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1. 发明申请

WO1993007272A1 TRANSGENIC PLANTS 审中-公开
标题翻译：转基因植物
公开(公告)号：WO1993007272A1
公开(公告)日：1993-04-15
申请号：PCT/AU1992000528
申请日：1992-10-02
申请人： CALGENE PACIFIC PTY. LTD. , LETHAM, David, Stuart , STEVENSON, Kim, Rochelle , TAO, Guo-Qing
发明人： CALGENE PACIFIC PTY. LTD.
IPC分类号： C12N15/29
CPC分类号： C12N9/1085 , C12N15/8249 , C12N15/8295
摘要： The present invention relates generally to transgenic plants and is particularly directed to transgenic tuber plants and to DNA constructs useful for producing same. The DNA constructs comprise a first nucleotide sequence corresponding to a promoter capable of functioning in a plant and a second nucleotide sequence under control of said promoter and encoding a molecule capable of enhancing levels of a cytokinin in said plant.
摘要翻译：本发明一般涉及转基因植物，特别涉及转基因块茎植物和可用于产生其的DNA构建体。所述DNA构建体包含对应于能够在植物中起作用的启动子的第一核苷酸序列和在所述启动子控制下编码能够增强所述植物中细胞分裂素水平的分子的第二核苷酸序列。

2. 发明授权

US09200323B2 Hybridization methods using natural base mismatches 有权
标题翻译：使用天然碱基错配的杂交方法
公开(公告)号：US09200323B2
公开(公告)日：2015-12-01
申请号：US12162286
申请日：2007-02-06
申请人： Huafang Gao , Ze Li , Dong Wang , Yanhua Liu , Xiang Liu , Yangzhou Jiang , Li Li , Chuanzan Zhao , Gengxin Lan , Tao Guo , Bin Cai , Jing Cheng
发明人： Huafang Gao , Ze Li , Dong Wang , Yanhua Liu , Xiang Liu , Yangzhou Jiang , Li Li , Chuanzan Zhao , Gengxin Lan , Tao Guo , Bin Cai , Jing Cheng
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6832 , C12Q2600/156 , C12Q2535/131 , C12Q2527/107
摘要： The present invention provides an improved nucleic acid hybridization process employing a modified oligonucleotide probe comprising naturally occurring nucleotide bases. At least one nucleotide in the modified oligonucleotide is artificially mismatched relative to the control nucleic acid in addition to any mismatches arising from a variant nucleic acid target containing a sequence variation. The artificial mismatch and the sequence variation positions are separated from one another on the oligonucleotide by six to nine nucleotide positions.
摘要翻译：本发明提供使用包含天然存在的核苷酸碱基的修饰的寡核苷酸探针的改进的核酸杂交方法。除了由含有序列变异的变体核酸靶产生的任何错配之外，修饰寡核苷酸中至少一个核苷酸相对于对照核酸人为错配。将人工错配和序列变异位置在寡核苷酸上彼此分开6至9个核苷酸位置。

3. 发明授权

US08871756B2 Compounds for the treatment and prophylaxis of Respiratory Syncytial Virus disease 有权
标题翻译：用于治疗和预防呼吸道合胞病毒疾病的化合物
公开(公告)号：US08871756B2
公开(公告)日：2014-10-28
申请号：US13561366
申请日：2012-07-30
申请人： Li Chen , Lichun Feng , Song Feng , Lu Gao , Tao Guo , Mengwei Huang , Chungen Liang , Yongfu Liu , Lisha Wang , Jason Christopher Wong , Jim Zhen Wu , Xihan Wu , Hongying Yun , Xiufang Zheng
发明人： Li Chen , Lichun Feng , Song Feng , Lu Gao , Tao Guo , Mengwei Huang , Chungen Liang , Yongfu Liu , Lisha Wang , Jason Christopher Wong , Jim Zhen Wu , Xihan Wu , Hongying Yun , Xiufang Zheng
IPC分类号： C07D493/10 , C07D487/04 , C07D413/04 , C07D407/14 , C07D401/04 , C07D417/14 , C07D417/04 , C07D409/14 , C07D491/107 , C07D413/14 , C07D405/14 , C07D401/14
CPC分类号： C07D493/10 , C07D401/04 , C07D401/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D487/04 , C07D491/107
摘要： A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R10, A, Q, X and Y are as defined in the specification and claims, and their use as a pharmaceutical for the treatment or prophylaxis of respiratory syncytial virus disease.
摘要翻译：式（I）化合物及其药学上可接受的盐，其中R 1至R 10，A，Q，X和Y如说明书和权利要求中所定义，及其作为治疗或预防呼吸道合胞体药物的用途病毒病。

4. 发明授权

US08829036B2 Heterocyclic aspartyl protease inhibitors 有权
公开(公告)号：US08829036B2
公开(公告)日：2014-09-09
申请号：US13420007
申请日：2012-03-14
申请人： Zhaoning Zhu , Brian McKittrick , Zhong-Yue Sun , Yuanzan C. Ye , Johannes H. Voight , Corey O. Strickland , Elizabeth M. Smith , Andrew W. Stamford , William J. Greenlee , Robert D. Mazzola, Jr. , John P. Caldwell , Jared N. Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Xiaoiang Liu , Tao Guo , Thuy X. E. Le , Kurt W. Saionz , Suresh D. Babu , Rachael C. Hunter , Michelle L. Morris , Huizhong Gu , Gang Qian , Dawit Tadesse , Ying Huang , Guoqing Li , Jianping Pan , Jeffrey A. Misiaszek , Gaifa Lai , Jingqi Duo , Chuanxing Qu , Yuefei Shao
发明人： Zhaoning Zhu , Brian McKittrick , Zhong-Yue Sun , Yuanzan C. Ye , Johannes H. Voight , Corey O. Strickland , Elizabeth M. Smith , Andrew W. Stamford , William J. Greenlee , Robert D. Mazzola, Jr. , John P. Caldwell , Jared N. Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Xiaoiang Liu , Tao Guo , Thuy X. E. Le , Kurt W. Saionz , Suresh D. Babu , Rachael C. Hunter , Michelle L. Morris , Huizhong Gu , Gang Qian , Dawit Tadesse , Ying Huang , Guoqing Li , Jianping Pan , Jeffrey A. Misiaszek , Gaifa Lai , Jingqi Duo , Chuanxing Qu , Yuefei Shao
IPC分类号： A61K31/4168 , A61K31/4178 , C07D403/06 , C07D233/88
CPC分类号： C07D233/88 , A61K31/4168 , A61K31/4178 , C07D239/22 , C07D401/06 , C07D401/10 , C07D403/06 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/10 , C07D417/14 , C07D495/10
摘要： Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein each variable in Formula 1 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.

5. 发明授权

US08673052B2 Process for preparing tantalum powder for capacitors 有权
标题翻译：电容器钽粉制备工艺
公开(公告)号：US08673052B2
公开(公告)日：2014-03-18
申请号：US12818379
申请日：2010-06-18
申请人： Wenfeng Shi , Xueqing Chen , Yong Li , Xudong Xi , Tao Guo
发明人： Wenfeng Shi , Xueqing Chen , Yong Li , Xudong Xi , Tao Guo
IPC分类号： B22F9/20 , B22F1/00
CPC分类号： C01G35/00 , B22F9/20 , B22F2998/10 , B22F2999/00 , C01P2004/03 , C01P2004/62 , C01P2006/10 , C01P2006/12 , C01P2006/40 , H01G9/0029 , H01G9/0525 , B22F2201/013 , B22F2201/20 , B22F2201/10 , B22F1/0096
摘要： The present invention provides a process for preparing a tantalum powder with high specific capacity, which process comprising the steps of, in sequence, (1) a first reduction step: mixing tantalum oxide powder and a first reducing agent powder homogenously, and then carrying out reduction reaction in hydrogen and/or inert gas or vacuum atmosphere to obtain a tantalum suboxides powder; (2) a second reduction step: mixing the tantalum suboxides powder obtained from the step (1), in which impurities have been removed, and a second reducing agent powder homogenously, and then carrying out reduction reaction in hydrogen and/or inert gas or vacuum atmosphere to obtain a tantalum powder having high oxygen content; (3) a third reduction step: mixing the tantalum powder having high oxygen content obtained from the step (2), in which impurities have been removed, with a third reducing agent powder homogenously, and then carrying out reduction reaction in hydrogen and/or inert gas or vacuum atmosphere to obtain a tantalum metal powder suitable for capacitors; wherein after each reduction step, the oxidation product of reducing agent and the residual reducing agent are removed from the reaction product.
摘要翻译：本发明提供一种制备高比容量的钽粉的方法，该方法包括以下步骤：（1）第一还原步骤：均匀混合氧化钽粉末和第一还原剂粉末，然后进行在氢气和/或惰性气体或真空气氛中还原反应，得到低氧化钽粉末; （2）第二还原步骤：将其中除去杂质的步骤（1）获得的低密度氧化钡粉末和均质的第二还原剂粉末混合，然后在氢气和/或惰性气体中进行还原反应，或真空气氛，得到氧含量高的钽粉末; （3）第三还原步骤：将已经除去杂质的步骤（2）获得的具有高氧含量的钽粉末与第三还原剂粉末均匀混合，然后在氢气和/或惰性气体或真空气氛，得到适合电容器的钽金属粉末; 其中在每个还原步骤之后，从反应产物中除去还原剂和剩余还原剂的氧化产物。

6. 发明授权

US08436183B2 Synthetic multimerizing agents 失效
标题翻译：合成多聚化剂
公开(公告)号：US08436183B2
公开(公告)日：2013-05-07
申请号：US13361082
申请日：2012-01-30
申请人： Dennis A. Holt , Terence P. Keenan , Tao Guo , Edgardo Laborde , Wu Yang
发明人： Dennis A. Holt , Terence P. Keenan , Tao Guo , Edgardo Laborde , Wu Yang
IPC分类号： C07D211/06 , C07D211/60 , C07D401/00 , C07D207/00
CPC分类号： C07D401/14 , C07D207/16 , C07D211/60 , C07D401/12 , C07D405/12
摘要： New compounds are disclosed for multimerizing immunophilins and proteins containing immunophilin or immunophilin-related domains. The compounds are of the formula M-L-Q where M is a synthetic ligand for an FKBP protein.
摘要翻译：公开了用于多聚化免疫亲和素和含有免疫亲和素相关结构域的蛋白质的新化合物。该化合物具有式M-L-Q，其中M是FKBP蛋白质的合成配体。

7. 发明申请

US20120276118A1 HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS 有权
标题翻译：异源ASPARTYL蛋白酶抑制剂
公开(公告)号：US20120276118A1
公开(公告)日：2012-11-01
申请号：US13420007
申请日：2012-03-14
申请人： Zhaoning Zhu , Brian McKittrick , Zhong-Yue Sun , Yuanzan C. Ye , Johannes H. Voight , Corey O. Strickland , Elizabeth M. Smith , Andrew Stamford , William J. Greenlee , Robert D. Mazzola , John P. Caldwell , Jared N. Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Xiaoxiang Liu , Tao Guo , Thuy X.E. Le , Kurt W. Saionz , Suresh D. Babu , Rachael C. Hunter , Michelle L. Morris , Huizhong Gu , Gang Qian , Dawit Tadesse , Ying Huang , Guoqing Li , Jianping Pan , Jeffrey A. Misiaszek , Gaifa Lai , Jingqi Duo , Chuanxing Qu , Yuefei Shao
发明人： Zhaoning Zhu , Brian McKittrick , Zhong-Yue Sun , Yuanzan C. Ye , Johannes H. Voight , Corey O. Strickland , Elizabeth M. Smith , Andrew Stamford , William J. Greenlee , Robert D. Mazzola , John P. Caldwell , Jared N. Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Xiaoxiang Liu , Tao Guo , Thuy X.E. Le , Kurt W. Saionz , Suresh D. Babu , Rachael C. Hunter , Michelle L. Morris , Huizhong Gu , Gang Qian , Dawit Tadesse , Ying Huang , Guoqing Li , Jianping Pan , Jeffrey A. Misiaszek , Gaifa Lai , Jingqi Duo , Chuanxing Qu , Yuefei Shao
IPC分类号： A61K39/395
CPC分类号： C07D233/88 , A61K31/4168 , A61K31/4178 , C07D239/22 , C07D401/06 , C07D401/10 , C07D403/06 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/10 , C07D417/14 , C07D495/10
摘要： Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein each variable in Formula 1 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.
摘要翻译：公开了式I化合物或其立体异构体，互变异构体或其药学上可接受的盐或溶剂化物，其中式1中的每个变量如说明书中所定义; 以及包含式I化合物的药物组合物。还公开了抑制天冬氨酰蛋白酶的方法，特别是治疗心血管疾病，认知和神经退行性疾病的方法，以及抑制人类免疫缺陷病毒，plasmepins，组织蛋白酶D和原生动物酶。还公开了使用式I化合物与胆碱酯酶抑制剂或毒蕈碱m1激动剂或m2拮抗剂组合治疗认知或神经变性疾病的方法。

8. 发明申请

US20120231018A1 HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS 有权
公开(公告)号：US20120231018A1
公开(公告)日：2012-09-13
申请号：US13416140
申请日：2012-03-09
申请人： Zhaoning Zhu , Brian McKittrick , Zhong-Yue Sun , Yuanzan C. Ye , Johannes H. Voigt , Corey O. Strickland , Elizabeth M. Smith , Andrew Stamford , William J. Greenlee , Robert D. Mozzola , John P. Caldwell , Jared N. Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Xiaoxiang Liu , Tao Guo , Thuy X. E. Le , Kurt W. Saionz , Suresh D. Babu , Rachael C. Hunter , Michelle L. Morris , Huizhong Gu , Gang Qian , Dawit Tadesse , Ying Huang , Guoqing Li , Jianping Pan , Jeffrey A. Misiaszek , Gaifa Lai , Jingqi Duo , Chuanxing Qu , Yuefei Shao
发明人： Zhaoning Zhu , Brian McKittrick , Zhong-Yue Sun , Yuanzan C. Ye , Johannes H. Voigt , Corey O. Strickland , Elizabeth M. Smith , Andrew Stamford , William J. Greenlee , Robert D. Mozzola , John P. Caldwell , Jared N. Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Xiaoxiang Liu , Tao Guo , Thuy X. E. Le , Kurt W. Saionz , Suresh D. Babu , Rachael C. Hunter , Michelle L. Morris , Huizhong Gu , Gang Qian , Dawit Tadesse , Ying Huang , Guoqing Li , Jianping Pan , Jeffrey A. Misiaszek , Gaifa Lai , Jingqi Duo , Chuanxing Qu , Yuefei Shao
IPC分类号： A61K31/513 , A61P25/28 , A61P31/10 , A61P25/00 , A61P29/00 , A61K39/395 , A61P31/04 , A61P9/00 , A61P33/02
CPC分类号： C07D233/88 , A61K31/4168 , A61K31/4178 , C07D239/22 , C07D401/06 , C07D401/10 , C07D403/06 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/10 , C07D417/14 , C07D495/10
摘要： Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein each variable in Formula 1 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.

9. 发明授权

US08242112B2 Heterocyclic aspartyl protease inhibitors 有权
公开(公告)号：US08242112B2
公开(公告)日：2012-08-14
申请号：US13108454
申请日：2011-05-16
申请人： Zhaoning Zhu , Brian McKittrick , Zhong-Yue Sun , Yuanzan C. Ye , Johannes H. Voigt , Corey Strickland , Elizabeth M. Smith , Andrew W. Stamford , William J. Greenlee , Robert D. Mazzola, Jr. , John P. Caldwell , Jared N. Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Tao Guo , Thuy X. H. Le , Kurt W. Saionz , Suresh D. Babu , Rachael C. Hunter , Michelle L. Morris , Huizhong Gu , Gang Qian , Dawit Tadesse
发明人： Zhaoning Zhu , Brian McKittrick , Zhong-Yue Sun , Yuanzan C. Ye , Johannes H. Voigt , Corey Strickland , Elizabeth M. Smith , Andrew W. Stamford , William J. Greenlee , Robert D. Mazzola, Jr. , John P. Caldwell , Jared N. Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Tao Guo , Thuy X. H. Le , Kurt W. Saionz , Suresh D. Babu , Rachael C. Hunter , Michelle L. Morris , Huizhong Gu , Gang Qian , Dawit Tadesse
IPC分类号： A61K31/535 , C07D273/04
CPC分类号： C07D233/46 , C07D233/70 , C07D233/88 , C07D239/22 , C07D239/70 , C07D271/07 , C07D273/00 , C07D401/04 , C07D401/08 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/10 , C07D403/12 , C07D405/10 , C07D409/04 , C07D409/10 , C07D409/14 , C07D413/10 , C07D413/12 , C07D417/06
摘要： Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein W is a bond, —C(═S)—, —S(O)—, —S(O)2—, —C(═O)—, —O—, —C(R6)(R7)—, —N(R5)— or —C(═N(R5))—; X is —O—, —N(R5)— or —C(R6)(R7)—; provided that when X is —O—, U is not —O—, —S(O)—, —S(O)2—, —C(═O)— or —C(═NR5)—; U is a bond, —S(O)—, —S(O)2—, —C(O)—, —O—, —P(O)(OR15)—, —C(═NR5)—, —(C(R6)(R7))b— or —N(R5)—; wherein b is 1 or 2; provided that when W is —S(O)—, —S(O)2—, —O—, or —N(R5)—, U is not —S(O)—, —S(O)2—, —O—, or —N(R5)—; provided that when X is —N(R5)— and W is —S(O)—, —S(O)2—, —O—, or —N(R5)—, then U is not a bond; and R1, R2, R3, R4, R5, R6, and R7 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes.Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.

10. 发明申请

US20120014059A1 POWER MODULE 有权
标题翻译：电源模块
公开(公告)号：US20120014059A1
公开(公告)日：2012-01-19
申请号：US13074539
申请日：2011-03-29
申请人： Jian-Hong ZENG , Shou-Yu Hong , Qi-Feng Ye , Xue-Tao Guo , Ai-Xing Tong
发明人： Jian-Hong ZENG , Shou-Yu Hong , Qi-Feng Ye , Xue-Tao Guo , Ai-Xing Tong
IPC分类号： H05K7/20 , H05K7/00
CPC分类号： H05K7/209 , H01L24/34 , H01L24/45 , H01L2224/0603 , H01L2224/45015 , H01L2224/45124 , H01L2224/45144 , H01L2224/45147 , H01L2224/48091 , H01L2224/48137 , H01L2224/48139 , H01L2224/48247 , H01L2224/48472 , H01L2224/4903 , H01L2224/49111 , H01L2224/49113 , H01L2224/49175 , H01L2224/73265 , H01L2924/01047 , H01L2924/13091 , H01L2924/181 , H01L2924/30107 , H01L2924/3011 , H02M7/003 , H05K5/065 , H05K7/1432 , H01L2924/00014 , H01L2924/00 , H01L2924/00012
摘要： A power module includes a first power chip and a second power chip, each of which has at least two electrodes. The power module is applied to a power converter having a power density higher than 15 W/inch3 and a maximum efficiency higher than 92%, or to a power converter having a power density higher than 20 W/inch3 or having a maximum efficiency higher than 93%. At least one of the power chips operates at a frequency higher than 25 kHz.
摘要翻译：功率模块包括第一功率芯片和第二功率芯片，每个芯片具有至少两个电极。功率模块被应用于功率密度高于15W / inch 3且最大效率高于92％的功率转换器，或者功率密度高于20W / inch 3的功率转换器或具有高于 93％。功率芯片中的至少一个以高于25kHz的频率工作。

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