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1. 发明申请

WO0211709A3 PHARMACEUTICAL, EFFERVESCENT FORMULATION CONTAINING RAMIPRIL 审中-公开
标题翻译：药物，含RAMIPRIL的刷子配方
公开(公告)号：WO0211709A3
公开(公告)日：2002-12-12
申请号：PCT/EP0108999
申请日：2001-08-03
申请人： HEXAL AG , KLOKKERS KARIN , FREUDENSPRUNG BRIGITTE , HAEGER ALEXANDRA
发明人： KLOKKERS KARIN , FREUDENSPRUNG BRIGITTE , HAEGER ALEXANDRA
IPC分类号： A61K9/22 , A61K9/46 , A61K31/403 , A61K38/55
CPC分类号： A61K31/403 , A61K9/0007
摘要： The invention relates to a stable, orally-dosable pharmaceutical effervescent formulation comprising the ACE-inhibitor ramipril and/or the pharmacologically acceptable salts and/or the pharmacologically acceptable esters thereof as active components, with a weight ratio of acid to carbonate/bicarbonate of 0.6 to 1.3 and a weight ratio of ramipril to effervescent formulation of 0.004 to 0.013.
摘要翻译：本发明涉及一种ACE抑制剂雷米普利和/或它的药学上可接受的盐和/或药学上可接受的酯的储存稳定的，口服药物泡腾剂与酸的重量比的活性组分，以碳酸盐/碳酸氢盐0.6〜1， 3，雷米普利与泡腾剂的重量比为0.004至0.013。

2. 发明申请

WO2007009800A2 ORAL, QUICKLY DISINTEGRATING FILM, WHICH CANNOT BE SPIT OUT, FOR AN ANTIEMETIC OR ANTIMIGRAINE AGENT 审中-公开
标题翻译： NON-AUSSPUCKBARER，口服快速降低观赏膜止吐药或抗偏头痛药
公开(公告)号：WO2007009800A2
公开(公告)日：2007-01-25
申请号：PCT/EP2006007176
申请日：2006-07-20
申请人： HEXAL AG , OBERMEIER PETRA , KOHR THOMAS , KRAMER KAI-THOMAS , KLOKKERS KARIN
发明人： OBERMEIER PETRA , KOHR THOMAS , KRAMER KAI-THOMAS , KLOKKERS KARIN
IPC分类号： A61K9/00 , A61K9/70 , A61K31/404 , A61P1/08 , A61P25/06
CPC分类号： A61K9/0056 , A61K9/7007 , A61K31/404
摘要： The invention relates to a film-shaped, single-layered and cavity-free preparation that does not contain any surfactants nor effervescent additives and flavor masking agents, comprised of film forming agents, one or more gelling agents and of one or more active substances selected from the group of antiemetics and antimigraine agents.
摘要翻译：膜状，单层和无模腔制剂不含表面活性剂，泡腾添加剂和掩味的一种或多种膜形成剂，一种或多种胶凝剂和选自止吐药和抗偏头痛剂的一种或多种活性物质构成。

3. 发明申请

WO9840069A3 STABILIZATION OF ACID SENSITIVE BENZIMIDAZOLS WITH AMINO/CYCLODEXTRIN COMBINATIONS 审中-公开
标题翻译：酸敏感苯扎昔单抗与氨基/环糊精组合的稳定性
公开(公告)号：WO9840069A3
公开(公告)日：1998-12-17
申请号：PCT/EP9801478
申请日：1998-03-13
申请人： HEXAL AG , KLOKKERS KARIN , KUTSCHERA MARION , FISCHER WILFRIED
发明人： KLOKKERS KARIN , KUTSCHERA MARION , FISCHER WILFRIED
IPC分类号： A61K9/16 , A61K9/48 , A61K9/50 , A61K9/52 , A61K31/44 , A61K31/4439 , A61K47/18 , A61K47/48 , A61P1/04
CPC分类号： A61K9/1617 , A61K9/1652 , A61K9/1694 , A61K9/4891 , A61K9/50 , A61K31/44 , A61K31/4439 , A61K47/6951 , B82Y5/00
摘要： A pharmaceutical formulation comprising a benzimidazole derivative as active ingredient, and as excipients, at least one cyclodextrin and at least one amino acid.
摘要翻译：一种药物制剂，其包含苯并咪唑衍生物作为活性成分，以及作为赋形剂，至少一种环糊精和至少一种氨基酸。

4. 发明申请

WO2007065638A2 MATRIX-CONTROLLED TRANSDERMAL SYSTEM COMPRISING SALTS OF ACE INHIBITOR DICARBOXYLIC ACIDS 审中-公开
标题翻译：用ACE-HEMMER-DICARBOXYLIC酸的盐控制MATRIX控制的TRANSDERMALES系统
公开(公告)号：WO2007065638A2
公开(公告)日：2007-06-14
申请号：PCT/EP2006011672
申请日：2006-12-05
申请人： HEXAL AG , KLOKKERS KARIN , HELFRICH MICHAEL , NINK JOERG
发明人： KLOKKERS KARIN , HELFRICH MICHAEL , NINK JOERG
CPC分类号： A61K31/401 , A61K9/7061 , A61K31/40 , A61K31/472 , A61K31/55
摘要： The invention relates to a salt of an ACE inhibitor dicarboxylic acid comprising an organic amine and/or an alkali compound, a transdermal therapeutic system comprising said salt, and a method for producing the transdermal therapeutic system.
摘要翻译：本发明涉及ACE抑制剂二羧酸与有机胺和/或碱性化合物的盐，具有该盐的透皮治疗系统和制备该透皮治疗系统的方法。

5. 发明申请

WO2005041934A2 PHARMACEUTICAL AGENT-CONTAINING FORMULATION COMPRISING A COATING 审中-公开
标题翻译：药物活性制剂
公开(公告)号：WO2005041934A2
公开(公告)日：2005-05-12
申请号：PCT/EP2004012230
申请日：2004-10-28
申请人： HEXAL AG , KLOKKERS KARIN , ZELLNER MARION , RILLMANN THOMAS , DAUER ANDREAS
发明人： KLOKKERS KARIN , ZELLNER MARION , RILLMANN THOMAS , DAUER ANDREAS
IPC分类号： A61K9/20 , A61K9/28 , A61K9/36 , A61K9/50 , A61K9/16
CPC分类号： A61K9/2077 , A61K9/2846 , A61K9/2866 , A61K9/5026 , A61K9/5078
摘要： The invention relates to an orally administered pharmaceutical agent-containing formulation which is coated with a single coating of a film-forming polymer. Said coating comprises a mixture of at least two separating agents and no stabilizer.
摘要翻译：本发明涉及一种用于含有活性物质，其涂覆有成膜聚合物的单一涂层口服给药的药物制剂，所述涂层包括至少两个脱模剂和不加入稳定剂的混合物。

6. 发明申请

WO0121153A3 PHARMACEUTICAL GEL CONTAINING ACTIVE SUBSTANCES 审中-公开
标题翻译：医药，ACTIVE含GEL
公开(公告)号：WO0121153A3
公开(公告)日：2001-10-11
申请号：PCT/EP0009059
申请日：2000-09-16
申请人： HEXAL AG , BEIER CORNELIA , KLOKKERS KARIN
发明人： BEIER CORNELIA , KLOKKERS KARIN
IPC分类号： A61K9/00 , A61K31/355 , A61K31/565 , A61K47/10 , A61K47/14 , A61K47/32 , A61K9/06
CPC分类号： A61K31/573 , A61K9/0014 , A61K31/355 , A61K31/565 , A61K47/10 , A61K47/14 , A61K47/32
摘要： The invention relates to a topically applied pharmaceutical gel which contains active substances and which has topical or systemic action, whereby the use of an otherwise common short-chain monovalent alcohol is forgone. In addition to having a very good activity, a formulation of this type can prevent skin irritations, skin damages or skin sensitivities. A particular embodiment of the invention depicts an emulsion gel for treating inflammatory skin diseases. This embodiment contains phospholipids and/or natural vitamin E and/or alpha -tocopherol and/or alpha -tocopherol derivatives, preferably alpha -tocopherol acetate as well as at least one corticosteroid, preferably prednicarbate. The gel is used to treat inflammatory skin diseases such as atopic dermatitis or neurodermatitis, psoriasis, acute and chronic eczema, burns and contact eczema. Another embodiment of the invention depicts an emulsion gel for systemically administering hormones containing phospholipids and/or alpha -tocopherol and/or alpha -tocopherol derivatives and at least one estrogen, preferably estradiol.
摘要翻译：本发明涉及一种局部到应用，制药，凝胶，具有局部或全身作用，其中可以用通常的短链，一元醇，以分配含药。除了一个非常良好的效果的皮肤刺激性，皮肤损伤或皮肤过敏可以与这样的制剂来避免。本发明的一个具体实施方案提供了用于治疗炎性皮肤治疗的疾病是一种乳液凝胶，含有磷脂和/或天然维生素E和/或α-生育酚和/或α-生育酚衍生物，优选α-生育酚乙酸酯，以及至少一种皮质类固醇，优选 prednicarbat。下炎性皮肤疾病的疾病，如特应性皮炎或湿疹，牛皮癣，急性和慢性湿疹，烧伤，和接触性皮炎在这里理解。本发明的另一个实施方案提供的激素，包括磷脂和/或α-生育酚和/或α-生育酚衍生物和最小的全身给药的乳液凝胶。是雌激素，优选雌二醇，代表。

7. 发明申请

WO0203970A3 MATRIX CONTROLLED TRANSDERMAL SYSTEM FOR STABILE DERIVATIVES OF ACE INHIBITORS 审中-公开
标题翻译： ACE-HEMMER稳定衍生物的矩阵控制TRANSDERMALES系统
公开(公告)号：WO0203970A3
公开(公告)日：2002-05-23
申请号：PCT/EP0108071
申请日：2001-07-12
申请人： HEXAL AG , KLOKKERS KARIN , KRAMER KAI THOMAS , FISCHER WILFRIED , SENDL LANG ANNA
发明人： KLOKKERS KARIN , KRAMER KAI-THOMAS , FISCHER WILFRIED , SENDL-LANG ANNA
IPC分类号： A61K9/70 , A61K31/551 , A61K31/675 , A61K38/55 , A61P9/12 , A61P43/00
CPC分类号： A61K9/703 , A61K9/7061 , A61K38/556
摘要： The invention relates to a matrix controlled transdermal therapeutic system comprising, (i) a top layer which is impervious to active ingredients, (ii) a self adhesive matrix layer or several matrix layers, whereby at least the exposed matrix layer is self adhesive when the system is applied, or comprising one or several matrix layers whose surface faces away from the top layer and is provided for adhesion to the place of application, said surface being covered with an adhesive. The matrix layers contain at least one ACE inhibitor (angiotensin converting enzyme inhibitor). The metabolite thereof is a dicarboxylic acid selected from the following group: diesters, a di-salt which is obtainable with one or several bases and a mono-salt which is obtainable with one or several acids and (iii) a tear-off protective layer.
摘要翻译：本发明涉及一种基质控制的透皮治疗系统包括：（i）活性成分不可渗透的覆盖层，（ⅱ）自粘性基质层或多个基质层，其中至少暴露在系统矩阵层的应用是自粘合，或一个或多个基质层从覆盖层，其背向和用于粘附在应用表面涂有压敏粘合剂，含有至少一种ACE抑制剂（血管紧张素转换酶）抑制剂，基质层，其代谢物是二羧酸和选自下面的组：二酯，（用碱 n）可用的二盐和一种或多种可获得的单盐的酸和（iii）可剥离的保护层。

8. 发明申请

WO9933451A2 MIXTURE AND PHARMACEUTICAL COMPOSITION COMPRISING Z-4-HYDROXYTAMOXIFEN AND CYCLODEXTRIN 审中-公开
标题翻译：含有Z-4-羟基喜树碱和环糊精的混合物和药物组合物
公开(公告)号：WO9933451A2
公开(公告)日：1999-07-08
申请号：PCT/EP9808437
申请日：1998-12-23
申请人： HEXAL AG , FISCHER WILFRIED , KLOKKERS KARIN , SENDL LANG ANNA
发明人： FISCHER WILFRIED , KLOKKERS KARIN , SENDL-LANG ANNA
IPC分类号： A61K47/40 , A61K31/135 , A61K31/138 , A61K47/48 , A61P35/00 , A61K31/00
CPC分类号： A61K31/138
摘要： The invention concerns a mixture and a pharmaceutical composition consisting of or comprising Z-4-hydroxy-tamoxifen and at least one cyclodextrin.
摘要翻译：本发明涉及一种由或包含Z-4-羟基他莫昔芬和至少一种环糊精组成的混合物和药物组合物。

9. 发明申请

WO2007009801A3 ORAL, QUICKLY DISINTEGRATING FILM, WHICH CANNOT BE SPIT OUT, FOR A NEUROLEPTIC DRUG 审中-公开
标题翻译： NON-AUSSPUCKBARER，口服快速降低WATCHING膜抗精神病药
公开(公告)号：WO2007009801A3
公开(公告)日：2007-06-21
申请号：PCT/EP2006007177
申请日：2006-07-20
申请人： HEXAL AG , OBERMEIER PETRA , KOHR THOMAS , KRAMER KAI-THOMAS , KLOKKERS KARIN
发明人： OBERMEIER PETRA , KOHR THOMAS , KRAMER KAI-THOMAS , KLOKKERS KARIN
IPC分类号： A61K9/00 , A61K9/70 , A61K31/551 , A61P25/18
CPC分类号： A61K9/006 , A61K9/0056 , A61K9/7007 , A61K31/551 , A61K31/5513
摘要： The invention relates to a film-shaped, single-layered and cavity-free preparation that does not contain any surfactants nor effervescent additives and flavor masking agents, comprised of film forming agents, one or more gelling agents and of one or more active substances selected from the group of neuroleptic drugs.
摘要翻译：膜状，单层和无模腔制剂不含表面活性剂，泡腾添加剂和掩味的一种或多种膜形成剂，一种或多种胶凝剂和选自精神病药物的一种或多种活性物质构成。

10. 发明申请

WO0203969A3 TRANSDERMAL THERAPEUTIC SYSTEM FOR HIGHLY DISPERSED SILICON DIOXIDE 审中-公开
标题翻译：具有高度分散的二氧化硅的透析治疗系统
公开(公告)号：WO0203969A3
公开(公告)日：2002-05-23
申请号：PCT/EP0108070
申请日：2001-07-12
申请人： HEXAL AG , KLOKKERS KARIN , KRAMER KAI THOMAS , WILHELM MARTINA
发明人： KLOKKERS KARIN , KRAMER KAI-THOMAS , WILHELM MARTINA
IPC分类号： A61J1/00 , A61K9/70 , A61K47/02 , A61K47/04 , A61M37/00
CPC分类号： A61K9/7053 , A61K9/7061 , A61K47/02
摘要： The invention relates to a transdermal therapeutic system comprising a surface layer which is impervious with respect to an active ingredient; a self-adherent matrix layer or a plurality of matrix layers, wherein the exposed matrix layer is, at least self-adherent when the system is applied. Said system also comprises a pull-off protective coating, whereby the matrix layer(s) contains(s) one or more active ingredients and/or one or more biologically active substances and highly dispersed silicon dioxide. Said system contains silicon dioxide in order to increase skin permeation.
摘要翻译：本发明涉及一种具有活性物质不可渗透的覆盖层，与多个基质层，其中至少暴露在系统矩阵层的应用程序中的自粘性基质层或透皮治疗系统是自粘合，并用可去除的保护层，所述基质层（多个）的一个或多个活性和/或一种或多种其他生物活性物质和煅制二氧化硅，该系统含有二氧化硅以增加皮肤渗透性。

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