIKE1, a organic anion transporting (OAT)-like protein, followed by an in vivo assay of the effect of the compound on said diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of UST3-LIKE1 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明涉及新型有机阴离子转运（OAT）样蛋白UST3-可能的多核苷酸序列。更具体地，本发明提供了包含核酸序列SEQ ID NO：1或与SEQ ID NO：1或其互补链杂交的核酸序列的多核苷酸序列。本发明还提供了与胃肠和肝脏疾病，代谢疾病，血液学疾病，呼吸系统疾病，神经系统疾病，泌尿系统疾病和心血管疾病相关的人类UST3-LIKE1，其是通过表达相对定量不同人体组织中的mRNA分布的结果剖析。本发明还提供用于鉴定可用于调节所述疾病的化合物的测定。本发明的方法包括无细胞和基于细胞的测定，其鉴定结合和/或活化或抑制UST3-LIKE1（有机阴离子转运（OAT）样蛋白）的活性的化合物，然后进行体内测定化合物对所述疾病的作用。本发明还涉及结合和/或活化或抑制UST3-LIKE1的活性的化合物以及包含这些化合物的药物组合物。

2. 发明授权

US06905842B1 Therapeutic and diagnostic agents 失效
公开(公告)号：US06905842B1
公开(公告)日：2005-06-14
申请号：US08962560
申请日：1997-10-31
申请人： Douglas J. Hilton , Warren S. Alexander , Elizabeth M. Viney , Tracy A. Willson , Rachael T. Richardson , Robyn Starr , Sandra E. Nicholson , Donald Metcalf , Nicos A. Nicola
发明人： Douglas J. Hilton , Warren S. Alexander , Elizabeth M. Viney , Tracy A. Willson , Rachael T. Richardson , Robyn Starr , Sandra E. Nicholson , Donald Metcalf , Nicos A. Nicola
IPC分类号： A61K38/00 , C07H21/04 , C07K14/47 , C12N15/09 , C12P21/06 , C12Q1/68 , G01N33/53 , G01N33/564 , G01N33/574 , G01N33/68 , C21P21/06 , C14P14/00
CPC分类号： G01N33/564 , A61K38/00 , C07K14/4703 , G01N33/574 , G01N33/6863
摘要： The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated signal transduction. The molecules of the present invention are useful, therefore, in modulating cellular responsiveness to cytokines as well as other mediators of signal transduction such as endogenous or exogenous molecules, antigens, microbes and microbial products, viruses or components thereof, ions, hormones and parasites.

3. 发明授权

US5827682A Two-step conversion of vegetable protein isoflavone conjugates to aglucones 失效
标题翻译：将植物蛋白异黄酮共轭物两步转化成甙元
公开(公告)号：US5827682A
公开(公告)日：1998-10-27
申请号：US730171
申请日：1996-10-15
申请人： Barbara A. Bryan , Maryann C. Allred , Mark A. Roussey
发明人： Barbara A. Bryan , Maryann C. Allred , Mark A. Roussey
IPC分类号： C07D311/36 , C07H17/07 , C12P17/06 , C21P21/06 , C07D311/64 , C12N9/24
CPC分类号： C12P17/06 , C07H17/07
摘要： Disclosed are methods for converting isoflavone conjugates in vegetable protein materials to isoflavone aglucones by forming an aqueous mixture of a vegetable protein material containing isoflavone conjugates, converting the isoflavone conjugates to isoflavone glucones, and converting the isoflavone glucones to isoflavone aglucones. The vegetable protein material may also contain isoflavone glucones which are converted to isoflavone aglucones. The isoflavone conjugates, isoflavone glucones, or isoflavone aglucones present in the vegetable protein material may be removed from the vegetable materials before, during, or after the conversion process.
摘要翻译：公开了通过形成含有异黄酮共轭物的植物蛋白材料的水性混合物，将异黄酮共轭物转化为异黄酮葡糖酸酯，并将异黄酮葡萄糖苷转化为异黄酮糖苷的方法，将植物蛋白材料中的异黄酮共轭物转化为异黄酮糖苷。植物蛋白材料还可以含有异黄酮葡萄糖甙，其被转化成异黄酮糖苷。存在于植物蛋白材料中的异黄酮共轭物，异黄酮葡萄糖甙或异黄酮甙元可以在转化过程之前，期间或之后从植物材料中除去。

4. 发明授权

US6146668A Preparation of isoflavones from legumes 失效
标题翻译：从豆类制备异黄酮
公开(公告)号：US6146668A
公开(公告)日：2000-11-14
申请号：US847850
申请日：1997-04-28
申请人： Graham E. Kelly , Jiu Li Huang , Mark G. Deacon-Shaw , Mark A. Waring
发明人： Graham E. Kelly , Jiu Li Huang , Mark G. Deacon-Shaw , Mark A. Waring
IPC分类号： C12P17/06 , C12P17/18 , C21P21/06 , A61K31/337 , A61K35/78 , C12N9/24
CPC分类号： C12P17/182 , C12P17/06
摘要： Processes for the production of isoflavones are described wherein plant material from plants of the genus leguminosae are contacted with water, an enzyme which cleaves isoflavone glycosides to the aglucone form and a C.sub.2 -C.sub.10 organic solvent, so as to form a combination, incubating the combination for a time sufficient to allow isoflavones of the aglucone form to partition into the organic solvent component, and thereafter recovering isoflavones from the organic solvent component.
摘要翻译：描述了用于生产异黄酮的方法，其中来自豆科植物的植物材料与水接触，将异黄酮糖苷切割成配基形式的酶和C2-C10有机溶剂，以形成组合，孵育组合足以允许配基形式的异黄酮分配到有机溶剂组分中，然后从有机溶剂组分中回收异黄酮。

5. 发明授权

US5726034A Aglucone isoflavone enriched vegetable protein extract and protein material, and high genistein and daidzein content materials and process for producing the same 失效
标题翻译：富含肌苷异黄酮的植物蛋白提取物和蛋白质材料，高染料木黄酮和黄豆苷原含量的材料及其制备方法
公开(公告)号：US5726034A
公开(公告)日：1998-03-10
申请号：US709026
申请日：1996-09-06
申请人： Barbara A. Bryan , Maryann C. Allred
发明人： Barbara A. Bryan , Maryann C. Allred
IPC分类号： C12P17/16 , A23J3/14 , A23J3/16 , A23L11/00 , A23L11/30 , A61K31/35 , A61K31/352 , C07D311/36 , C07K14/415 , C12P17/06 , C21P21/06 , A61K35/78 , C12N9/24 , A61K31/337
CPC分类号： C12P17/06 , A23J3/14 , A23J3/16 , A23L11/07 , A23L11/33 , A23L11/34
摘要： An aglucone is isoflavone enriched vegetable protein extract and protein material are provided, as well as a high genistein content material and a high daidzein content material. Isoflavone conjugates in a vegetable material are converted to isoflavone glucosides by treating the vegetable material at a temperature and a pH for a period of time sufficient to effect the conversion. The isoflavone glycosides are converted to glucose isoflavones by enzymatic reaction. The vegetable material is extracted with an aqueous extractant having a pH above about the isoelectric point of protein in the vegetable material to extract protein and the isoflavones either before or after conversion of the isoflavone conjugates to isoflavone glucosides or the conversion of the isoflavone glucosides to aglucone isoflavones. An aglucone isoflavone enriched protein material is produced by precipitating the protein and aglucone isoflavones from the extract. A high genistein content material or a high daidzein content material may be produced from the aglucone isoflavone enriched protein extract or aglucone isoflavone enriched protein material by separating the high genistein or high daidzein content material from the extract or protein material.
摘要翻译：配基是富含异黄酮的植物蛋白提取物和蛋白质材料，以及高染料木黄酮含量的材料和高黄豆苷原含量的材料。将植物材料中的异黄酮共轭物通过在温度和pH下处理植物材料一段足以实现转化的时间转化为异黄酮糖苷。异黄酮糖苷通过酶反应转化成葡萄糖异黄酮。植物材料用pH高于植物原料蛋白质等电点的水提取剂提取，以在将异黄酮共轭物转化为异黄酮糖苷之前或之后提取蛋白质和异黄酮，或将异黄酮糖苷转化成配基异黄酮通过从提取物中沉淀蛋白质和配基异黄酮产生富含配基异黄酮的蛋白质材料。通过从提取物或蛋白质材料中分离高染料木黄酮或高黄豆苷原含量的材料，可以从富含配基异黄酮的蛋白质提取物或富含配基异黄酮的蛋白质材料中产生高染料木黄酮含量的材料或高黄豆苷原含量的材料。

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