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1. 发明授权

US06583490B2 One time programmable semiconductor nonvolatile memory device and method for production of same 有权
公开(公告)号：US06583490B2
公开(公告)日：2003-06-24
申请号：US09888534
申请日：2001-06-26
申请人： Yoshiaki Hagiwara , Hideaki Kuroda , Michitaka Kubota , Akira Nakagawara
发明人： Yoshiaki Hagiwara , Hideaki Kuroda , Michitaka Kubota , Akira Nakagawara
IPC分类号： H01L2900
CPC分类号： G11C17/16 , G11C2213/33 , G11C2213/71 , G11C2213/77 , G11C2213/79 , H01L27/112 , H01L2224/48091 , H01L2225/06568 , H01L2924/13091 , H01L2924/00014 , H01L2924/00
摘要： A semiconductor nonvolatile memory device improving reproducibility and reliability of insulation breakage of a silicon oxide film and capable of reducing the manufacturing cost and a method for production of the same, wherein each of the memory cells arranged in a matrix form has an insulating film breakage type fuse comprising an impurity region of a first conductivity type formed on a semiconductor substrate, a first insulating film formed on the semiconductor substrate while covering the impurity region, an opening formed in the first insulating film so as to reach the impurity region, and a first semiconductor layer of a first conductivity type, a second insulating film, and a second semiconductor layer of a second conductivity type successively stacked in the opening from the impurity region side, or has an insulating film breakage type fuse comprising an impurity region of a first conductivity type in the first semiconductor layer having an SOI structure, a first insulating film on the SOI layer, an opening reaching the impurity region, and a second insulating film and a second semiconductor layer of a second conductivity type stacked in the opening.

2. 发明授权

US06800527B2 One time programmable semiconductor nonvolatile memory device and method for production of same 有权
标题翻译：一次可编程半导体非易失性存储器件及其制造方法
公开(公告)号：US06800527B2
公开(公告)日：2004-10-05
申请号：US10366564
申请日：2003-02-14
申请人： Yoshiaki Hagiwara , Hideaki Kuroda , Michitaka Kubota , Akira Nakagawara
发明人： Yoshiaki Hagiwara , Hideaki Kuroda , Michitaka Kubota , Akira Nakagawara
IPC分类号： H01L218236
CPC分类号： G11C17/16 , G11C2213/33 , G11C2213/71 , G11C2213/77 , G11C2213/79 , H01L27/112 , H01L2224/48091 , H01L2225/06568 , H01L2924/13091 , H01L2924/00014 , H01L2924/00
摘要： A semiconductor nonvolatile memory device improving reproducibility and reliability of insulation breakage of a silicon oxide film and capable of reducing the manufacturing cost and a method for production of the same, wherein each of the memory cells arranged in a matrix form has an insulating film breakage type fuse comprising an impurity region of a first conductivity type formed on a semiconductor substrate, a first insulating film formed on the semiconductor substrate while covering the impurity region, an opening formed in the first insulating film so as to reach the impurity region, and a first semiconductor layer of a first conductivity type, a second insulating film, and a second semiconductor layer of a second conductivity type successively stacked in the opening from the impurity region side, or has an insulating film breakage type fuse comprising an impurity region of a first conductivity type in the first semiconductor layer having an SOI structure, a first insulating film on the SOI layer, an opening reaching the impurity region, and a second insulating film and a second semiconductor layer of a second conductivity type stacked in the opening.
摘要翻译：一种提高氧化硅膜的绝缘破坏的再现性和可靠性的能够降低制造成本的半导体非易失性存储器件及其制造方法，其中以矩阵形式布置的每个存储单元具有绝缘膜破损型保险丝，其包括形成在半导体衬底上的第一导电类型的杂质区，形成在所述半导体衬底上的第一绝缘膜，同时覆盖所述杂质区;形成在所述第一绝缘膜中的开口以到达所述杂质区;以及第一绝缘膜第一导电类型的半导体层，第二绝缘膜和第二导电类型的第二半导体层，其从杂质区侧连续地堆叠在开口中，或者具有包含第一导电性的杂质区的绝缘膜断裂型熔丝键入具有SOI结构的第一半导体层，第一绝缘膜在SOI层上，到达杂质区的开口，以及层叠在开口中的第二绝缘膜和第二导电类型的第二半导体层。

3. 发明申请

US20100055691A1 SCREENING METHOD FOR THERAPEUTIC AGENT FOR AMYOTROPHIC LATERAL SCLEROSIS 审中-公开
标题翻译：用于治疗前列腺切除术的治疗方法的筛选方法
公开(公告)号：US20100055691A1
公开(公告)日：2010-03-04
申请号：US12439760
申请日：2007-08-24
申请人： Akira Nakagawara , Tian-Ling Liu , Tadayuki Koda
发明人： Akira Nakagawara , Tian-Ling Liu , Tadayuki Koda
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N33/6896 , G01N2333/9121 , G01N2800/2814
摘要： The objective of the present invention is to provide methods of screening therapeutic agents for juvenile familial amyotrophic lateral sclerosis (ALS2). The invention provides a method of screening therapeutic agents for juvenile familial amyotrophic lateral sclerosis, comprising a step of assessing a substance that suppresses the expression of Tollip in cells as a therapeutic agent for juvenile familial amyotrophic lateral sclerosis; a method of screening therapeutic agents for juvenile familial amyotrophic lateral sclerosis, comprising a step of assessing a substance that promotes migration of Tollip in cells from the cytoplasm to the cell nucleus as a therapeutic agent for juvenile familial amyotrophic lateral sclerosis; and a method of screening therapeutic agents for juvenile familial amyotrophic lateral sclerosis, comprising a step of assessing a substance that inhibits the interaction between Tollip and IRAK-1 in cells as a therapeutic agent for juvenile familial amyotrophic lateral sclerosis.
摘要翻译：本发明的目的是提供筛选青少年家族性肌萎缩性侧索硬化症（ALS2）的治疗剂的方法。本发明提供一种筛选青少年家族性肌萎缩性侧索硬化症的治疗剂的方法，包括评估抑制作为幼年家族性肌萎缩性侧索硬化症的治疗剂的细胞中Tollip的表达的物质的步骤; 筛选青少年家族性肌萎缩性侧索硬化症的治疗剂的方法，包括评估促进细胞中细胞中Tollip从细胞质迁移到细胞核的物质的步骤，作为青少年家族性肌萎缩性侧索硬化症的治疗剂; 以及筛选用于青少年家族性肌萎缩性侧索硬化症的治疗剂的方法，包括评估抑制细胞中Tollip和IRAK-1之间相互作用的物质作为幼年家族性肌萎缩性侧索硬化症的治疗剂的步骤。

4. 发明申请

US20090269794A1 SCREENING METHOD FOR COMPOUND INHIBITING DEVELOPMENT OR PROGRESSION OF FAMILIAL AMYOTROPHIC LATERAL SCLEROSIS AND DIAGNOSTIC METHOD FOR FAMILIAL AMYOTROPHIC LATERAL SCLEROSIS 审中-公开
标题翻译：化合物抑制家族性间质性黄斑病的发展或进展的筛选方法及家族性间质性黄斑病的诊断方法
公开(公告)号：US20090269794A1
公开(公告)日：2009-10-29
申请号：US12063347
申请日：2006-08-09
申请人： Akira Nakagawara , Keizo Takenaga , Shigenobu Mochizuki
发明人： Akira Nakagawara , Keizo Takenaga , Shigenobu Mochizuki
IPC分类号： C12Q1/02
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要： A screening method comprising the following steps is provided. A step of culturing cells in the presence and in the absence of a test compound, a step of measuring HIF-1α expression in the respective cultured cells, and a step of determining the test compound to be a compound that inhibits onset or progression of familial amyotrophic lateral sclerosis if the HIF-1α expression in the cells cultured in the presence of the test compound is less than the HIF-1α expression in the cells cultured in the absence of the test compound.
摘要翻译：提供了包括以下步骤的筛选方法。在存在和不存在测试化合物的情况下培养细胞的步骤，测量各培养细胞中HIF-1α表达的步骤和测定化合物成为抑制家族性发作或进展的化合物的步骤在受试化合物存在下培养的细胞中HIF-1α表达低于在不存在测试化合物时培养的细胞中的HIF-1α表达，肌萎缩性侧索硬化。

5. 发明授权

US07238796B2 Human BMCC1 gene 有权
标题翻译：人类BMCC1基因
公开(公告)号：US07238796B2
公开(公告)日：2007-07-03
申请号：US10487593
申请日：2002-08-23
申请人： Akira Nakagawara , Masahira Hattori , Yoshiyuki Sakaki
发明人： Akira Nakagawara , Masahira Hattori , Yoshiyuki Sakaki
IPC分类号： C07H21/02
CPC分类号： C07K14/47
摘要： Human BMCC1 protein having an amino acid sequence set forth in SEQ ID NO:1 in the Sequence Listing and its variant protein, as well as human BMCC1 gene having a base sequence set forth in SEQ ID NO:2 in the Sequence Listing and its variant gene.
摘要翻译：具有序列表中SEQ ID NO：1所示的氨基酸序列及其变体蛋白质的人BMCC1蛋白质，以及具有序列表的序列号2所示的碱基序列的人BMCC1基因及其变体基因。

6. 发明申请

US20060240417A1 Agent controlling the apoptosis induction by p73 审中-公开
标题翻译：通过p73控制凋亡诱导的药剂
公开(公告)号：US20060240417A1
公开(公告)日：2006-10-26
申请号：US10502449
申请日：2003-01-23
申请人： Akira Nakagawara
发明人： Akira Nakagawara
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C07K14/4747 , A61K48/00
摘要： Elucidation of the interaction between p73 and ΔNp73 on the genetic and protein level, regulators for p73 or p53 apoptosis-inducing activity, a method of accelerating apoptosis of tumor cells by utilizing the regulators, p53 and p73 transactivation regulators comprising the p73 gene and ΔNp73 gene, nucleic acid pharmaceutical compositions comprising compositions for gene therapy which act as the regulators, and a method of screening for the regulators. By forming a heterooligomer by a substance which binds with ΔNp73 promoter to p73 in an antagonistic manner in tumor cells (for example, nucleic acid including a base sequence which hybridizes to the base sequence listed as SEQ ID NO: 1) to control the promoter activity, it is possible to regulate the apoptosis-inducing activity of p73 and augment apoptosis of the tumor cells.
摘要翻译：阐明p73和DeltaNp73对遗传和蛋白质水平的相互作用，p73或p53凋亡诱导活性的调节因子，通过利用调节剂加速肿瘤细胞凋亡的方法，包含p73基因和DeltaNp73基因的p53和p73转移激活调节物，包含充当调节剂的用于基因治疗的组合物的核酸药物组合物，以及筛选调节剂的方法。通过在肿瘤细胞（例如包含与SEQ ID NO：1所示的碱基序列杂交的碱基序列的核酸）中以拮抗方式与DeltaNp73启动子结合至p73的物质形成异寡聚体以控制启动子活性，可以调节p73的凋亡诱导活性，增加肿瘤细胞的凋亡。

7. 发明授权

US5345416A High density nonvolatile memory and decoder of the same 失效
标题翻译：高密度非易失性存储器和解码器相同
公开(公告)号：US5345416A
公开(公告)日：1994-09-06
申请号：US928442
申请日：1992-08-12
申请人： Akira Nakagawara
发明人： Akira Nakagawara
IPC分类号： G11C17/00 , G11C8/12 , G11C16/02 , G11C16/04 , H01L21/8247 , H01L27/115 , G11C13/00
CPC分类号： H01L27/115 , G11C16/0491 , G11C8/12
摘要： A non-volatile memory comprises memory cells M arranged in a matrix (MB), word lines (W1 to Wn) for row selection, sub-bit lines (B: B12, B21, B22, B31), sub-column lines (C: C11, C12, C22), a column selection circuit 1, a bit line selection circuit 2, and a column line selection circuit 3. The word lines (W1 to Wn) are used as gates common to the rows of the memory cells M, a group of sub-bit lines B and sub-column lines C is selected by the column selection circuit 1, an even-numbered or odd-numbered sub-bit line B is selected from each group and connected to any one of main bit lines (B1, B2 and B3) by the bit line selection circuit 2, and an even-numbered or odd-numbered sub-column line (C) is selected from each group and connected to any one of main column lines (C1 and C2) by the column line selection circuit 3.
摘要翻译：非易失性存储器包括以矩阵（MB）排列的存储单元M，用于行选择的字线（W1至Wn），子位线（B：B12，B21，B22，B31），子列线（C ：C11，C12，C22），列选择电路1，位线选择电路2和列线选择电路3.字线（W1至Wn）用作存储单元M的行共用的门，通过列选择电路1选择一组子位线B和子列线C，从每组中选择偶数或奇数子位线B，并连接到主位由位线选择电路2产生的线（B1，B2和B3），并且从每个组中选择偶数或奇数子列线（C），并连接到主列线（C1和C2）中的任何一个）通过列线选择电路3。

8. 发明授权

US07985556B2 Method of screening apoptosis accelerating compound or anti-apoptotic compound and method of determining malignancy of neurodegenerative disease 有权
标题翻译：筛选凋亡加速化合物或抗凋亡化合物的方法及测定神经退行性疾病恶性肿瘤的方法
公开(公告)号：US07985556B2
公开(公告)日：2011-07-26
申请号：US12063381
申请日：2006-08-09
申请人： Akira Nakagawara , Toshinori Ozaki
发明人： Akira Nakagawara , Toshinori Ozaki
IPC分类号： G01N33/53 , G01N33/567
CPC分类号： G01N33/574 , G01N33/5011 , G01N33/6896 , G01N2333/4748 , G01N2500/02 , G01N2510/00
摘要： Screening methods for determining pro-apoptotic compounds or anti-apoptotic compounds comprise measuring the interaction between p53 and NEDL1 in the presence and in the absence of a test compound, and comparing the strength of interaction between p53 and NEDL1 in the presence and in the absence of the test compound.
摘要翻译：用于测定促凋亡化合物或抗凋亡化合物的筛选方法包括在存在和不存在测试化合物的情况下测量p53和NEDL1之间的相互作用，并且比较p53和NEDL1在存在和不存在下的相互作用强度的试验化合物。

9. 发明授权

US07601532B2 Microarray for predicting the prognosis of neuroblastoma and method for predicting the prognosis of neuroblastoma 有权
标题翻译：用于预测神经母细胞瘤预后的微阵列和预测神经母细胞瘤预后的方法
公开(公告)号：US07601532B2
公开(公告)日：2009-10-13
申请号：US10947249
申请日：2004-09-23
申请人： Akira Nakagawara , Miki Ohira , Shin Ishii , Takeshi Goto , Hiroyuki Kubo , Takahiro Hirata , Yasuko Yoshida , Saichi Yamada
发明人： Akira Nakagawara , Miki Ohira , Shin Ishii , Takeshi Goto , Hiroyuki Kubo , Takahiro Hirata , Yasuko Yoshida , Saichi Yamada
IPC分类号： C12M3/00 , C12M1/34 , C07H21/02 , C07H21/04 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6886 , C12Q2600/118
摘要： A microarray for predicting the prognosis of neuroblastoma, wherein the microarray has 25 to 45 probes related to good prognosis, which are hybridized to a gene transcript whose expression is increased in a good prognosis patient with neuroblastoma and are selected from 96 polynucleotides consisting of the nucleotide sequences of SEQ. ID NOs. 1, 5, 6, 14. 16, 17, 19, 22-24, 28, 29, 31, 37, 39, 40, 43, 44, 47-52, 54, 57-60, 62, 64, 65, 67, 68, 72-75, 77, 78, 80-82, 84, 87, 89-91, 94, 100, 103, 112, 113, 118, 120, 129, 130, 132, 136, 138, 142, 144, 145, 148, 150-153, 155, 158-160, 163-165, 169-171, 173, 174, 177, 178, 180-182, 184, 186, 187, 189, 191, 192, 194, 195, 198-200 or their partial continuous sequences or their complementary strands, and 25 to 45 probes related to poor prognosis, which are hybridized to a gene transcript whose expression is increased in a poor prognosis patient with neuroblastoma and are selected from 104 polynucleotides consisting of the nucleotide sequences of SEQ. ID NOs. 2-4, 7-13, 15, 18, 20, 21, 25-27, 30, 32-36, 38, 41, 42, 45, 46, 53, 55, 56, 61, 63, 66, 69-71, 76, 79, 83, 85, 86, 88, 92, 93, 95-99, 101, 102, 104-111, 114-117, 119, 121-128, 131, 133-135, 137, 139-141, 143, 146, 147, 149, 154, 156, 157, 161, 162, 166-168, 172, 175, 176, 179, 183, 185, 188, 190, 193, 196, 197 or their partial continuous sequences or their complementary strands.
摘要翻译：一种用于预测神经母细胞瘤的预后的微阵列，其中所述微阵列具有与良好预后相关的25至45个探针，其与在具有神经母细胞瘤的良好预后患者中表达增加的基因转录物杂交，并且选自96个由核苷酸 SEQ。身份证号 1，5，6，14，16，17，19，22-24，28，29，31，37，39，40，43，44，47-52，54，57-60，62，64，65， 67，68，72-75，77，78，80-82，84，87，89-91，94，100，103，112，113，118，120，129，130，132，136，138， 144,145,148,150-153,155,158-160,163-165,169-171,173,174,177,178,180-182,184,186,187,189,191,192,194， 195，198-200或其部分连续序列或其互补链，以及与不良预后相关的25至45个探针，其与在具有神经母细胞瘤的不良预后患者中表达增加的基因转录物杂交，并且选自104个多核苷酸的SEQ ID NO：身份证号 2-4，7-13，15，18，20，21，25-27，30，32-36，38，41，42，45，46，53，55，56，61，63，66，69- 71,76,79,83,85,86,88,92,93,95-99,101,102,104-111,114-117,119,121-128,131,133-135,137,139- 141,143,146,147,149,154,156,157,161,162,166-168,172,175,176,179,183,185,188,190,193,196,197或其部分连续序列或其互补链。

10. 发明授权

US07214782B2 Nucleic acid of novel human kinesin-related gene protein encoded by the nucleic acid peptide fragment thereof and anticancer agents comprising the nucleic acid and the like 有权
标题翻译：由其核酸肽片段编码的新型人驱动蛋白相关基因蛋白质的核酸和包含核酸等的抗癌剂
公开(公告)号：US07214782B2
公开(公告)日：2007-05-08
申请号：US10381792
申请日：2001-10-01
申请人： Akira Nakagawara
发明人： Akira Nakagawara
IPC分类号： C07H21/04
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00
摘要： There are provided base sequence data for human kinesin-related genes with a motor domain, as well as information relating to the functions of the proteins encoded by the human kinesin-related gene and the motor domain-lacking human kinesin-related gene, which data may be utilized for diagnosis (for example, judging prognosis of neuroblastoma) and treatment (particularly as antisense nucleic acids for malignant tumors).
摘要翻译：提供了与运动结构域相关的人类驱动蛋白相关基因的碱基序列数据，以及与人驱动蛋白相关基因编码的蛋白质和缺乏运动区的驱动蛋白相关基因的功能相关的信息，该数据可用于诊断（例如，判断神经母细胞瘤的预后）和治疗（特别是用于恶性肿瘤的反义核酸）。

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