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1. 发明授权

US06498139B1 Remedies for diseases caused by insulin resistance 失效
标题翻译：治疗由胰岛素抵抗引起的疾病
公开(公告)号：US06498139B1
公开(公告)日：2002-12-24
申请号：US09508691
申请日：2000-03-29
申请人： Yoshio Yazaki , Tomoichiro Asano , Hideo Kubo , Akira Kanda
发明人： Yoshio Yazaki , Tomoichiro Asano , Hideo Kubo , Akira Kanda
IPC分类号： A01N3718
CPC分类号： A61K38/17
摘要： The present invention provides methods of inhibiting or sequestering 14-3-3 protein from binding to the insulin receptor substrate −1 or −2 by administering a substance which inhibits the interaction of these two proteins.
摘要翻译：本发明提供通过施用抑制这两种蛋白质的相互作用的物质来抑制或隔离14-3-3蛋白与胰岛素受体底物-1或-2结合的方法。

2. 发明授权

US4943427A Diagnostic agent for heart disease and use thereof 失效
标题翻译：心脏病诊断剂及其用途
公开(公告)号：US4943427A
公开(公告)日：1990-07-24
申请号：US715815
申请日：1985-03-25
申请人： Yoshio Yazaki , Masahito Sugi
发明人： Yoshio Yazaki , Masahito Sugi
IPC分类号： G01N33/53 , A61K39/395 , A61K49/00 , A61K51/00 , A61K51/10 , C12N15/02 , C12P21/08 , G01N33/573 , G01N33/577 , G01N33/60 , G01N33/68
CPC分类号： G01N33/60 , A61K51/1018 , G01N33/6887 , A61K2123/00 , Y10S530/866
摘要： A diagnostic agent for heart disease comprising a radiolabeled monoclonal antibody having specificity to cardiac myosin heavy chain or its active fragment is disclosed. The diagnostic agent is useful for topographic diagnosis of heart disease such as myocardial infarction and myocardial disease by imaging.
摘要翻译：公开了一种心脏病诊断剂，其包含对心肌肌球蛋白重链或其活性片段具有特异性的放射性标记的单克隆抗体。诊断剂可用于通过成像对心脏病如心肌梗死和心肌疾病的地形诊断。

3. 发明授权

US4716442A Exposure device and exposure control method 失效
标题翻译：曝光装置和曝光控制方法
公开(公告)号：US4716442A
公开(公告)日：1987-12-29
申请号：US832436
申请日：1986-02-24
申请人： Yoshio Yazaki
发明人： Yoshio Yazaki
IPC分类号： G03B27/54 , G03B27/72 , G03F7/20 , H05K3/00
CPC分类号： G03F7/70058 , G03B27/72 , H05K3/0082
摘要： In an exposure device, the light rays emitted from a light source and radiated at an illumination surface, the light rays directly incident to the illuminated surface, the light rays incident to the illuminated surface at greater angles of incidents and the light rays which cause the overexposure of the object to be exposed are interrupted by an optical shielding plate interposed between the light source and the illuminated surface so that the unwanted light rays can be cut-off.The illuminated surface has a specific illumination distribution pattern inherent to the light source used so that the integrated quantities of light rays each incident to each point on the surface of the object to be exposed do not become uniform. According to the present invention, the object to be exposed or reciprocated across the illuminated surface and the angular position of the light sources varied in the forward and return strokes so that the illumination distribution pattern of the exposure light emitted from the light source is also varied. In addition, upon rotation of the light source an angle of incidents of each exposure light ray which is not perpendicular to the surface of the object to be exposed is inclined to the opposite direction to the surface of the object to be exposed.
摘要翻译：在曝光装置中，从光源发射并在照明面发射的光线，直接入射到被照射面的光线，以更大的入射角入射到被照射面的光线，曝光物体的过度曝光被介于光源和照射表面之间的光屏蔽板中断，从而可以切断不想要的光线。被照射的表面具有所使用的光源固有的特定照明分布图案，使得每个入射到被曝光物体表面上的每个点的光线的积分量不变得均匀。根据本发明，在被照射的表面上被曝光或往复运动的物体和光源的角度位置在前进和返回行程中变化，使得从光源发射的曝光光的照明分布图案也变化。此外，在光源旋转时，不垂直于被曝光物体的表面的每个曝光光线的事件角度倾斜于与被曝光物体的表面相反的方向。

4. 发明授权

US5750825A Mouse with defective endotheline-1 gene function 失效
标题翻译：具有缺陷内皮素-1基因功能的小鼠
公开(公告)号：US5750825A
公开(公告)日：1998-05-12
申请号：US325181
申请日：1995-04-24
申请人： Yoshio Yazaki , Hiroki Kurihara , Yukiko Kurihara , Hiroshi Suzuki , Tatsuhiko Kodama
发明人： Yoshio Yazaki , Hiroki Kurihara , Yukiko Kurihara , Hiroshi Suzuki , Tatsuhiko Kodama
IPC分类号： A01K67/027 , C07K14/575 , C12N15/09 , C12N15/85 , C12N5/00 , C12N15/00
CPC分类号： C12N15/8509 , A01K67/0276 , C07K14/57536 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0375
摘要： There is provided a mouse lacking the function of the endotheline-1 gene by insertion of another gene into the endotheline-1 gene. The mouse is useful for elucidation of the pathological physiology and causes of and development of therapies for cardiovascular diseases such as hypertension, arteriosclerosis and ischemic heart disease.
摘要翻译： PCT No.PCT / JP93 / 01522 Sec。 371日期1995年04月24日 102（e）日期1995年4月24日PCT提交1993年10月21日PCT公布。第WO94 / 09621号公报日期1994年5月11日通过将另一基因插入内皮素-1基因，提供缺乏内皮素-1基因功能的小鼠。该小鼠可用于阐明心血管疾病如高血压，动脉硬化和缺血性心脏病的病理生理学及其治疗原因和发展。

5. 发明授权

US4599297A Method of manufacturing printed boards 失效
标题翻译：制造印刷电路板的方法
公开(公告)号：US4599297A
公开(公告)日：1986-07-08
申请号：US448245
申请日：1982-12-09
申请人： Yoshio Yazaki , Shinya Ogawa
发明人： Yoshio Yazaki , Shinya Ogawa
IPC分类号： H05K3/06 , G03F7/16 , G03F7/30 , H05K1/00 , H05K3/00 , G03C11/12
CPC分类号： G03F7/30 , G03F7/161 , H05K3/0073 , H05K3/0097 , H05K1/0393 , H05K2201/0108 , H05K2203/1509 , H05K2203/1545 , H05K2203/1572 , H05K3/0082
摘要： At least one strip of dry film assembly is supplied continuously to a plurality of mutually spaced apart boards which are also being fed continuously. The film assembly consists of a photosensitive layer sandwiched between a protective film and a base. The base is removed from the assembly when the assembly is supplied to the boards, so that each of the boards may be bonded to the photosensitive layer. The boards and the film assembly are fed intermittently, and the photosensitive layer is exposed to light to print a predetermined pattern on each board. The protective film is removed from the film assembly, and each printed board is subjected to developing treatment.
摘要翻译：至少一个干膜组件条被连续地供应到也被连续供给的多个相互间隔开的板。膜组件由夹在保护膜和基底之间的感光层组成。当将组件提供给板时，将基座从组件移除，使得每个板可以结合到感光层。板和膜组件被间歇地进给，并且感光层暴露于光以在每个板上印刷预定图案。从膜组件中取出保护膜，并对每个印刷板进行显影处理。

6. 发明授权

US4241255A Ultraviolet ray projector 失效
标题翻译：紫外线投影机
公开(公告)号：US4241255A
公开(公告)日：1980-12-23
申请号：US2601
申请日：1979-01-11
申请人： Mitsuru Sugiyama , Yoshitake Fukui , Yoshio Yazaki , Haruaki Ono , Shusaku Nakanishi
发明人： Mitsuru Sugiyama , Yoshitake Fukui , Yoshio Yazaki , Haruaki Ono , Shusaku Nakanishi
IPC分类号： B05D3/06 , B44D3/24 , G01J1/00
CPC分类号： B05D3/06 , B44D3/24
摘要： An ultraviolet ray projector comprises a reflector; a mercury lamp disposed in the reflector; a casing having one opening port which receives the reflector and the mercury lamp; a holder connected on an outer wall of the casing.The opening port of the casing has a shielding mechanism for controlling diffusion of ultraviolet rays.
摘要翻译：紫外线投影仪包括反射器; 设置在反射器中的水银灯; 壳体，其具有接收反射器和汞灯的一个开口; 连接在外壳的外壁上的支架。壳体的开口具有用于控制紫外线扩散的屏蔽机构。

7. 发明授权

US4981950A Vasoconstrictor peptide 失效
标题翻译：血管收缩肽
公开(公告)号：US4981950A
公开(公告)日：1991-01-01
申请号：US249429
申请日：1988-09-26
申请人： Tomoh Masaki , Katsutoshi Goto , Sadao Kimura , Youji Mitsui , Yoshio Yazaki , Masashi Yanagisawa , Hiroki Kurihara
发明人： Tomoh Masaki , Katsutoshi Goto , Sadao Kimura , Youji Mitsui , Yoshio Yazaki , Masashi Yanagisawa , Hiroki Kurihara
IPC分类号： A61K38/00 , C07K14/575
CPC分类号： C07K14/57536 , A61K38/00
摘要： Disclosed is a vasoconstrictor peptide called Endothelin having a molecular weight of 2,500.+-.300. Endothelin contains 21 amino acid residues, wherein four cysteines form two sets of S--S bond.In order to obtain the vasoconstrictor factors of the present invention, it is preferable to culture the endothelial cells collected from the vascular inner walls in a serum-free medium.The vasoconstrictor peptides of the present invention can be utilized as hypotension therapeutic agents or local vasoconstrictors to animals including humans.

8. 发明授权

US4721980A Transfer type each-side exposure apparatus 失效
标题翻译：转印式各面曝光装置
公开(公告)号：US4721980A
公开(公告)日：1988-01-26
申请号：US870357
申请日：1986-06-04
申请人： Yoshio Yazaki
发明人： Yoshio Yazaki
IPC分类号： G03F7/20 , H05K3/00 , G03B27/32 , G03B27/52
CPC分类号： G03F7/2022
摘要： Disclosed is a transfer type each-side exposure apparatus which comprises light sources which oppose each other and transfer means which transfer materials to be exposed between the light sources. In one aspect, the apparatus further comprises light shielding means which prevent the passage of the light rays for irradiation as required, and control means which controls the actuation of the light shielding means. In another aspect, the apparatus further comprises reflectors which consist each of a cold mirror. In still another aspect, the apparatus is such that the light sources are each disposed in a manner that a cathode constituting its light emitting portion is displaced by a small distance from one of focal points of a corresponding reflector provided in the light source.
摘要翻译：公开了一种转印型的每一侧曝光装置，其包括彼此相对的光源和转印装置，其转印要在光源之间曝光的材料。一方面，该装置还包括防止根据需要照射光线通过的遮光装置和控制遮光装置的致动的控制装置。在另一方面，该装置还包括由冷镜组成的反射器。另一方面，该装置是这样的，每个光源各自以构成其发光部分的阴极相对于设置在光源中的相应反射器的焦点之一的距离偏移的方式设置。

9. 发明授权

US4565443A Printing apparatus 失效
标题翻译：印刷装置
公开(公告)号：US4565443A
公开(公告)日：1986-01-21
申请号：US656924
申请日：1984-10-02
申请人： Yoshio Yazaki
发明人： Yoshio Yazaki
IPC分类号： G03B27/02 , G03B27/04 , G03F7/20 , H01L21/027 , H05K3/00
CPC分类号： G03B27/04 , H05K3/0082
摘要： A printing apparatus for exposing works, such as printed circuit boards, to light uses a pallet in which a number of works and at least one associated mask are stored. The works are located in stacked relation to one another. The mask is located above the works. The printing apparatus comprises an exposure device including light sources and transparent plates, an admitting device for holding the pallet in an access position and for holding the uppermost one of the mask and works in the pallet at a certain height, a conveying device including a rail extending from the access position to a takeout position past an exposure position at which an exposure operation is performed, and an attraction device including attraction plates having a number of attraction pads mounted to the underside thereof for attracting and holding the mask and works. Each attraction plate is vertically movable while keeping a horizontal posture. The conveying device further includes two cases one of which can reciprocate between the access position and the exposure position along the rail, the other being capable of reciprocating between the exposure position and the takeout position along the rail.
摘要翻译：用于将诸如印刷电路板的工作曝光的打印设备使用其中存储有多个作品和至少一个相关联的掩模的托盘。作品相互重叠。面具位于作品的上方。该打印装置包括一个包括光源和透明板的曝光装置，一个用于将托盘保持在进入位置并用于保持最上面的一个面罩并在一定高度上工作在托盘中的允许装置，一个包括导轨从进入位置延伸到经过曝光操作的曝光位置的取出位置;以及吸引装置，其包括具有安装在其下侧的用于吸引和保持面罩的吸引垫的数量的吸引板并进行工作。每个吸引板在保持水平姿势的同时可垂直移动。输送装置还包括两个壳体，其中一个可沿着轨道在进入位置和曝光位置之间往复运动，另一个能够沿着轨道在曝光位置和取出位置之间往复运动。

10. 发明授权

US4866351A Annular light source unit using electrodeless discharge and a method of lighting the same 失效
标题翻译：使用无电极放电的环形光源单元及其照明方法
公开(公告)号：US4866351A
公开(公告)日：1989-09-12
申请号：US182449
申请日：1988-04-18
申请人： Yoshio Yazaki
发明人： Yoshio Yazaki
IPC分类号： H05B41/24 , F21S2/00 , H01J65/04 , H05B41/16
CPC分类号： H05B41/16
摘要： Disclosed are an annular light source unit using electrodeless discharge and a method of lighting the same. The unit comprises an annular electrodeless discharge tube, a bowl-shaped microwave cavity device, and a plurality of microwave oscillators. The cavity unit is disposed in such a manner as to cover substantially the whole outer surface of the discharge tube excluding an underside thereof. The unit has slit antennas at a plurality of portions thereof prepared by dividing into substantially equal parts a whole circumferential portion thereof facing a whole circumferential surface of the discharge tube. The method comprises the step of individually sequentially starting the operations of the microwave oscillators after the stabilization of the discharge at a portion of the discharge tube in the vicinity of the corresponding slit antenna due to supply, therefrom, of microwave powers transmitted from the immediately preceding microwave oscillator.
摘要翻译：公开了一种使用无电极放电的环形光源单元及其照明方法。该单元包括环形无电极放电管，碗状微波腔装置和多个微波振荡器。空腔单元以除了其下侧以外的基本上覆盖放电管的整个外表面的方式设置。该单元在其多个部分具有狭缝天线，其通过将面向放电管的整个圆周表面的整个周边部分分成大致相等的部分而制备。该方法包括以下步骤：在相应的狭缝天线附近在放电管的一部分处的放电稳定之后，分别依次启动微波振荡器的操作，从而提供从前一个发送的微波功率微波振荡器。

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