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1. 发明授权

US5130126A Polymer-drug conjugate and a method of producing it 失效
标题翻译：聚合物 - 药物共轭物及其生产方法
公开(公告)号：US5130126A
公开(公告)日：1992-07-14
申请号：US676384
申请日：1991-03-28
申请人： Yoshiyuki Koyama , Shuji Kojima , Tsuyoshi Miyazaki , Akinori Suginaka , Takeo Matsumoto , Yoshishige Murata
发明人： Yoshiyuki Koyama , Shuji Kojima , Tsuyoshi Miyazaki , Akinori Suginaka , Takeo Matsumoto , Yoshishige Murata
IPC分类号： A61K31/557 , A61K47/48
CPC分类号： A61K47/48215 , A61K31/557 , Y10S514/925
摘要： The present invention provides a polymer-combined drug having directional characteristics to digestive organs, wherein it comprises a medicine combined with a polymer which has an alkyleneoxy group as a repeating unit. The polymer-combined drug is produced by reacting a polyoxyalkylene glycol having one or more terminal functional groups and a medicine, if necessary in a solvent, and if necessary in the presence of a catalyst. It is able to administer the drug orally or by intravenous injection so as to maintain the concentration in blood stably for a long time, and to absorb or take in digestive organs such as the stomach and intestines directly.
摘要翻译：本发明提供了具有消化器官方向特性的聚合物组合药物，其中包含与具有亚烷基氧基作为重复单元的聚合物组合的药物。通过使具有一个或多个末端官能团的聚氧亚烷基二醇和药物（如果需要在溶剂中）和必要时在催化剂存在下反应来制备聚合物组合药物。能够口服给药或静脉注射，以保持血液中的浓度长时间稳定，并直接吸收或摄入消化器官如肠胃。

2. 发明授权

US5478575A Polymers having benzeneboronic acid groups and insulin complexes of same of a sugar response type 失效
标题翻译：具有苯硼酸基团的聚合物和具有糖响应型的相同的胰岛素复合物
公开(公告)号：US5478575A
公开(公告)日：1995-12-26
申请号：US37383
申请日：1993-03-26
申请人： Tsuyoshi Miyazaki , Yoshishige Murata , Daijiro Shiino , Kazunori Waki , Yasuhisa Sakurai , Teruo Okano , Kazunori Kataoka , Yoshiyuki Koyama , Masayuki Yokoyama , Shigeru Kitano
发明人： Tsuyoshi Miyazaki , Yoshishige Murata , Daijiro Shiino , Kazunori Waki , Yasuhisa Sakurai , Teruo Okano , Kazunori Kataoka , Yoshiyuki Koyama , Masayuki Yokoyama , Shigeru Kitano
IPC分类号： A61K9/00 , A61K47/32 , A61K47/36 , A61K47/48 , A61K38/28
CPC分类号： A61K9/0019 , A61K47/32 , A61K47/36 , A61K47/48176 , A61K47/4823 , Y10S514/866
摘要： The present invention provides a polymer complex of a sugar response type having boronic acid groups in the polymer. Medicines may be contained or linked, preferably, the medicines have hydroxy groups. The polymer having boronic acid groups and the medicine having hydroxy groups may be linked by boronic acid ester bonds. The complex may also comprises polymers having boronic acid groups and polymers having hydroxy groups, and these polymers may be cross-linked.
摘要翻译：本发明提供了在聚合物中具有硼酸基团的糖响应型聚合物复合物。药物可以包含或连接，优选地，药物具有羟基。具有硼酸基团的聚合物和具有羟基的药物可以通过硼酸酯键连接。络合物还可以包含具有硼酸基团的聚合物和具有羟基的聚合物，并且这些聚合物可以是交联的。

3. 发明授权

US5461433A Highly hydrous soft contact lens and a treating solution for contact lenses 失效
标题翻译：高含水软性隐形眼镜和隐形眼镜治疗液
公开(公告)号：US5461433A
公开(公告)日：1995-10-24
申请号：US290099
申请日：1994-08-15
申请人： Nobuo Nakabayashi , Kazuhiko Ishihara , Yoshishige Murata , Nobuharu Nakada , Takeo Matsumoto , Yasumi Koinuma
发明人： Nobuo Nakabayashi , Kazuhiko Ishihara , Yoshishige Murata , Nobuharu Nakada , Takeo Matsumoto , Yasumi Koinuma
IPC分类号： C08F230/02 , C11D3/00 , C11D3/37 , G02B1/04 , G02C13/00 , B08B11/00 , C08K5/05
CPC分类号： C11D3/37 , C08F230/02 , C11D3/0078 , G02B1/043 , Y10S525/937
摘要： A highly hydrous soft contact lens comprising a copolymer which contains as an ingredient a monomer having constitution similar to that of phospholipid represented by the following general formula: ##STR1## n is an integer of 1-20, and, R.sub.2, R.sub.3 and R.sub.4 are the same or different groups and alkyl or hydroxyalkyl of 1-8 carbon atoms.Further, a treating solution for contact lenses which comprises a polymer containing as an ingredient the above monomer and a solvent which can dissolve the polymer.
摘要翻译：一种高含水软性隐形眼镜，其包含共聚物，其含有具有与由以下通式表示的磷脂类似的结构的单体作为成分：图像Y是CH 2，CH 2 O，CH 2 CH 2 O，CH 2 CH 2 CH 2 CH 2 O，n 是1-20的整数，R2，R3和R4是相同或不同的基团和1-8个碳原子的烷基或羟烷基。此外，本发明提供一种隐形眼镜用处理液，其包含含有作为上述单体的成分的聚合物和可溶解聚合物的溶剂。

4. 发明授权

US5981786A Process for producing (meth)acrylate derivatives 有权
标题翻译：（甲基）丙烯酸酯衍生物的制造方法
公开(公告)号：US5981786A
公开(公告)日：1999-11-09
申请号：US230605
申请日：1999-01-27
申请人： Shigeru Kitano , Toshihiko Ohta , Hiroshi Suzuki , Akio Hayashi , Yoshishige Murata , Kazuo Matsuyama , Kenichiro Nakamoto
发明人： Shigeru Kitano , Toshihiko Ohta , Hiroshi Suzuki , Akio Hayashi , Yoshishige Murata , Kazuo Matsuyama , Kenichiro Nakamoto
IPC分类号： C07F9/09 , C07F9/6574 , C07F9/10
CPC分类号： C07F9/65742 , C07F9/091
摘要： A process for producing a (meth)acrylate derivative including reacting a compound of formula (1) (wherein R.sup.1 is H or CH.sub.3 ; A is C.sub.1 -C.sub.10 alkylene; and p is 1 to 10) with a chloro-dioxaphosphorus compound of formula (2) (wherein q is 0 or 1) in the presence of a secondary amine of formula (3) (wherein R.sup.2 and R.sub.3 are each C.sub.3 -C.sub.8 alkyl, cycloalkyl, C.sub.6 -C.sub.9 aryl, arylalkyl, etc.) to produce a (meth)acrylate derivative of formula (4) and further reacting the same with a tertiary amine of formula (5) (wherein R.sup.4, R.sup.5 and R.sup.6 are each C.sub.1 -C.sub.4 alkyl etc.) to provide a (meth)acrylate derivative of formula (6). ##STR1##
摘要翻译： PCT No.PCT / JP98 / 02357 Sec。 371日期1999年1月27日第 102（e）日期1999年1月27日PCT提交1998年5月28日PCT公布。公开号WO98 / 54194 日期：1988年12月3日一种制备（甲基）丙烯酸酯衍生物的方法，包括使式（1）的化合物（其中R 1为H或CH 3; A为C 1 -C 10亚烷基; p为1至10）式（2）的二氧杂磷化合物（其中q为0或1）在式（3）的仲胺存在下（其中R 2和R 3各自为C 3 -C 8烷基，环烷基，C 6 -C 9芳基，芳基烷基等））以制备式（4）的（甲基）丙烯酸酯衍生物，并使其与式（5）的叔胺进一步反应（其中R 4，R 5和R 6各自为C 1 -C 4烷基等），以提供（甲基）丙烯酸酯衍生物（6）。

5. 发明授权

US5883152A Contact lens 失效
标题翻译：隐形眼镜
公开(公告)号：US5883152A
公开(公告)日：1999-03-16
申请号：US882660
申请日：1997-06-25
申请人： Keizo Anan , Yoshishige Murata , Naoyuki Amaya , Tuyoshi Miyazaki
发明人： Keizo Anan , Yoshishige Murata , Naoyuki Amaya , Tuyoshi Miyazaki
IPC分类号： C08F222/14 , C08F230/08 , G02B1/04 , G02C7/04 , C08F18/20
CPC分类号： G02B1/043 , C08F222/14 , C08F230/08
摘要： A contact lens contains a copolymer obtained by copolymerizing, as an indispensable feed monomer, 2 to 95 wt. % of a carboxylic acid ester monomer and 98 to 5 wt. % of a copolymerizable monomer. The carboxylic acid ester monomer is represented by the formula (I) ##STR1## wherein R.sub.1 stands for a hydrogen atom, an alkyl group having 1 to 12 carbon atoms, an alkenyl group having 1 to 12 carbon atoms, a cyclic alkyl group having 3 to 12 carbon atoms or an aryl group, and X stands for ##STR2## in which R.sub.2 and R.sub.3 each stand for a hydrogen atom, an alkyl group having 1 to 12 carbon atoms, an alkenyl group having 1 to 12 carbon atoms, a cyclic alkyl group having 3 to 12 carbon atoms or an aryl group, m and 1 being integers of from 0 to 4, at least one of R.sub.1, R.sub.2 and R.sub.3 being a group containing a fluorine atom and n being an integer of from 0 to 4.
摘要翻译：隐形眼镜包含共聚物，其作为不可或缺的进料单体共聚合2〜95重量份。％的羧酸酯单体和98〜5重量％％的可共聚单体。羧酸酯单体由式（I）表示，其中R 1表示氢原子，具有1至12个碳原子的烷基，具有1至12个碳原子的烯基，环烷基具有3至12个碳原子的基团或芳基，X表示其中R 2和R 3各自表示氢原子，具有1至12个碳原子的烷基的或具有1至12个碳原子的烯基，具有3至12个碳原子的环状烷基或芳基，m和1为0至4的整数，R 1，R 2和R 3中的至少一个为含有氟原子，n为0〜4的整数。

6. 发明授权

US4933406A Contact lens article made of silicon- and fluorine-containing resin 失效
标题翻译：由含硅和含氟树脂制成的隐形眼镜制品
公开(公告)号：US4933406A
公开(公告)日：1990-06-12
申请号：US403484
申请日：1989-09-06
申请人： Keizo Anan , Naoyuki Amaya , Yoshishige Murata , Takayuki Otsu , Hiroshi Kawashima , Satoshi Kubota , Masaru Egawa
发明人： Keizo Anan , Naoyuki Amaya , Yoshishige Murata , Takayuki Otsu , Hiroshi Kawashima , Satoshi Kubota , Masaru Egawa
IPC分类号： C08F230/08 , G02B1/04
CPC分类号： G02B1/043 , C08F230/08
摘要： A contact lens article comprises a resin obtained by copolymerizing starting monomer components containing a silicon-containing compound (A) represented by the formula ##STR1## wherein R.sub.1 represents a hydrogen atom or a methyl group, X.sub.1 and X.sub.2 each represent a methyl group or ##STR2## l represents 0 or 1, m represents an integer of 1 to 3 and n and p each represent an integer of 0 to 3; a fluorine-containing compound (B) represented by the formula (II) of: ##STR3## wherein at least one of R.sub.2 and R.sub.3 represents a straight chain or branched chain fluoroalkyl group represented by --C.sub.h H.sub.k F.sub.2h+l-k in which h represents an integer of 2 to 18, k represents an integer of 1 to 2 multiplied by h and when one of R.sub.2 and R.sub.3 is --C.sub.h H.sub.k F.sub.2h+l-k, the other of R.sub.2 and R.sub.3 represents an alkyl group having 1 to 12 carbon atoms, an alkenyl group having 2 to 12 carbon atoms or a cycloalkyl group having 3 to 12 carbon atoms; and a radical polymerizable vinyl monomer.
摘要翻译：隐形眼镜制品包括通过共聚包含由式表示的含硅化合物（A）的起始单体成分得到的树脂，其中R 1表示氢原子或甲基，X 1和X 2各自表示甲基组或 l表示0或1，m表示1至3的整数，n和p各自表示0至3的整数; 由式（II）表示的含氟化合物（B）：其中R 2和R 3中的至少一个表示由-ChHkF 2h + lk表示的直链或支链氟烷基，其中h表示 2〜18，k表示1〜2的整数乘以h，当R2和R3之一为-ChHkF2h + lk时，R2和R3中的另一个为碳原子数1〜12的烷基，烯基为2 至12个碳原子或具有3至12个碳原子的环烷基; 和可自由基聚合的乙烯基单体。

7. 发明授权

US5209847A Ultrathin membrane of polymethacrylate or polycrotonate and device provided with ultrathin membrane 失效
标题翻译：聚甲基丙烯酸酯或聚氯乙烯的超薄膜和超声波膜提供的装置
公开(公告)号：US5209847A
公开(公告)日：1993-05-11
申请号：US590908
申请日：1990-10-01
申请人： Norihiro Kaiya , Naoyuki Amaya , Yoshishige Murata , Mikio Takagi , Kazuichi Tsuda , Kiyotaka Shigehara , Akira Yamada , Takayuki Otsu
发明人： Norihiro Kaiya , Naoyuki Amaya , Yoshishige Murata , Mikio Takagi , Kazuichi Tsuda , Kiyotaka Shigehara , Akira Yamada , Takayuki Otsu
IPC分类号： B05D1/20 , C09K19/56
CPC分类号： B05D1/202 , B82Y30/00 , B82Y40/00 , C09K19/56
摘要： An ultrathin polymeric membrane has a membrane thickness of 10 to 1,000 .ANG.. The membrane is constituted of polycarboxylate and obtained by the spin coating method or by the Langmuir-Blodgett method. The polycarboxylate contains recurrent units represented by the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 represent different groups and each stands for a methyl group or a hydrogen atom, and R represents a hydrocarbon group selected from the group consisting of a branched alkyl group having 3 to 12 carbon atoms, a cycloalkyl group having 3 to 12 carbon atoms, a substituted alkyl group having 2 to 6 carbon atoms, a substituted cycloalkyl group having 3 to 10 carbon atoms and a siloxanic hydrocarbon group.

8. 发明授权

US4948854A Transparent optical article and process for preparing same 失效
标题翻译：透明光学制品及其制备方法
公开(公告)号：US4948854A
公开(公告)日：1990-08-14
申请号：US418813
申请日：1989-10-03
申请人： Naoyuki Amaya , Keizo Anan , Yoshishige Murata , Takao Mogami , Yoshio Sano , Haruhiro Ikebe , Rumiko Seita
发明人： Naoyuki Amaya , Keizo Anan , Yoshishige Murata , Takao Mogami , Yoshio Sano , Haruhiro Ikebe , Rumiko Seita
IPC分类号： C08F22/14 , G02B1/04
CPC分类号： G02B1/04 , C08F22/14
摘要： A transparent optical article is constituted of an optical resin. The optical resin in obtained by polymerizing a feed monomer containing at least a diester of unsaturated dicarboxylic acid selected from the group consisting of itaconic acid, citraconic acid and mesaconic acid. The ester group forming the diester is ##STR1## or R, wherein X represents a halogen atom, m represents zero or an integer of 1 to 5 and R represents an alkyl group having 1 to 12 carbon atoms, an alkenyl group having 1 to 12 carbon atoms or a cycloalkyl group having 3 to 12 carbon atoms. At least one of the ester groups has an aromatic ring defined above.
摘要翻译：透明光学物品由光学树脂构成。通过聚合含有至少选自衣康酸，柠康酸和中康酸的不饱和二羧酸的二酯的进料单体获得的光学树脂。形成二酯的酯基是X或R，其中X表示卤素原子，m表示0或1〜5的整数，R表示碳原子数1〜12的烷基，1〜12的烯基碳原子或碳原子数为3〜12的环烷基。酯基中的至少一个具有上述的芳环。

9. 发明授权

US4930879A Synthetic resin lens 失效
标题翻译：合成树脂镜片
公开(公告)号：US4930879A
公开(公告)日：1990-06-05
申请号：US249314
申请日：1988-09-26
申请人： Takeaki Iryo , Satoshi Kubota , Yoshio Sano , Yoshishige Murata , Yasumi Koinuma
发明人： Takeaki Iryo , Satoshi Kubota , Yoshio Sano , Yoshishige Murata , Yasumi Koinuma
IPC分类号： C09D183/04 , G02B1/04 , G02B1/10
CPC分类号： G02B1/105 , C09D183/04 , G02B1/041
摘要： A Synthetic resin lens having a surface hard coating comprises a synthetic resin lens body and a surface hard coat deposited on the lens body. The synthetic resin lens body is made of a resin obtained by copolymerizing monomers consisting essentially as synthetic resinous components of 10 to 80 percent by weight of at least one diester of itaconic acid and mesaconic acid, 10 to 80 percent by weight of at least one allyl compound and 5 to 50 percent by weight of diethyleneglycol bis(allylcarbonate). The surface hard coat is formed by curing a coating composition comprising 50 to 800 parts by weight of at least one organic silicon compound, 100 parts by weight of colloidal silica, 50 to 600 parts by weight of a polyfunctional compound such as a polyfunctional epoxy compound, a polyalcohol, a polycarboxylic acid, or a polycarboxylic anhydride and 0.01 to 5.0 percent by weight of a curing catalyst based on the residual solids in the composition after curing.
摘要翻译：具有表面硬涂层的合成树脂透镜包括合成树脂透镜体和沉积在透镜体上的表面硬涂层。合成树脂透镜体由以下组成的树脂制成，所述树脂通过共聚基本上由10至80重量％的合成树脂组分组成的单体，至少一种衣康酸和中康酸的二酯，10至80重量％的至少一种烯丙基化合物和5至50重量％的二甘醇双（烯丙基碳酸酯）。表面硬涂层通过固化包含50至800重量份的至少一种有机硅化合物，100重量份胶体二氧化硅，50至600重量份多官能化合物如多官能环氧化合物，多元醇，多元羧酸或多元羧酸酐和0.01-5.0重量％的固化催化剂，基于固化后组合物中的残留固体。

10. 发明授权

US4907038A Langmuir Blodgett ultrathin membrane of polyfumarate 失效
标题翻译： Langmuir Blodgett多功能富马酸超薄膜
公开(公告)号：US4907038A
公开(公告)日：1990-03-06
申请号：US47887
申请日：1987-05-08
申请人： Kiyotaka Shigehara , Akira Yamada , Masahiko Hara , Hidenari Nakahama , Seizo Miyata , Yoshishige Murata
发明人： Kiyotaka Shigehara , Akira Yamada , Masahiko Hara , Hidenari Nakahama , Seizo Miyata , Yoshishige Murata
IPC分类号： B01D69/12 , B05D1/20 , H01L21/28 , H01L21/312 , H01L29/51 , H01L51/30 , H01L51/50
CPC分类号： H01L51/5012 , B01D69/122 , B05D1/202 , B82Y30/00 , B82Y40/00 , H01L21/28167 , H01L21/28264 , H01L21/3128 , H01L29/51 , H01L29/518 , H01L51/0075 , Y10S428/91 , Y10T428/268
摘要： A Langmuir-Blodgett ultrathin membrane is constituted of polyfumarate having a degree of polymerization of 20 to 10,000. The polyfumarate is obtained by polymerizing fumarate represented by the general formula of: ##STR1## wherein at least one of R.sub.1 and R.sub.2 represents a bulky hydrocarbon group such as a branched alkyl group, a cycloalkyl group or a substituent thereof, a fluorine-substituted hydrocarbon group, a hetero atom-containing hydrocarbon group or a silicon-containing group.
摘要翻译： Langmuir-Blodgett超薄膜由聚合度为20〜10,000的聚富马酸盐构成。聚富马酸盐通过聚合由以下通式表示的富马酸盐获得：其中R 1和R 2中的至少一个表示大体积的烃基，例如支链烷基，环烷基或其取代基，氟取代的烃基团，含杂原子的烃基或含硅基团。

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