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1. 发明授权

US06803383B2 Inhibition of angiogenesis and tumor growth 失效
标题翻译：抑制血管生成和肿瘤生长
公开(公告)号：US06803383B2
公开(公告)日：2004-10-12
申请号：US10240141
申请日：2002-09-27
申请人： Dale L. Boger , David A. Cheresh
发明人： Dale L. Boger , David A. Cheresh
IPC分类号： A01N3718
CPC分类号： C07C237/22 , C07C271/22
摘要： Compounds which inhibit tumor growth and angiogenesis, of general formula (II) are provided. These compounds include glycyl lysine derivatives bound to a central aromatic linking core.
摘要翻译：提供通式（II）抑制肿瘤生长和血管生成的化合物。这些化合物包括与中心芳族连接核心结合的甘氨酰赖氨酸衍生物。

2. 发明授权

US06776994B2 Fungicidal active compound combinations 失效
标题翻译：杀真菌活性化合物组合
公开(公告)号：US06776994B2
公开(公告)日：2004-08-17
申请号：US10022136
申请日：2001-12-13
申请人： Wilhelm Brandes , Heinz-Wilhelm Dehne , Stefan Dutzmann , Karl-Heinz Kuck , Bernd-Wieland Krüger
发明人： Wilhelm Brandes , Heinz-Wilhelm Dehne , Stefan Dutzmann , Karl-Heinz Kuck , Bernd-Wieland Krüger
IPC分类号： A01N3718
CPC分类号： A01N37/24 , A01N59/16 , A01N59/02 , A01N57/12 , A01N55/00 , A01N53/00 , A01N47/38 , A01N47/34 , A01N47/26 , A01N47/20 , A01N47/18 , A01N47/14 , A01N47/04 , A01N43/76 , A01N43/653 , A01N43/64 , A01N43/54 , A01N43/40 , A01N43/36 , A01N43/32 , A01N37/46 , A01N37/38 , A01N37/34 , A01N2300/00
摘要： There are described new active compound combinations of a compound of the formula (I) with known fungicidal active compounds, and their use for the control of phytopathogenic fungi.
摘要翻译：描述了式（I）化合物与已知的杀真菌活性化合物的新的活性化合物组合，以及它们用于控制植物病原真菌的用途。

3. 发明授权

US06730705B1 Alkoximino acetic acid amides 失效
标题翻译：铝肟酸乙酰胺
公开(公告)号：US06730705B1
公开(公告)日：2004-05-04
申请号：US09608864
申请日：2000-06-30
申请人： Thomas Seitz , Gerd Hänssler , Klaus Stenzel
发明人： Thomas Seitz , Gerd Hänssler , Klaus Stenzel
IPC分类号： A01N3718
CPC分类号： C07D277/20 , A01N37/50 , A01N43/08 , A01N43/10 , A01N43/12 , A01N43/38 , A01N43/40 , A01N43/54 , A01N43/78 , C07C251/48 , C07C255/44 , C07C255/62 , C07C323/63 , C07C2601/02 , C07C2601/14 , C07D209/42 , C07D307/54 , C07D333/24 , C07D333/68 , C07D333/70
摘要： The invention relates to new alkoximinoacetic acid amides, a process for their preparation and their use as agents for combating pests.
摘要翻译：本发明涉及新的肟基乙酰胺，其制备方法及其作为防治害虫的药剂。

4. 发明授权

US06710028B2 Method for treating disturbances in iron metabolism using a combination of erythropoietin and iron 有权
标题翻译：使用红细胞生成素和铁的组合治疗铁代谢紊乱的方法
公开(公告)号：US06710028B2
公开(公告)日：2004-03-23
申请号：US10047749
申请日：2001-10-23
申请人： Paul Lehmann
发明人： Paul Lehmann
IPC分类号： A01N3718
CPC分类号： A61K45/06 , A61K38/1816 , A61K33/26 , A61K31/295 , A61K2300/00
摘要： A pharmaceutical composition comprising 250-20,000 U of an EPO preparation and 5-20 mg of a Fe(III) complex is disclosed. This pharmaceutical composition is useful in treating anaemias as well or as haemodialysis patients.
摘要翻译：公开了包含250-20,000U EPO制剂和5-20mg Fe（III）络合物的药物组合物。该药物组合物也用于治疗贫血以及血液透析患者。

5. 发明授权

US06696408B1 Contulakin-G, analogs thereof and uses therefor 有权
公开(公告)号：US06696408B1
公开(公告)日：2004-02-24
申请号：US09606247
申请日：2000-06-29
申请人： A. Grey Craig , David Griffen , Baldomero M. Olivera , Maren Watkins , David R. Hillyard , Julita Imperial , Lourdes J. Cruz , John D. Wagstaff , Richard T. Layer , Robert M. Jones , R. Tyler McCabe
发明人： A. Grey Craig , David Griffen , Baldomero M. Olivera , Maren Watkins , David R. Hillyard , Julita Imperial , Lourdes J. Cruz , John D. Wagstaff , Richard T. Layer , Robert M. Jones , R. Tyler McCabe
IPC分类号： A01N3718
CPC分类号： C07K7/08 , A61K38/00 , C07K9/001 , C07K14/575
摘要： The present invention is directed to contulakin-G (which is the native glycosylated peptide), a des-glycosylated contulakin-G (termed Thr10-contulakin-G), and derivatives thereof, to a cDNA clone encoding a precursor of this mature peptide and to a precursor peptide. The invention is further directed to the use of this peptide as a therapeutic for anti-seizure, anti-inflammatory, anti-shock, anti-thrombus, hypotensive, analgesia, anti-psychotic, Parkinson's disease, gastrointestinal disorders, depressive states, cognitive dysfunction, anxiety, tardive dyskinesia, drug dependency, panic attack, mania, irritable bowel syndrome, diarrhea, ulcer, GI tumors, Tourette's syndrome, Huntington's chorea, vascular leakage, anti-arteriosclerosis, vascular and vasodilation disorders, as well as neurological, neuropharmalogical and neuropsychopharmacological disorders.

6. 发明授权

US06689743B1 Bacillus thuringiensis isolates and toxins 失效
标题翻译：苏云金芽孢杆菌分离株和毒素
公开(公告)号：US06689743B1
公开(公告)日：2004-02-10
申请号：US09706541
申请日：2000-11-03
申请人： Jewel Payne , Kenneth E. Narva , Kendrick Akira Uyeda , Christine Julie Stalder , Tracy Ellis Michaels
发明人： Jewel Payne , Kenneth E. Narva , Kendrick Akira Uyeda , Christine Julie Stalder , Tracy Ellis Michaels
IPC分类号： A01N3718
CPC分类号： C12R1/075 , A01N63/00 , A61K38/00 , C07K14/325 , Y02A50/473
摘要： Disclosed claimed are toxins produced by novel Bacillus thuringiensis isolates designated B.t. PS92J, B.t. PS196S1, B.t. PS201L1, and B.t. PS201T6, which have dipteran and/or corn rootworm activity. Thus, the isolates, or mutants therof, can be used to control such pests. Further, claimed are novel genes encoding these &dgr;-endotoxins, which can be expressed in other hosts. Expression of the &dgr;-endotoxins in such hosts results in the control of susceptible insect pests in the environment of such hosts.
摘要翻译：所公开的是由命名为B.t.的新型苏云金芽孢杆菌分离株产生的毒素。 PS92J，B.t. PS196S1，B.t. PS201L1和B.t. PS201T6，其具有dipteran和/或玉米根虫活性。因此，分离物或突变体可以用于控制这些害虫。此外，要求的是编码这些δ-内毒素的新基因，其可以在其他宿主中表达。这种宿主中δ-内毒素的表达导致对这种宿主环境中易感虫害的控制。

7. 发明授权

US06610748B1 Preventives/remedies for skin aging 有权
标题翻译：皮肤老化的预防/补救措施
公开(公告)号：US06610748B1
公开(公告)日：2003-08-26
申请号：US09622053
申请日：2000-12-15
申请人： Tsuguo Yabuta , Mitsuru Yasumura , Kunio Nakahara , Yusuke Furukawa , Kazuhiko Nomura , Manabu Murakami
发明人： Tsuguo Yabuta , Mitsuru Yasumura , Kunio Nakahara , Yusuke Furukawa , Kazuhiko Nomura , Manabu Murakami
IPC分类号： A01N3718
CPC分类号： A61K38/03 , A61K38/005 , A61K38/04
摘要： A composition for prophylaxis and therapy of dermal aging which comprises a substance having human leukocyte elastase inhibitory activity as an active ingredient.
摘要翻译：用于预防和治疗皮肤老化的组合物，其包含具有人白细胞弹性蛋白酶抑制活性的物质作为活性成分。

8. 发明授权

US06610650B1 Modulation of cellular transcription factor activity 失效
标题翻译：调节细胞转录因子活性
公开(公告)号：US06610650B1
公开(公告)日：2003-08-26
申请号：US09610264
申请日：2000-07-06
申请人： Benget Norden , Pernilla Wittung , Ole Buchardt , Michael Egholm , Peter E. Nielsen , Rolf Berg
发明人： Benget Norden , Pernilla Wittung , Ole Buchardt , Michael Egholm , Peter E. Nielsen , Rolf Berg
IPC分类号： A01N3718
CPC分类号： C12N15/113 , A61K38/00 , B82Y5/00 , C07H21/00 , C07K14/003 , C12N15/1132 , C12N15/1135 , C12N2310/13 , C12N2310/15 , C12N2310/3181 , C12N2310/3513 , C12Q1/6813 , C12Q2525/107 , C12Q2537/119
摘要： A novel class of compounds, known as peptide nucleic acids, form double-stranded structures with one another and with ssDNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
摘要翻译：一类新的化合物，称为肽核酸，形成双链结构，并与ssDNA形成双链结构。肽核酸通常包含配体，例如通过合适的接头连接到肽主链上的天然存在的DNA碱基。

9. 发明授权

US06605588B1 Low density lipoprotein binding proteins and their use in diagnosing and treating atherosclerosis 失效
公开(公告)号：US06605588B1
公开(公告)日：2003-08-12
申请号：US09517849
申请日：2000-03-02
申请人： Ann M. Lees , Robert S. Lees , Simon W. Law , Anibal A. Arjona
发明人： Ann M. Lees , Robert S. Lees , Simon W. Law , Anibal A. Arjona
IPC分类号： A01N3718
CPC分类号： A61K49/0004 , A61K38/00 , A61K39/00 , C07K14/47 , C07K14/705 , G01N33/6893 , G01N33/92 , G01N2800/044 , G01N2800/323 , Y10S514/814
摘要： Isolated polynucleotides encoding novel polypeptides which are capable of binding to native and methylated LDL (low density lipoprotein), the isolated polypeptides, called LBPs (LDL binding proteins), and biologically active fragments and analogs thereof, are described. Also described are methods for determining if an animal is at risk for atherosclerosis, methods for evaluating an agent for use in treating atherosclerosis, methods for treating atherosclerosis, and methods for treating a cell having an abnormality in structure or metabolism of LBP. Pharmaceutical compositions and vaccine compositions are also provided.

10. 发明授权

US06596688B1 Method for promoting hematopoiesis 失效
标题翻译：促进造血的方法
公开(公告)号：US06596688B1
公开(公告)日：2003-07-22
申请号：US09675776
申请日：2000-09-29
申请人： Robert C. Gallo , Joseph Bryant , Yanto Lunardi-Iskandar
发明人： Robert C. Gallo , Joseph Bryant , Yanto Lunardi-Iskandar
IPC分类号： A01N3718
CPC分类号： C07K14/59
摘要： The present invention relates to peptides of one or more portions of the human chorionic gonadotropin &bgr;-chain as well as methods of promoting hematopoiesis, using human chorionic gonadotropin, employing the &bgr;-chain of human chorionic gonadotropin, peptides containing a sequence of one or more portions of the &bgr;-chain of human chorionic gonadotropin and derivatives and analogues thereof. The invention further relates to fractions of sources and or perparations of human chorionic gonadotropin, such as fractions of humna early pregnancy urine, which fractions have pro-hematopoietic activity. The present invention further relates to pharmaceutical compositions for promoting hematopoiesis.
摘要翻译：本发明涉及人绒毛膜促性腺激素β链的一个或多个部分的肽以及使用人绒毛膜促性腺激素促进造血的方法，其使用人绒毛膜促性腺激素的β链，含有一个或多个人绒毛膜促性腺激素的β-链的部分及其衍生物和类似物。本发明进一步涉及人绒毛膜促性腺激素的来源和/或起始部分，例如妊娠期尿液的部分，这些部分具有促造血活性。本发明还涉及用于促进造血作用的药物组合物。

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