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1. 发明专利

AU2003246345B2 High Potency Dihydroergotamine Compositions 未知
公开(公告)号：AU2003246345B2
公开(公告)日：2005-04-14
申请号：AU2003246345
申请日：2003-09-16
申请人： POZEN INC
发明人： PLACHETKA JOHN R , GILBERT DONNA
IPC分类号： A61K9/00 , A61K9/08 , A61K31/48 , A61K31/495 , A61K31/52 , A61K31/522 , A61K31/56 , A61K47/02 , A61K47/10 , A61P25/06 , A61K009/08 , A61K031/48 , A61K047/10 , A61K047/02 , A61P025/06
摘要： The present invention is directed to improved formulations for dihydroergotamine in which the drug is present at a concentration of at least 2.9 mM. The invention encompasses methods for using these formulations in treating patients for migraine headaches and the packaging of formulation into prefilled syringes for self-administration by patients.

2. 发明专利

AU2001272535B2 Transdermal therapeutic system for highly dispersed silicon dioxide 未知
公开(公告)号：AU2001272535B2
公开(公告)日：2005-04-28
申请号：AU2001272535
申请日：2001-07-12
申请人： HEXAL AG
发明人： WILHELM MARTINA , KRAMER KAI-THOMAS , KLOKKERS KARIN
IPC分类号： A61J1/00 , A61K9/70 , A61K47/02 , A61K47/04 , A61M37/00 , A61K009/70 , A61K047/02
摘要： In a transdermal therapeutic system (TTS) comprising an impermeable backing layer, one or more matrix layers (at least one of which is self-adhesive) containing active agent(s) (A) and a removable backing layer, highly dispersed silicon dioxide (I) is contained in the matrix layer(s) to increase permeation through the skin. Independent claims are included for two alternative forms of the TTS, in which: (a) the matrix layer(s) is/are coated with an adhesive layer (rather than being self-adhesive) and (I) is contained in the adhesive layer; or (b) the matrix layer(s) is/are replaced by an (A)-containing reservoir layer provided with a semipermeable membrane and an adhesive layer, (I) being contained in the adhesive layer.

3. 发明专利

AU2001246883B2 Stabilized pharmaceutical compositions containing calcium channel blockers 未知
公开(公告)号：AU2001246883B2
公开(公告)日：2004-08-12
申请号：AU2001246883
申请日：2001-04-10
申请人： SANKYO CO , UBE INDUSTRIES
发明人： NISHIMURA KENJI , USUI FUSAO , WAKIYAMA NAOKI
IPC分类号： A61K9/20 , A61K31/4418 , A61K31/4422 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/675 , A61K47/02 , A61P9/12 , C07D211/90 , C07D401/06 , C07F9/6571 , A61K031/4422 , C07D405/06 , C07D211/92 , A61K047/02 , A61K031/4545 , A61K031/443 , A61K031/675 , A61K031/444 , A61K031/4439 , A61K031/4427 , C07F009/59
摘要： The present invention provides a pharmaceutical composition containing a calcium blocker of the following formula or a pharmacologically acceptable salt thereof and a pharmacologically acceptable alkaline material which is added to an extent such that an aqueous solution or dispersion solution of said pharmaceutical composition containing a calcium blocker has a pH of at least 8: Äwherein R represents an optionally substituted C1-C4 alkyl group, an amino group or a cyano group; R represents an optionally substituted C1-C4 alkyl group, a substituted C3-C4 alkenyl group, or a substituted 4- to 6-membered cyclic amino group; R represents a substituted phenyl group; R represents an optionally substituted C1-C4 alkoxycarbonyl group, a 1,3,2-phosphorinan-2-yl group, or a 5,5-dimethyl-1,3,2-phosphorinan-2-yl group, R represents a C1-C4 alkyl groupÜ.

4. 发明专利

AU2001273268B2 Compositions containing therapeutically active components having enhanced solubility 未知
公开(公告)号：AU2001273268B2
公开(公告)日：2005-08-25
申请号：AU2001273268
申请日：2001-07-09
申请人： ALLERGAN INC
发明人： KERSLAKE EDWARD D S , OLEJNIK OREST
IPC分类号： C07D241/42 , A61K9/00 , A61K9/08 , A61K31/4164 , A61K31/498 , A61K47/02 , A61K47/04 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/42 , A61P25/02 , A61P27/02 , A61P43/00 , C07D403/12 , A61K031/557 , A61K047/02 , A61K047/38 , A61K009/08
摘要： The invention relates to an aqueous composition comprising a solution of: a quinoxaline component; a solubility enhancing component selected from the group consisting of carboxymethyl cellulose and mixtures thereof; and a liquid carrier component, whereby the following composition is excluded:

5. 发明专利

CZ5190U1 Antimicrobial therapeutic composition 未知
公开(公告)号：CZ5190U1
公开(公告)日：1996-11-13
申请号：CZ556296
申请日：1996-07-15
申请人： SUROVEC JAN , JALOVCIAR VLADIMIR ING , VUTCH CHEMITEX
发明人： SUROVEC JAN ING , JALOVCIAR VLADIMIR ING , SLAVIK JURAJ ING , KABATOVA VIERA ING
IPC分类号： A61K33/38 , A61K47/02 , A61K033/38 , A61K047/02

6. 发明专利

AU2001249860B2 Oral delivery method and composition for solid medications or dietary supplements 未知
公开(公告)号：AU2001249860B2
公开(公告)日：2005-12-01
申请号：AU2001249860
申请日：2001-04-05
申请人： MONOSOL RX LLC
发明人： FUISZ RICHARD
IPC分类号： A23L1/30 , A61K9/00 , A61K9/08 , A61K9/20 , A61K9/22 , A61K9/28 , A61K9/48 , A61K31/60 , A61K47/02 , A61K47/12 , A61K47/16 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/46 , A61K047/00 , A61K009/20 , A61K047/02 , A61K009/22 , A61K009/10
摘要： An oral delivery composition and method are provided for facilitating the swallowing of a solid object such as a pill, tablet, capsule or caplet. The oral delivery composition is made up of a mixture of a base liquid and at least one additive. The additive is selected and is present in the oral delivery composition in a sufficient concentration such that the oral delivery composition has improved physical properties, in comparison with the base liquid, so that when the oral delivery composition and a solid object to be swallowed by a user are administered together to the user and swallowed, the solid object is less likely to become lodged or stuck on tongue, throat, palate or esophageal surfaces of the user, in comparison to when the base liquid and the solid object are administered together and swallowed.

7. 发明专利

AU2001233738B2 Improved paste formulations 未知
公开(公告)号：AU2001233738B2
公开(公告)日：2005-11-03
申请号：AU2001233738
申请日：2001-02-05
申请人： BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC
发明人： CHEN JUN
IPC分类号： A61K9/06 , A61K9/00 , A61K31/341 , A61K45/00 , A61K47/02 , A61K47/04 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/20 , A61K47/22 , A61K47/24 , A61K47/26 , A61K47/36 , A61K47/38 , A61P1/00 , A61P5/26 , A61P5/30 , A61P15/00 , A61P19/02 , A61P25/02 , A61P29/00 , A61P31/04 , A61P33/14 , A61P43/00 , A61K047/02 , A61K047/18 , A61K047/34 , A61K047/10 , A61K047/26
摘要： This invention provides for a pharmaceutical or veterinary paste formulation comprising: an effective amount of a therapeutic agent; fumed silica; a viscosity modifier; a hydrophilic carrier; optionally, an absorbent; and optionally, a colorant, stabilizer, surfactant, or preservative. This invention also provides for methods of using these formulations for treating various disease states as well.

8. 发明专利

AU2005100024B4 Aqueous insecticidal pour-on formulation 未知
公开(公告)号：AU2005100024B4
公开(公告)日：2005-05-12
申请号：AU2005100024
申请日：2005-01-11
申请人： SCHERING PLOUGH PTY LTD
发明人： SHEPHERD STANLEY
IPC分类号： A61K9/10 , A01N25/00 , A01N25/04 , A01N47/34 , A61K9/00 , A61K9/12 , A61K31/17 , A61K31/231 , A61K31/435 , A61K47/02 , A61K47/04 , A61K47/32 , A61K47/36 , A61K47/38 , A61P33/00 , A61P33/14 , A61K031/17 , A61P033/00 , A61K047/02 , A61K047/36 , A01N047/34
摘要： A topically acceptable aqueous pour-on formulation adapted for localized external application to an animal, which format includes an effective amount of a water insoluble insect growth regulator (IGR), a suspending agent, a surfactant or mixture of surfactants, and an aqueous carrier.

9. 发明申请

US20020041903A1 TOPICAL DELIVERY OF ARGININE OF CAUSE BENEFICIAL EFFECTS 失效
标题翻译：导致神经系统受损的原因
公开(公告)号：US20020041903A1
公开(公告)日：2002-04-11
申请号：US08932227
申请日：1997-09-17
发明人： ERIC T. FOSSEL
IPC分类号： A61K033/00 , A61K047/02
CPC分类号： A61K31/198 , A61K8/0208 , A61K8/14 , A61K8/44 , A61K9/127 , A61K9/7023 , A61K47/02 , A61K47/186 , A61Q7/00 , A61Q19/00
摘要： A preparation is disclosed for producing enhanced blood flow in tissue thus causing beneficial effects such as promoting hair growth on scalp tissuelacking sufficient hair, restoring normal sexual function in males with erectile dysfunction. Specifically, this is a preparation which provides local delivery of the amino acid L-arginine, an important biological precursor to the main substance which is responsible for relaxation of blood vessels permitting enhancement of blood flow. In the preferred embodiments, the L-arginine is provided so that it can be topically applied to the scalp or penis. The preparation also contains an agent which aids in the transfer of L-arginine into the tissue. In the preferred embodiments this agent overcomes the resistance to transfer caused by the high charge density of L-arginine. In the preferred embodiments this means is high ionic strength created by addition of choline chloride, magnesium chloride and sodium chloride. This preparation when applied nightly to scalp tissue lacking sufficient hair for a period of time causes substantial growth of hair on the scalp. Further, when applied to the penis of a subject with erectile dysfunction causes restoration of normal sexual function.
摘要翻译：公开了用于在组织中产生增强的血液流动的制剂，从而引起有益效果，例如促进头皮组织充足头发的毛发生长，恢复男性与勃起功能障碍的正常性功能。具体地说，这是提供氨基酸L-精氨酸的局部递送的制剂，L-精氨酸是主要物质的重要生物前体，其负责放松允许增加血液流动的血管。在优选的实施方案中，提供L-精氨酸使得其可以局部施用于头皮或阴茎。该制剂还含有有助于将L-精氨酸转移到组织中的试剂。在优选的实施方案中，该试剂克服了由L-精氨酸的高电荷密度引起的转移阻力。在优选的实施方案中，这意味着通过加入氯化胆碱，氯化镁和氯化钠产生的高离子强度。这种制剂当每晚施用于缺乏足够头发一段时间的头皮组织时会引起头皮上的头发的显着增长。此外，当应用于具有勃起功能障碍的受试者的阴茎引起恢复正常的性功能时。

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