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1. 发明申请

US20100155242A1 Method of Analyzing a Sample by Capillary Electrophoresis 审中-公开
标题翻译：通过毛细管电泳分析样品的方法
公开(公告)号：US20100155242A1
公开(公告)日：2010-06-24
申请号：US12635472
申请日：2009-12-10
申请人： Yusuke Nakayama , Koji Sugiyama , Yoshihide Tanaka , Shinichi Wakida , Satoshi Yonehara
发明人： Yusuke Nakayama , Koji Sugiyama , Yoshihide Tanaka , Shinichi Wakida , Satoshi Yonehara
IPC分类号： C07K1/26 , G01N27/00
CPC分类号： C07K1/16 , C07K1/26 , G01N27/44747
摘要： The present invention is directed to the described capillary electrophoresis apparatus and methods of using such apparatus for separating and analyzing components of a sample.
摘要翻译：本发明涉及所述毛细管电泳装置和使用这种装置分离和分析样品组分的方法。

2. 发明授权

US09121821B2 Process for analyzing sample by capillary electrophoresis method 有权
标题翻译：毛细管电泳法分析样品的方法
公开(公告)号：US09121821B2
公开(公告)日：2015-09-01
申请号：US12376739
申请日：2007-08-29
申请人： Yoshihide Tanaka , Shinichi Wakida , Yusuke Nakayama , Satoshi Yonehara
发明人： Yoshihide Tanaka , Shinichi Wakida , Yusuke Nakayama , Satoshi Yonehara
IPC分类号： G01N27/447
CPC分类号： G01N27/447 , G01N27/44756
摘要： A process for analyzing a sample by a capillary electrophoresis method is provided that allows for high analytic precision and reduction in apparatus size, and can be readily carried out by electrophoresing a complex of a sample and an anionic group-containing compound in the capillary channel, wherein the capillary channel includes an A layer that is coated on an inner wall thereof and a B layer that is coated on the A layer, where the A and B layers are as described.
摘要翻译：提供了通过毛细管电泳方法分析样品的方法，其允许高分析精度和装置尺寸的降低，并且可以容易地通过在毛细通道中电泳样品和含阴离子基团的化合物的络合物来进行，其中毛细通道包括涂覆在其内壁上的A层和涂覆在A层上的B层，其中A层和B层如上所述。

3. 发明授权

US08137512B2 Process for analyzing sample by capillary electrophoresis method 有权
标题翻译：毛细管电泳法分析样品的方法
公开(公告)号：US08137512B2
公开(公告)日：2012-03-20
申请号：US12376744
申请日：2007-08-29
申请人： Yoshihide Tanaka , Shinichi Wakida , Yusuke Nakayama , Satoshi Yonehara
发明人： Yoshihide Tanaka , Shinichi Wakida , Yusuke Nakayama , Satoshi Yonehara
IPC分类号： B01D57/02 , B01D59/42 , C02F1/469 , C07K1/26
CPC分类号： G01N27/447 , G01N27/44756
摘要： A process for analyzing a sample by a capillary electrophoresis method is provided that allows the apparatus to be reduced in size, allows a high analytical precision to be obtained, and can be carried out easily. The analytical process of the present invention is a process for analyzing a sample by a capillary electrophoresis method. The analytical process includes preparing a capillary tube to be used for the capillary electrophoresis method, and performing electrophoretic separation of a complex of a sample and an anionic group-containing compound that are bonded together, in the capillary tube, wherein the capillary tube includes an anionic layer that is formed of the anionic group-containing compound and that is coated on the inner wall of the capillary tube, and the anionic layer is fixed to the inner wall of the capillary tube by a covalent bond.
摘要翻译：提供了一种通过毛细管电泳方法分析样品的方法，其允许减小装置的尺寸，允许获得高分析精度，并且可以容易地进行。本发明的分析方法是通过毛细管电泳法分析样品的方法。分析方法包括制备用于毛细管电泳方法的毛细管，并且在毛细管中进行电泳分离粘合在一起的样品和含阴离子基团的化合物的络合物，其中毛细管包括阴离子层，其由含阴离子基团的化合物形成并被涂布在毛细管的内壁上，阴离子层通过共价键固定在毛细管的内壁上。

4. 发明申请

US20100187110A1 PROCESS FOR ANALYZING SAMPLE BY CAPILLARY ELECTROPHORESIS METHOD 有权
标题翻译：毛细管电泳法分析样品的方法
公开(公告)号：US20100187110A1
公开(公告)日：2010-07-29
申请号：US12376744
申请日：2007-08-29
申请人： Yoshihide Tanaka , Shinichi Wakida , Yusuke Nakayama , Satoshi Yonehara
发明人： Yoshihide Tanaka , Shinichi Wakida , Yusuke Nakayama , Satoshi Yonehara
IPC分类号： G01N27/26
CPC分类号： G01N27/447 , G01N27/44756
摘要： A process for analyzing a sample by a capillary electrophoresis method is provided that allows the apparatus to be reduced in size, allows a high analytical precision to be obtained, and can be carried out easily. The analytical process of the present invention is a process for analyzing a sample by a capillary electrophoresis method. The analytical process includes preparing a capillary tube to be used for the capillary electrophoresis method, and performing electrophoretic separation of a complex of a sample and an anionic group-containing compound that are bonded together, in the capillary tube, wherein the capillary tube includes an anionic layer that is formed of the anionic group-containing compound and that is coated on the inner wall of the capillary tube, and the anionic layer is fixed to the inner wall of the capillary tube by a covalent bond.
摘要翻译：提供了一种通过毛细管电泳方法分析样品的方法，其允许减小装置的尺寸，允许获得高分析精度，并且可以容易地进行。本发明的分析方法是通过毛细管电泳法分析样品的方法。分析方法包括制备用于毛细管电泳方法的毛细管，并且在毛细管中进行电泳分离粘合在一起的样品和含阴离子基团的化合物的络合物，其中毛细管包括阴离子层，其由含阴离子基团的化合物形成并被涂布在毛细管的内壁上，阴离子层通过共价键固定在毛细管的内壁上。

5. 发明申请

US20100116660A1 Electrophoresis Chip, Electrophoresis Apparatus, and Method for Analyzing Sample by Capillary Electrophoresis 有权
标题翻译：电泳芯片，电泳装置和毛细管电泳分析样品的方法
公开(公告)号：US20100116660A1
公开(公告)日：2010-05-13
申请号：US12515994
申请日：2008-04-28
申请人： Yoshihide Tanaka , Yusuke Nakayama , Satoshi Yonehara
发明人： Yoshihide Tanaka , Yusuke Nakayama , Satoshi Yonehara
IPC分类号： G01N27/447
CPC分类号： G01N27/44791 , G01N27/44743
摘要： An electrophoresis chip that can be small and simple and that can analyze a sample with high accuracy is provided. The electrophoresis chip includes an upper substrate 4, a lower substrate 1, an introduction reservoir 2a, a recovery reservoir 2b and a capillary channel for sample analysis 3x. The introduction reservoir 2a and the recovery reservoir 2b are formed in the lower substrate 1. The introduction reservoir 2a and the recovery reservoir 2b are in communication with each other via the capillary channel for sample analysis 3x. The introduction reservoir 2a receives a sample to be measured. The sample is electrophoretically introduced directly into the capillary channel for sample analysis 3x by creating a potential difference between the introduction reservoir 2a and the recovery reservoir 2b, and is also analyzed in the capillary channel for sample analysis 3x during the separation of the sample while the sample is being continuously supplied.
摘要翻译：提供可以小而简单并且可以高精度地分析样品的电泳芯片。电泳芯片包括上基板4，下基板1，导入槽2a，回收槽2b和用于样品分析的毛细通道3x。引入储存器2a和回收储存器2b形成在下基板1中。引入储存器2a和回收储存器2b经由用于样本分析3x的毛细通道彼此连通。引入容器2a接收要测量的样品。通过在引入储存器2a和回收储存器2b之间产生电位差，将样品电泳引入毛细通道3x进行样品分析，并在样品分离过程中在毛细管通道中进行样品分析3x分析，同时样品正在连续供应。

6. 发明授权

US09494553B2 Electrophoresis chip, electrophoresis apparatus, and method for analyzing sample by capillary electrophoresis 有权
标题翻译：电泳芯片，电泳仪，毛细管电泳分析样品
公开(公告)号：US09494553B2
公开(公告)日：2016-11-15
申请号：US12515994
申请日：2008-04-28
申请人： Yoshihide Tanaka , Yusuke Nakayama , Satoshi Yonehara
发明人： Yoshihide Tanaka , Yusuke Nakayama , Satoshi Yonehara
IPC分类号： G01N27/447
CPC分类号： G01N27/44791 , G01N27/44743
摘要： An electrophoresis chip that can be small and simple and that can analyze a sample with high accuracy is provided. The electrophoresis chip includes an upper substrate 4, a lower substrate 1, an introduction reservoir 2a, a recovery reservoir 2b and a capillary channel for sample analysis 3x. The introduction reservoir 2a and the recovery reservoir 2b are formed in the lower substrate 1. The introduction reservoir 2a and the recovery reservoir 2b are in communication with each other via the capillary channel for sample analysis 3x. The introduction reservoir 2a receives a sample to be measured. The sample is electrophoretically introduced directly into the capillary channel for sample analysis 3x by creating a potential difference between the introduction reservoir 2a and the recovery reservoir 2b, and is also analyzed in the capillary channel for sample analysis 3x during the separation of the sample while the sample is being continuously supplied.
摘要翻译：提供可以小而简单并且可以高精度地分析样品的电泳芯片。电泳芯片包括上基板4，下基板1，导入槽2a，回收槽2b和用于样本分析的毛细通道3x。引入储存器2a和回收储存器2b形成在下基板1中。引入储存器2a和回收储存器2b经由用于样本分析3x的毛细通道彼此连通。引入容器2a接收要测量的样品。通过在引入储存器2a和回收储存器2b之间产生电位差，将样品电泳引入毛细通道3x进行样品分析，并在样品分离过程中在毛细管通道中进行样品分析3x分析，同时样品正在连续供应。

7. 发明申请

US20120012462A1 Electrophoresis Chip and Electrophoresis Apparatus 审中-公开
标题翻译：电泳芯片和电泳仪
公开(公告)号：US20120012462A1
公开(公告)日：2012-01-19
申请号：US13222982
申请日：2011-08-31
申请人： Koji Sugiyama , Satoshi Yonehara , Yusuke Nakayama
发明人： Koji Sugiyama , Satoshi Yonehara , Yusuke Nakayama
IPC分类号： G01N27/447 , G01N33/50
CPC分类号： G01N27/44791 , B01L3/50273 , B01L2300/0867 , B01L2300/0887 , B01L2300/16 , B01L2400/0421 , C07K1/26
摘要： An electrophoresis chip that enables an apparatus to be small, analysis time to be short and glycosylated hemoglobin to be analyzed highly accurately is provided. The electrophoresis chip includes an upper substrate 4, a lower substrate 1, a first introduction reservoir 2a, a first recovery reservoir 2b and a capillary channel for sample analysis 3x; the first introduction reservoir 2a and the first recovery reservoir 2b are formed in the lower substrate 1; and the first introduction reservoir 2a and the first recovery reservoir 2b are in communication with each other via the capillary channel for sample analysis 3x.
摘要翻译：提供能够使装置小型，分析时间短并能够高精度地分析糖基化血红蛋白的电泳芯片。电泳芯片包括上基板4，下基板1，第一引入槽2a，第一回收槽2b和用于样品分析的毛细通道3x; 第一引入槽2a和第一回收槽2b形成在下基板1中; 并且第一引入槽2a和第一回收槽2b经由用于样品分析3x的毛细通道彼此连通。

8. 发明申请

US20100032297A1 Electrophoresis Chip and Electrophoresis Apparatus 审中-公开
标题翻译：电泳芯片和电泳仪
公开(公告)号：US20100032297A1
公开(公告)日：2010-02-11
申请号：US12514301
申请日：2008-04-23
申请人： Koji Sugiyama , Satoshi Yonehara , Yusuke Nakayama
发明人： Koji Sugiyama , Satoshi Yonehara , Yusuke Nakayama
IPC分类号： G01N27/447
CPC分类号： G01N27/44791 , B01L3/50273 , B01L2300/0867 , B01L2300/0887 , B01L2300/16 , B01L2400/0421 , C07K1/26
摘要： An electrophoresis chip that enables an apparatus to be small, analysis time to be short and glycosylated hemoglobin to be analyzed highly accurately is provided. The electrophoresis chip includes an upper substrate 4, a lower substrate 1, a first introduction reservoir 2a, a first recovery reservoir 2b and a capillary channel for sample analysis 3x; the first introduction reservoir 2a and the first recovery reservoir 2b are formed in the lower substrate 1; and the first introduction reservoir 2a and the first recovery reservoir 2b are in communication with each other via the capillary channel for sample analysis 3x.
摘要翻译：提供能够使装置小型，分析时间短并能够高精度地分析糖基化血红蛋白的电泳芯片。电泳芯片包括上基板4，下基板1，第一引入槽2a，第一回收槽2b和用于样品分析的毛细通道3x; 第一引入槽2a和第一回收槽2b形成在下基板1中; 并且第一引入槽2a和第一回收槽2b经由用于样品分析3x的毛细通道彼此连通。

9. 发明申请

US20100258440A1 ANALYSIS APPARATUS AND ANALYSIS METHOD FOR CAPILLARY ELECTROPHORESIS 审中-公开
标题翻译：用于毛细管电泳的分析装置和分析方法
公开(公告)号：US20100258440A1
公开(公告)日：2010-10-14
申请号：US12506917
申请日：2009-07-21
申请人： Koji Sugiyama , Yukio Higashiisokawa , Yusuke Nakayama , Yoshihide Tanaka
发明人： Koji Sugiyama , Yukio Higashiisokawa , Yusuke Nakayama , Yoshihide Tanaka
IPC分类号： C07K1/26
CPC分类号： G01N27/44791 , B01D57/02 , C07K1/26 , G01N27/403 , G01N27/44721 , G01N33/6893 , G01N33/721 , G01N33/726 , G01N2800/042
摘要： A capillary electrophoresis analysis apparatus is provided for analyzing samples by a capillary electrophoresis method that allows for rapid and highly accurate separation and detection, wherein the apparatus may be used in the diagnosis and/or monitoring of selected diseases.
摘要翻译：提供毛细管电泳分析装置，用于通过毛细管电泳方法分析样品，其允许快速和高度精确的分离和检测，其中该装置可用于诊断和/或监测所选择的疾病。

10. 发明授权

US08361292B2 Method for analyzing hemoglobin by capillary electrophoresis and additive used therein 有权
标题翻译：通过毛细管电泳分析血红蛋白的方法及其中使用的添加剂
公开(公告)号：US08361292B2
公开(公告)日：2013-01-29
申请号：US12514293
申请日：2008-04-23
申请人： Yusuke Nakayama , Satoshi Yonehara
发明人： Yusuke Nakayama , Satoshi Yonehara
IPC分类号： G01N27/447
CPC分类号： G01N27/44747
摘要： The present invention provides a method for analyzing hemoglobin by capillary electrophoresis, that allows the apparatus to be smaller in size, allows a highly precise analysis to be obtained, and allows the analysis to be performed in a short period of time. The analytical method of the present invention are methods for analyzing hemoglobin by capillary electrophoresis, comprising: a sample-providing step of providing a sample containing hemoglobin; a capillary tube-providing step of providing a capillary tube containing a buffer solution; and an electrophoresis step of carrying out electrophoresis of the sample, by introducing the sample into the buffer solution in the capillary tube, and applying a voltage across both ends of the capillary tube; wherein the electrophoresis is carried out following at least one of modes (A) and (B) below: (A) the electrophoresis is carried out with a surfactant (a) added to the buffer solution, the surfactant (a) being a non-ionic surfactant having an alkyl group as a hydrophobic portion and a sugar as a hydrophilic portion; and (B) the electrophoresis is carried out with a surfactant (b) added to the sample, the surfactant (b) being a betaine-type amphoteric surfactant.
摘要翻译：本发明提供了一种通过毛细管电泳分析血红蛋白的方法，其允许装置尺寸更小，可以获得高精度分析，并允许在短时间内进行分析。本发明的分析方法是通过毛细管电泳分析血红蛋白的方法，包括：提供含有血红蛋白的样品的样品提供步骤; 毛细管提供步骤，提供含有缓冲溶液的毛细管; 以及电泳步骤，通过将样品引入毛细管中的缓冲溶液中并在毛细管的两端施加电压，进行样品的电泳; 其中所述电泳按照以下模式（A）和（B）中的至少一种进行：（A）用添加到缓冲溶液中的表面活性剂（a）进行电泳，所述表面活性剂（a）具有作为疏水部分的烷基和作为亲水部分的糖的离子表面活性剂; （B）用表面活性剂（b）进行电泳，表面活性剂（b）为甜菜碱型两性表面活性剂。

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