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1. 发明授权

US06355491B1 Individually addressable micro-electromagnetic unit array chips 有权
标题翻译：单独寻址微电磁单元阵列芯片
公开(公告)号：US06355491B1
公开(公告)日：2002-03-12
申请号：US09399299
申请日：1999-09-17
申请人： Yuxiang Zhou , Litian Liu , Ken Chen , Depu Chen , Jia Wang , Zewen Liu , Zhimin Tan , Junquan Xu , Xiaoshan Zhu , Xuezhong He , Wenzhang Xie , Zhiming Li , Xiumei Liu
发明人： Yuxiang Zhou , Litian Liu , Ken Chen , Depu Chen , Jia Wang , Zewen Liu , Zhimin Tan , Junquan Xu , Xiaoshan Zhu , Xuezhong He , Wenzhang Xie , Zhiming Li , Xiumei Liu
IPC分类号： G01N33543
CPC分类号： B01L3/502761 , B01J19/0046 , B01J2219/00317 , B01J2219/00468 , B01J2219/005 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00614 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00639 , B01J2219/00648 , B01J2219/00653 , B01J2219/00659 , B01J2219/00722 , B01L3/5025 , B01L2200/0647 , B01L2200/0668 , B01L2300/0636 , B01L2300/0645 , B01L2300/0877 , B01L2300/089 , B01L2400/043 , C40B40/06 , C40B60/14 , G01N35/0098 , Y10S436/806
摘要： This invention provides electromagnetic chips and electromagnetic biochips having arrays of individually addressable micro-electromagnetic units, as well as methods of utilizing these chips for directed manipulation of micro-particles and micro-structures such as biomolecules and chemical reagents. An electromagnetic biochip comprises an individually addressable micro-electromagnetic unit chip with ligand molecules immobilized on its surface. By controlling the electromagnetic field at each unit of the array and combining this control with magnetic modification of biomolecules, these chips can be used for directed manipulation, synthesis and release of biomolecules in order to increase sensitivity of biochemical or chemical analysis and reduce assay time. Other advantages with these chips include minimized damages to biological molecules and increased reproducibility of assay results.
摘要翻译：本发明提供具有独立寻址的微电磁单元阵列的电磁芯片和电磁生物芯片，以及利用这些芯片来定向操纵微粒和微结构如生物分子和化学试剂的方法。电磁生物芯片包括具有固定在其表面上的配体分子的单独可寻址的微电磁单元芯片。通过控制阵列的每个单元的电磁场并将该控制与生物分子的磁性修饰相组合，这些芯片可用于生物分子的定向操作，合成和释放，以提高生物化学或化学分析的灵敏度并减少测定时间。这些芯片的其他优点包括对生物分子的最小化损害和提高测定结果的再现性。

2. 发明授权

US06806050B2 Individually addressable micro-electromagnetic unit array chips 有权
标题翻译：单独寻址微电磁单元阵列芯片
公开(公告)号：US06806050B2
公开(公告)日：2004-10-19
申请号：US09955343
申请日：2001-09-18
申请人： Yuxiang Zhou , Litian Liu , Ken Chen , Depu Chen , Jia Wang , Zewen Liu , Zhimin Tan , Junquan Xu , Xiaoshan Zhu , Xuezhong He , Wenzhang Xie , Zhiming Li , Xiumel Liu
发明人： Yuxiang Zhou , Litian Liu , Ken Chen , Depu Chen , Jia Wang , Zewen Liu , Zhimin Tan , Junquan Xu , Xiaoshan Zhu , Xuezhong He , Wenzhang Xie , Zhiming Li , Xiumel Liu
IPC分类号： G01N33543
CPC分类号： B01L3/502761 , B01J19/0046 , B01J2219/00317 , B01J2219/00468 , B01J2219/005 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00614 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00639 , B01J2219/00648 , B01J2219/00653 , B01J2219/00659 , B01J2219/00722 , B01L3/5025 , B01L2200/0647 , B01L2200/0668 , B01L2300/0636 , B01L2300/0645 , B01L2300/0877 , B01L2300/089 , B01L2400/043 , C40B40/06 , C40B60/14 , G01N35/0098 , Y10S436/806
摘要： This invention provides electromagnetic chips and electromagnetic biochips having arrays of individually addressable micro-electromagnetic units, as well as methods of utilizing these chips for directed manipulation of micro-particles and micro-structures such as biomolecules and chemical reagents. An electromagnetic biochip comprises an individually addressable micro-electromagnetic unit chip with ligand molecules immobilized on its surface. By controlling the electromagnetic field at each unit of the array and combining this control with magnetic modification of biomolecules, these chips can be used for directed manipulation, synthesis and release of biomolecules in order to increase sensitivity of biochemical or chemical analysis and reduce assay time. Other advantages with these chips include minimized damages to biological molecules and increased reproducibility of assay results.
摘要翻译：本发明提供具有独立寻址的微电磁单元阵列的电磁芯片和电磁生物芯片，以及利用这些芯片来定向操纵微粒和微结构如生物分子和化学试剂的方法。电磁生物芯片包括具有固定在其表面上的配体分子的单独可寻址的微电磁单元芯片。通过控制阵列的每个单元的电磁场并将该控制与生物分子的磁性修饰相组合，这些芯片可用于生物分子的定向操作，合成和释放，以提高生物化学或化学分析的灵敏度并减少测定时间。这些芯片的其他优点包括对生物分子的最小化损害和提高测定结果的再现性。

3. 发明申请

US20060003466A1 Nanometer-sized up-converting phosphor fluoride particles and process of preparation 有权
标题翻译：纳米级上转换氟化磷颗粒及其制备方法
公开(公告)号：US20060003466A1
公开(公告)日：2006-01-05
申请号：US10511363
申请日：2003-04-15
申请人： Guangshun Yi , Baoquan Sun , Depu Chen , Yuxiang Zhou , Jing Cheng , Wenjun Yang , Yue Ge , Lianghong Guo
发明人： Guangshun Yi , Baoquan Sun , Depu Chen , Yuxiang Zhou , Jing Cheng , Wenjun Yang , Yue Ge , Lianghong Guo
IPC分类号： G01N33/553
CPC分类号： C09K11/7772 , C09K11/7773 , Y10S977/83 , Y10S977/834
摘要： Nanometer-scaled up-converting fluoride phosphor particles and processes of making them are disclosed. In the process, an aqueous solution consisting of soluble salts of rare-earth metal ions at a molar ratio of (yttrium, lanthanum or gadolinium): ytterbium:(erbium, holmium, terbium or thulium)=(70-90):(0-29):(0.001-15) is mixed a rare-earth metal chelator and a soluble fluoride salt to form precipitates, which are then annealed at an elevated temperature to produce nanometer-scaled up-converting fluoride phosphor particles. The particle size is between 35 nm and 200 nm, and can be controlled by the amount of the metal chelator added to the solution. The nanometer-sized particle is applicable to many biological assays.
摘要翻译：公开了纳米级上转换氟化物荧光体颗粒及其制备方法。在该方法中，以（钇，镧或钆）的摩尔比形成的稀土金属离子的可溶性盐：镱（铒，钬，铽或ium）=（70-90）：（0） -29）:( 0.001-15）混合稀土金属螯合剂和可溶性氟化物盐形成析出物，然后在升高的温度下退火，生成纳米级的上转换氟化物荧光体颗粒。粒径在35nm和200nm之间，并且可以通过添加到溶液中的金属螯合剂的量来控制。纳米级粒子适用于许多生物测定。

4. 发明授权

US07422703B2 Nanometer-sized up-converting phosphor fluoride particles and process of preparation 有权
标题翻译：纳米级上转换氟化磷颗粒及其制备方法
公开(公告)号：US07422703B2
公开(公告)日：2008-09-09
申请号：US10511363
申请日：2003-04-15
申请人： Guangshun Yi , Baoquan Sun , Depu Chen , Yuxiang Zhou , Jing Cheng , Wenjun Yang , Yue Ge , Lianghong Guo
发明人： Guangshun Yi , Baoquan Sun , Depu Chen , Yuxiang Zhou , Jing Cheng , Wenjun Yang , Yue Ge , Lianghong Guo
IPC分类号： C09K11/85
CPC分类号： C09K11/7772 , C09K11/7773 , Y10S977/83 , Y10S977/834
摘要： Nanometer-scaled up-converting fluoride phosphor particles and processes of making them are disclosed. In the process, an aqueous solution consisting of soluble salts of rare-earth metal ions at a molar ratio of (yttrium, lanthanum or gadolinium): ytterbium:(erbium, holmium, terbium or thulium)=(70-90):(0-29):(0.001-15) is mixed a rare-earth metal chelator and a soluble fluoride salt to form precipitates, which are then annealed at an elevated temperature to produce nanometer-scaled up-converting fluoride phosphor particles. The particle size is between 35 nm and 200 nm, and can be controlled by the amount of the metal chelator added to the solution. The nanometer-sized particle is applicable to many biological assays.
摘要翻译：公开了纳米级上转换氟化物荧光体颗粒及其制备方法。在该方法中，以（钇，镧或钆）的摩尔比形成的稀土金属离子的可溶性盐：镱（铒，钬，铽或ium）=（70-90）：（0） -29）:( 0.001-15）混合稀土金属螯合剂和可溶性氟化物盐形成析出物，然后在升高的温度下退火，生成纳米级的上转换氟化物荧光体颗粒。粒径在35nm和200nm之间，并且可以通过添加到溶液中的金属螯合剂的量来控制。纳米级粒子适用于许多生物测定。

5. 发明申请

US20100270176A1 AUTOMATIC POSITIONING AND SENSING MICROELECTRODE ARRAYS 有权
标题翻译：自动定位和感应微电极阵列
公开(公告)号：US20100270176A1
公开(公告)日：2010-10-28
申请号：US12667507
申请日：2007-07-04
申请人： Guangxin Xiang , Liangbin Pan , Wanli Xing , Lihua Huang , Zhongyao Yu , Jing Zhu , Yuxiang Zhou , Jing Cheng
发明人： Guangxin Xiang , Liangbin Pan , Wanli Xing , Lihua Huang , Zhongyao Yu , Jing Zhu , Yuxiang Zhou , Jing Cheng
IPC分类号： G01N33/50 , G01N27/26
CPC分类号： G01N33/4836 , B01J2219/00653 , B01J2219/00743 , B01L3/502707 , B01L2300/0645 , B01L2400/0421 , B01L2400/0424
摘要： A microelectrode sensing device includes a substrate and an array of microelectrode sensors. Each sensor includes a first conductive layer that at least partially conducts electricity. The first conductive layer is formed above the substrate and patterned to include a recording electrode that measures electrical activities of target cells. Each sensor also includes a second conductive layer that at least partially conducts electricity. The second conductive layer is elevated above the first layer and patterned to include multiple positioning electrodes arranged to define a sensing region above the recording electrode. The positioning electrodes are designed to generate an electric field pattern in the sensing region to move and confine the target cells to a sub-region of the sensing region that at least partially overlaps the recording electrode.
摘要翻译：微电极感测装置包括基板和微电极传感器阵列。每个传感器包括至少部分地导电的第一导电层。第一导电层形成在衬底上并被图案化以包括测量靶细胞的电活动的记录电极。每个传感器还包括至少部分地传导电的第二导电层。第二导电层在第一层之上被升高并且被图案化以包括布置成限定记录电极上方的感测区域的多个定位电极。定位电极被设计成在感测区域中产生电场图案以移动并将目标单元限制在至少部分地与记录电极重叠的感测区域的子区域上。

6. 发明申请

US20090239758A1 METHODS, MICROARRAY, AND KITS FOR DETECTION OF DRUG RESISTANCE GENES IN GRAM-NEGATIVE BACTERIA 有权
标题翻译：用于检测抗菌细菌中耐药基因的方法，微阵列和试剂盒
公开(公告)号：US20090239758A1
公开(公告)日：2009-09-24
申请号：US12097237
申请日：2007-01-18
申请人： Lingxiang Zhu , Zhiwei Zhang , Di Jiang , Ning Du , Can Wang , Huawei Yang , Qiong Zhang , Huafang Gao , Yuxiang Zhou , Jing Cheng
发明人： Lingxiang Zhu , Zhiwei Zhang , Di Jiang , Ning Du , Can Wang , Huawei Yang , Qiong Zhang , Huafang Gao , Yuxiang Zhou , Jing Cheng
IPC分类号： C40B30/04 , C40B40/08 , C12Q1/68
CPC分类号： C12Q1/689 , C12Q2600/156 , C12Q2600/16 , C12Q2600/166
摘要： The present invention provides kits and microarrays containing primer pairs for amplifying drug resistance genes and/or probes for detection of drug resistance genes. Also provided are methods of detecting drug resistance genes using kits and microarrays described herein.
摘要翻译：本发明提供了包含用于扩增用于检测药物抗性基因的药物抗性基因和/或探针的引物对的试剂盒和微阵列。还提供了使用本文所述的试剂盒和微阵列检测药物抗性基因的方法。

7. 发明授权

US08784633B2 Automatic positioning and sensing microelectrode arrays 有权
标题翻译：自动定位和感应微电极阵列
公开(公告)号：US08784633B2
公开(公告)日：2014-07-22
申请号：US12667507
申请日：2007-07-04
申请人： Guangxin Xiang , Liangbin Pan , Wanli Xing , Lihua Huang , Zhongyao Yu , Jing Zhu , Yuxiang Zhou , Jing Cheng
发明人： Guangxin Xiang , Liangbin Pan , Wanli Xing , Lihua Huang , Zhongyao Yu , Jing Zhu , Yuxiang Zhou , Jing Cheng
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： G01N33/4836 , B01J2219/00653 , B01J2219/00743 , B01L3/502707 , B01L2300/0645 , B01L2400/0421 , B01L2400/0424
摘要： A microelectrode sensing device includes a substrate and an array of microelectrode sensors. Each sensor includes a first conductive layer that at least partially conducts electricity. The first conductive layer is formed above the substrate and patterned to include a recording electrode that measures electrical activities of target cells. Each sensor also includes a second conductive layer that at least partially conducts electricity. The second conductive layer is elevated above the first layer and patterned to include multiple positioning electrodes arranged to define a sensing region above the recording electrode. The positioning electrodes are designed to generate an electric field pattern in the sensing region to move and confine the target cells to a sub-region of the sensing region that at least partially overlaps the recording electrode.
摘要翻译：微电极感测装置包括基板和微电极传感器阵列。每个传感器包括至少部分地导电的第一导电层。第一导电层形成在衬底上并被图案化以包括测量靶细胞的电活动的记录电极。每个传感器还包括至少部分地传导电的第二导电层。第二导电层在第一层之上被升高并且被图案化以包括布置成限定记录电极上方的感测区域的多个定位电极。定位电极被设计成在感测区域中产生电场图案以移动并将目标单元限制在至少部分地与记录电极重叠的感测区域的子区域上。

8. 发明申请

US20090143245A1 MICROARRAYS FOR GENOTYPING AND METHODS OF USE 审中-公开
标题翻译：用于基因组的微阵列和使用方法
公开(公告)号：US20090143245A1
公开(公告)日：2009-06-04
申请号：US12093504
申请日：2006-02-20
申请人： Huafang Gao , Ze Li , Dong Wang , Yanhua Liu , Xiang Liu , Yangzhou Jiang , Chuanzan Zhao , Li Li , Gengxin Lan , Tao Guo , Bin Cai , Wanli Xing , Yuxiang Zhou , Jing Cheng
发明人： Huafang Gao , Ze Li , Dong Wang , Yanhua Liu , Xiang Liu , Yangzhou Jiang , Chuanzan Zhao , Li Li , Gengxin Lan , Tao Guo , Bin Cai , Wanli Xing , Yuxiang Zhou , Jing Cheng
IPC分类号： C40B30/10 , C40B40/08 , C40B50/06
CPC分类号： C12Q1/6881 , C12Q1/6837 , C12Q2600/156
摘要： The present invention provides a microarray for detecting a genotype at a polymorphic site in a plurality of nucleic acid samples, comprising a first set of nucleic acid fragments derived from the samples and a second set of nucleic acid fragments derived from a plurality of references immobilized thereon. The invention also provides a microarray comprising a set of nucleic acid fragments immobilized on the surface of the microarray, wherein the nucleic acid fragments are derived from the samples by amplifying a region in the sample containing the polymorphism through asymmetric PCR amplification. Methods of using and making the microarrays are also provided.
摘要翻译：本发明提供了用于检测多个核酸样品中多态性位点处的基因型的微阵列，其包含衍生自样品的第一组核酸片段和衍生自多个固定在其上的参考文献的第二组核酸片段。本发明还提供了一种微阵列，其包含固定在微阵列表面上的一组核酸片段，其中通过不对称PCR扩增扩增含有多态性的样品中的区域，来从样品衍生出核酸片段。还提供了使用和制造微阵列的方法。

9. 发明申请

US20070042367A1 Lab-on-chip system for analying nucleic acid 审中-公开
标题翻译：用于分析核酸的片上系统
公开(公告)号：US20070042367A1
公开(公告)日：2007-02-22
申请号：US10547742
申请日：2003-05-06
申请人： Shengce Tao , Jing Cheng , Xuemei Ma , Qiong Zhang , Yuxiang Zhou
发明人： Shengce Tao , Jing Cheng , Xuemei Ma , Qiong Zhang , Yuxiang Zhou
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： B01L3/508 , B01J2219/00385 , B01J2219/00527 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00722 , B01L7/52 , B01L2300/0636 , B01L2300/0822 , B01L2300/163 , C12Q1/6837 , C40B40/06 , C40B60/14 , C12Q2547/101 , C12Q2531/131
摘要： This invention relates generally to the field of nucleic acid detection. In particular, the invention provides a lab-on-chip system for analyzing a nucleic acid, which system comprises, inter alia, controllably closed space, and a target nucleic acid can be prepared and/or amplified, and hybridized to a nucleic acid probe, and the hybridization signal can be acquired if desirable, in the controllably closed space without any material exchange between the controllably closed space and the outside environment. Methods for analyzing a nucleic acid using the lab-on-chip system is also provided.
摘要翻译：本发明一般涉及核酸检测领域。特别地，本发明提供了用于分析核酸的片上实验室系统，该系统尤其包括可控制的封闭空间，并且靶核酸可以制备和/或扩增，并与核酸探针杂交，并且如果需要，可以在可控制的封闭空间中获取杂交信号，而在可控制的封闭空间和外部环境之间没有任何物质交换。还提供了使用片上实验室系统分析核酸的方法。

10. 发明申请

US20060052101A1 Method for assigning and searching a roaming number of mobile subsribers 审中-公开
标题翻译：分配和搜索漫游数量的移动子载体的方法
公开(公告)号：US20060052101A1
公开(公告)日：2006-03-09
申请号：US10534013
申请日：2003-10-21
申请人： Yuxiang Zhou
发明人： Yuxiang Zhou
IPC分类号： H04Q7/20
CPC分类号： H04W8/06
摘要： The present invention provides a method for assigning and searching a mobile subscriber roaming number, wherein in a Visitor Location Register, the mobile subscriber roaming number is managed by a plurality of Visitor Location Register modules, said method of assigning a mobile subscriber roaming number is characterized in that, said mobile subscriber roaming number comprises a Visitor Location Register module number, and said Visitor Location Register module number is utilized to directly determine the correspondence relationship between said assigned mobile subscriber roaming number and the Visitor Location Register module in said Visitor Location Register that manages said mobile subscriber roaming number.
摘要翻译：本发明提供了一种用于分配和搜索移动用户漫游号码的方法，其中在访客位置寄存器中，移动用户漫游号码由多个访客位置寄存器模块管理，所述分配移动用户漫游号码的方法被表征因为所述移动用户漫游号码包括访客位置寄存器模块号，并且所述访客位置寄存器模块号用于直接确定所述分配的移动用户漫游号码和所述访问者位置寄存器中的访问者位置寄存器模块之间的对应关系，管理所述移动用户漫游号码。

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