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1. 发明申请

US20130040369A1 Gammaretrovirus Associated With Cancer 审中-公开
标题翻译：与癌症相关的恶性肿瘤病毒
公开(公告)号：US20130040369A1
公开(公告)日：2013-02-14
申请号：US13551286
申请日：2012-07-17
申请人： Robert H. Silverman , Eric A. Klein , Graham Casey , Joseph DeRisi , Don Ganem
发明人： Robert H. Silverman , Eric A. Klein , Graham Casey , Joseph DeRisi , Don Ganem
IPC分类号： C12N7/00 , C07K14/15
CPC分类号： C12N7/00 , A61K39/00 , C07K14/005 , C07K16/1036 , C12N9/22 , C12N2740/13021 , C12N2740/13022 , C12Q1/6886 , C12Q1/70 , C12Q1/701 , C12Q2600/136
摘要： The present invention provides for isolated nucleic acid sequences encoding viruses; isolated polypeptides comprising amino acid sequences of the virus; vectors comprising the viral nucleic acid sequences; cells comprising the vectors; antibodies and antigen binding fragments thereof which have binding specificity for the virus; methods of detecting or screening for the virus (e.g., in an individual); methods of identifying agents that inhibit the virus; methods of inducing an immune response to the virus; methods of treating disease associated with the presence of XMRV in an individual (e.g., cancer such as prostate cancer); methods of detecting asymptomatic cancer (e.g., prostate cancer); methods of identifying an individual at risk for developing cancer (e.g., prostate cancer); and kits for detecting the virus.
摘要翻译：本发明提供了编码病毒的分离的核酸序列; 包含病毒的氨基酸序列的分离的多肽; 包含病毒核酸序列的载体; 包含载体的细胞; 对病毒具有结合特异性的抗体及其抗原结合片段; 检测或筛选病毒的方法（例如，在个体中）; 识别抑制病毒的药剂的方法; 诱导对病毒的免疫应答的方法; 治疗与个体（例如癌症如前列腺癌）中XMRV存在相关的疾病的方法; 检测无症状癌症的方法（例如前列腺癌）; 识别患有癌症风险的个体（例如前列腺癌）的方法; 和用于检测病毒的工具包。

2. 发明授权

US08263085B2 Gammaretrovirus associated with cancer 失效
标题翻译：与癌症相关的瘤胃病毒
公开(公告)号：US08263085B2
公开(公告)日：2012-09-11
申请号：US11903756
申请日：2007-09-24
申请人： Robert H. Silverman , Eric A. Klein , Graham Casey , Joseph DeRisi , Don Ganem
发明人： Robert H. Silverman , Eric A. Klein , Graham Casey , Joseph DeRisi , Don Ganem
IPC分类号： A61K39/21 , C12N5/071 , C12N7/00
CPC分类号： C12N7/00 , A61K39/00 , C07K14/005 , C07K16/1036 , C12N9/22 , C12N2740/13021 , C12N2740/13022 , C12Q1/6886 , C12Q1/70 , C12Q1/701 , C12Q2600/136
摘要： The present invention provides for isolated nucleic acid sequences encoding viruses; isolated polypeptides comprising amino acid sequences of the virus; vectors comprising the viral nucleic acid sequences; cells comprising the vectors; antibodies and antigen binding fragments thereof which have binding specificity for the virus; methods of detecting or screening for the virus (e.g., in an individual); methods of identifying agents that inhibit the virus; methods of inducing an immune response to the virus; methods of treating disease associated with the presence of XMRV in an individual (e.g., cancer such as prostate cancer); methods of detecting asymptomatic cancer (e.g., prostate cancer); methods of identifying an individual at risk for developing cancer (e.g., prostate cancer); and kits for detecting the virus.
摘要翻译：本发明提供了编码病毒的分离的核酸序列; 包含病毒的氨基酸序列的分离的多肽; 包含病毒核酸序列的载体; 包含载体的细胞; 对病毒具有结合特异性的抗体及其抗原结合片段; 检测或筛选病毒的方法（例如，在个体中）; 识别抑制病毒的药剂的方法; 诱导对病毒的免疫应答的方法; 治疗与个体（例如癌症如前列腺癌）中XMRV存在相关的疾病的方法; 检测无症状癌症的方法（例如前列腺癌）; 识别患有癌症风险的个体（例如前列腺癌）的方法; 和用于检测病毒的工具包。

3. 发明申请

US20100166797A1 Gammaretrovirus associated with cancer 失效
标题翻译：与癌症相关的瘤胃病毒
公开(公告)号：US20100166797A1
公开(公告)日：2010-07-01
申请号：US11903756
申请日：2007-09-24
申请人： Robert H. Silverman , Eric A. Klein , Graham Casey , Joseph DeRisi , Don Ganem
发明人： Robert H. Silverman , Eric A. Klein , Graham Casey , Joseph DeRisi , Don Ganem
IPC分类号： A61K39/21 , C12N7/00 , C07K2/00 , C12N15/74 , C12N5/10 , C07K16/00 , C12Q1/70 , A61K39/00 , A61P35/00 , A61P31/12 , A61P37/04
CPC分类号： C12N7/00 , A61K39/00 , C07K14/005 , C07K16/1036 , C12N9/22 , C12N2740/13021 , C12N2740/13022 , C12Q1/6886 , C12Q1/70 , C12Q1/701 , C12Q2600/136
摘要： The present invention provides for isolated nucleic acid sequences encoding viruses; isolated polypeptides comprising amino acid sequences of the virus; vectors comprising the viral nucleic acid sequences; cells comprising the vectors; antibodies and antigen binding fragments thereof which have binding specificity for the virus; methods of detecting or screening for the virus (e.g., in an individual); methods of identifying agents that inhibit the virus; methods of inducing an immune response to the virus; methods of treating disease associated with the presence of XMRV in an individual (e.g., cancer such as prostate cancer); methods of detecting asymptomatic cancer (e.g., prostate cancer); methods of identifying an individual at risk for developing cancer (e.g., prostate cancer); and kits for detecting the virus.
摘要翻译：本发明提供了编码病毒的分离的核酸序列; 包含病毒的氨基酸序列的分离的多肽; 包含病毒核酸序列的载体; 包含载体的细胞; 对病毒具有结合特异性的抗体及其抗原结合片段; 检测或筛选病毒的方法（例如，在个体中）; 识别抑制病毒的药剂的方法; 诱导对病毒的免疫应答的方法; 治疗与个体（例如癌症如前列腺癌）中XMRV存在相关的疾病的方法; 检测无症状癌症的方法（例如前列腺癌）; 识别患有癌症风险的个体（例如前列腺癌）的方法; 和用于检测病毒的工具包。

4. 发明授权

US4607612A Fireplace furnace 失效
标题翻译：壁炉炉
公开(公告)号：US4607612A
公开(公告)日：1986-08-26
申请号：US737274
申请日：1985-05-23
申请人： Joseph DeRisi
发明人： Joseph DeRisi
IPC分类号： F24B1/19 , F24B7/02 , F24B7/00
CPC分类号： F24B1/1902 , F24B7/025
摘要： A furnace insert (10) for an enclosed fireplace is disclosed. Furnace (10) includes an outer housing (11) and an inner housing (50) which define a firebox (11A). A plurality of tubular steel ducts (45-52), inclusive, are mounted within firebox (11A) and heat air as it rises through the ducts from inlets at the bottom and out of outlets at the top. Additional heat is recovered from the furnace and, in addition, an insulating effect is created which prevents damage to the fireplace walls by a heat exchange chamber (54) which is defined by a space between inner housing (11) and outer housing (50) which has an air inlet (54A) at the bottom and an air outlet (54A) at the top.
摘要翻译：公开了一种用于封闭壁炉的炉子插入件（10）。炉（10）包括限定火箱（11A）的外壳（11）和内壳（50）。多个管状钢管（45-52）（包括端部）安装在火箱（11A）中，并且当空气从底部的入口和顶部的出口排出时，加热空气通过管道。另外，从炉子回收额外的热量，此外还产生了绝热效果，其通过由内壳体（11）和外壳（50）之间的空间限定的热交换室（54）来防止对壁炉壁的损坏，其在底部具有空气入口（54A），在顶部具有空气出口（54A）。

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