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1. 发明授权

US09121821B2 Process for analyzing sample by capillary electrophoresis method 有权
标题翻译：毛细管电泳法分析样品的方法
公开(公告)号：US09121821B2
公开(公告)日：2015-09-01
申请号：US12376739
申请日：2007-08-29
申请人： Yoshihide Tanaka , Shinichi Wakida , Yusuke Nakayama , Satoshi Yonehara
发明人： Yoshihide Tanaka , Shinichi Wakida , Yusuke Nakayama , Satoshi Yonehara
IPC分类号： G01N27/447
CPC分类号： G01N27/447 , G01N27/44756
摘要： A process for analyzing a sample by a capillary electrophoresis method is provided that allows for high analytic precision and reduction in apparatus size, and can be readily carried out by electrophoresing a complex of a sample and an anionic group-containing compound in the capillary channel, wherein the capillary channel includes an A layer that is coated on an inner wall thereof and a B layer that is coated on the A layer, where the A and B layers are as described.
摘要翻译：提供了通过毛细管电泳方法分析样品的方法，其允许高分析精度和装置尺寸的降低，并且可以容易地通过在毛细通道中电泳样品和含阴离子基团的化合物的络合物来进行，其中毛细通道包括涂覆在其内壁上的A层和涂覆在A层上的B层，其中A层和B层如上所述。

2. 发明授权

US08361292B2 Method for analyzing hemoglobin by capillary electrophoresis and additive used therein 有权
标题翻译：通过毛细管电泳分析血红蛋白的方法及其中使用的添加剂
公开(公告)号：US08361292B2
公开(公告)日：2013-01-29
申请号：US12514293
申请日：2008-04-23
申请人： Yusuke Nakayama , Satoshi Yonehara
发明人： Yusuke Nakayama , Satoshi Yonehara
IPC分类号： G01N27/447
CPC分类号： G01N27/44747
摘要： The present invention provides a method for analyzing hemoglobin by capillary electrophoresis, that allows the apparatus to be smaller in size, allows a highly precise analysis to be obtained, and allows the analysis to be performed in a short period of time. The analytical method of the present invention are methods for analyzing hemoglobin by capillary electrophoresis, comprising: a sample-providing step of providing a sample containing hemoglobin; a capillary tube-providing step of providing a capillary tube containing a buffer solution; and an electrophoresis step of carrying out electrophoresis of the sample, by introducing the sample into the buffer solution in the capillary tube, and applying a voltage across both ends of the capillary tube; wherein the electrophoresis is carried out following at least one of modes (A) and (B) below: (A) the electrophoresis is carried out with a surfactant (a) added to the buffer solution, the surfactant (a) being a non-ionic surfactant having an alkyl group as a hydrophobic portion and a sugar as a hydrophilic portion; and (B) the electrophoresis is carried out with a surfactant (b) added to the sample, the surfactant (b) being a betaine-type amphoteric surfactant.
摘要翻译：本发明提供了一种通过毛细管电泳分析血红蛋白的方法，其允许装置尺寸更小，可以获得高精度分析，并允许在短时间内进行分析。本发明的分析方法是通过毛细管电泳分析血红蛋白的方法，包括：提供含有血红蛋白的样品的样品提供步骤; 毛细管提供步骤，提供含有缓冲溶液的毛细管; 以及电泳步骤，通过将样品引入毛细管中的缓冲溶液中并在毛细管的两端施加电压，进行样品的电泳; 其中所述电泳按照以下模式（A）和（B）中的至少一种进行：（A）用添加到缓冲溶液中的表面活性剂（a）进行电泳，所述表面活性剂（a）具有作为疏水部分的烷基和作为亲水部分的糖的离子表面活性剂; （B）用表面活性剂（b）进行电泳，表面活性剂（b）为甜菜碱型两性表面活性剂。

3. 发明授权

US08137512B2 Process for analyzing sample by capillary electrophoresis method 有权
标题翻译：毛细管电泳法分析样品的方法
公开(公告)号：US08137512B2
公开(公告)日：2012-03-20
申请号：US12376744
申请日：2007-08-29
申请人： Yoshihide Tanaka , Shinichi Wakida , Yusuke Nakayama , Satoshi Yonehara
发明人： Yoshihide Tanaka , Shinichi Wakida , Yusuke Nakayama , Satoshi Yonehara
IPC分类号： B01D57/02 , B01D59/42 , C02F1/469 , C07K1/26
CPC分类号： G01N27/447 , G01N27/44756
摘要： A process for analyzing a sample by a capillary electrophoresis method is provided that allows the apparatus to be reduced in size, allows a high analytical precision to be obtained, and can be carried out easily. The analytical process of the present invention is a process for analyzing a sample by a capillary electrophoresis method. The analytical process includes preparing a capillary tube to be used for the capillary electrophoresis method, and performing electrophoretic separation of a complex of a sample and an anionic group-containing compound that are bonded together, in the capillary tube, wherein the capillary tube includes an anionic layer that is formed of the anionic group-containing compound and that is coated on the inner wall of the capillary tube, and the anionic layer is fixed to the inner wall of the capillary tube by a covalent bond.
摘要翻译：提供了一种通过毛细管电泳方法分析样品的方法，其允许减小装置的尺寸，允许获得高分析精度，并且可以容易地进行。本发明的分析方法是通过毛细管电泳法分析样品的方法。分析方法包括制备用于毛细管电泳方法的毛细管，并且在毛细管中进行电泳分离粘合在一起的样品和含阴离子基团的化合物的络合物，其中毛细管包括阴离子层，其由含阴离子基团的化合物形成并被涂布在毛细管的内壁上，阴离子层通过共价键固定在毛细管的内壁上。

4. 发明申请

US20100116660A1 Electrophoresis Chip, Electrophoresis Apparatus, and Method for Analyzing Sample by Capillary Electrophoresis 有权
标题翻译：电泳芯片，电泳装置和毛细管电泳分析样品的方法
公开(公告)号：US20100116660A1
公开(公告)日：2010-05-13
申请号：US12515994
申请日：2008-04-28
申请人： Yoshihide Tanaka , Yusuke Nakayama , Satoshi Yonehara
发明人： Yoshihide Tanaka , Yusuke Nakayama , Satoshi Yonehara
IPC分类号： G01N27/447
CPC分类号： G01N27/44791 , G01N27/44743
摘要： An electrophoresis chip that can be small and simple and that can analyze a sample with high accuracy is provided. The electrophoresis chip includes an upper substrate 4, a lower substrate 1, an introduction reservoir 2a, a recovery reservoir 2b and a capillary channel for sample analysis 3x. The introduction reservoir 2a and the recovery reservoir 2b are formed in the lower substrate 1. The introduction reservoir 2a and the recovery reservoir 2b are in communication with each other via the capillary channel for sample analysis 3x. The introduction reservoir 2a receives a sample to be measured. The sample is electrophoretically introduced directly into the capillary channel for sample analysis 3x by creating a potential difference between the introduction reservoir 2a and the recovery reservoir 2b, and is also analyzed in the capillary channel for sample analysis 3x during the separation of the sample while the sample is being continuously supplied.
摘要翻译：提供可以小而简单并且可以高精度地分析样品的电泳芯片。电泳芯片包括上基板4，下基板1，导入槽2a，回收槽2b和用于样品分析的毛细通道3x。引入储存器2a和回收储存器2b形成在下基板1中。引入储存器2a和回收储存器2b经由用于样本分析3x的毛细通道彼此连通。引入容器2a接收要测量的样品。通过在引入储存器2a和回收储存器2b之间产生电位差，将样品电泳引入毛细通道3x进行样品分析，并在样品分离过程中在毛细管通道中进行样品分析3x分析，同时样品正在连续供应。

5. 发明授权

US08702941B2 Method of analyzing hemoglobin by electrophoresis 有权
标题翻译：电泳分析血红蛋白的方法
公开(公告)号：US08702941B2
公开(公告)日：2014-04-22
申请号：US12978280
申请日：2010-12-23
申请人： Yusuke Nakayama , Satoshi Yonehara
发明人： Yusuke Nakayama , Satoshi Yonehara
IPC分类号： G01N27/26 , G01N27/447
CPC分类号： G01N27/44747 , G01N27/44791 , G01N33/721
摘要： A method for analyzing hemoglobin by electrophoresis, capable of analyzing hemoglobin A1c (HbA1c) and modified hemoglobin with improved accuracy in a shortened analysis time is provided. The method for analyzing hemoglobin by electrophoresis includes performing electrophoresis under conditions in which an acidic substance having two or more carboxyl groups is present in an electrophoresis solution. At least two of the carboxyl groups of the acidic substance each have an acid dissociation constant (pKa) lower than the pH of the electrophoresis solution at the time of analysis.
摘要翻译：提供了一种通过电泳分析血红蛋白的方法，其能够在缩短的分析时间内以更高的精度分析血红蛋白A1c（HbA1c）和改良的血红蛋白。通过电泳分析血红蛋白的方法包括在电泳液中存在具有两个以上羧基的酸性物质的条件下进行电泳。酸性物质的至少两个羧基在分析时各自具有低于电泳溶液pH值的酸解离常数（pKa）。

6. 发明申请

US20100187110A1 PROCESS FOR ANALYZING SAMPLE BY CAPILLARY ELECTROPHORESIS METHOD 有权
标题翻译：毛细管电泳法分析样品的方法
公开(公告)号：US20100187110A1
公开(公告)日：2010-07-29
申请号：US12376744
申请日：2007-08-29
申请人： Yoshihide Tanaka , Shinichi Wakida , Yusuke Nakayama , Satoshi Yonehara
发明人： Yoshihide Tanaka , Shinichi Wakida , Yusuke Nakayama , Satoshi Yonehara
IPC分类号： G01N27/26
CPC分类号： G01N27/447 , G01N27/44756
摘要： A process for analyzing a sample by a capillary electrophoresis method is provided that allows the apparatus to be reduced in size, allows a high analytical precision to be obtained, and can be carried out easily. The analytical process of the present invention is a process for analyzing a sample by a capillary electrophoresis method. The analytical process includes preparing a capillary tube to be used for the capillary electrophoresis method, and performing electrophoretic separation of a complex of a sample and an anionic group-containing compound that are bonded together, in the capillary tube, wherein the capillary tube includes an anionic layer that is formed of the anionic group-containing compound and that is coated on the inner wall of the capillary tube, and the anionic layer is fixed to the inner wall of the capillary tube by a covalent bond.
摘要翻译：提供了一种通过毛细管电泳方法分析样品的方法，其允许减小装置的尺寸，允许获得高分析精度，并且可以容易地进行。本发明的分析方法是通过毛细管电泳法分析样品的方法。分析方法包括制备用于毛细管电泳方法的毛细管，并且在毛细管中进行电泳分离粘合在一起的样品和含阴离子基团的化合物的络合物，其中毛细管包括阴离子层，其由含阴离子基团的化合物形成并被涂布在毛细管的内壁上，阴离子层通过共价键固定在毛细管的内壁上。

7. 发明申请

US20100155242A1 Method of Analyzing a Sample by Capillary Electrophoresis 审中-公开
标题翻译：通过毛细管电泳分析样品的方法
公开(公告)号：US20100155242A1
公开(公告)日：2010-06-24
申请号：US12635472
申请日：2009-12-10
申请人： Yusuke Nakayama , Koji Sugiyama , Yoshihide Tanaka , Shinichi Wakida , Satoshi Yonehara
发明人： Yusuke Nakayama , Koji Sugiyama , Yoshihide Tanaka , Shinichi Wakida , Satoshi Yonehara
IPC分类号： C07K1/26 , G01N27/00
CPC分类号： C07K1/16 , C07K1/26 , G01N27/44747
摘要： The present invention is directed to the described capillary electrophoresis apparatus and methods of using such apparatus for separating and analyzing components of a sample.
摘要翻译：本发明涉及所述毛细管电泳装置和使用这种装置分离和分析样品组分的方法。

8. 发明申请

US20110174621A1 Method for Analyzing Sample by Electrophoresis and Use of the Same 审中-公开
标题翻译：通过电泳分析样品的方法及其应用
公开(公告)号：US20110174621A1
公开(公告)日：2011-07-21
申请号：US13006197
申请日：2011-01-13
申请人： Satoshi Yonehara , Yusuke Nakayama
发明人： Satoshi Yonehara , Yusuke Nakayama
IPC分类号： G01N27/447 , C25B7/00
CPC分类号： G01N27/44747 , G01N27/44791
摘要： A sample analysis method with improved separation accuracy is provided. The method relates to a method for analyzing a sample by electrophoresis using an electrophoresis apparatus provided with a channel and a sample reservoir formed in the channel. The method includes: placing the sample in the sample reservoir of the electrophoresis apparatus with the channel being filled with an electrophoresis running buffer; and performing electrophoresis by applying a voltage to both ends of the channel. The concentration of at least one of a) and b) is set to be approximately the same between the sample and the electrophoresis running buffer; wherein a) and b) are defined as follows: a) an ion that moves in the same direction as an analyte in the sample by the electrophoresis and has a smaller degree of mobility than the analyte, and b) an ion that moves in the opposite direction to the analyte.
摘要翻译：提供了一种提高分离精度的样品分析方法。该方法涉及一种使用电泳装置进行电泳分析样品的方法，所述电泳装置设置有形成在通道中的通道和样品储存器。该方法包括：将样品放置在电泳装置的样品容器中，其中通道充满电泳缓冲液; 并通过向通道的两端施加电压来进行电泳。 a）和b）中的至少一个的浓度被设置为在样品和电泳运行缓冲液之间大致相同; 其中a）和b）定义如下：a）通过电泳在与样品中的分析物相同的方向上移动并且具有比分析物更低的迁移率的离子，以及b）在与分析物相反的方向。

9. 发明授权

US09494553B2 Electrophoresis chip, electrophoresis apparatus, and method for analyzing sample by capillary electrophoresis 有权
标题翻译：电泳芯片，电泳仪，毛细管电泳分析样品
公开(公告)号：US09494553B2
公开(公告)日：2016-11-15
申请号：US12515994
申请日：2008-04-28
申请人： Yoshihide Tanaka , Yusuke Nakayama , Satoshi Yonehara
发明人： Yoshihide Tanaka , Yusuke Nakayama , Satoshi Yonehara
IPC分类号： G01N27/447
CPC分类号： G01N27/44791 , G01N27/44743
摘要： An electrophoresis chip that can be small and simple and that can analyze a sample with high accuracy is provided. The electrophoresis chip includes an upper substrate 4, a lower substrate 1, an introduction reservoir 2a, a recovery reservoir 2b and a capillary channel for sample analysis 3x. The introduction reservoir 2a and the recovery reservoir 2b are formed in the lower substrate 1. The introduction reservoir 2a and the recovery reservoir 2b are in communication with each other via the capillary channel for sample analysis 3x. The introduction reservoir 2a receives a sample to be measured. The sample is electrophoretically introduced directly into the capillary channel for sample analysis 3x by creating a potential difference between the introduction reservoir 2a and the recovery reservoir 2b, and is also analyzed in the capillary channel for sample analysis 3x during the separation of the sample while the sample is being continuously supplied.
摘要翻译：提供可以小而简单并且可以高精度地分析样品的电泳芯片。电泳芯片包括上基板4，下基板1，导入槽2a，回收槽2b和用于样本分析的毛细通道3x。引入储存器2a和回收储存器2b形成在下基板1中。引入储存器2a和回收储存器2b经由用于样本分析3x的毛细通道彼此连通。引入容器2a接收要测量的样品。通过在引入储存器2a和回收储存器2b之间产生电位差，将样品电泳引入毛细通道3x进行样品分析，并在样品分离过程中在毛细管通道中进行样品分析3x分析，同时样品正在连续供应。

10. 发明申请

US20120012462A1 Electrophoresis Chip and Electrophoresis Apparatus 审中-公开
标题翻译：电泳芯片和电泳仪
公开(公告)号：US20120012462A1
公开(公告)日：2012-01-19
申请号：US13222982
申请日：2011-08-31
申请人： Koji Sugiyama , Satoshi Yonehara , Yusuke Nakayama
发明人： Koji Sugiyama , Satoshi Yonehara , Yusuke Nakayama
IPC分类号： G01N27/447 , G01N33/50
CPC分类号： G01N27/44791 , B01L3/50273 , B01L2300/0867 , B01L2300/0887 , B01L2300/16 , B01L2400/0421 , C07K1/26
摘要： An electrophoresis chip that enables an apparatus to be small, analysis time to be short and glycosylated hemoglobin to be analyzed highly accurately is provided. The electrophoresis chip includes an upper substrate 4, a lower substrate 1, a first introduction reservoir 2a, a first recovery reservoir 2b and a capillary channel for sample analysis 3x; the first introduction reservoir 2a and the first recovery reservoir 2b are formed in the lower substrate 1; and the first introduction reservoir 2a and the first recovery reservoir 2b are in communication with each other via the capillary channel for sample analysis 3x.
摘要翻译：提供能够使装置小型，分析时间短并能够高精度地分析糖基化血红蛋白的电泳芯片。电泳芯片包括上基板4，下基板1，第一引入槽2a，第一回收槽2b和用于样品分析的毛细通道3x; 第一引入槽2a和第一回收槽2b形成在下基板1中; 并且第一引入槽2a和第一回收槽2b经由用于样品分析3x的毛细通道彼此连通。

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