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1. 发明申请

US20050287541A1 Microarray for predicting the prognosis of neuroblastoma and method for predicting the prognosis of neuroblastoma 有权
标题翻译：用于预测神经母细胞瘤预后的微阵列和预测神经母细胞瘤预后的方法
公开(公告)号：US20050287541A1
公开(公告)日：2005-12-29
申请号：US10947249
申请日：2004-09-23
申请人： Akira Nakagawara , Miki Ohira , Shin Ishii , Takeshi Goto , Hiroyuki Kubo , Takahiro Hirata , Yasuko Yoshida , Saichi Yamada
发明人： Akira Nakagawara , Miki Ohira , Shin Ishii , Takeshi Goto , Hiroyuki Kubo , Takahiro Hirata , Yasuko Yoshida , Saichi Yamada
IPC分类号： C12M1/34 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6886 , C12Q2600/118
摘要： A microarray for predicting the prognosis of neuroblastoma, wherein the microarray has 25 to 45 probes related to good prognosis, which are hybridized to a gene transcript whose expression is increased in a good prognosis patient with neuroblastoma and are selected from 96 polynucleotides consisting of the nucleotide sequences of Seq. ID No. 1 to 96 or their partial continuous sequences or their complementary strands, and 25 to 45 probes related to poor prognosis, which are hybridized to a gene transcript whose expression is increased in a poor prognosis patient with neuroblastoma and are selected from 104 polynucleotides consisting of the nucleotide sequences of Seq. ID No. 97 to 200 or their partial continuous sequences or their complementary strands.
摘要翻译：一种用于预测神经母细胞瘤的预后的微阵列，其中所述微阵列具有与良好预后相关的25至45个探针，其与在具有神经母细胞瘤的良好预后患者中表达增加的基因转录物杂交，并且选自96个由核苷酸序列Seq。 ID No.1至96或其部分连续序列或其互补链，以及与不良预后相关的25至45个探针，其与在具有神经母细胞瘤的不良预后患者中表达增加的基因转录物杂交并选自104个多核苷酸由Seq的核苷酸序列组成。 ID号97至200或其部分连续序列或其互补链。

2. 发明授权

US07601532B2 Microarray for predicting the prognosis of neuroblastoma and method for predicting the prognosis of neuroblastoma 有权
标题翻译：用于预测神经母细胞瘤预后的微阵列和预测神经母细胞瘤预后的方法
公开(公告)号：US07601532B2
公开(公告)日：2009-10-13
申请号：US10947249
申请日：2004-09-23
申请人： Akira Nakagawara , Miki Ohira , Shin Ishii , Takeshi Goto , Hiroyuki Kubo , Takahiro Hirata , Yasuko Yoshida , Saichi Yamada
发明人： Akira Nakagawara , Miki Ohira , Shin Ishii , Takeshi Goto , Hiroyuki Kubo , Takahiro Hirata , Yasuko Yoshida , Saichi Yamada
IPC分类号： C12M3/00 , C12M1/34 , C07H21/02 , C07H21/04 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6886 , C12Q2600/118
摘要： A microarray for predicting the prognosis of neuroblastoma, wherein the microarray has 25 to 45 probes related to good prognosis, which are hybridized to a gene transcript whose expression is increased in a good prognosis patient with neuroblastoma and are selected from 96 polynucleotides consisting of the nucleotide sequences of SEQ. ID NOs. 1, 5, 6, 14. 16, 17, 19, 22-24, 28, 29, 31, 37, 39, 40, 43, 44, 47-52, 54, 57-60, 62, 64, 65, 67, 68, 72-75, 77, 78, 80-82, 84, 87, 89-91, 94, 100, 103, 112, 113, 118, 120, 129, 130, 132, 136, 138, 142, 144, 145, 148, 150-153, 155, 158-160, 163-165, 169-171, 173, 174, 177, 178, 180-182, 184, 186, 187, 189, 191, 192, 194, 195, 198-200 or their partial continuous sequences or their complementary strands, and 25 to 45 probes related to poor prognosis, which are hybridized to a gene transcript whose expression is increased in a poor prognosis patient with neuroblastoma and are selected from 104 polynucleotides consisting of the nucleotide sequences of SEQ. ID NOs. 2-4, 7-13, 15, 18, 20, 21, 25-27, 30, 32-36, 38, 41, 42, 45, 46, 53, 55, 56, 61, 63, 66, 69-71, 76, 79, 83, 85, 86, 88, 92, 93, 95-99, 101, 102, 104-111, 114-117, 119, 121-128, 131, 133-135, 137, 139-141, 143, 146, 147, 149, 154, 156, 157, 161, 162, 166-168, 172, 175, 176, 179, 183, 185, 188, 190, 193, 196, 197 or their partial continuous sequences or their complementary strands.
摘要翻译：一种用于预测神经母细胞瘤的预后的微阵列，其中所述微阵列具有与良好预后相关的25至45个探针，其与在具有神经母细胞瘤的良好预后患者中表达增加的基因转录物杂交，并且选自96个由核苷酸 SEQ。身份证号 1，5，6，14，16，17，19，22-24，28，29，31，37，39，40，43，44，47-52，54，57-60，62，64，65， 67，68，72-75，77，78，80-82，84，87，89-91，94，100，103，112，113，118，120，129，130，132，136，138， 144,145,148,150-153,155,158-160,163-165,169-171,173,174,177,178,180-182,184,186,187,189,191,192,194， 195，198-200或其部分连续序列或其互补链，以及与不良预后相关的25至45个探针，其与在具有神经母细胞瘤的不良预后患者中表达增加的基因转录物杂交，并且选自104个多核苷酸的SEQ ID NO：身份证号 2-4，7-13，15，18，20，21，25-27，30，32-36，38，41，42，45，46，53，55，56，61，63，66，69- 71,76,79,83,85,86,88,92,93,95-99,101,102,104-111,114-117,119,121-128,131,133-135,137,139- 141,143,146,147,149,154,156,157,161,162,166-168,172,175,176,179,183,185,188,190,193,196,197或其部分连续序列或其互补链。

3. 发明申请

US20070281296A1 Nucleic Acids Isolated From Stage 4 Nueroblastoma 有权
标题翻译：从第4期成骨细胞瘤分离的核酸
公开(公告)号：US20070281296A1
公开(公告)日：2007-12-06
申请号：US10533158
申请日：2003-10-30
申请人： Akira Nakagawara , Miki Ohira
发明人： Akira Nakagawara , Miki Ohira
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： G01N33/57484 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
摘要： Diagnostic agent or kit for the prognosis of neuroblastoma is used to diagnose the prognosis of neuroblastoma (particularly, classifying its progress and determining stage 4s neuroblastoma), which agent or kit comprising a nucleic acid probe, nucleic acid primers, or a nucleic acid microarray utilizing a nucleic acid comprising one sequence selected from the group consisting of nucleic acids set forth in SEQ ID NO:1 to SEQ ID NO:174, a fragment thereof, or a combination of either or both.
摘要翻译：用于神经母细胞瘤预后的诊断剂或试剂盒用于诊断神经母细胞瘤的预后（特别是对其进展进行分类并确定阶段4s神经母细胞瘤），所述试剂或试剂盒包含核酸探针，核酸引物或核酸微阵列，其利用包含选自SEQ ID NO：1至SEQ ID NO：174所示核酸的一个序列的核酸，其片段，或其中任一者或两者的组合。

4. 发明授权

US07429451B2 Nucleic acids isolated from stage 4 neuroblastoma 有权
标题翻译：从第4期神经母细胞瘤分离的核酸
公开(公告)号：US07429451B2
公开(公告)日：2008-09-30
申请号：US10533158
申请日：2003-10-30
申请人： Akira Nakagawara , Miki Ohira
发明人： Akira Nakagawara , Miki Ohira
IPC分类号： C12Q1/68 , C07H21/02
CPC分类号： G01N33/57484 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
摘要： Diagnostic agent or kit for the prognosis of neuroblastoma is used to diagnose the prognosis of neuroblastoma (particularly, classifying its progress and determining stage 4s neuroblastoma), which agent or kit comprising a nucleic acid probe, nucleic acid primers, or a nucleic acid microarray utilizing a nucleic acid comprising one sequence selected from the group consisting of nucleic acids set forth in SEQ ID NO:1 to SEQ ID NO:174, a fragment thereof, or a combination of either or both.
摘要翻译：用于神经母细胞瘤预后的诊断剂或试剂盒用于诊断神经母细胞瘤的预后（特别是对其进展进行分类并确定阶段4s神经母细胞瘤），所述试剂或试剂盒包含核酸探针，核酸引物或核酸微阵列，其利用包含选自SEQ ID NO：1至SEQ ID NO：174所示核酸的一个序列的核酸，其片段，或其中任一者或两者的组合。

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