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1. 发明授权

US09512001B2 Fluorescent magnetic nanoparticles and process of preparation 有权
标题翻译：荧光磁性纳米颗粒及其制备方法
公开(公告)号：US09512001B2
公开(公告)日：2016-12-06
申请号：US12970688
申请日：2010-12-16
申请人： Huachang Lu , Guangshun Yi , Depu Chen , Lianghong Guo , Jing Cheng
发明人： Huachang Lu , Guangshun Yi , Depu Chen , Lianghong Guo , Jing Cheng
IPC分类号： G01N33/543 , B82Y15/00 , G01N33/58
CPC分类号： B82Y15/00 , G01N33/54326 , G01N33/588 , Y10T428/2991
摘要： This invention provides nanometer-sized fluorescent magnetic particles and processes of making them. The nanoparticle has a core particle comprising a magnetic material and a fluorescent material, and the particle size is less than about 1 micrometer. The nanoparticles can be coated with an inorganic or organic layer and can be surface-modified. The nanoparticles can be used in many biological assays.
摘要翻译：本发明提供纳米级荧光磁性颗粒及其制备方法。纳米颗粒具有包含磁性材料和荧光材料的核心颗粒，并且其粒径小于约1微米。纳米颗粒可以用无机或有机层涂覆并且可以进行表面改性。纳米颗粒可用于许多生物测定。

2. 发明申请

US20060003466A1 Nanometer-sized up-converting phosphor fluoride particles and process of preparation 有权
标题翻译：纳米级上转换氟化磷颗粒及其制备方法
公开(公告)号：US20060003466A1
公开(公告)日：2006-01-05
申请号：US10511363
申请日：2003-04-15
申请人： Guangshun Yi , Baoquan Sun , Depu Chen , Yuxiang Zhou , Jing Cheng , Wenjun Yang , Yue Ge , Lianghong Guo
发明人： Guangshun Yi , Baoquan Sun , Depu Chen , Yuxiang Zhou , Jing Cheng , Wenjun Yang , Yue Ge , Lianghong Guo
IPC分类号： G01N33/553
CPC分类号： C09K11/7772 , C09K11/7773 , Y10S977/83 , Y10S977/834
摘要： Nanometer-scaled up-converting fluoride phosphor particles and processes of making them are disclosed. In the process, an aqueous solution consisting of soluble salts of rare-earth metal ions at a molar ratio of (yttrium, lanthanum or gadolinium): ytterbium:(erbium, holmium, terbium or thulium)=(70-90):(0-29):(0.001-15) is mixed a rare-earth metal chelator and a soluble fluoride salt to form precipitates, which are then annealed at an elevated temperature to produce nanometer-scaled up-converting fluoride phosphor particles. The particle size is between 35 nm and 200 nm, and can be controlled by the amount of the metal chelator added to the solution. The nanometer-sized particle is applicable to many biological assays.
摘要翻译：公开了纳米级上转换氟化物荧光体颗粒及其制备方法。在该方法中，以（钇，镧或钆）的摩尔比形成的稀土金属离子的可溶性盐：镱（铒，钬，铽或ium）=（70-90）：（0） -29）:( 0.001-15）混合稀土金属螯合剂和可溶性氟化物盐形成析出物，然后在升高的温度下退火，生成纳米级的上转换氟化物荧光体颗粒。粒径在35nm和200nm之间，并且可以通过添加到溶液中的金属螯合剂的量来控制。纳米级粒子适用于许多生物测定。

3. 发明授权

US08636954B2 Calibration slide for fluorescence detection instruments and process of preparation 有权
标题翻译：用于荧光检测仪器的校准载玻片和制备过程
公开(公告)号：US08636954B2
公开(公告)日：2014-01-28
申请号：US11660469
申请日：2004-11-22
申请人： Yu Ge , Wenjun Yang , Shuying Zhao , Lianghong Guo , Jing Cheng
发明人： Yu Ge , Wenjun Yang , Shuying Zhao , Lianghong Guo , Jing Cheng
IPC分类号： G01N21/64
CPC分类号： G01N21/6452 , G01N21/278 , Y10T436/255
摘要： The present invention relates to calibration slides for fluorescence detection instruments and processing method of making them. The aim of this invention is to disclose calibration slides with high photostability and long lifetime for fluorescence detection instruments. The calibration slides are fabricated by patterning calibration spot arrays of modified inorganic phosphors on the glass slide. The process for producing a calibration slide comprises the following procedure: 1) Dispersing the inorganic phosphors of rare-earth doped complex in water; 2) Patterning the array of the above suspension on the glass slide. The calibration slides in the present invention employ a very stable fluorescing material that is insensitive to photobleaching, has long lifetime and stability under mild storage condition. The calibration slides in the present invention can be used to calibrate and test for some fluorescence instruments, i.e. microarray scanner, fluorescent microscopy, fluorescence spectrometer, fluorescent multiwell-plate reader.
摘要翻译：本发明涉及用于荧光检测仪器的校准载片及其制作方法。本发明的目的是公开具有高荧光检测仪器的高光稳定性和长寿命的校准载玻片。通过在玻璃载片上图案化修饰的无机磷光体的校准点阵列来制造校准载玻片。制备校准载玻片的方法包括以下步骤：1）将稀土掺杂络合物的无机磷光体分散在水中; 2）将上述悬浮液的阵列图案化在载玻片上。本发明中的校准载玻片使用对光漂白不敏感的非常稳定的荧光材料，在温和储存条件下具有长寿命和稳定性。本发明中的校准载玻片可用于校准和测试一些荧光仪器，即微阵列扫描仪，荧光显微镜，荧光光谱仪，荧光多孔板读数器。

4. 发明申请

US20110177339A1 FLUORESCENT MAGNETIC NANOPARTICLES AND PROCESS OF PREPARATION 有权
标题翻译：荧光磁性纳米粒子及其制备方法
公开(公告)号：US20110177339A1
公开(公告)日：2011-07-21
申请号：US12970688
申请日：2010-12-16
申请人： Huachang Lu , Guangshun Yi , Depu Chen , Lianghong Guo , Jing Cheng
发明人： Huachang Lu , Guangshun Yi , Depu Chen , Lianghong Guo , Jing Cheng
IPC分类号： B32B5/16 , B05D7/00 , B06B1/20
CPC分类号： B82Y15/00 , G01N33/54326 , G01N33/588 , Y10T428/2991
摘要： This invention provides nanometer-sized fluorescent magnetic particles and processes of making them. The nanoparticle has a core particle comprising a magnetic material and a fluorescent material, and the particle size is less than about 1 micrometer. The nanoparticles can be coated with an inorganic or organic layer and can be surface-modified. The nanoparticles can be used in many biological assays.
摘要翻译：本发明提供纳米级荧光磁性颗粒及其制备方法。纳米颗粒具有包含磁性材料和荧光材料的核心颗粒，并且其粒径小于约1微米。纳米颗粒可以用无机或有机层涂覆并且可以进行表面改性。纳米颗粒可用于许多生物测定。

5. 发明授权

US07422703B2 Nanometer-sized up-converting phosphor fluoride particles and process of preparation 有权
标题翻译：纳米级上转换氟化磷颗粒及其制备方法
公开(公告)号：US07422703B2
公开(公告)日：2008-09-09
申请号：US10511363
申请日：2003-04-15
申请人： Guangshun Yi , Baoquan Sun , Depu Chen , Yuxiang Zhou , Jing Cheng , Wenjun Yang , Yue Ge , Lianghong Guo
发明人： Guangshun Yi , Baoquan Sun , Depu Chen , Yuxiang Zhou , Jing Cheng , Wenjun Yang , Yue Ge , Lianghong Guo
IPC分类号： C09K11/85
CPC分类号： C09K11/7772 , C09K11/7773 , Y10S977/83 , Y10S977/834
摘要： Nanometer-scaled up-converting fluoride phosphor particles and processes of making them are disclosed. In the process, an aqueous solution consisting of soluble salts of rare-earth metal ions at a molar ratio of (yttrium, lanthanum or gadolinium): ytterbium:(erbium, holmium, terbium or thulium)=(70-90):(0-29):(0.001-15) is mixed a rare-earth metal chelator and a soluble fluoride salt to form precipitates, which are then annealed at an elevated temperature to produce nanometer-scaled up-converting fluoride phosphor particles. The particle size is between 35 nm and 200 nm, and can be controlled by the amount of the metal chelator added to the solution. The nanometer-sized particle is applicable to many biological assays.
摘要翻译：公开了纳米级上转换氟化物荧光体颗粒及其制备方法。在该方法中，以（钇，镧或钆）的摩尔比形成的稀土金属离子的可溶性盐：镱（铒，钬，铽或ium）=（70-90）：（0） -29）:( 0.001-15）混合稀土金属螯合剂和可溶性氟化物盐形成析出物，然后在升高的温度下退火，生成纳米级的上转换氟化物荧光体颗粒。粒径在35nm和200nm之间，并且可以通过添加到溶液中的金属螯合剂的量来控制。纳米级粒子适用于许多生物测定。

6. 发明申请

US20070059705A1 Fluorescent magnetic nanoparticles and process of preparation 有权
标题翻译：荧光磁性纳米颗粒及其制备方法
公开(公告)号：US20070059705A1
公开(公告)日：2007-03-15
申请号：US10567535
申请日：2003-08-13
申请人： Huachang Lu , Guangshun Yi , Depu Chen , Lianghong Guo , Jing Cheng
发明人： Huachang Lu , Guangshun Yi , Depu Chen , Lianghong Guo , Jing Cheng
IPC分类号： C12Q1/68 , G01N33/555 , G01N33/551
CPC分类号： B82Y15/00 , G01N33/54326 , G01N33/588 , Y10T428/2991
摘要： This invention provides nanometer-sized fluorescent magnetic particles and processes of making them. The nanoparticle has a core particle comprising a magnetic material and a fluorescent material, and the particle size is less than about 1 micrometer. The nanoparticles can be coated with an inorganic or organic layer and can be surface-modified. The nanoparticles can be used in many biological assays.
摘要翻译：本发明提供纳米级荧光磁性颗粒及其制备方法。纳米颗粒具有包含磁性材料和荧光材料的核心颗粒，并且其粒径小于约1微米。纳米颗粒可以用无机或有机层涂覆并且可以进行表面改性。纳米颗粒可用于许多生物测定。

7. 发明授权

US08603750B2 Methods for assaying analytes using photoelectrochemical labels 有权
标题翻译：使用光电化学标记测定分析物的方法
公开(公告)号：US08603750B2
公开(公告)日：2013-12-10
申请号：US10535905
申请日：2003-05-06
申请人： Lianghong Guo , Dong Dong , Dong Zheng , Fuquan Wang , Xiqiang Yang , Jing Cheng
发明人： Lianghong Guo , Dong Dong , Dong Zheng , Fuquan Wang , Xiqiang Yang , Jing Cheng
IPC分类号： G01N33/53 , G01N21/76
CPC分类号： G01N33/582 , C12Q1/6816 , G01N2458/30 , C12Q2563/113 , C12Q2523/313
摘要： The present invention provides apparatus, kits and methods for assaying analytes using photoelectrochemical molecules as labels. Specifically, the present invention provides a method for assaying an analyte, comprising: a) contacting a sample suspected of containing an analyte with a reactant capable of binding and/or reacting with the analyte under suitable conditions to allow binding of analyte, if present in the sample, to the reactant; and b) assessing binding and/or reacting between the analyte and the reactant to determine presence and/or amount of analyte in the sample, wherein the reactant, analyte, or additional reactant or additional analyte or analyte analog is labeled with a photoelectrochemically active molecule. The assessing step also comprises converting the photoelectrochemically active molecule with light to an excited state in the presence of an electrode, and assessing an electric current generated by an electron transfer between the excited photoelectrochemically active molecule and the electrode.
摘要翻译：本发明提供了使用光电化学分子作为标记来测定分析物的装置，试剂盒和方法。具体地，本发明提供了一种用于分析分析物的方法，其包括：a）在合适的条件下将疑似含有分析物的样品与能够与分析物结合和/或反应的反应物接触，以使分析物（如果存在于样品，反应物; 和b）评估分析物和反应物之间的结合和/或反应以确定样品中分析物的存在和/或量，其中反应物，分析物或附加反应物或其他分析物或分析物类似物用光电化学活性分子标记。评估步骤还包括在电极存在下将光电化学活性分子与光转化为激发态，并评估由激发的光电化学活性分子和电极之间的电子转移产生的电流。

8. 发明申请

US20110318226A1 Calibration slide for fluorescence detection instruments and process of preparation 有权
标题翻译：用于荧光检测仪器的校准载玻片和制备过程
公开(公告)号：US20110318226A1
公开(公告)日：2011-12-29
申请号：US11660469
申请日：2004-11-22
申请人： Yu Ge , Wenjun Yang , Shuying Zhao , Lianghong Guo , Jing Cheng
发明人： Yu Ge , Wenjun Yang , Shuying Zhao , Lianghong Guo , Jing Cheng
IPC分类号： G01N33/00
CPC分类号： G01N21/6452 , G01N21/278 , Y10T436/255
摘要： The present invention relates to calibration slides for fluorescence detection instruments and processing method of making them. The aim of this invention is to disclose calibration slides with high photostability and long lifetime for fluorescence detection instruments. The calibration slides are fabricated by patterning calibration spot arrays of modified inorganic phosphors on the glass slide. The process for producing a calibration slide comprises the following procedure: 1) Dispersing the inorganic phosphors of rare-earth doped complex in water; 2) Patterning the affay of the above suspension on the glass slide. The calibration slides in the present invention employ a very stable fluorescing material that is insensitive to photobleaching, has long lifetime and stability under mild storage condition. The calibration slides in the present invention can be used to calibrate and test for some fluorescence instruments, i.e. microarray scanner, fluorescent microscopy, fluorescence spectrometer, fluorescent multiwell-plate reader
摘要翻译：本发明涉及用于荧光检测仪器的校准载片及其制作方法。本发明的目的是公开具有高荧光检测仪器的高光稳定性和长寿命的校准载玻片。通过在玻璃载片上图案化修饰的无机磷光体的校准点阵列来制造校准载玻片。制备校准载玻片的方法包括以下步骤：1）将稀土掺杂络合物的无机磷光体分散在水中; 2）将上述悬浮液的印刷图案化在玻璃载玻片上。本发明中的校准载玻片使用对光漂白不敏感的非常稳定的荧光材料，在温和储存条件下具有长寿命和稳定性。本发明中的校准载玻片可用于校准和测试一些荧光仪器，即微阵列扫描仪，荧光显微镜，荧光光谱仪，荧光多孔板读数器

9. 发明授权

US07875466B2 Fluorescent magnetic nanoparticles and process of preparation 有权
标题翻译：荧光磁性纳米颗粒及其制备方法
公开(公告)号：US07875466B2
公开(公告)日：2011-01-25
申请号：US10567535
申请日：2003-08-13
申请人： Huachang Lu , Guangshun Yi , Depu Chen , Lianghong Guo , Jing Cheng
发明人： Huachang Lu , Guangshun Yi , Depu Chen , Lianghong Guo , Jing Cheng
IPC分类号： G01N33/553 , G01N1/00
CPC分类号： B82Y15/00 , G01N33/54326 , G01N33/588 , Y10T428/2991
摘要： This invention provides nanometer-sized fluorescent magnetic particles and processes of making them. The nanoparticle has a core particle comprising a magnetic material and a fluorescent material, and the particle size is less than about 1 micrometer. The nanoparticles can be coated with an inorganic or organic layer and can be surface-modified. The nanoparticles can be used in many biological assays.
摘要翻译：本发明提供纳米级荧光磁性颗粒及其制备方法。纳米颗粒具有包含磁性材料和荧光材料的核心颗粒，并且其粒径小于约1微米。纳米颗粒可以用无机或有机层涂覆并且可以进行表面改性。纳米颗粒可用于许多生物测定。

10. 发明申请

US20060148102A1 Apparatuses and methods for assaying analytes using photoelectrochemical labels 有权
标题翻译：使用光电化学标记分析分析物的装置和方法
公开(公告)号：US20060148102A1
公开(公告)日：2006-07-06
申请号：US10535905
申请日：2003-05-06
申请人： Lianghong Guo , Dong Dong , Dong Zheng , Fuquan Wang , Xiqiang Yang , Jing Cheng
发明人： Lianghong Guo , Dong Dong , Dong Zheng , Fuquan Wang , Xiqiang Yang , Jing Cheng
IPC分类号： G01N33/551
CPC分类号： G01N33/582 , C12Q1/6816 , G01N2458/30 , C12Q2563/113 , C12Q2523/313
摘要： The present invention provides apparatus, kits and methods for assaying analytes using photoelectrochemical molecules as labels. Specifically, the present invention provides a method for assaying an analyte, comprising: a) contacting a sample suspected of containing an analyte with a reactant capable of binding and/or reacting with the analyte under suitable conditions to allow binding of analyte, if present in the sample, to the reactant; and b) assessing binding and/or reacting between the analyte and the reactant to determine presence and/or amount of analyte in the sample, wherein the reactant, analyte, or additional reactant or additional analyte or analyte analog is labeled with a photoelectrochemically active molecule. The assessing step also comprises converting the photoelectrochemically active molecule with light to an excited state in the presence of an electrode, and assessing an electric current generated by an electron transfer between the excited photoelectrochemically active molecule and the electrode.
摘要翻译：本发明提供了使用光电化学分子作为标记来测定分析物的装置，试剂盒和方法。具体地，本发明提供了一种用于分析分析物的方法，其包括：a）在合适的条件下将疑似含有分析物的样品与能够与分析物结合和/或反应的反应物接触，以使分析物（如果存在于样品，反应物; 和b）评估分析物和反应物之间的结合和/或反应以确定样品中分析物的存在和/或量，其中反应物，分析物或附加反应物或其他分析物或分析物类似物用光电化学活性分子标记。评估步骤还包括在电极存在下将光电化学活性分子与光转化为激发态，并评估由激发的光电化学活性分子和电极之间的电子转移产生的电流。

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