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1. 发明申请

US20100055691A1 SCREENING METHOD FOR THERAPEUTIC AGENT FOR AMYOTROPHIC LATERAL SCLEROSIS 审中-公开
标题翻译：用于治疗前列腺切除术的治疗方法的筛选方法
公开(公告)号：US20100055691A1
公开(公告)日：2010-03-04
申请号：US12439760
申请日：2007-08-24
申请人： Akira Nakagawara , Tian-Ling Liu , Tadayuki Koda
发明人： Akira Nakagawara , Tian-Ling Liu , Tadayuki Koda
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N33/6896 , G01N2333/9121 , G01N2800/2814
摘要： The objective of the present invention is to provide methods of screening therapeutic agents for juvenile familial amyotrophic lateral sclerosis (ALS2). The invention provides a method of screening therapeutic agents for juvenile familial amyotrophic lateral sclerosis, comprising a step of assessing a substance that suppresses the expression of Tollip in cells as a therapeutic agent for juvenile familial amyotrophic lateral sclerosis; a method of screening therapeutic agents for juvenile familial amyotrophic lateral sclerosis, comprising a step of assessing a substance that promotes migration of Tollip in cells from the cytoplasm to the cell nucleus as a therapeutic agent for juvenile familial amyotrophic lateral sclerosis; and a method of screening therapeutic agents for juvenile familial amyotrophic lateral sclerosis, comprising a step of assessing a substance that inhibits the interaction between Tollip and IRAK-1 in cells as a therapeutic agent for juvenile familial amyotrophic lateral sclerosis.
摘要翻译：本发明的目的是提供筛选青少年家族性肌萎缩性侧索硬化症（ALS2）的治疗剂的方法。本发明提供一种筛选青少年家族性肌萎缩性侧索硬化症的治疗剂的方法，包括评估抑制作为幼年家族性肌萎缩性侧索硬化症的治疗剂的细胞中Tollip的表达的物质的步骤; 筛选青少年家族性肌萎缩性侧索硬化症的治疗剂的方法，包括评估促进细胞中细胞中Tollip从细胞质迁移到细胞核的物质的步骤，作为青少年家族性肌萎缩性侧索硬化症的治疗剂; 以及筛选用于青少年家族性肌萎缩性侧索硬化症的治疗剂的方法，包括评估抑制细胞中Tollip和IRAK-1之间相互作用的物质作为幼年家族性肌萎缩性侧索硬化症的治疗剂的步骤。

2. 发明申请

US20090269794A1 SCREENING METHOD FOR COMPOUND INHIBITING DEVELOPMENT OR PROGRESSION OF FAMILIAL AMYOTROPHIC LATERAL SCLEROSIS AND DIAGNOSTIC METHOD FOR FAMILIAL AMYOTROPHIC LATERAL SCLEROSIS 审中-公开
标题翻译：化合物抑制家族性间质性黄斑病的发展或进展的筛选方法及家族性间质性黄斑病的诊断方法
公开(公告)号：US20090269794A1
公开(公告)日：2009-10-29
申请号：US12063347
申请日：2006-08-09
申请人： Akira Nakagawara , Keizo Takenaga , Shigenobu Mochizuki
发明人： Akira Nakagawara , Keizo Takenaga , Shigenobu Mochizuki
IPC分类号： C12Q1/02
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要： A screening method comprising the following steps is provided. A step of culturing cells in the presence and in the absence of a test compound, a step of measuring HIF-1α expression in the respective cultured cells, and a step of determining the test compound to be a compound that inhibits onset or progression of familial amyotrophic lateral sclerosis if the HIF-1α expression in the cells cultured in the presence of the test compound is less than the HIF-1α expression in the cells cultured in the absence of the test compound.
摘要翻译：提供了包括以下步骤的筛选方法。在存在和不存在测试化合物的情况下培养细胞的步骤，测量各培养细胞中HIF-1α表达的步骤和测定化合物成为抑制家族性发作或进展的化合物的步骤在受试化合物存在下培养的细胞中HIF-1α表达低于在不存在测试化合物时培养的细胞中的HIF-1α表达，肌萎缩性侧索硬化。

3. 发明授权

US07238796B2 Human BMCC1 gene 有权
标题翻译：人类BMCC1基因
公开(公告)号：US07238796B2
公开(公告)日：2007-07-03
申请号：US10487593
申请日：2002-08-23
申请人： Akira Nakagawara , Masahira Hattori , Yoshiyuki Sakaki
发明人： Akira Nakagawara , Masahira Hattori , Yoshiyuki Sakaki
IPC分类号： C07H21/02
CPC分类号： C07K14/47
摘要： Human BMCC1 protein having an amino acid sequence set forth in SEQ ID NO:1 in the Sequence Listing and its variant protein, as well as human BMCC1 gene having a base sequence set forth in SEQ ID NO:2 in the Sequence Listing and its variant gene.
摘要翻译：具有序列表中SEQ ID NO：1所示的氨基酸序列及其变体蛋白质的人BMCC1蛋白质，以及具有序列表的序列号2所示的碱基序列的人BMCC1基因及其变体基因。

4. 发明申请

US20060240417A1 Agent controlling the apoptosis induction by p73 审中-公开
标题翻译：通过p73控制凋亡诱导的药剂
公开(公告)号：US20060240417A1
公开(公告)日：2006-10-26
申请号：US10502449
申请日：2003-01-23
申请人： Akira Nakagawara
发明人： Akira Nakagawara
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C07K14/4747 , A61K48/00
摘要： Elucidation of the interaction between p73 and ΔNp73 on the genetic and protein level, regulators for p73 or p53 apoptosis-inducing activity, a method of accelerating apoptosis of tumor cells by utilizing the regulators, p53 and p73 transactivation regulators comprising the p73 gene and ΔNp73 gene, nucleic acid pharmaceutical compositions comprising compositions for gene therapy which act as the regulators, and a method of screening for the regulators. By forming a heterooligomer by a substance which binds with ΔNp73 promoter to p73 in an antagonistic manner in tumor cells (for example, nucleic acid including a base sequence which hybridizes to the base sequence listed as SEQ ID NO: 1) to control the promoter activity, it is possible to regulate the apoptosis-inducing activity of p73 and augment apoptosis of the tumor cells.
摘要翻译：阐明p73和DeltaNp73对遗传和蛋白质水平的相互作用，p73或p53凋亡诱导活性的调节因子，通过利用调节剂加速肿瘤细胞凋亡的方法，包含p73基因和DeltaNp73基因的p53和p73转移激活调节物，包含充当调节剂的用于基因治疗的组合物的核酸药物组合物，以及筛选调节剂的方法。通过在肿瘤细胞（例如包含与SEQ ID NO：1所示的碱基序列杂交的碱基序列的核酸）中以拮抗方式与DeltaNp73启动子结合至p73的物质形成异寡聚体以控制启动子活性，可以调节p73的凋亡诱导活性，增加肿瘤细胞的凋亡。

5. 发明授权

US5345416A High density nonvolatile memory and decoder of the same 失效
标题翻译：高密度非易失性存储器和解码器相同
公开(公告)号：US5345416A
公开(公告)日：1994-09-06
申请号：US928442
申请日：1992-08-12
申请人： Akira Nakagawara
发明人： Akira Nakagawara
IPC分类号： G11C17/00 , G11C8/12 , G11C16/02 , G11C16/04 , H01L21/8247 , H01L27/115 , G11C13/00
CPC分类号： H01L27/115 , G11C16/0491 , G11C8/12
摘要： A non-volatile memory comprises memory cells M arranged in a matrix (MB), word lines (W1 to Wn) for row selection, sub-bit lines (B: B12, B21, B22, B31), sub-column lines (C: C11, C12, C22), a column selection circuit 1, a bit line selection circuit 2, and a column line selection circuit 3. The word lines (W1 to Wn) are used as gates common to the rows of the memory cells M, a group of sub-bit lines B and sub-column lines C is selected by the column selection circuit 1, an even-numbered or odd-numbered sub-bit line B is selected from each group and connected to any one of main bit lines (B1, B2 and B3) by the bit line selection circuit 2, and an even-numbered or odd-numbered sub-column line (C) is selected from each group and connected to any one of main column lines (C1 and C2) by the column line selection circuit 3.
摘要翻译：非易失性存储器包括以矩阵（MB）排列的存储单元M，用于行选择的字线（W1至Wn），子位线（B：B12，B21，B22，B31），子列线（C ：C11，C12，C22），列选择电路1，位线选择电路2和列线选择电路3.字线（W1至Wn）用作存储单元M的行共用的门，通过列选择电路1选择一组子位线B和子列线C，从每组中选择偶数或奇数子位线B，并连接到主位由位线选择电路2产生的线（B1，B2和B3），并且从每个组中选择偶数或奇数子列线（C），并连接到主列线（C1和C2）中的任何一个）通过列线选择电路3。

6. 发明授权

US07985556B2 Method of screening apoptosis accelerating compound or anti-apoptotic compound and method of determining malignancy of neurodegenerative disease 有权
标题翻译：筛选凋亡加速化合物或抗凋亡化合物的方法及测定神经退行性疾病恶性肿瘤的方法
公开(公告)号：US07985556B2
公开(公告)日：2011-07-26
申请号：US12063381
申请日：2006-08-09
申请人： Akira Nakagawara , Toshinori Ozaki
发明人： Akira Nakagawara , Toshinori Ozaki
IPC分类号： G01N33/53 , G01N33/567
CPC分类号： G01N33/574 , G01N33/5011 , G01N33/6896 , G01N2333/4748 , G01N2500/02 , G01N2510/00
摘要： Screening methods for determining pro-apoptotic compounds or anti-apoptotic compounds comprise measuring the interaction between p53 and NEDL1 in the presence and in the absence of a test compound, and comparing the strength of interaction between p53 and NEDL1 in the presence and in the absence of the test compound.
摘要翻译：用于测定促凋亡化合物或抗凋亡化合物的筛选方法包括在存在和不存在测试化合物的情况下测量p53和NEDL1之间的相互作用，并且比较p53和NEDL1在存在和不存在下的相互作用强度的试验化合物。

7. 发明授权

US07601532B2 Microarray for predicting the prognosis of neuroblastoma and method for predicting the prognosis of neuroblastoma 有权
标题翻译：用于预测神经母细胞瘤预后的微阵列和预测神经母细胞瘤预后的方法
公开(公告)号：US07601532B2
公开(公告)日：2009-10-13
申请号：US10947249
申请日：2004-09-23
申请人： Akira Nakagawara , Miki Ohira , Shin Ishii , Takeshi Goto , Hiroyuki Kubo , Takahiro Hirata , Yasuko Yoshida , Saichi Yamada
发明人： Akira Nakagawara , Miki Ohira , Shin Ishii , Takeshi Goto , Hiroyuki Kubo , Takahiro Hirata , Yasuko Yoshida , Saichi Yamada
IPC分类号： C12M3/00 , C12M1/34 , C07H21/02 , C07H21/04 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6886 , C12Q2600/118
摘要： A microarray for predicting the prognosis of neuroblastoma, wherein the microarray has 25 to 45 probes related to good prognosis, which are hybridized to a gene transcript whose expression is increased in a good prognosis patient with neuroblastoma and are selected from 96 polynucleotides consisting of the nucleotide sequences of SEQ. ID NOs. 1, 5, 6, 14. 16, 17, 19, 22-24, 28, 29, 31, 37, 39, 40, 43, 44, 47-52, 54, 57-60, 62, 64, 65, 67, 68, 72-75, 77, 78, 80-82, 84, 87, 89-91, 94, 100, 103, 112, 113, 118, 120, 129, 130, 132, 136, 138, 142, 144, 145, 148, 150-153, 155, 158-160, 163-165, 169-171, 173, 174, 177, 178, 180-182, 184, 186, 187, 189, 191, 192, 194, 195, 198-200 or their partial continuous sequences or their complementary strands, and 25 to 45 probes related to poor prognosis, which are hybridized to a gene transcript whose expression is increased in a poor prognosis patient with neuroblastoma and are selected from 104 polynucleotides consisting of the nucleotide sequences of SEQ. ID NOs. 2-4, 7-13, 15, 18, 20, 21, 25-27, 30, 32-36, 38, 41, 42, 45, 46, 53, 55, 56, 61, 63, 66, 69-71, 76, 79, 83, 85, 86, 88, 92, 93, 95-99, 101, 102, 104-111, 114-117, 119, 121-128, 131, 133-135, 137, 139-141, 143, 146, 147, 149, 154, 156, 157, 161, 162, 166-168, 172, 175, 176, 179, 183, 185, 188, 190, 193, 196, 197 or their partial continuous sequences or their complementary strands.
摘要翻译：一种用于预测神经母细胞瘤的预后的微阵列，其中所述微阵列具有与良好预后相关的25至45个探针，其与在具有神经母细胞瘤的良好预后患者中表达增加的基因转录物杂交，并且选自96个由核苷酸 SEQ。身份证号 1，5，6，14，16，17，19，22-24，28，29，31，37，39，40，43，44，47-52，54，57-60，62，64，65， 67，68，72-75，77，78，80-82，84，87，89-91，94，100，103，112，113，118，120，129，130，132，136，138， 144,145,148,150-153,155,158-160,163-165,169-171,173,174,177,178,180-182,184,186,187,189,191,192,194， 195，198-200或其部分连续序列或其互补链，以及与不良预后相关的25至45个探针，其与在具有神经母细胞瘤的不良预后患者中表达增加的基因转录物杂交，并且选自104个多核苷酸的SEQ ID NO：身份证号 2-4，7-13，15，18，20，21，25-27，30，32-36，38，41，42，45，46，53，55，56，61，63，66，69- 71,76,79,83,85,86,88,92,93,95-99,101,102,104-111,114-117,119,121-128,131,133-135,137,139- 141,143,146,147,149,154,156,157,161,162,166-168,172,175,176,179,183,185,188,190,193,196,197或其部分连续序列或其互补链。

8. 发明授权

US07214782B2 Nucleic acid of novel human kinesin-related gene protein encoded by the nucleic acid peptide fragment thereof and anticancer agents comprising the nucleic acid and the like 有权
标题翻译：由其核酸肽片段编码的新型人驱动蛋白相关基因蛋白质的核酸和包含核酸等的抗癌剂
公开(公告)号：US07214782B2
公开(公告)日：2007-05-08
申请号：US10381792
申请日：2001-10-01
申请人： Akira Nakagawara
发明人： Akira Nakagawara
IPC分类号： C07H21/04
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00
摘要： There are provided base sequence data for human kinesin-related genes with a motor domain, as well as information relating to the functions of the proteins encoded by the human kinesin-related gene and the motor domain-lacking human kinesin-related gene, which data may be utilized for diagnosis (for example, judging prognosis of neuroblastoma) and treatment (particularly as antisense nucleic acids for malignant tumors).
摘要翻译：提供了与运动结构域相关的人类驱动蛋白相关基因的碱基序列数据，以及与人驱动蛋白相关基因编码的蛋白质和缺乏运动区的驱动蛋白相关基因的功能相关的信息，该数据可用于诊断（例如，判断神经母细胞瘤的预后）和治疗（特别是用于恶性肿瘤的反义核酸）。

9. 发明申请

US20050042613A1 Nucleic acids having expression differentails between hepatoblastoma and normal liver 失效
标题翻译：在肝母细胞瘤和正常肝脏之间具有表达差异的核酸
公开(公告)号：US20050042613A1
公开(公告)日：2005-02-24
申请号：US10487422
申请日：2002-08-26
申请人： Akira Nakagawara
发明人： Akira Nakagawara
IPC分类号： C07K14/47 , C12N15/12 , C12Q1/68 , G01N33/574 , C07H21/04
CPC分类号： G01N33/57496 , C07K14/4748 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158
摘要： A nucleic acid comprising any one of base sequences set forth in SEQ ID NO:1 to NO:104 in the Sequence Listing and a protein encoded by the nucleic acid, particularly a nucleic acid displaying differential expression levels in hepatoblastoma and normal liver based on comparison therebetween and a protein encoded by the nucleic acid as well as tumor detection utilizing the foregoing.
摘要翻译：包含序列表中SEQ ID NO：1至NO：104所示的碱基序列中的任一种的核酸和由核酸编码的蛋白质，特别是基于比较显示肝母细胞瘤和正常肝脏中差异表达水平的核酸和由核酸编码的蛋白质以及利用前述物质的肿瘤检测。

10. 发明授权

US5278089A Method for producing a read-only memory having a plurality of MISFET 失效
标题翻译：一种具有多个MISFET的只读存储器的制造方法
公开(公告)号：US5278089A
公开(公告)日：1994-01-11
申请号：US886737
申请日：1992-05-21
申请人： Akira Nakagawara
发明人： Akira Nakagawara
IPC分类号： G11C17/12 , H01L21/8246 , H01L27/112 , H01L21/70 , H01L27/00
CPC分类号： G11C17/126 , Y10S438/981
摘要： A read-only memory device includes a number of MIS transistors forming memory cells arranged in a matrix configuration to provide a NOR type memory device with high current driving capability for the memory cells. Bit lines and column lines are arrayed alternately in common in each cell column so as to be used in common by adjacent memory cells in the word line extending direction. The bit lines for reading out signals from the memory cells function as the sources or drains of the MIS transistors of the memory cells, whereas the column lines for supplying the constant voltage to the memory cells function as the drains or sources of the MIS transistors of the memory cells. For column selection, there is provided a first selection switch for selecting a group consisting of a plurality of bit lines and a plurality of column lines. A second selection switch and a third selection switch are provided for selecting the bit line and the column line of the group, respectively. The second and the third selection switches may be arranged with a layout allowance and, if these second and third selection switches are formed by MIS transistors similar to those of the memory cells, the direction in common with the memory cells may be the channel direction to contribute to improved circuit integration. The MIS transistor constituting the memory cell may be of such a construction in which the source and drain regions may be provided below the thick insulating film formed on the substrate surface, such as field oxide film.
摘要翻译：只读存储器件包括多个MIS晶体管，形成以矩阵配置布置的存储器单元，以为存储器单元提供具有高电流驱动能力的NOR型存储器件。位线和列线在每个单元列中共同交替排列，以便在字线延伸方向上被相邻存储单元共同使用。用于从存储器单元读出信号的位线用作存储器单元的MIS晶体管的源极或漏极，而用于向存储器单元提供恒定电压的列线用作MIS晶体管的漏极或源极记忆细胞。为了列选择，提供了用于选择由多个位线和多个列线组成的组的第一选择开关。提供第二选择开关和第三选择开关，用于分别选择组的位线和列线。第二选择开关和第三选择开关可以布置为布局容许，并且如果这些第二和第三选择开关由与存储器单元相似的MIS晶体管形成，则与存储单元共同的方向可以是通道方向有助于改善电路集成度。构成存储单元的MIS晶体管可以具有这样的结构，其中源区和漏区可以设置在形成在衬底表面上的厚绝缘膜的下方，例如场氧化物膜。

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