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1. 发明授权

CN1187095C 可生产病毒颗粒的被囊化细胞失效
公开(公告)号：CN1187095C
公开(公告)日：2005-02-02
申请号：CN96195050.1
申请日：1996-06-24
申请人：巴法里安诺迪克有限公司 , GSF环境与健康研究中心有限公司
发明人：罗伯特·M·萨勒 , 沃尔特·H·冈兹伯格 , 布赖恩·萨蒙斯
IPC分类号： A61K48/00 , C12N11/04 , A61K9/50 , A61P35/00 , A61P43/00
CPC分类号： C12N15/86 , A61K9/5026 , A61K9/5042 , A61K48/00 , C12N7/00 , C12N11/04 , C12N2740/13021 , C12N2740/13043
摘要：本发明涉及可生产病毒颗粒(特别是含有携带有治疗基因的逆转录病毒载体基因组的逆转录病毒颗粒)的被囊化细胞；制备这种被囊化细胞的方法；以及用这种被囊化细胞治疗疾病的应用。

2. 发明公开

CN1189104A 可生产病毒颗粒的被囊化细胞失效
公开(公告)号：CN1189104A
公开(公告)日：1998-07-29
申请号：CN96195050.1
申请日：1996-06-24
申请人：巴法理安诺迪克研究协会有限公司 , GSF环境与健康研究中心有限公司
发明人：罗伯特·M·萨勒 , 沃尔特·H·冈兹伯格 , 布赖恩·萨蒙斯
IPC分类号： A61K48/00 , C12N11/04 , A61K9/50
CPC分类号： C12N15/86 , A61K9/5026 , A61K9/5042 , A61K48/00 , C12N7/00 , C12N11/04 , C12N2740/13021 , C12N2740/13043
摘要：本发明涉及可生产病毒颗粒(特别是含有携带有治疗基因的逆转录病毒载体基因组的逆转录病毒颗粒)的被囊化细胞;制备这种被囊化细胞的方法;以及用这种被囊化细胞治疗疾病的应用。

3. 发明公开

EP1882032A2 GAMMARETROVIRUS ASSOCIATED WITH CANCER 审中-公开
标题翻译：与癌症相关的GAMMA逆转录病毒
公开(公告)号：EP1882032A2
公开(公告)日：2008-01-30
申请号：EP06749572.1
申请日：2006-04-07
申请人： THE CLEVELAND CLINIC FOUNDATION , The Regents of the University of California
发明人： SILVERMAN, Robert , KLEIN, Eric, A. , DERISI, Joseph , GANEM, Don , CASEY, Graham
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , A61K39/00 , C07K14/005 , C07K16/1036 , C12N9/22 , C12N2740/13021 , C12N2740/13022 , C12Q1/6886 , C12Q1/70 , C12Q1/701 , C12Q2600/136
摘要： The present invention provides for isolated nucleic acid sequences encoding viruses; isolated polypeptides comprising amino acid sequences of the virus; vectors comprising the viral nucleic acid sequences; cells comprising the vectors; antibodies and antigen binding fragments thereof which have binding specificity for the virus; methods of detecting or screening for the virus (e.g., in an individual); methods of identifying agents that inhibit the virus; methods of inducing an immune response to the virus; methods of treating disease associated with the presence of XMRV in an individual (e.g., cancer such as prostate cancer); methods of detecting asymptomatic cancer (e.g., prostate cancer); methods of identifying an individual at risk for developing cancer (e.g., prostate cancer); and kits for detecting the virus.

4. 发明申请

US20180251786A1 RECOMBINANT VECTORS COMPRISING 2A PEPTIDE 审中-公开
公开(公告)号：US20180251786A1
公开(公告)日：2018-09-06
申请号：US15757292
申请日：2016-09-01
申请人： Tocagen Inc.
发明人： Douglas J. Jolly , Amy H. Lin , Andrew Hofacre , Daniel J. Hogan , Derek G. Ostertag
IPC分类号： C12N15/86 , A61P35/00 , C07K14/535 , C07K14/705
CPC分类号： C12N15/86 , A61K48/00 , A61K48/005 , A61P35/00 , C07K14/535 , C07K14/70507 , C07K16/2827 , C07K2317/76 , C07K2319/30 , C07K2319/50 , C07K2319/60 , C07K2319/75 , C12N15/1138 , C12N2310/141 , C12N2740/13021 , C12N2740/13022 , C12N2740/13043 , C12N2840/20 , C12N2840/203
摘要： This disclosure provides modified recombinant retroviruses comprisings containing a 2A-peptide or peptide-like coding sequence operably linked to a heterologous polynucleotide. The disclosure further relates to cells and vector expressing or comprising such vectors and methods of using such modified vectors in the treatment of disease and disorders.

5. 发明授权

US09107892B2 Identification of a novel retrovirus in patients with benign prostatic hyperplasia 有权
标题翻译：在良性前列腺增生患者中鉴定出新型逆转录病毒
公开(公告)号：US09107892B2
公开(公告)日：2015-08-18
申请号：US13282888
申请日：2011-10-27
申请人： Denise S. O'Keefe
发明人： Denise S. O'Keefe
IPC分类号： A61K39/21 , C12Q1/70 , C12N7/00 , C12Q1/68 , C12Q1/00 , A61K39/00
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/545 , C12N7/00 , C12N2740/13011 , C12N2740/13021 , C12N2740/13022 , C12N2740/13034 , C12Q1/00 , C12Q1/6844 , C12Q1/6846 , C12Q1/686 , C12Q1/701
摘要： Methods for producing an immune response to a benign prostatic hyperplasia (BPH) virus are disclosed herein. In several examples, the immune response is a protective immune response. In additional embodiments, methods are disclosed for inhibiting an infection with BPH virus, or treating an infection with BPH virus. Also disclosed are methods for detecting presence of BPH virus in a subject. The methods include detecting the presence of one or more BPH virus polynucleotides or polypeptides in a sample from the subject, or presence of at least one antibody that specifically binds to a BPH virus polypeptide.
摘要翻译：本文公开了产生对良性前列腺增生（BPH）病毒的免疫应答的方法。在几个实例中，免疫应答是保护性免疫应答。在另外的实施方案中，公开了用于抑制BPH病毒感染或治疗BPH病毒感染的方法。还公开了用于检测受试者中BPH病毒存在的方法。所述方法包括检测来自受试者的样品中一种或多种BPH病毒多核苷酸或多肽的存在，或至少一种与BPH病毒多肽特异性结合的抗体的存在。

6. 发明授权

US08263085B2 Gammaretrovirus associated with cancer 失效
标题翻译：与癌症相关的瘤胃病毒
公开(公告)号：US08263085B2
公开(公告)日：2012-09-11
申请号：US11903756
申请日：2007-09-24
申请人： Robert H. Silverman , Eric A. Klein , Graham Casey , Joseph DeRisi , Don Ganem
发明人： Robert H. Silverman , Eric A. Klein , Graham Casey , Joseph DeRisi , Don Ganem
IPC分类号： A61K39/21 , C12N5/071 , C12N7/00
CPC分类号： C12N7/00 , A61K39/00 , C07K14/005 , C07K16/1036 , C12N9/22 , C12N2740/13021 , C12N2740/13022 , C12Q1/6886 , C12Q1/70 , C12Q1/701 , C12Q2600/136
摘要： The present invention provides for isolated nucleic acid sequences encoding viruses; isolated polypeptides comprising amino acid sequences of the virus; vectors comprising the viral nucleic acid sequences; cells comprising the vectors; antibodies and antigen binding fragments thereof which have binding specificity for the virus; methods of detecting or screening for the virus (e.g., in an individual); methods of identifying agents that inhibit the virus; methods of inducing an immune response to the virus; methods of treating disease associated with the presence of XMRV in an individual (e.g., cancer such as prostate cancer); methods of detecting asymptomatic cancer (e.g., prostate cancer); methods of identifying an individual at risk for developing cancer (e.g., prostate cancer); and kits for detecting the virus.
摘要翻译：本发明提供了编码病毒的分离的核酸序列; 包含病毒的氨基酸序列的分离的多肽; 包含病毒核酸序列的载体; 包含载体的细胞; 对病毒具有结合特异性的抗体及其抗原结合片段; 检测或筛选病毒的方法（例如，在个体中）; 识别抑制病毒的药剂的方法; 诱导对病毒的免疫应答的方法; 治疗与个体（例如癌症如前列腺癌）中XMRV存在相关的疾病的方法; 检测无症状癌症的方法（例如前列腺癌）; 识别患有癌症风险的个体（例如前列腺癌）的方法; 和用于检测病毒的工具包。

7. 发明申请

US20070196386A1 Stable retrovirus and methods of use 失效
标题翻译：稳定的逆转录病毒及使用方法
公开(公告)号：US20070196386A1
公开(公告)日：2007-08-23
申请号：US11677110
申请日：2007-02-21
申请人： Halong N. Vu , Daniel W. Pack , Joshua Ramsey
发明人： Halong N. Vu , Daniel W. Pack , Joshua Ramsey
IPC分类号： A61K39/395 , A61K39/12
CPC分类号： C07K14/005 , C12N7/00 , C12N2740/13021 , C12N2740/13022 , Y10S930/221
摘要： The present invention is a mutant retroviral protease which confers an increase in retroviral stability. Retroviruses expressing the instant mutant retroviral protease exhibit at least a 2-fold increase in infectivity half-life as compared to wild-type retrovirus. Unexpectedly, a Gly119Glu mutation in the protease enhances retroviral stability in the presence of various wild-type envelope proteins including wild-type amphotropic, ecotropic and 10A1 murine leukemia viruses. The improved stability of the mutant retrovirus leads to more facile virus production and enhanced infection efficiency.
摘要翻译：本发明是赋予逆转录病毒稳定性增加的突变型逆转录病毒蛋白酶。与野生型逆转录病毒相比，表达本发明突变逆转录病毒蛋白酶的逆转录病毒体的感染性半衰期至少提高2倍。意外的是，蛋白质中的Gly119Glu突变增强了在各种野生型包膜蛋白的存在下的逆转录病毒稳定性，包括野生型和平嗜性，嗜酸性和10A1鼠白血病病毒。改进的突变逆转录病毒的稳定性导致更容易的病毒生产和增强的感染效率。

8. 发明授权

US5616487A Stabilized retrovirus compositions 失效
标题翻译：稳定的逆转录病毒组合物
公开(公告)号：US5616487A
公开(公告)日：1997-04-01
申请号：US307862
申请日：1994-09-15
申请人： Bernhard O. Palsson , Timothy M. Eisfeld
发明人： Bernhard O. Palsson , Timothy M. Eisfeld
IPC分类号： A61K48/00 , C12N7/00 , C12N7/01 , C12N15/867 , C12N5/10
CPC分类号： C12N15/86 , C12N7/00 , A61K48/00 , C12N2740/13021 , C12N2740/13043 , C12N2740/13051
摘要： The present invention provides a stabilized virus, which is modified using a stabilizing agent. The invention also provides a process for producing a stabilized virus by culturing viral producing cells with a stabilizing agent at a temperature below 37.degree. C. The invention further provides methods to introduce an exogenous nucleotide sequence into a cell using a stabilized virus containing the exogenous nucleotide sequence. The invention also provides methods for administering an exogenous nucleotide sequence to a subject using a stabilized virus containing the exogenous nucleotide sequence. The invention further provides a method to produce a protein by infecting a cell with a stabilized virus containing a exogenous nucleotide sequence encoding the protein and then isolating the protein produced by the infected cells.
摘要翻译：本发明提供了使用稳定剂改性的稳定的病毒。本发明还提供了通过在37℃以下的温度下用稳定剂培养病毒产生细胞来生产稳定的病毒的方法。本发明还提供了使用含有外源核苷酸的稳定化病毒将外源核苷酸序列引入细胞的方法序列。本发明还提供了使用含有外源核苷酸序列的稳定化病毒向受试者施用外源核苷酸序列的方法。本发明还提供了通过用含有编码该蛋白质的外源核苷酸序列的稳定化病毒感染细胞，然后分离由感染细胞产生的蛋白质来生产蛋白质的方法。

9. 发明申请

WO2006110589A8 GAMMARETROVIRUS ASSOCIATED WITH CANCER 审中-公开
标题翻译： GAMMARETROVIRUS与癌症相关
公开(公告)号：WO2006110589A8
公开(公告)日：2007-03-01
申请号：PCT/US2006013167
申请日：2006-04-07
申请人： CLEVELAND CLINIC FOUNDATION , UNIV CALIFORNIA , SILVERMAN ROBERT , KLEIN ERIC A , DERISI JOSEPH , GANEM DON , CASEY GRAHAM
发明人： SILVERMAN ROBERT , KLEIN ERIC A , DERISI JOSEPH , GANEM DON , CASEY GRAHAM
IPC分类号： C12N7/00 , A61K39/21 , C07K14/15 , C12N5/10 , C12N7/02 , C12N15/11 , C12N15/63 , C12Q1/68 , G01N33/50 , G01N33/569
CPC分类号： C12N7/00 , A61K39/00 , C07K14/005 , C07K16/1036 , C12N9/22 , C12N2740/13021 , C12N2740/13022 , C12Q1/6886 , C12Q1/70 , C12Q1/701 , C12Q2600/136
摘要： The present invention provides for isolated nucleic acid sequences encoding viruses; isolated polypeptides comprising amino acid sequences of the virus; vectors comprising the viral nucleic acid sequences; cells comprising the vectors; antibodies and antigen binding fragments thereof which have binding specificity for the virus; methods of detecting or screening for the virus (e.g., in an individual); methods of identifying agents that inhibit the virus; methods of inducing an immune response to the virus; methods of treating disease associated with the presence of XMRV in an individual (e.g., cancer such as prostate cancer); methods of detecting asymptomatic cancer (e.g., prostate cancer); methods of identifying an individual at risk for developing cancer (e.g., prostate cancer); and kits for detecting the virus.
摘要翻译：本发明提供了编码病毒的分离的核酸序列; 包含病毒的氨基酸序列的分离的多肽; 包含病毒核酸序列的载体; 包含载体的细胞; 对病毒具有结合特异性的抗体及其抗原结合片段; 检测或筛选病毒（例如在个体中）的方法; 鉴定抑制病毒的物质的方法; 诱导对病毒的免疫应答的方法; 治疗与个体中XMRV存在相关的疾病（例如癌症，例如前列腺癌）的方法; 检测无症状癌症（例如前列腺癌）的方法; 鉴定处于发展成癌症风险中的个体（例如前列腺癌）的方法; 和检测病毒的工具包。

10. 发明申请

US20120107338A1 IDENTIFICATION OF A NOVEL RETROVIRUS IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA 有权
标题翻译：鉴别患有胆碱性高血压的患者的新型逆转录病毒
公开(公告)号：US20120107338A1
公开(公告)日：2012-05-03
申请号：US13282888
申请日：2011-10-27
申请人： Denise S. O'Keefe
发明人： Denise S. O'Keefe
IPC分类号： A61K39/21 , C12N15/48 , A61P31/14 , C07K14/15 , A61P37/04 , C12Q1/70 , C12N15/63
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/545 , C12N7/00 , C12N2740/13011 , C12N2740/13021 , C12N2740/13022 , C12N2740/13034 , C12Q1/00 , C12Q1/6844 , C12Q1/6846 , C12Q1/686 , C12Q1/701
摘要： Methods for producing an immune response to a benign prostatic hyperplasia (BPH) virus are disclosed herein. In several examples, the immune response is a protective immune response. In additional embodiments, methods are disclosed for inhibiting an infection with BPH virus, or treating an infection with BPH virus. Also disclosed are methods for detecting presence of BPH virus in a subject. The methods include detecting the presence of one or more BPH virus polynucleotides or polypeptides in a sample from the subject, or presence of at least one antibody that specifically binds to a BPH virus polypeptide.
摘要翻译：本文公开了产生对良性前列腺增生（BPH）病毒的免疫应答的方法。在几个实例中，免疫应答是保护性免疫应答。在另外的实施方案中，公开了用于抑制BPH病毒感染或治疗BPH病毒感染的方法。还公开了用于检测受试者中BPH病毒存在的方法。所述方法包括检测来自受试者的样品中一种或多种BPH病毒多核苷酸或多肽的存在，或至少一种与BPH病毒多肽特异性结合的抗体的存在。

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