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1. 发明授权

US08921563B2 1-[(4-hydroxypiperidin-4-yl)methyl]pyridin-2(1H)-one derivatives, preparation methods and uses thereof 有权
标题翻译： 1 - [（4-羟基哌啶-4-基）甲基]吡啶-2（1H） - 酮衍生物，其制备方法和用途
公开(公告)号：US08921563B2
公开(公告)日：2014-12-30
申请号：US13697857
申请日：2011-04-08
申请人： Yunfeng Li , Rifang Yang , Youzhi Zhang , Yongzhen Li , Zengliang Jin , Peng Li , Li Yuan , Liuhong Yun , Nan Zhao , Cheng Zhang , Xiaodan Xu , Rusheng Zhao , Hongxia Chen , Rui Xue , Juanjuan Qin , Zhenzhen Wang , Jiazhi Yao
发明人： Yunfeng Li , Rifang Yang , Youzhi Zhang , Yongzhen Li , Zengliang Jin , Peng Li , Li Yuan , Liuhong Yun , Nan Zhao , Cheng Zhang , Xiaodan Xu , Rusheng Zhao , Hongxia Chen , Rui Xue , Juanjuan Qin , Zhenzhen Wang , Jiazhi Yao
IPC分类号： A61K31/445 , A61K31/505 , C07D211/68 , C07D239/02 , C07D401/06
CPC分类号： C07D401/06
摘要： Provided are N-[(4-hydroxypiperidin-4-yl)methyl]pyridin-2(1H)-one derivatives represented by formula I, stereoisomers, pharmaceutically acceptable salts or solvates thereof. The above compounds have the dual activities of 5-hydroxytryptamine 1A receptor ligand and selective serotonin reuptake inhibitor. The preparation methods of the above compounds, the uses of these compounds for the prevention or treatment of nervous system diseases related to 5-hydroxytryptamine system dysfunction and the pharmaceutical compositions containing these compounds are also provided.
摘要翻译：提供由式I表示的N - [（4-羟基哌啶-4-基）甲基]吡啶-2（1H） - 酮衍生物，其立体异构体，药学上可接受的盐或溶剂合物。上述化合物具有5-羟色胺1A受体配体和选择性5-羟色胺再摄取抑制剂的双重活性。还提供了上述化合物的制备方法，这些化合物用于预防或治疗与5-羟色胺系统功能障碍有关的神经系统疾病的用途和含有这些化合物的药物组合物。

2. 发明申请

US20130231369A1 1-[(4-hydroxypiperidin-4-yl)methyl]pyridin-2(1H)-one derivatives, preparation methods and uses thereof 有权
标题翻译： 1 - [（4-羟基哌啶-4-基）甲基]吡啶-2（1H） - 酮衍生物，其制备方法和用途
公开(公告)号：US20130231369A1
公开(公告)日：2013-09-05
申请号：US13697857
申请日：2011-04-08
申请人： Yunfeng Li , Rifang Yang , Youzhi Zhang , Yongzhen Li , Zengliang Jin , Peng Li , Li Yuan , Liuhong Yun , Nan Zhao , Cheng Zhang , Xiaodan Xu , Rusheng Zhao , Hongxia Chen , Rui Xue , Juanjuan Qin , Zhenzhen Wang , Jiazhi Yao
发明人： Yunfeng Li , Rifang Yang , Youzhi Zhang , Yongzhen Li , Zengliang Jin , Peng Li , Li Yuan , Liuhong Yun , Nan Zhao , Cheng Zhang , Xiaodan Xu , Rusheng Zhao , Hongxia Chen , Rui Xue , Juanjuan Qin , Zhenzhen Wang , Jiazhi Yao
IPC分类号： C07D401/06
CPC分类号： C07D401/06
摘要： Provided are N-[(4-hydroxypiperidin-4-yl)methyl]pyridin-2(1H)-one derivatives represented by formula I, stereoisomers, pharmaceutically acceptable salts or solvates thereof. The above compounds have the dual activities of 5-hydroxytryptamine 1A receptor ligand and selective serotonin reuptake inhibitor. The preparation methods of the above compounds, the uses of these compounds for the prevention or treatment of nervous system diseases related to 5-hydroxytryptamine system dysfunction and the pharmaceutical compositions containing these compounds are also provided.
摘要翻译：提供由式I表示的N - [（4-羟基哌啶-4-基）甲基]吡啶-2（1H） - 酮衍生物，其立体异构体，药学上可接受的盐或溶剂合物。上述化合物具有5-羟色胺1A受体配体和选择性5-羟色胺再摄取抑制剂的双重活性。还提供了上述化合物的制备方法，这些化合物用于预防或治疗与5-羟色胺系统功能障碍有关的神经系统疾病的用途和含有这些化合物的药物组合物。

3. 发明申请

US20100135161A1 METHOD AND APPARATUS FOR PROVIDING AUTOMATED PROCESSING OF A MULTICAST SERVICE ALARM 有权
标题翻译：用于提供自动处理多媒体服务报警的方法和装置
公开(公告)号：US20100135161A1
公开(公告)日：2010-06-03
申请号：US12325520
申请日：2008-12-01
申请人： Teh-Hsin K. Wu , Paritosh Bajpay , Jackson Liu , Zhenzhen Wang
发明人： Teh-Hsin K. Wu , Paritosh Bajpay , Jackson Liu , Zhenzhen Wang
IPC分类号： G06F11/30
CPC分类号： H04L41/06 , H04L12/18 , H04L41/145 , H04L41/5074 , H04L43/50
摘要： A method and apparatus for providing automatic processing of an alarm related to a multicast service in a network are disclosed. For example, the method receives an alarm related to a multicast service, and retrieves multicast data, wherein said multicast data comprises one or more of: a source Internet Protocol (IP) address for a source, a group IP address, and Protocol Independent Multicast (PIM) data. The method retrieves interface information, wherein the interface information comprises one or more of: an interface IP address, a PIM mode, and a Designated Router (DR) IP address. The method retrieves a status of a neighbor of the source in accordance with the source IP address, and determines if a neighbor is established for the source IP address.
摘要翻译：公开了一种用于在网络中提供与多播服务相关的警报的自动处理的方法和装置。例如，该方法接收与多播服务相关的警报，并且检索多播数据，其中所述多播数据包括以下中的一个或多个：源的源互联网协议（IP）地址，组IP地址和协议无关组播（PIM）数据。该方法检索接口信息，其中接口信息包括接口IP地址，PIM模式和指定路由器（DR）IP地址中的一个或多个。该方法根据源IP地址检索源的邻居状态，并确定源IP地址是否建立邻居。

4. 发明授权

US07860023B2 Layer 2 network rule-based non-intrusive testing verification methodology 失效
标题翻译：基于第2层网络规则的非侵入性测试验证方法
公开(公告)号：US07860023B2
公开(公告)日：2010-12-28
申请号：US12288496
申请日：2008-10-21
申请人： Zhenzhen Wang , Paritosh Bajpay , Jackson Liu , Teh-Hsin Wu
发明人： Zhenzhen Wang , Paritosh Bajpay , Jackson Liu , Teh-Hsin Wu
IPC分类号： H04J1/16
CPC分类号： H04L41/5074 , H04L41/0213 , H04L41/5009 , H04L41/507
摘要： Systems and methods are described that that analyze Layer 2 network performance and identify problems without having to disrupt customer service. Embodiments employ a two-phase approach to identify network problems. For an ingress switch, embodiments monitor frame relay Management Information Base (MIB) port and channel objects. A trouble ticket with various test results may be issued and a network work center notified with recommendations that include switch checking, network checking, Layer 1 access testing and network connectivity testing.
摘要翻译：描述了分析第2层网络性能并识别问题而不必中断客户服务的系统和方法。实施例采用两阶段方法来识别网络问题。对于入口交换机，实施例监视帧中继管理信息库（MIB）端口和信道对象。可以发出带有各种测试结果的故障单，并通知网络工作中心，其中包括切换检查，网络检查，第1层访问测试和网络连接测试。

5. 发明申请

US20100131799A1 Trouble emulator for a rules-based diagnostic system 失效
标题翻译：基于规则的诊断系统的故障仿真器
公开(公告)号：US20100131799A1
公开(公告)日：2010-05-27
申请号：US12275905
申请日：2008-11-21
申请人： Teh-Hsin K. Wu , Paritosh Bajpay , Jackson Liu , Zhenzhen Wang
发明人： Teh-Hsin K. Wu , Paritosh Bajpay , Jackson Liu , Zhenzhen Wang
IPC分类号： G06F11/34 , G06N5/02 , G06F11/36
CPC分类号： H04L41/0663 , G05B23/0278 , H04L41/145 , H04L41/16 , H04L43/0817
摘要： Embodiments of the present invention are directed to validating a rules-based diagnostic system for a network. Emulated data for use by the rules-based diagnostic system can be generated that includes a trouble ticket to emulate a problem associated at least one of Layer 1 and Layer 2 network services and includes network information associated with the problem. Responses from the rules-based diagnostic system can be received in response to the emulated data being processed by the rules-based diagnostic system. A log generated by the rules-based diagnostic system can be analyzed to determine rules implemented by the rules-based diagnostic system in response to the emulated data, thereby validating operation of the rules-based diagnostic system.
摘要翻译：本发明的实施例涉及验证网络的基于规则的诊断系统。可以生成由基于规则的诊断系统使用的仿真数据，其包括故障单以模拟与第1层和第2层网络服务中的至少一个相关联的问题，并且包括与该问题相关联的网络信息。响应于基于规则的诊断系统处理的仿真数据，可以接收基于规则的诊断系统的响应。可以分析由基于规则的诊断系统生成的日志，以确定基于规则的诊断系统响应于仿真数据实现的规则，从而验证基于规则的诊断系统的操作。

6. 发明申请

US20130102605A1 INHIBITORS OF AKT ACTIVITY 审中-公开
标题翻译： AKT活动的抑制剂
公开(公告)号：US20130102605A1
公开(公告)日：2013-04-25
申请号：US13642958
申请日：2011-04-21
申请人： Peng Liang , Morihiro Mitsuya , Yoshio Ogino , Changhe Qi , Hidekazu Takahashi , Paul Tempest , Jiabing Wang , Yuguang Wang , Zhenzhen Wang , Shaohua Zhang , Nanyan Zhou , Jiuxiang Zhu
发明人： Peng Liang , Morihiro Mitsuya , Yoshio Ogino , Changhe Qi , Hidekazu Takahashi , Paul Tempest , Jiabing Wang , Yuguang Wang , Zhenzhen Wang , Shaohua Zhang , Nanyan Zhou , Jiuxiang Zhu
IPC分类号： C07D417/04 , C07D417/14
CPC分类号： C07D417/04 , C07D277/28 , C07D417/14 , C07D487/08
摘要： The instant invention provides for substituted thiazoles that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.
摘要翻译：本发明提供抑制Akt活性的取代的噻唑。特别地，所公开的化合物选择性地抑制一种或两种Akt同种型。本发明还提供了包含这种抑制化合物的组合物和通过将该化合物给予需要治疗癌症的患者来抑制Akt活性的方法。

7. 发明授权

US08194639B2 Method and apparatus for providing automated processing of a multicast service alarm 有权
标题翻译：提供多播服务报警自动处理的方法和装置
公开(公告)号：US08194639B2
公开(公告)日：2012-06-05
申请号：US12325520
申请日：2008-12-01
申请人： Teh-Hsin K. Wu , Paritosh Bajpay , Jackson Liu , Zhenzhen Wang
发明人： Teh-Hsin K. Wu , Paritosh Bajpay , Jackson Liu , Zhenzhen Wang
IPC分类号： H04L12/28
CPC分类号： H04L41/06 , H04L12/18 , H04L41/145 , H04L41/5074 , H04L43/50
摘要： A method and apparatus for providing automatic processing of an alarm related to a multicast service in a network are disclosed. For example, the method receives an alarm related to a multicast service, and retrieves multicast data, wherein said multicast data comprises one or more of: a source Internet Protocol (IP) address for a source, a group IP address, and Protocol Independent Multicast (PIM) data. The method retrieves interface information, wherein the interface information comprises one or more of: an interface IP address, a PIM mode, and a Designated Router (DR) IP address. The method retrieves a status of a neighbor of the source in accordance with the source IP address, and determines if a neighbor is established for the source IP address.
摘要翻译：公开了一种用于在网络中提供与多播服务相关的警报的自动处理的方法和装置。例如，该方法接收与多播服务相关的警报，并且检索多播数据，其中所述多播数据包括以下中的一个或多个：源的源互联网协议（IP）地址，组IP地址和协议无关组播（PIM）数据。该方法检索接口信息，其中接口信息包括接口IP地址，PIM模式和指定路由器（DR）IP地址中的一个或多个。该方法根据源IP地址检索源的邻居状态，并确定源IP地址是否建立邻居。

8. 发明授权

US07908519B2 Trouble emulator for a rules-based diagnostic system 失效
标题翻译：基于规则的诊断系统的故障仿真器
公开(公告)号：US07908519B2
公开(公告)日：2011-03-15
申请号：US12275905
申请日：2008-11-21
申请人： Teh-Hsin K Wu , Paritosh Bajpay , Jackson Liu , Zhenzhen Wang
发明人： Teh-Hsin K Wu , Paritosh Bajpay , Jackson Liu , Zhenzhen Wang
IPC分类号： G06F11/00
CPC分类号： H04L41/0663 , G05B23/0278 , H04L41/145 , H04L41/16 , H04L43/0817
摘要： Embodiments of the present invention are directed to validating a rules-based diagnostic system for a network. Emulated data for use by the rules-based diagnostic system can be generated that includes a trouble ticket to emulate a problem associated at least one of Layer 1 and Layer 2 network services and includes network information associated with the problem. Responses from the rules-based diagnostic system can be received in response to the emulated data being processed by the rules-based diagnostic system. A log generated by the rules-based diagnostic system can be analyzed to determine rules implemented by the rules-based diagnostic system in response to the emulated data, thereby validating operation of the rules-based diagnostic system.
摘要翻译：本发明的实施例涉及验证网络的基于规则的诊断系统。可以生成由基于规则的诊断系统使用的仿真数据，其包括故障单以模拟与第1层和第2层网络服务中的至少一个相关联的问题，并且包括与该问题相关联的网络信息。响应于基于规则的诊断系统处理的仿真数据，可以接收基于规则的诊断系统的响应。可以分析由基于规则的诊断系统生成的日志，以确定基于规则的诊断系统响应于仿真数据实现的规则，从而验证基于规则的诊断系统的操作。

9. 发明申请

US20100097944A1 Layer 2 network rule-based non-intrusive testing verification methodology 失效
公开(公告)号：US20100097944A1
公开(公告)日：2010-04-22
申请号：US12288496
申请日：2008-10-21
申请人： Zhenzhen Wang , Paritosh Bajpay , Jackson Liu , Teh-Hsin Wu
发明人： Zhenzhen Wang , Paritosh Bajpay , Jackson Liu , Teh-Hsin Wu
IPC分类号： G06F11/30
CPC分类号： H04L41/5074 , H04L41/0213 , H04L41/5009 , H04L41/507
摘要： Systems and methods are described that that analyze Layer 2 network performance and identify problems without having to disrupt customer service. Embodiments employ a two-phase approach to identify network problems. For an ingress switch, embodiments monitor frame relay Management Information Base (MIB) port and channel objects. A trouble ticket with various test results may be issued and a network work center notified with recommendations that include switch checking, network checking, Layer 1 access testing and network connectivity testing.

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