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1. 发明申请

US20130231369A1 1-[(4-hydroxypiperidin-4-yl)methyl]pyridin-2(1H)-one derivatives, preparation methods and uses thereof 有权
标题翻译： 1 - [（4-羟基哌啶-4-基）甲基]吡啶-2（1H） - 酮衍生物，其制备方法和用途
公开(公告)号：US20130231369A1
公开(公告)日：2013-09-05
申请号：US13697857
申请日：2011-04-08
申请人： Yunfeng Li , Rifang Yang , Youzhi Zhang , Yongzhen Li , Zengliang Jin , Peng Li , Li Yuan , Liuhong Yun , Nan Zhao , Cheng Zhang , Xiaodan Xu , Rusheng Zhao , Hongxia Chen , Rui Xue , Juanjuan Qin , Zhenzhen Wang , Jiazhi Yao
发明人： Yunfeng Li , Rifang Yang , Youzhi Zhang , Yongzhen Li , Zengliang Jin , Peng Li , Li Yuan , Liuhong Yun , Nan Zhao , Cheng Zhang , Xiaodan Xu , Rusheng Zhao , Hongxia Chen , Rui Xue , Juanjuan Qin , Zhenzhen Wang , Jiazhi Yao
IPC分类号： C07D401/06
CPC分类号： C07D401/06
摘要： Provided are N-[(4-hydroxypiperidin-4-yl)methyl]pyridin-2(1H)-one derivatives represented by formula I, stereoisomers, pharmaceutically acceptable salts or solvates thereof. The above compounds have the dual activities of 5-hydroxytryptamine 1A receptor ligand and selective serotonin reuptake inhibitor. The preparation methods of the above compounds, the uses of these compounds for the prevention or treatment of nervous system diseases related to 5-hydroxytryptamine system dysfunction and the pharmaceutical compositions containing these compounds are also provided.
摘要翻译：提供由式I表示的N - [（4-羟基哌啶-4-基）甲基]吡啶-2（1H） - 酮衍生物，其立体异构体，药学上可接受的盐或溶剂合物。上述化合物具有5-羟色胺1A受体配体和选择性5-羟色胺再摄取抑制剂的双重活性。还提供了上述化合物的制备方法，这些化合物用于预防或治疗与5-羟色胺系统功能障碍有关的神经系统疾病的用途和含有这些化合物的药物组合物。

2. 发明授权

US08921563B2 1-[(4-hydroxypiperidin-4-yl)methyl]pyridin-2(1H)-one derivatives, preparation methods and uses thereof 有权
标题翻译： 1 - [（4-羟基哌啶-4-基）甲基]吡啶-2（1H） - 酮衍生物，其制备方法和用途
公开(公告)号：US08921563B2
公开(公告)日：2014-12-30
申请号：US13697857
申请日：2011-04-08
申请人： Yunfeng Li , Rifang Yang , Youzhi Zhang , Yongzhen Li , Zengliang Jin , Peng Li , Li Yuan , Liuhong Yun , Nan Zhao , Cheng Zhang , Xiaodan Xu , Rusheng Zhao , Hongxia Chen , Rui Xue , Juanjuan Qin , Zhenzhen Wang , Jiazhi Yao
发明人： Yunfeng Li , Rifang Yang , Youzhi Zhang , Yongzhen Li , Zengliang Jin , Peng Li , Li Yuan , Liuhong Yun , Nan Zhao , Cheng Zhang , Xiaodan Xu , Rusheng Zhao , Hongxia Chen , Rui Xue , Juanjuan Qin , Zhenzhen Wang , Jiazhi Yao
IPC分类号： A61K31/445 , A61K31/505 , C07D211/68 , C07D239/02 , C07D401/06
CPC分类号： C07D401/06
摘要： Provided are N-[(4-hydroxypiperidin-4-yl)methyl]pyridin-2(1H)-one derivatives represented by formula I, stereoisomers, pharmaceutically acceptable salts or solvates thereof. The above compounds have the dual activities of 5-hydroxytryptamine 1A receptor ligand and selective serotonin reuptake inhibitor. The preparation methods of the above compounds, the uses of these compounds for the prevention or treatment of nervous system diseases related to 5-hydroxytryptamine system dysfunction and the pharmaceutical compositions containing these compounds are also provided.
摘要翻译：提供由式I表示的N - [（4-羟基哌啶-4-基）甲基]吡啶-2（1H） - 酮衍生物，其立体异构体，药学上可接受的盐或溶剂合物。上述化合物具有5-羟色胺1A受体配体和选择性5-羟色胺再摄取抑制剂的双重活性。还提供了上述化合物的制备方法，这些化合物用于预防或治疗与5-羟色胺系统功能障碍有关的神经系统疾病的用途和含有这些化合物的药物组合物。

3. 发明申请

US20110178127A1 AMINE COMPOUNDS AND MEDICAL USES THEREOF 有权
标题翻译：胺化合物及其医疗用途
公开(公告)号：US20110178127A1
公开(公告)日：2011-07-21
申请号：US13001379
申请日：2009-06-23
申请人： Bohua Zhong , Youzhi Zhang , Yangping Zhang , Rui Xue , Xinhua He , Yunfeng Li , Hongxia Chen , Nan Zhao , Melying Li
发明人： Bohua Zhong , Youzhi Zhang , Yangping Zhang , Rui Xue , Xinhua He , Yunfeng Li , Hongxia Chen , Nan Zhao , Melying Li
IPC分类号： A61K31/381 , C07D409/12 , C07D409/14 , C07D407/12 , A61K31/4025 , A61K31/4535 , A61K31/36 , A61K31/357 , A61P25/24
CPC分类号： C07D407/12 , C07D407/14 , C07D409/12 , C07D409/14
摘要： The present invention relates to a new amine compound or a pharmaceutically acceptable salt thereof, wherein the definitions of X, R1, R2 and n are given in the description, to a pharmaceutical composition containing the compound as active ingredient, and to use of the amine compound or its pharmaceutically acceptable salt for the manufacture of an anti-depressent drug.
摘要翻译：本发明涉及一种新的胺化合物或其药学上可接受的盐，其中X，R 1，R 2和n的定义在说明书中给出含有该化合物作为活性成分的药物组合物，以及使用该胺化合物或其药学上可接受的盐，用于制造抗抑郁药物。

4. 发明授权

US08318772B2 Amine compounds and medical uses thereof 有权
标题翻译：胺化合物及其医疗用途
公开(公告)号：US08318772B2
公开(公告)日：2012-11-27
申请号：US13001379
申请日：2009-06-23
申请人： Bohua Zhong , Youzhi Zhang , Yanping Zhang , Rui Xue , Xinhua He , Yunfeng Li , Hongxia Chen , Nan Zhao , Meiying Li
发明人： Bohua Zhong , Youzhi Zhang , Yanping Zhang , Rui Xue , Xinhua He , Yunfeng Li , Hongxia Chen , Nan Zhao , Meiying Li
IPC分类号： A61K31/4535 , A61K31/4025 , A61K31/381 , A61K31/357 , A61K31/36 , C07D407/12 , C07D409/14 , C07D409/12
CPC分类号： C07D407/12 , C07D407/14 , C07D409/12 , C07D409/14
摘要： The present invention relates to a new amine compound or a pharmaceutically acceptable salt thereof, wherein the definitions of X, R1, R2 and n are given in the description, to a pharmaceutical composition containing the compound as active ingredient, and to use of the amine compound or its pharmaceutically acceptable salt for the manufacture of an anti-depressent drug.
摘要翻译：本发明涉及一种新的胺化合物或其药学上可接受的盐，其中X，R 1，R 2和n的定义在说明书中给出含有该化合物作为活性成分的药物组合物，以及使用该胺化合物或其药学上可接受的盐，用于制造抗抑郁药物。

5. 发明授权

US10077823B2 Multimode electromechanical variable speed transmission apparatus and method of control 有权
公开(公告)号：US10077823B2
公开(公告)日：2018-09-18
申请号：US14694881
申请日：2015-04-23
申请人： Xiaolin Ai , Rui Xue , Zhonghe Xue , Xiaozhi Ai
发明人： Xiaolin Ai , Rui Xue , Zhonghe Xue , Xiaozhi Ai
IPC分类号： F16H3/72 , B60W10/02 , B60K1/02 , B60K6/543 , B60K6/445 , B60K6/365 , B60K6/547 , B60W10/08 , B60W10/11 , B60L11/12 , B60L11/14 , B60L11/18 , B60L15/20 , F16H37/08 , F16H37/10
CPC分类号： F16H3/728 , B60K1/02 , B60K6/365 , B60K6/445 , B60K6/543 , B60K6/547 , B60L15/2054 , B60L50/16 , B60L50/61 , B60L58/21 , B60L2240/12 , B60L2240/421 , B60L2240/423 , B60L2240/441 , B60L2240/443 , B60L2240/486 , B60W10/02 , B60W10/08 , B60W10/11 , F16H2037/0873 , F16H2037/101 , F16H2037/103 , F16H2037/104 , F16H2200/0034 , F16H2200/2005 , F16H2200/2007 , F16H2200/2023 , F16H2200/2035 , F16H2200/2038 , F16H2200/2064 , F16H2200/2082 , F16H2200/2094 , F16H2200/2097 , Y02T10/6217 , Y02T10/6239 , Y02T10/645 , Y02T10/7005 , Y02T10/7061 , Y02T10/7077 , Y02T10/72 , Y02T10/7275 , Y10S903/911 , Y10T477/23 , Y10T477/26
摘要： The current invention discloses a multi-mode electro-mechanical variable speed transmission. The transmission includes an input shaft, an output system, planetary gear set having at least three braches each represents a co-axial rotating member, two electric machines along with the associated controllers for the electric machines, and a clutch. The first branch couples to the first electric machine with a constant speed ratio; the second branch couples to the output system with a constant speed ratio; and the third branch couples to the input shaft with a constant speed ratio; the second electric machine selectively couples to two different the branches of the planetary gear set with two different constant speed ratios, respectively. The multi-mode electro-mechanical variable speed transmission is capable of providing multiple operation modes including two electric drive modes and two power split operation modes. Different operation modes cover different speed ratio regimes and are suitable for different power requirements. At the mode switching point, the corresponding clutch or clutches is automatically synchronized. This avoids shock loads during operation mode switching. The transmission is capable of providing operations with at least a fixed output to input speed ratio.

6. 发明授权

US09108624B2 Dual mode electromechanical variable speed transmission apparatus and method of control 有权
标题翻译：双模式机电变速传动装置及其控制方法
公开(公告)号：US09108624B2
公开(公告)日：2015-08-18
申请号：US14249845
申请日：2014-04-10
申请人： Rui Xue , Zhonghe Xue , Xiaozhi Al , Xiaolin Al
发明人： Rui Xue , Zhonghe Xue , Xiaozhi Al , Xiaolin Al
IPC分类号： F16H3/72 , B60W10/08 , B60K6/365 , B60K6/445 , B60K6/547 , B60W10/02 , B60W10/11 , B60K1/02 , F16H37/08 , F16H37/10
CPC分类号： B60W10/08 , B60K1/02 , B60K6/365 , B60K6/445 , B60K6/547 , B60W10/02 , B60W10/11 , F16H3/728 , F16H2037/0873 , F16H2037/101 , F16H2037/103 , F16H2037/104 , F16H2200/0034 , F16H2200/2005 , F16H2200/2007 , F16H2200/2035 , F16H2200/2097 , Y02T10/6239 , Y10T477/23 , Y10T477/26
摘要： A dual-mode electro-mechanical variable speed transmission includes an input shaft, an output shaft system, a gear system having at least three branches, two electric machines, and at least a clutch. The first electric machine couples to a branch of the gear system, the output shaft system couples to another branch of the gear system, the input shaft couples to the remaining branch or one of the remaining branches of the gear system, and the second electric machine selectively couples either to the same branch that is coupled to the output shaft system with a speed ratio or to one of the remaining branches that is not coupled to the first electric machine with a different speed ratio. The transmission provides at least two power splitting modes to cover different speed ratio regimes. The transmission can also provide at least a fixed output shaft to input shaft speed ratio.
摘要翻译：双模式机电变速传动装置包括输入轴，输出轴系统，具有至少三个分支的齿轮系统，两个电机以及至少一个离合器。第一电机耦合到齿轮系的分支，输出轴系耦合到齿轮系的另一分支，输入轴耦合到齿轮系统的剩余分支或其余分支中的一个，第二电机选择性地将其耦合到以一个速度比耦合到输出轴系统的相同分支，或者以不同速度比与第一电机耦合的其余分支之一。该传输提供至少两个功率分离模式以覆盖不同的速比比方案。变速箱还可以提供至少一个固定的输出轴来输入轴转速比。

7. 发明授权

US08277350B2 Two mode electro-mechanical transmission and control 有权
标题翻译：两模式机电传动和控制
公开(公告)号：US08277350B2
公开(公告)日：2012-10-02
申请号：US12304870
申请日：2007-04-10
申请人： Xiaolin Ai , Xiaozhi Ai , Rui Xue , Zhonghe Xue
发明人： Xiaolin Ai , Xiaozhi Ai , Rui Xue , Zhonghe Xue
IPC分类号： F16H37/06
CPC分类号： B60W20/20 , B60K1/02 , B60K6/26 , B60K6/365 , B60K6/40 , B60K6/445 , B60K6/547 , B60L2240/423 , B60L2240/441 , B60L2240/486 , B60W10/06 , B60W10/08 , B60W10/115 , B60W20/00 , B60W2510/0638 , B60W2510/1005 , B60W2540/10 , B60W2540/12 , B60W2710/0644 , B60W2710/0666 , B60W2710/083 , B60W2710/105 , F16H3/728 , F16H2037/0866 , F16H2037/103 , F16H2037/106 , F16H2200/2023 , Y02T10/6239 , Y02T10/6286 , Y02T10/642
摘要： A two mode power-split electric hybrid system and a method of control said hybrid system. The hybrid system is comprised of an engine, a transmission, an energy storage device and a control system for effecting said control method. Said transmission is a reconfigurable power split system, comprising a power-splitting device and an output power path selecting device. The power splitting device includes a compound planetary gear system and two electric machines which form a local series electric hybrid system. Said transmission regulates the output power state of said hybrid system by controlling power flow within said local series hybrid system. The hybrid system provides at least two operating mode, an output power split mode and a compound power split mode. Said control system includes multiple controllers and control modules. In accordance with the operating conditions of the hybrid system, said control system computes and sets system power requirement, allocates ob board power resources and sets engine operating speed and torque. In addition, said control system sets the operation mode of the transmission and controls the engine speed by adjusting operating torque of electric machines, based on the differential signal between reference engine speed and actual engine speed. Said control system is also capable of controlling engine torque through engine controller.
摘要翻译：一种双模式电力分离电动混合动力系统及其控制方法。混合动力系统包括发动机，变速器，能量存储装置和用于实现所述控制方法的控制系统。所述传输是可重配置功率分配系统，包括功率分配装置和输出功率路径选择装置。动力分配装置包括复合行星齿轮系统和形成局部串联电动混合动力系统的两台电动机。所述传输通过控制所述局部串联混合系统内的功率流来调节所述混合系统的输出功率状态。混合系统提供至少两种操作模式，输出功率分离模式和复合功率分离模式。所述控制系统包括多个控制器和控制模块。根据混合动力系统的运行条件，所述控制系统计算和设定系统功率需求，分配机载电源资源，设定发动机运行速度和转矩。另外，所述控制系统根据基准发动机转速和实际发动机转速之间的差动信号，通过调整电机的运转转矩来设定变速箱的动作模式，控制发动机的转速。所述控制系统还能够通过发动机控制器控制发动机转矩。

8. 发明授权

US08734281B2 Dual-mode electromechanical variable speed transmission apparatus and method of control 有权
标题翻译：双模机电变速传动装置及其控制方法
公开(公告)号：US08734281B2
公开(公告)日：2014-05-27
申请号：US12744584
申请日：2008-11-28
申请人： Xiaolin Ai , Rui Xue , Zhonghe Xue , Xiaozhi Ai
发明人： Xiaolin Ai , Rui Xue , Zhonghe Xue , Xiaozhi Ai
IPC分类号： F16H37/06 , F16H3/72 , F16H48/06 , B60K6/20 , B60K6/445
CPC分类号： B60W10/08 , B60K1/02 , B60K6/365 , B60K6/445 , B60K6/547 , B60W10/02 , B60W10/11 , F16H3/728 , F16H2037/0873 , F16H2037/101 , F16H2037/103 , F16H2037/104 , F16H2200/0034 , F16H2200/2005 , F16H2200/2007 , F16H2200/2035 , F16H2200/2097 , Y02T10/6239 , Y10T477/23 , Y10T477/26
摘要： A dual-mode electro-mechanical variable speed transmission includes an input shaft, an output shaft system, a gear system having at least three branches, two electric machines, and at least a clutch. The first electric machine couples to a branch of the gear system, the output shaft system couples to another branch of the gear system, the input shaft couples to the remaining branch or one of the remaining branches of the gear system, and the second electric machine selectively couples either to the same branch that is coupled to the output shaft system with a speed ratio or to one of the remaining branches that that is not coupled to the first electric machine with a different speed ratio. The transmission provides at least two power splitting modes to cover different speed ratio regimes. The transmission can also provide at least a fixed output shaft to input shaft speed ratio.
摘要翻译：双模式机电变速传动装置包括输入轴，输出轴系统，具有至少三个分支的齿轮系统，两个电机以及至少一个离合器。第一电机耦合到齿轮系的分支，输出轴系耦合到齿轮系的另一分支，输入轴耦合到齿轮系统的剩余分支或其余分支中的一个，第二电机选择性地连接到以速度比耦合到输出轴系统的相同分支，或者以不同于速度比的耦合到第一电机的其余分支之一。该传输提供至少两个功率分离模式以覆盖不同的速比比方案。变速箱还可以提供至少一个固定的输出轴来输入轴转速比。

9. 发明申请

US20100261565A1 DUAL-MODE ELECTROMECHANICAL VARIABLE SPEED TRANSMISSION APPARATUS AND METHOD OF CONTROL 有权
标题翻译：双模式电动变速传动装置及其控制方法
公开(公告)号：US20100261565A1
公开(公告)日：2010-10-14
申请号：US12744584
申请日：2008-11-28
申请人： Xiaolin Ai , Rui Xue , Zhonghe Xue , Xiaozhi Ai
发明人： Xiaolin Ai , Rui Xue , Zhonghe Xue , Xiaozhi Ai
IPC分类号： B60W10/04 , B60W20/00 , F16H61/66 , B62D65/10
CPC分类号： B60W10/08 , B60K1/02 , B60K6/365 , B60K6/445 , B60K6/547 , B60W10/02 , B60W10/11 , F16H3/728 , F16H2037/0873 , F16H2037/101 , F16H2037/103 , F16H2037/104 , F16H2200/0034 , F16H2200/2005 , F16H2200/2007 , F16H2200/2035 , F16H2200/2097 , Y02T10/6239 , Y10T477/23 , Y10T477/26
摘要： The current invention discloses a dual-mode electro-mechanical variable speed transmission. Said transmission includes an input shaft, an output shaft system, a planetary gear system having at least three co-axial rotating members, two electric machines along with the associated controllers for the electric machines, and at least a clutch. Said planetary gear system has at least three branches; each branch corresponds to a co-axial rotating member. The first branch couples to the first electric machine with a fixed speed ratio; another branch couples to the input shaft with a fixed speed ratio; and yet anther branch couples to the output shaft system with a fixed speed ratio; the second electric machine couples selectively to two of the branches in the planetary gear system with different speed ratios. Said two branches are not the first branch and one of the said two branches is connected to the output shaft system. Said dual-mode electro-mechanical variable speed transmission is capable of providing at least two power splitting operation modes, including an output power splitting mode. Different operation modes cover different speed ratio regimes. At the mode switching point, the corresponding clutch or clutches is automatically synchronized. Thus the speeds of the rotation members of the transmission are continuous, and the transmission is free from shock loads at the operating mode switching point. In addition, said transmission is capable of providing operations with at least a fixed input-to-output speed ratio.
摘要翻译：本发明公开了一种双模机电变速传动装置。所述变速器包括输入轴，输出轴系统，具有至少三个同轴旋转构件的行星齿轮系统，两个电机以及用于电机的相关联的控制器，以及至少一个离合器。所述行星齿轮系具有至少三个分支; 每个分支对应于同轴旋转构件。第一分支以固定速比耦合到第一台电机; 另一个分支以固定的速比耦合到输入轴; 而花药分支以固定的速比耦合到输出轴系统; 第二电机以不同的速比选择性地耦合在行星齿轮系中的两个分支中。所述两个分支不是第一分支，并且所述两个分支中的一个连接到输出轴系统。所述双模机电变速传动能够提供至少两个功率分离操作模式，包括输出功率分配模式。不同的运行模式涵盖不同的速比方式。在模式切换点，相应的离合器或离合器自动同步。因此，变速器的旋转构件的速度是连续的，并且变速器在操作模式切换点处没有冲击载荷。此外，所述传输能够提供至少具有固定的输入到输出速度比的操作。

10. 发明申请

US20090209381A1 TWO MODE ELECTRO-MECHANICAL TRANSMISSION AND CONTROL 有权
标题翻译：双模式机电传动与控制
公开(公告)号：US20090209381A1
公开(公告)日：2009-08-20
申请号：US12304870
申请日：2007-04-10
申请人： Xiaolin Ai , Xiaozhi Ai , Rui Xue , Zhonghe Xue
发明人： Xiaolin Ai , Xiaozhi Ai , Rui Xue , Zhonghe Xue
IPC分类号： F16H57/08 , G06F17/00
CPC分类号： B60W20/20 , B60K1/02 , B60K6/26 , B60K6/365 , B60K6/40 , B60K6/445 , B60K6/547 , B60L2240/423 , B60L2240/441 , B60L2240/486 , B60W10/06 , B60W10/08 , B60W10/115 , B60W20/00 , B60W2510/0638 , B60W2510/1005 , B60W2540/10 , B60W2540/12 , B60W2710/0644 , B60W2710/0666 , B60W2710/083 , B60W2710/105 , F16H3/728 , F16H2037/0866 , F16H2037/103 , F16H2037/106 , F16H2200/2023 , Y02T10/6239 , Y02T10/6286 , Y02T10/642
摘要： A two mode power-split electric hybrid system and a method of control said hybrid system. The hybrid system is comprised of an engine, a transmission, an energy storage device and a control system for effecting said control method. Said transmission is a reconfigurable power split system, comprising a power-splitting device and an output power path selecting device. The power splitting device includes a compound planetary gear system and two electric machines which form a local series electric hybrid system. Said transmission regulates the output power state of said hybrid system by controlling power flow within said local series hybrid system. The hybrid system provides at least two operating mode, an output power split mode and a compound power split mode. Said control system includes multiple controllers and control modules. In accordance with the operating conditions of the hybrid system, said control system computes and sets system power requirement, allocates ob board power resources and sets engine operating speed and torque. In addition, said control system sets the operation mode of the transmission and controls the engine speed by adjusting operating torque of electric machines, based on the differential signal between reference engine speed and actual engine speed. Said control system is also capable of controlling engine torque through engine controller.
摘要翻译：一种双模式电力分离电动混合动力系统及其控制方法。混合动力系统包括发动机，变速器，能量存储装置和用于实现所述控制方法的控制系统。所述传输是可重配置功率分配系统，包括功率分配装置和输出功率路径选择装置。动力分配装置包括复合行星齿轮系统和形成局部串联电动混合动力系统的两台电动机。所述传输通过控制所述局部串联混合系统内的功率流来调节所述混合系统的输出功率状态。混合系统提供至少两种操作模式，输出功率分离模式和复合功率分离模式。所述控制系统包括多个控制器和控制模块。根据混合动力系统的运行条件，所述控制系统计算和设定系统功率需求，分配机载电源资源，设定发动机运行速度和转矩。另外，所述控制系统根据基准发动机转速和实际发动机转速之间的差动信号，通过调整电机的运转转矩来设定变速箱的动作模式，控制发动机的转速。所述控制系统还能够通过发动机控制器控制发动机转矩。

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