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1. 发明申请

US20130231369A1 1-[(4-hydroxypiperidin-4-yl)methyl]pyridin-2(1H)-one derivatives, preparation methods and uses thereof 有权
标题翻译： 1 - [（4-羟基哌啶-4-基）甲基]吡啶-2（1H） - 酮衍生物，其制备方法和用途
公开(公告)号：US20130231369A1
公开(公告)日：2013-09-05
申请号：US13697857
申请日：2011-04-08
申请人： Yunfeng Li , Rifang Yang , Youzhi Zhang , Yongzhen Li , Zengliang Jin , Peng Li , Li Yuan , Liuhong Yun , Nan Zhao , Cheng Zhang , Xiaodan Xu , Rusheng Zhao , Hongxia Chen , Rui Xue , Juanjuan Qin , Zhenzhen Wang , Jiazhi Yao
发明人： Yunfeng Li , Rifang Yang , Youzhi Zhang , Yongzhen Li , Zengliang Jin , Peng Li , Li Yuan , Liuhong Yun , Nan Zhao , Cheng Zhang , Xiaodan Xu , Rusheng Zhao , Hongxia Chen , Rui Xue , Juanjuan Qin , Zhenzhen Wang , Jiazhi Yao
IPC分类号： C07D401/06
CPC分类号： C07D401/06
摘要： Provided are N-[(4-hydroxypiperidin-4-yl)methyl]pyridin-2(1H)-one derivatives represented by formula I, stereoisomers, pharmaceutically acceptable salts or solvates thereof. The above compounds have the dual activities of 5-hydroxytryptamine 1A receptor ligand and selective serotonin reuptake inhibitor. The preparation methods of the above compounds, the uses of these compounds for the prevention or treatment of nervous system diseases related to 5-hydroxytryptamine system dysfunction and the pharmaceutical compositions containing these compounds are also provided.
摘要翻译：提供由式I表示的N - [（4-羟基哌啶-4-基）甲基]吡啶-2（1H） - 酮衍生物，其立体异构体，药学上可接受的盐或溶剂合物。上述化合物具有5-羟色胺1A受体配体和选择性5-羟色胺再摄取抑制剂的双重活性。还提供了上述化合物的制备方法，这些化合物用于预防或治疗与5-羟色胺系统功能障碍有关的神经系统疾病的用途和含有这些化合物的药物组合物。

2. 发明授权

US08921563B2 1-[(4-hydroxypiperidin-4-yl)methyl]pyridin-2(1H)-one derivatives, preparation methods and uses thereof 有权
标题翻译： 1 - [（4-羟基哌啶-4-基）甲基]吡啶-2（1H） - 酮衍生物，其制备方法和用途
公开(公告)号：US08921563B2
公开(公告)日：2014-12-30
申请号：US13697857
申请日：2011-04-08
申请人： Yunfeng Li , Rifang Yang , Youzhi Zhang , Yongzhen Li , Zengliang Jin , Peng Li , Li Yuan , Liuhong Yun , Nan Zhao , Cheng Zhang , Xiaodan Xu , Rusheng Zhao , Hongxia Chen , Rui Xue , Juanjuan Qin , Zhenzhen Wang , Jiazhi Yao
发明人： Yunfeng Li , Rifang Yang , Youzhi Zhang , Yongzhen Li , Zengliang Jin , Peng Li , Li Yuan , Liuhong Yun , Nan Zhao , Cheng Zhang , Xiaodan Xu , Rusheng Zhao , Hongxia Chen , Rui Xue , Juanjuan Qin , Zhenzhen Wang , Jiazhi Yao
IPC分类号： A61K31/445 , A61K31/505 , C07D211/68 , C07D239/02 , C07D401/06
CPC分类号： C07D401/06
摘要： Provided are N-[(4-hydroxypiperidin-4-yl)methyl]pyridin-2(1H)-one derivatives represented by formula I, stereoisomers, pharmaceutically acceptable salts or solvates thereof. The above compounds have the dual activities of 5-hydroxytryptamine 1A receptor ligand and selective serotonin reuptake inhibitor. The preparation methods of the above compounds, the uses of these compounds for the prevention or treatment of nervous system diseases related to 5-hydroxytryptamine system dysfunction and the pharmaceutical compositions containing these compounds are also provided.
摘要翻译：提供由式I表示的N - [（4-羟基哌啶-4-基）甲基]吡啶-2（1H） - 酮衍生物，其立体异构体，药学上可接受的盐或溶剂合物。上述化合物具有5-羟色胺1A受体配体和选择性5-羟色胺再摄取抑制剂的双重活性。还提供了上述化合物的制备方法，这些化合物用于预防或治疗与5-羟色胺系统功能障碍有关的神经系统疾病的用途和含有这些化合物的药物组合物。

3. 发明授权

US5661775A X-ray device having a co-axial laser aiming system in an opposed configuration 失效
标题翻译：具有相对配置的同轴激光瞄准系统的X射线装置
公开(公告)号：US5661775A
公开(公告)日：1997-08-26
申请号：US716509
申请日：1996-09-17
申请人： Steven Lee Cramer , Li Yuan
发明人： Steven Lee Cramer , Li Yuan
IPC分类号： A61B6/08 , A61B17/17
CPC分类号： A61B17/1725 , A61B17/1703 , A61B6/08 , A61B90/13
摘要： An improved x-ray laser aiming system providing coaxial laser aiming in a configuration opposed to the x-ray emitter is disclosed. The present invention comprises two basic components: 1) a laser sight coupled to an x-ray emitter, and 2) a laser device assembly coupled to an x-ray collector. The laser sight provides a means for aligning the x-ray emitter with a laser beam during surgical or diagnostic procedures. The laser device assembly is removably coupled to the image intensifier or x-ray collector. The laser device assembly contains a point laser source and a fixed reflective surface or mirror for directing a laser beam coaxially with the center ray of the x-rays emitted by the x-ray emitter, but in the opposite direction. The laser source is, therefore, in a configuration opposed or opposite to the x-ray emitter. The laser aiming system of the present invention may be used to provide a reference point during orthopedic alignment procedures such as pinning and for vascular procedures such as balloon angioplasty, and correction of conditions involving embolisms, aneurysms, or arterial venous malformations (AVM's).
摘要翻译：公开了一种改进的x射线激光瞄准系统，提供瞄准与x射线发射器相对的构造的同轴激光器。本发明包括两个基本组件：1）耦合到x射线发射器的激光瞄准器，以及2）耦合到x射线收集器的激光装置组件。激光瞄准器提供了在手术或诊断过程中将X射线发射器与激光束对准的手段。激光装置组件可移除地耦合到图像增强器或X射线收集器。激光装置组件包含点激光源和固定的反射表面或反射镜，用于将激光束与X射线发射器发射的x射线的中心射线同轴地引导激光束，但反方向。因此，激光源处于与x射线发射器相对或相对的构造。本发明的激光瞄准系统可以用于在整形外科对准过程中提供参考点，例如钉扎和血管手术，例如球囊血管成形术，以及矫正涉及栓塞，动脉瘤或动脉静脉畸形（AVM's）的病症。

4. 发明授权

US08969640B2 Dehydrogenation of alkanols to increase yield of aromatics 有权
标题翻译：链烷醇的脱氢以提高芳族化合物的产率
公开(公告)号：US08969640B2
公开(公告)日：2015-03-03
申请号：US13304052
申请日：2011-11-23
申请人： Paul G. Blommel , Li Yuan , Matthew Van Straten , Warren Lyman , Randy D. Cortright
发明人： Paul G. Blommel , Li Yuan , Matthew Van Straten , Warren Lyman , Randy D. Cortright
IPC分类号： C07C1/20 , C07C45/00 , C07C1/207 , C07C51/16 , C10G3/00
CPC分类号： C07C1/2072 , C07C1/2076 , C07C1/2078 , C07C29/32 , C07C45/002 , C07C51/00 , C07C51/16 , C07C67/293 , C07C2521/04 , C07C2521/06 , C07C2521/08 , C07C2521/12 , C07C2523/06 , C07C2523/08 , C07C2523/30 , C07C2523/72 , C07C2523/755 , C07C2525/00 , C07C2527/14 , C07C2529/40 , C07C2529/46 , C07C2529/65 , C07C2529/70 , C07C2529/83 , C07C2529/85 , C10G3/42 , C10G3/49 , C10G2400/30 , Y02P20/52 , Y02P30/20 , C07C15/04 , C07C15/06 , C07C15/08 , C07C47/06 , C07C47/02 , C07C53/08 , C07C53/02
摘要： The present invention provides methods, reactor systems, and catalysts for increasing the yield of aromatic hydrocarbons produced while converting alkanols to hydrocarbons. The invention includes methods of using catalysts to increase the yield of benzene, toluene, and mixed xylenes in the hydrocarbon product.
摘要翻译：本发明提供了在将烷醇转化为烃时提高芳族烃产率的方法，反应器系统和催化剂。本发明包括使用催化剂提高烃产物中苯，甲苯和混合二甲苯的产率的方法。

5. 发明授权

US08809987B2 Normally-off III-nitride metal-2DEG tunnel junction field-effect transistors 有权
标题翻译：常规III族氮化物金属 - 2DEG隧道结场效应晶体管
公开(公告)号：US08809987B2
公开(公告)日：2014-08-19
申请号：US13699296
申请日：2010-09-08
申请人： Jing Chen , Li Yuan , Hongwei Chen , Chunhua Zhou
发明人： Jing Chen , Li Yuan , Hongwei Chen , Chunhua Zhou
IPC分类号： H01L29/47 , H01L21/28 , H01L29/20 , H01L29/872
CPC分类号： H01L29/1608 , H01L29/2003 , H01L29/402 , H01L29/7781 , H01L29/7786 , H01L29/7788 , H01L29/872 , H01L29/88 , H01L2224/06181 , H01L2924/12032 , H01L2924/13062 , H01L2924/00
摘要： Structures, devices and methods are provided for creating heterojunction AlGaN/GaN metal two-dimensional electron gas (2DEG) tunnel-junction field-effect transistors (TJ-FET). In one aspect, metal-2DEG Schottky tunnel junctions can be employed in group III-Nitride field-effect devices that enable normally-off operation, large breakdown voltage, low leakage current, and high on/off current ratio. As a further advantage, AlGaN/GaN metal-2DEG TJ-FETs are disclosed that can be fabricated in a lateral configuration and/or a vertical configuration. Further non-limiting embodiments are provided that illustrate the advantages and flexibility of the disclosed structures.
摘要翻译：提供了用于产生异质结AlGaN / GaN金属二维电子气（2DEG）隧道结场效应晶体管（TJ-FET）的结构，器件和方法。在一方面，金属2DEG肖特基隧道结可以用于能够进行常关断操作，大的击穿电压，低漏电流和高导通/截止电流比的III-N型氮化物场效应器件中。作为另外的优点，公开了可以以横向配置和/或垂直配置制造的AlGaN / GaN金属2DEG TJ-FET。提供了另外的非限制性实施例，其示出了所公开的结构的优点和灵活性。

6. 发明申请

US20130131411A1 DEHYDROGENATION OF ALKANOLS TO INCREASE YIELD OF AROMATICS 有权
公开(公告)号：US20130131411A1
公开(公告)日：2013-05-23
申请号：US13304052
申请日：2011-11-23
申请人： Paul G. Blommel , Li Yuan , Matt Van Straten , Warren Lyman , Randy D. Cortright
发明人： Paul G. Blommel , Li Yuan , Matt Van Straten , Warren Lyman , Randy D. Cortright
IPC分类号： C07C1/207
CPC分类号： C07C1/2072 , C07C1/2076 , C07C1/2078 , C07C29/32 , C07C45/002 , C07C51/00 , C07C51/16 , C07C67/293 , C07C2521/04 , C07C2521/06 , C07C2521/08 , C07C2521/12 , C07C2523/06 , C07C2523/08 , C07C2523/30 , C07C2523/72 , C07C2523/755 , C07C2525/00 , C07C2527/14 , C07C2529/40 , C07C2529/46 , C07C2529/65 , C07C2529/70 , C07C2529/83 , C07C2529/85 , C10G3/42 , C10G3/49 , C10G2400/30 , Y02P20/52 , Y02P30/20 , C07C15/04 , C07C15/06 , C07C15/08 , C07C47/06 , C07C47/02 , C07C53/08 , C07C53/02
摘要： The present invention provides methods, reactor systems, and catalysts for increasing the yield of aromatic hydrocarbons produced while converting alkanols to hydrocarbons. The invention includes methods of using catalysts to increase the yield of benzene, toluene, and mixed xylenes in the hydrocarbon product.

7. 发明授权

US07787459B2 Method and system for implementing traversal through network address translation 有权
标题翻译：通过网络地址转换实现遍历的方法和系统
公开(公告)号：US07787459B2
公开(公告)日：2010-08-31
申请号：US10584212
申请日：2004-12-24
申请人： Li Yuan , Jun Yan
发明人： Li Yuan , Jun Yan
IPC分类号： H04B3/20
CPC分类号： H04L29/12009 , H04L29/06027 , H04L29/12405 , H04L29/125 , H04L29/12537 , H04L61/2528 , H04L61/2564 , H04L61/2578 , H04L63/0281 , H04L63/029 , H04L65/1006 , H04L65/103 , H04L65/104 , H04L65/1069
摘要： The present invention discloses a method for implementing traversal through network address translation. The method adopts a FULL PROXY mode for implementing traversal through Network Address Translation (NAT) server or Firewall (FW) by simultaneously relaying call signalings and media streams from a user terminal in a private network. Meanwhile, a system for implementing traversal through network address translation is disclosed. In accordance with this invention, no reconstruction of existing NAT/FWs and user terminals are needed for implementing traversal in any networking architecture while issues of Quality of Service (QoS), security, and aged mapping list of NAT can be solved.
摘要翻译：本发明公开了一种通过网络地址转换实现遍历的方法。该方法采用FULL PROXY模式，通过网络地址转换（NAT）服务器或防火墙（FW）实现遍历，同时中继专用网络中用户终端的呼叫信号和媒体流。同时，公开了一种通过网络地址转换实现遍历的系统。根据本发明，在任何网络架构中不需要重构现有的NAT / FW和用户终端，同时可以解决NAT的服务质量（QoS），安全性和老化映射列表的问题。

8. 发明授权

US08806925B2 Mechanical packaging technique of attaching MEMS and flex circuit 有权
标题翻译： MEMS和柔性电路的机械封装技术
公开(公告)号：US08806925B2
公开(公告)日：2014-08-19
申请号：US13430528
申请日：2012-03-26
申请人： Ihioma U. Nzeadibe , Javed Hussain , Joseph Castagna , Li Yuan , Roger Horton
发明人： Ihioma U. Nzeadibe , Javed Hussain , Joseph Castagna , Li Yuan , Roger Horton
IPC分类号： G01M15/08 , G01L23/14
CPC分类号： G01L23/145
摘要： The present invention disclosed provides for a rugged, compact sensing device for various implementations including those of automotive, marine, and other combustion technologies that require low cost accurate pressure sensing during internal combustion engine process. In one or more aspects of the present invention, a MEMS sensor connection with a flexible circuit is presented and the communication of which is preferably achieved through the use of wire bond technology.
摘要翻译：所公开的本发明提供了用于各种实现的坚固，紧凑的感测装置，包括在内燃机过程中需要低成本精确的压力感测的汽车，船舶和其他燃烧技术的那些。在本发明的一个或多个方面中，提出了具有柔性电路的MEMS传感器连接，并且其通信优选通过使用引线键合技术实现。

9. 发明申请

US20070217407A1 Method and System for Implementing Traversal Through Network Address Translation 有权
标题翻译：通过网络地址转换实现遍历的方法和系统
公开(公告)号：US20070217407A1
公开(公告)日：2007-09-20
申请号：US10584212
申请日：2004-12-24
申请人： Li Yuan , Jun Yan
发明人： Li Yuan , Jun Yan
IPC分类号： H04L12/28
CPC分类号： H04L29/12009 , H04L29/06027 , H04L29/12405 , H04L29/125 , H04L29/12537 , H04L61/2528 , H04L61/2564 , H04L61/2578 , H04L63/0281 , H04L63/029 , H04L65/1006 , H04L65/103 , H04L65/104 , H04L65/1069
摘要： The present invention discloses a method for implementing traversal through network address translation. The method adopts a FULL PROXY mode for implementing traversal through Network Address Translation (NAT) server or Firewall (FW) by simultaneously relaying call signalings and media streams from a user terminal in a private network. Meanwhile, a system for implementing traversal through network address translation is disclosed. In accordance with this invention, no reconstruction of existing NAT/FWs and user terminals are needed for implementing traversal in any networking architecture while issues of Quality of Service (QoS), security, and aged mapping list of NAT can be solved.
摘要翻译：本发明公开了一种通过网络地址转换实现遍历的方法。该方法采用FULL PROXY模式，通过网络地址转换（NAT）服务器或防火墙（FW）实现遍历，同时中继专用网络中用户终端的呼叫信号和媒体流。同时，公开了一种通过网络地址转换实现遍历的系统。根据本发明，在任何网络架构中不需要重构现有的NAT / FW和用户终端，同时可以解决NAT的服务质量（QoS），安全性和老化映射列表的问题。

10. 发明授权

US5283808A X-ray device having a co-axial laser aiming system in an opposed configuration 失效
标题翻译：具有相对配置的同轴激光瞄准系统的X射线装置
公开(公告)号：US5283808A
公开(公告)日：1994-02-01
申请号：US908320
申请日：1992-07-01
申请人： Steven L. Cramer , Li Yuan
发明人： Steven L. Cramer , Li Yuan
IPC分类号： A61B6/08 , A61B17/17
CPC分类号： A61B17/1725 , A61B17/1703 , A61B6/08 , A61B90/13
摘要： An improved x-ray laser aiming system providing coaxial laser aiming in a configuration opposed to the x-ray emitter is disclosed. The present invention comprises two basic components: 1) a laser sight coupled to an x-ray emitter, and 2) a laser housing coupled to an x-ray collector. The laser sight provides a means for aligning the x-ray emitter with a laser beam during surgical or diagnostic procedures. The laser housing is removably coupled to the image intensifier or x-ray collector. The laser housing contains a point laser source and a fixed reflective surface or mirror for directing a laser beam coaxially with the center ray of the x-rays emitted by the x-ray emitter, but in the opposite direction. The laser source is, therefore, in a configuration opposed or opposite to the x-ray emitter. The laser aiming system of the present invention may be used to provide a reference point during orthopedic alignment procedures such as pinning and for vascular procedures such as balloon angioplasty, and correction of conditions involving embolisms, aneurysms, or arterial venous malformations (AVM's).
摘要翻译：公开了一种改进的x射线激光瞄准系统，提供瞄准与x射线发射器相对的构造的同轴激光器。本发明包括两个基本部件：1）耦合到x射线发射器的激光瞄准器，以及2）耦合到x射线收集器的激光器壳体。激光瞄准器提供了在手术或诊断过程中将X射线发射器与激光束对准的手段。激光外壳可移除地耦合到图像增强器或X射线收集器。激光器壳体包含点激光源和固定反射表面或反射镜，用于将激光束与X射线发射器发射的X射线的中心射线同轴地引导，但是在相反方向。因此，激光源处于与x射线发射器相对或相对的构造。本发明的激光瞄准系统可以用于在整形外科对准过程中提供参考点，例如钉扎和血管手术，例如球囊血管成形术，以及矫正涉及栓塞，动脉瘤或动脉静脉畸形（AVM's）的病症。

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