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1. 发明专利

JP2010270118A Ondansetron film composition 审中-公开
标题翻译： ONDANSETRON膜组合物
公开(公告)号：JP2010270118A
公开(公告)日：2010-12-02
申请号：JP2010128307
申请日：2010-05-18
申请人： Monosol Rx Llc , モノソルアールエックスリミテッドライアビリティカンパニー
发明人： MYERS GARY L , HARIHARAN MADHUSUDAN , SANGHVI PRADEEP
IPC分类号： A61K9/70 , A61K31/4178 , A61K47/04 , A61K47/30 , A61K47/34 , A61K47/38 , A61P43/00
CPC分类号： A61K31/4178 , A23G4/06 , A61K9/006
摘要： PROBLEM TO BE SOLVED: To provide a film composition which is based on an active component and effectively shields foul taste of the active component.
SOLUTION: A self-supported film pharmaceutical preparation composition is provided, which includes a polymer, an active ingredient, and at least one kind of slowly soluble alkaline components. In particular, the self-supported film pharmaceutical preparation composition includes an active ingredient with a content of about 10-15 mass% of the composition, at least one kind of a slowly soluble alkaline component with a content of about 1-10 mass% of the composition, and a polymer matrix with a content of about 75-89 mass% of the composition.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种基于活性成分的薄膜组合物，并有效地屏蔽活性组分的恶臭。解决方案：提供一种自支撑膜药物制剂组合物，其包括聚合物，活性成分和至少一种缓慢溶解的碱性成分。特别地，自支撑膜药物制剂组合物包含含量为组合物约10-15质量％的活性成分，至少一种缓慢溶解的碱性成分含量为约1-10质量％所述组合物和所述组合物的含量为约75-89质量％的聚合物基质。版权所有（C）2011，JPO＆INPIT

2. 发明专利

JP2009233334A Tearable package for medicament and method 审中-公开
标题翻译：药物和方法的可折叠包装
公开(公告)号：JP2009233334A
公开(公告)日：2009-10-15
申请号：JP2009076121
申请日：2009-03-26
申请人： Monosol Rx Llc , モノソル・アールエックス・エルエルシー
发明人： BRUCE D DETWILER , RICHARD C FUISZ
IPC分类号： A61J1/00 , B65D75/32 , B65D75/62
CPC分类号： B65D75/5805 , B65D2215/04
摘要： PROBLEM TO BE SOLVED: To provide a method for efficiently and effectively packaging a medicament and the other consumption articles in the field of packaging technology to resist water and air from mingling, protect a susceptible active factors (such as perfume oil or a pharmaceutical active ingredient), elongate a validity term, reduce contamination, facilitate access to a packaged content, and suppress a child from easily mischievous access to a content. SOLUTION: A tearable package 10 for a medicament includes (i) a first layer 12 containing a flexible material sheet, and (ii) a second layer 14 containing a flexible material sheet, these layers overlapping with each other and being melted in their peripheral sealing areas to unite with each other so as to form a cavity for storing the medicament between the layers, wherein any one of the layers has a discontinuous area in the sealing area, through which the package can be folded and torn to take out the medicament content. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于在包装技术领域中有效和有效地包装药物和其它消费品以抵抗水和空气混合的方法，保护敏感的活性因子（例如香水油或药物活性成分），延长有效期限，减少污染，促进对包装内容的访问，以及抑制儿童容易恶作剧地访问内容。解决方案：用于药物的可撕裂包装10包括（i）包含柔性材料片的第一层12和（ii）包含柔性材料片的第二层14，这些层彼此重叠并熔化在它们的周边密封区域彼此结合，以形成用于在两层之间存储药物的空腔，其中任何一个层在密封区域中具有不连续区域，通过该区域可以折叠和撕开包装以取出药物含量。版权所有（C）2010，JPO＆INPIT

3. 发明专利

JP2011140507A Uniform film for rapid-dissolve dosage form incorporating taste-masking composition 有权
标题翻译：用于快速吸收成分的快速溶解剂型的均匀膜
公开(公告)号：JP2011140507A
公开(公告)日：2011-07-21
申请号：JP2011051478
申请日：2011-03-09
申请人： Monosol Rx Llc , モノソル・アールエックス・エルエルシー
发明人： FUISZ RICHARD C , YANG ROBERT K , MYERS GARY L
IPC分类号： A61K9/68 , A61K9/00 , A61K9/16 , A61K9/70 , A61K45/00 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/44 , A61P1/04 , A61P11/10 , A61P11/14 , A61P25/04 , A61P25/16 , A61P29/00 , A61P31/04 , A61P37/08
CPC分类号： A61K9/7007 , A61K9/006 , A61K9/1635 , A61K9/1652
摘要： PROBLEM TO BE SOLVED: To obtain a film having a low content of an adjuvant remedy, a high content of a taste-masked pharmaceutically active material and improved flexibility, structural completeness and uniformity, and to provide a new method for forming a composition containing a component uniformly distributed throughout the whole film. SOLUTION: There is provided a cast wet film delivery system containing (i) a flowable wet film-forming matrix which is at least partly soluble in water or at least partly swelling with water, (ii) a particulate bioeffecting material uniformly disposed in and/or on the wet matrix and (iii) a taste-masking agent coated with the particulate bioeffecting material or intimately associated with the particulate bioeffecting material, wherein the average particle diameter of the particulate bioeffecting material and the taste-masking agent is smaller than 500-1,500 μm (20-60 mil) which is the thickness of the wet film matrix. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：为了获得具有低含量佐剂补救剂的膜，高含量的掩味药学活性物质和改善的柔韧性，结构完整性和均匀性，并提供了一种形成含有均匀分布在整个薄膜中的组分的组合物。提供一种流延湿膜输送系统，其包含（i）至少部分可溶于水或至少部分地用水膨胀的可流动的湿膜形成基质，（ii）均匀设置的颗粒状生物影响材料在湿基质中和/或湿基质上，和（iii）涂覆有颗粒状生物影响材料或与颗粒生物影响材料密切相关的掩味剂，其中颗粒状生物影响材料和掩味剂的平均粒径较小超过500-1,500μm（20-60密耳），其为湿膜基质的厚度。版权所有（C）2011，JPO＆INPIT

4. 发明专利

JP2011093936A Thin film with non-self-aggregating uniform heterogeneity, method for producing the same, and drug delivery system made therefrom 有权
标题翻译：具有非自聚集均匀异质性的薄膜，其制造方法及其制造的药物输送系统
公开(公告)号：JP2011093936A
公开(公告)日：2011-05-12
申请号：JP2011025894
申请日：2011-02-09
申请人： Monosol Rx Llc , モノソル・アールエックス・エルエルシー
发明人： YANG ROBERT K , FUISZ RICHARD C , MYERS GARY L , FUISZ JOSEPH M
IPC分类号： A61K9/70 , A61K8/02 , A61K8/66 , A61K8/72 , A61K8/73 , A61K8/81 , A61K8/86 , A61K8/89 , A61K8/891 , A61K8/96 , A61K9/00 , A61K9/16 , A61K31/167 , A61K31/192 , A61K31/4545 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61P17/00 , A61P29/00 , A61Q11/00 , B29C41/12 , B29K1/00 , B29L7/00 , C08J5/18
CPC分类号： A61K9/7015 , A61K9/006 , A61K9/1635 , A61K9/1652 , A61K9/7007
摘要： PROBLEM TO BE SOLVED: To provide film products that demonstrate a non-self-aggregating uniform heterogeneity, and methods of their preparation. SOLUTION: Desirably, the films disintegrate in water and may be formed by controlled drying process, or other processes that maintain the required uniformity of the film. Desirably, the films contain a pharmaceutical and/or cosmetic active agent with no more than a 10% variation of the pharmaceutical and/or cosmetic active agent per unit area of the film. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供证明非自聚集均匀异质性的薄膜产品及其制备方法。解决方案：期望的是，膜在水中分解并且可以通过受控的干燥过程或保持膜所需均匀性的其它方法形成。期望地，膜含有药物和/或化妆品活性剂，其每单位面积膜的药物和/或美容活性剂的变化不超过10％。版权所有（C）2011，JPO＆INPIT

5. 发明专利

JP2013028635A Thin film with non-self-aggregating uniform heterogeneity and drug delivery system made from the same 审中-公开
标题翻译：具有非自我聚集均匀异质性和药物递送系统的薄膜
公开(公告)号：JP2013028635A
公开(公告)日：2013-02-07
申请号：JP2012219164
申请日：2012-10-01
申请人： Monosol Rx Llc , モノソル・アールエックス・エルエルシー
发明人： YANG ROBERT K , FUISZ RICHARD C , MYERS GARY L , FUISZ JOSEPH M
IPC分类号： A61K9/70 , A61K9/00 , A61K45/00 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , F26B13/20
CPC分类号： A61K9/006 , A61K9/7015 , F26B13/104
摘要： PROBLEM TO BE SOLVED: To provide film products containing desired levels of active components and methods for preparing the same.SOLUTION: Desirably, the films disintegrate in water and are formed by a controlled drying process, or other process that maintains the required uniformity of the film. Desirably, the films are exposed to temperatures above that at which the active components typically degrade without concern for loss of the desired activity.
摘要翻译：要解决的问题：提供含有所需水平的活性组分的薄膜产品及其制备方法。解决方案：期望的是，膜在水中分解并通过受控的干燥过程或保持膜所需均匀性的其它方法形成。期望地，将膜暴露于高于活性组分通常降解的温度，而不考虑所需活性的损失。版权所有（C）2013，JPO＆INPIT

6. 发明专利

JP2011162266A Method for guided tearing of pouch laminate to enable product removal 有权
标题翻译：用于引导层压板的方法用于使产品移除
公开(公告)号：JP2011162266A
公开(公告)日：2011-08-25
申请号：JP2011040783
申请日：2011-02-08
申请人： Monosol Rx Llc , モノソルアールエックスリミテッドライアビリティカンパニー
发明人： SLOMINSKI GREG , BOGUE BEUFORD A , HARIHARAN MADHU , EASTON KURT , CLEMENTE THEODORE JR
IPC分类号： B65D77/20 , B31B50/00 , B31B50/25 , B65B61/02 , B65D33/00
CPC分类号： B65D75/5805
摘要： PROBLEM TO BE SOLVED: To provide a reliable sealed package capable of tearing along a guided tearing line so as to allow a dosage to be administered in an effective and secure manner. SOLUTION: The safe and effective package (10) for housing a dosage, which is easily opened by a user yet, provides a secure and contaminant-free environment for the dosage housed therein. The package may include a guided tear line (30) extending along at least one edge of the package, thereby allowing a user to safely and effectively open the package without risk of compromising the dosage housed therein. In some embodiments, the dosage is a substantially flat dosage, such as a film. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种能够沿着导引的撕裂线撕裂的可靠的密封包装，以允许以有效和安全的方式施用剂量。
解决方案：用于容纳用户容易打开的剂量的安全有效的包装（10）为其中容纳的剂量提供安全且无污染的环境。包装可以包括沿着包装的至少一个边缘延伸的引导撕裂线（30），从而允许使用者安全有效地打开包装，而不会危及容纳在其中的剂量的风险。在一些实施方案中，剂量是基本上平坦的剂量，例如膜。版权所有（C）2011，JPO＆INPIT

7. 发明专利

JP2011068689A Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made from the same 有权
标题翻译：具有非自我聚集均匀异质性和药物递送系统的薄膜
公开(公告)号：JP2011068689A
公开(公告)日：2011-04-07
申请号：JP2011000174
申请日：2011-01-04
申请人： Monosol Rx Llc , モノソル・アールエックス・エルエルシー
发明人： YANG ROBERT K , FUISZ RICHARD C , MYERS GARY L , FUISZ JOSEPH M
IPC分类号： A61K9/70 , A61K8/02 , A61K8/66 , A61K8/67 , A61K8/73 , A61K8/81 , A61K8/86 , A61K9/00 , A61K38/43 , A61K45/00 , A61K47/32 , A61K47/36 , A61K47/38 , A61Q13/00 , F26B13/20
CPC分类号： A61K9/006 , A61K9/7015 , F26B13/104
摘要： PROBLEM TO BE SOLVED: To provide a film product containing a concentration of a desired active component and a preparation method of the same. SOLUTION: Desirably, the film disintegrates in water and is formed by a controlled drying process or by another method to maintain required uniformity of the film. Desirably, the film is capable of being exposed to a higher temperature than a temperature at which the active component degrades usually, without concern for a loss of desired activity. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供含有所需活性成分浓度的薄膜产品及其制备方法。解决方案：期望地，膜在水中分解并通过受控的干燥过程或通过其它方法形成以保持膜的均匀性。理想地，膜能够暴露于比活性成分通常降解的温度更高的温度，而不用担心所需活性的损失。版权所有（C）2011，JPO＆INPIT

8. 发明专利

JP2011050394A Multi-layer film having uniform content 审中-公开
标题翻译：具有均匀内容的多层膜
公开(公告)号：JP2011050394A
公开(公告)日：2011-03-17
申请号：JP2010250001
申请日：2010-11-08
申请人： Monosol Rx Llc , モノソル・アールエックス・エルエルシー
发明人： FUISZ RICHARD C , FUISZ JOSEPH M , MYERS GARRY L
IPC分类号： A23L1/00
CPC分类号： B32B27/28 , A23L27/79 , A23L29/262 , A23P20/20 , A61K9/0056 , A61K9/009 , A61K9/0095 , A61K9/7007 , B32B9/02 , B32B9/04 , B32B23/04 , B32B23/08 , B32B23/22 , B32B27/08 , B32B27/285 , B32B2250/24 , B32B2270/00 , B32B2307/54 , B32B2307/5825 , B32B2307/7166 , B32B2439/46 , B32B2439/70 , B65D65/46
摘要： PROBLEM TO BE SOLVED: To provide edible multi-layer films (10) that dissolve in water. SOLUTION: The edible multi-layer films (10) have a first water-soluble film layer (100) and one or more additional water-soluble film layers (200) in at least partial face-to-face engagement with the first film layer (100). The film layers (100, 200) include a polymer composition which contains polyethylene oxide alone or in combination with at least one water-soluble polymer. The edible multi-layer films (10) may include pockets defined between the layers (100, 200) and housing an active component. Upon addition of water, the multi-layer film (10) dissolves, thereby releasing the active component into the water. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供溶解在水中的食用多层膜（10）。解决方案：可食用多层膜（10）具有第一水溶性薄膜层（100）和一种或多种另外的水溶性薄膜层（200），其与第一膜层（100）。膜层（100,200）包括单独含有聚环氧乙烷或与至少一种水溶性聚合物组合的聚合物组合物。可食用多层膜（10）可以包括限定在层（100,200）之间并容纳活性组分的凹穴。加入水后，多层膜（10）溶解，从而将活性成分释放到水中。版权所有（C）2011，JPO＆INPIT

9. 发明申请

WO2014043346A3 ANTI-PAIN AND ANTI-NAUSEA AND/OR VOMITING COMBINATORIAL COMPOSITIONS 审中-公开
公开(公告)号：WO2014043346A3
公开(公告)日：2014-03-20
申请号：PCT/US2013/059460
申请日：2013-09-12
申请人： MONOSOL RX, LLC
发明人： DADEY, Eric , MYERS, Garry , BARBER, Daniel , SCHOBEL, Mark
IPC分类号： A61K9/00 , A61K31/00 , A61K47/10 , A61K47/38 , A61K9/70
摘要： In one aspect, the present invention discloses combinational compositions for treating users experiencing symptoms associated with a migraine or other central nervous system related pain disorder that can cause or exacerbate nausea and/or vomiting or other central nervous system related pain disorder that can cause or exacerbate nausea and/or vomiting. The combinational composition includes a first pharmaceutical active component for treating pain, and a second pharmaceutical active component for treating nausea and/or vomiting and/or vomiting in a user.

10. 发明申请

WO2011072208A1 PH SENSITIVE COMPOUNDS IN TASTE MASKING WITHIN ORAL THIN FILM STRIPS 审中-公开
标题翻译：敏感化合物在口服薄膜条纹中的掩蔽
公开(公告)号：WO2011072208A1
公开(公告)日：2011-06-16
申请号：PCT/US2010/059851
申请日：2010-12-10
申请人： MonoSol Rx, LLC , SCHOBEL, A. Mark , DAVIDSON, Kevin , MILOSHOFF, Laura , SANGHVI, Pradeep , HARIHARAN, Madhu
发明人： SCHOBEL, A. Mark , DAVIDSON, Kevin , MILOSHOFF, Laura , SANGHVI, Pradeep , HARIHARAN, Madhu
IPC分类号： A61K47/06 , A61K9/14
CPC分类号： A61K9/006 , A61K9/7007
摘要： The present invention relates to an edible film dosage form that includes a film- forming polymer and a coated active composition capable of taste -masking an active contained therein. An edible film that includes an edible, water-soluble film forming polymer and an active with at least two coating layers is also disclosed.
摘要翻译：本发明涉及一种可食用膜剂型，其包括成膜聚合物和能够掩蔽其中所含活性物质的包被的活性组合物。还公开了包含可食用的水溶性成膜聚合物和具有至少两个涂层的活性物质的可食用膜。

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