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    • 4. 发明授权
    • Process for analyzing sample by capillary electrophoresis method
    • 毛细管电泳法分析样品的方法
    • US08137512B2
    • 2012-03-20
    • US12376744
    • 2007-08-29
    • Yoshihide TanakaShinichi WakidaYusuke NakayamaSatoshi Yonehara
    • Yoshihide TanakaShinichi WakidaYusuke NakayamaSatoshi Yonehara
    • B01D57/02B01D59/42C02F1/469C07K1/26
    • G01N27/447G01N27/44756
    • A process for analyzing a sample by a capillary electrophoresis method is provided that allows the apparatus to be reduced in size, allows a high analytical precision to be obtained, and can be carried out easily. The analytical process of the present invention is a process for analyzing a sample by a capillary electrophoresis method. The analytical process includes preparing a capillary tube to be used for the capillary electrophoresis method, and performing electrophoretic separation of a complex of a sample and an anionic group-containing compound that are bonded together, in the capillary tube, wherein the capillary tube includes an anionic layer that is formed of the anionic group-containing compound and that is coated on the inner wall of the capillary tube, and the anionic layer is fixed to the inner wall of the capillary tube by a covalent bond.
    • 提供了一种通过毛细管电泳方法分析样品的方法,其允许减小装置的尺寸,允许获得高分析精度,并且可以容易地进行。 本发明的分析方法是通过毛细管电泳法分析样品的方法。 分析方法包括制备用于毛细管电泳方法的毛细管,并且在毛细管中进行电泳分离粘合在一起的样品和含阴离子基团的化合物的络合物,其中毛细管包括 阴离子层,其由含阴离子基团的化合物形成并被涂布在毛细管的内壁上,阴离子层通过共价键固定在毛细管的内壁上。
    • 5. 发明申请
    • Electrophoresis Chip, Electrophoresis Apparatus, and Method for Analyzing Sample by Capillary Electrophoresis
    • 电泳芯片,电泳装置和毛细管电泳分析样品的方法
    • US20100116660A1
    • 2010-05-13
    • US12515994
    • 2008-04-28
    • Yoshihide TanakaYusuke NakayamaSatoshi Yonehara
    • Yoshihide TanakaYusuke NakayamaSatoshi Yonehara
    • G01N27/447
    • G01N27/44791G01N27/44743
    • An electrophoresis chip that can be small and simple and that can analyze a sample with high accuracy is provided. The electrophoresis chip includes an upper substrate 4, a lower substrate 1, an introduction reservoir 2a, a recovery reservoir 2b and a capillary channel for sample analysis 3x. The introduction reservoir 2a and the recovery reservoir 2b are formed in the lower substrate 1. The introduction reservoir 2a and the recovery reservoir 2b are in communication with each other via the capillary channel for sample analysis 3x. The introduction reservoir 2a receives a sample to be measured. The sample is electrophoretically introduced directly into the capillary channel for sample analysis 3x by creating a potential difference between the introduction reservoir 2a and the recovery reservoir 2b, and is also analyzed in the capillary channel for sample analysis 3x during the separation of the sample while the sample is being continuously supplied.
    • 提供可以小而简单并且可以高精度地分析样品的电泳芯片。 电泳芯片包括上基板4,下基板1,导入槽2a,回收槽2b和用于样品分析的毛细通道3x。 引入储存器2a和回收储存器2b形成在下基板1中。引入储存器2a和回收储存器2b经由用于样本分析3x的毛细通道彼此连通。 引入容器2a接收要测量的样品。 通过在引入储存器2a和回收储存器2b之间产生电位差,将样品电泳引入毛细通道3x进行样品分析,并在样品分离过程中在毛细管通道中进行样品分析3x分析,同时 样品正在连续供应。
    • 7. 发明申请
    • PROCESS FOR ANALYZING SAMPLE BY CAPILLARY ELECTROPHORESIS METHOD
    • 毛细管电泳法分析样品的方法
    • US20100187110A1
    • 2010-07-29
    • US12376744
    • 2007-08-29
    • Yoshihide TanakaShinichi WakidaYusuke NakayamaSatoshi Yonehara
    • Yoshihide TanakaShinichi WakidaYusuke NakayamaSatoshi Yonehara
    • G01N27/26
    • G01N27/447G01N27/44756
    • A process for analyzing a sample by a capillary electrophoresis method is provided that allows the apparatus to be reduced in size, allows a high analytical precision to be obtained, and can be carried out easily. The analytical process of the present invention is a process for analyzing a sample by a capillary electrophoresis method. The analytical process includes preparing a capillary tube to be used for the capillary electrophoresis method, and performing electrophoretic separation of a complex of a sample and an anionic group-containing compound that are bonded together, in the capillary tube, wherein the capillary tube includes an anionic layer that is formed of the anionic group-containing compound and that is coated on the inner wall of the capillary tube, and the anionic layer is fixed to the inner wall of the capillary tube by a covalent bond.
    • 提供了一种通过毛细管电泳方法分析样品的方法,其允许减小装置的尺寸,允许获得高分析精度,并且可以容易地进行。 本发明的分析方法是通过毛细管电泳法分析样品的方法。 分析方法包括制备用于毛细管电泳方法的毛细管,并且在毛细管中进行电泳分离粘合在一起的样品和含阴离子基团的化合物的络合物,其中毛细管包括 阴离子层,其由含阴离子基团的化合物形成并被涂布在毛细管的内壁上,阴离子层通过共价键固定在毛细管的内壁上。
    • 9. 发明授权
    • Electrophoresis chip, electrophoresis apparatus, and method for analyzing sample by capillary electrophoresis
    • 电泳芯片,电泳仪,毛细管电泳分析样品
    • US09494553B2
    • 2016-11-15
    • US12515994
    • 2008-04-28
    • Yoshihide TanakaYusuke NakayamaSatoshi Yonehara
    • Yoshihide TanakaYusuke NakayamaSatoshi Yonehara
    • G01N27/447
    • G01N27/44791G01N27/44743
    • An electrophoresis chip that can be small and simple and that can analyze a sample with high accuracy is provided. The electrophoresis chip includes an upper substrate 4, a lower substrate 1, an introduction reservoir 2a, a recovery reservoir 2b and a capillary channel for sample analysis 3x. The introduction reservoir 2a and the recovery reservoir 2b are formed in the lower substrate 1. The introduction reservoir 2a and the recovery reservoir 2b are in communication with each other via the capillary channel for sample analysis 3x. The introduction reservoir 2a receives a sample to be measured. The sample is electrophoretically introduced directly into the capillary channel for sample analysis 3x by creating a potential difference between the introduction reservoir 2a and the recovery reservoir 2b, and is also analyzed in the capillary channel for sample analysis 3x during the separation of the sample while the sample is being continuously supplied.
    • 提供可以小而简单并且可以高精度地分析样品的电泳芯片。 电泳芯片包括上基板4,下基板1,导入槽2a,回收槽2b和用于样本分析的毛细通道3x。 引入储存器2a和回收储存器2b形成在下基板1中。引入储存器2a和回收储存器2b经由用于样本分析3x的毛细通道彼此连通。 引入容器2a接收要测量的样品。 通过在引入储存器2a和回收储存器2b之间产生电位差,将样品电泳引入毛细通道3x进行样品分析,并在样品分离过程中在毛细管通道中进行样品分析3x分析,同时 样品正在连续供应。
    • 10. 发明申请
    • PROCESS FOR ANALYZING SAMPLE BY CAPILLARY ELECTROPHORESIS METHOD
    • 毛细管电泳法分析样品的方法
    • US20100175996A1
    • 2010-07-15
    • US12376739
    • 2007-08-29
    • Yoshihide TanakaShinichi WakidaSatoshi Yonehara
    • Yoshihide TanakaShinichi WakidaSatoshi Yonehara
    • G01N27/26
    • G01N27/447G01N27/44756
    • A process for analyzing a sample by a capillary electrophoresis method is provided that allows the apparatus to be reduced in size, allows a high analytical precision to be obtained, and can be carried out easily. The analytical process of the present invention is a process for analyzing a sample by a capillary electrophoresis method. The process includes a step of preparing a capillary channel to be used for the capillary electrophoresis method and a step of electrophoresing a complex of a sample and an anionic group-containing compound that are bonded together, in the capillary channel, wherein the capillary channel includes an A layer that is coated on an inner wall thereof and a B layer that is coated on the A layer.A layer: a spacer layer formed of at least one selected from the group consisting of polydiallyldimethylammoniumchloride, a nonpolar polymer, and a cationic group-containing compound, wherein the polydiallyldimethylammoniumchloride is coated on the inner wall of the capillary channel by physical adsorption when the layer includes the polydiallyldimethylammoniumchloride, and at least one of the nonpolar polymer and the cationic group-containing compound is coated on the inner wall of the capillary channel by covalent bond when the layer includes at least one of the nonpolar polymer and the cationic group-containing compound B layer: an anionic layer formed of an anionic group-containing compound
    • 提供了一种通过毛细管电泳方法分析样品的方法,其允许减小装置的尺寸,允许获得高分析精度,并且可以容易地进行。 本发明的分析方法是通过毛细管电泳法分析样品的方法。 该方法包括制备用于毛细管电泳方法的毛细管通道的步骤和在毛细通道中电泳接合在一起的样品和含阴离子基团的化合物的络合物的步骤,其中毛细管通道包括 涂覆在其内壁上的A层和涂覆在A层上的B层。 层:由选自聚二烯丙基二甲基氯化铵,非极性聚合物和含阳离子基团的化合物组成的组中的至少一种形成的间隔层,其中通过物理吸附将聚二烯丙基二甲基氯化铵涂覆在毛细通道的内壁上, 包括聚二烯丙基二甲基氯化铵,并且当该层包含至少一种非极性聚合物和含阳离子基团的化合物时,通过共价键将至少一种非极性聚合物和含阳离子基团的化合物涂覆在毛细通道的内壁上 B层:由含阴离子性基团的化合物形成的阴离子层