专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20070238769A1 Bone Densifying Agent Characterized By Use Of Cathepsin K Inhibitor With Pth 失效
标题翻译：通过使用组织蛋白酶K抑制剂与Pth特征的骨密度剂
公开(公告)号：US20070238769A1
公开(公告)日：2007-10-11
申请号：US11587557
申请日：2005-04-25
申请人： Yasuo Ochi , Makoto Tanaka , Naoki Kawada , Hiroyuki Yamada , Hiroshi Mori , Ryouji Kayasuga
发明人： Yasuo Ochi , Makoto Tanaka , Naoki Kawada , Hiroyuki Yamada , Hiroshi Mori , Ryouji Kayasuga
IPC分类号： A61K31/426 , A61K31/27
CPC分类号： A61K45/06 , A61K31/4015 , A61K31/426 , A61K31/427 , A61K38/29 , A61K2300/00
摘要： The present invention relates to an agent for increasing BMD characterized by use of a cathepsin K inhibitor as a bone resorption inhibitor in combination with a type of PTH as a bone formation stimulator. This agent for increasing BMD is useful for the treatment of osteoporosis, bone fracture, arthritis, rheumatoid arthritis, osteoarthritis, hypercalcemia, osteometastasis of carcinoma, periodontal disease, bone Paget's disease and other bone metabolic diseases. For example, as the cathepsin K inhibitor, there can be mentioned a compound of formula (W) and a salt thereof, etc.
摘要翻译：本发明涉及用于增加BMD的试剂，其特征在于使用组织蛋白酶K抑制剂作为骨吸收抑制剂与一种PTH作为骨形成刺激剂的组合。用于增加BMD的该药物可用于治疗骨质疏松症，骨折，关节炎，类风湿性关节炎，骨关节炎，高钙血症，癌的骨转移，牙周病，骨佩吉特氏病和其他骨代谢疾病。例如，作为组织蛋白酶K抑制剂，可以举出式（W）的化合物及其盐等。

2. 发明授权

US07632813B2 Bone densifying agent characterized by use of cathepsin K inhibitor with PTH 失效
标题翻译：骨密集剂，其特征在于使用组织蛋白酶K抑制剂与PTH
公开(公告)号：US07632813B2
公开(公告)日：2009-12-15
申请号：US11587557
申请日：2005-04-25
申请人： Yasuo Ochi , Makoto Tanaka , Naoki Kawada , Hiroyuki Yamada , Hiroshi Mori , Ryouji Kayasuga
发明人： Yasuo Ochi , Makoto Tanaka , Naoki Kawada , Hiroyuki Yamada , Hiroshi Mori , Ryouji Kayasuga
IPC分类号： A61K31/70 , A61K31/425
CPC分类号： A61K45/06 , A61K31/4015 , A61K31/426 , A61K31/427 , A61K38/29 , A61K2300/00
摘要： The present invention relates to an agent for increasing BMD characterized by use of a cathepsin K inhibitor as a bone resorption inhibitor in combination with a type of PTH as a bone formation stimulator. This agent for increasing BMD is useful for the treatment of osteoporosis, bone fracture, arthritis, rheumatoid arthritis, osteoarthritis, hypercalcemia, osteometastasis of carcinoma, periodontal disease, bone Paget's disease and other bone metabolic diseases. For example, as the cathepsin K inhibitor, there can be mentioned a compound of formula (W) and a salt thereof, etc.
摘要翻译：本发明涉及用于增加BMD的试剂，其特征在于使用组织蛋白酶K抑制剂作为骨吸收抑制剂与一种PTH作为骨形成刺激剂的组合。用于增加BMD的该药物可用于治疗骨质疏松症，骨折，关节炎，类风湿性关节炎，骨关节炎，高钙血症，癌的骨转移，牙周病，骨佩吉特氏病和其他骨代谢疾病。例如，作为组织蛋白酶K抑制剂，可以举出式（W）的化合物及其盐等。

3. 发明申请

US20070197510A1 Nitriles and medicinal compositions containing the same as the active ingredient 审中-公开
标题翻译：含有与活性成分相同的腈和药物组合物
公开(公告)号：US20070197510A1
公开(公告)日：2007-08-23
申请号：US10592117
申请日：2005-03-09
申请人： Kazuyuki Ohmoto , Katsuya Hisaichi , Motohiro Okuma , Makoto Tanaka , Naoki Kawada
发明人： Kazuyuki Ohmoto , Katsuya Hisaichi , Motohiro Okuma , Makoto Tanaka , Naoki Kawada
IPC分类号： A61K31/5513 , A61K31/5383 , A61K31/52 , A61K31/519 , A61K31/53 , C07D491/02 , C07D487/02 , C07D473/02 , A61K31/428 , A61K31/423
CPC分类号： C07D487/04
摘要： The present invention relates to a compound of formula (I) wherein Y and Z each is independently N or C; ring A is a carbocyclic group or a heterocyclic group; ring B is a heterocyclic group containing at least one nitrogen atom; R is a hydrogen atom, a substitutent, etc.; n is 0, or an integer of from 1 to 10, a salt thereof, a solvate thereof, or an N-oxide thereof, or a prodrug thereof. The compound of formula (I), a salt thereof, a solvate thereof, or an N-oxide thereof, or a prodrug thereof has an inhibitory activity against cysteine protease, and it is useful for the prophylaxis and/or treatment of a cysteine protease-related disease such as osteoporosis, etc.
摘要翻译：本发明涉及式（I）化合物，其中Y和Z各自独立地为N或C; 环A是碳环基或杂环基; 环B是含有至少一个氮原子的杂环基; R是氢原子，取代基等; n为0或1〜10的整数，其盐，其溶剂化物或其N-氧化物，或其前药。式（I）化合物，其盐，其溶剂合物或其N-氧化物或其前药对半胱氨酸蛋白酶具有抑制活性，可用于预防和/或治疗半胱氨酸蛋白酶相关疾病如骨质疏松症等

4. 发明授权

US5356812A Processes for production of optically active 3-phenyl-1,3-propanediol by asymmetric assimilation 失效
标题翻译：通过不对称同化生产光学活性3-苯基-1,3-丙二醇的方法
公开(公告)号：US5356812A
公开(公告)日：1994-10-18
申请号：US844609
申请日：1992-04-07
申请人： Akinobu Matsuyama , Michio Ito , Yoshinori Kobayashi , Naoki Kawada
发明人： Akinobu Matsuyama , Michio Ito , Yoshinori Kobayashi , Naoki Kawada
IPC分类号： C12P7/22 , C12P41/00
CPC分类号： C12P41/001 , C12P7/22 , Y10S435/822 , Y10S435/911
摘要： A microorganism or a preparation thereof is permitted to act on a mixture of enantiomers of 3-phenyl-1, 3-propanediol, and the residual optically active 3-phenyl-1,3-propanediol is harvested.The genera of those microorganisms which are able to leave (R)-3-phenyl-1,3-propanediol include Candida, Hansenula, Rhodotorula, Protaminobacter, Aspergillus, Alternaria, Macrophomina, Preussia and Talaromyces.The genera of those microorganisms which are able to leave (S)-3-phenyl-1,3-propanediol include Candida, Geotrichum, Leucosporidium, Pichia, Torulaspora, Trichosporon, Escherichia, Micrococcus, Corynebacterium, Gordona, Rhodococcus, Aspergillus, Emericella, Absidia, Fusarium, Dactylium, Serratia and Pseudomonas.
摘要翻译： PCT No.PCT / JP91 / 01064 Sec。 371日期：1992年4月7日 102（e）日期1992年4月7日PCT 1991年8月9日PCT PCT。出版物WO92 / 02631 日期：1992年2月20日。允许微生物或其制剂作用于3-苯基-1,3-丙二醇的对映异构体的混合物，并且收集残留的光学活性3-苯基-1,3-丙二醇。能够离开（R）-3-苯基-1,3-丙二醇的那些微生物属包括假丝酵母属，汉逊酵母属，红酵母属，普氏杆菌属，曲霉属，链格孢属，大孔雀类，杜鹃和马鞭草属。能够离开（S）-3-苯基-1,3-丙二醇的那些微生物的属包括假丝酵母属（Candida），地热霉属（Geotrichum），隐孢子虫属（Bottelogporidium），毕赤酵母属（Pichia），孢子虫属（Trichosporon），丝孢杆菌属（Trichosporon），大肠杆菌属（Escherichia），微球菌属，棒状杆菌属，戈尔多纳氏菌属茜草属，镰孢属，睾丸，沙雷氏菌属和假单胞菌属。

5. 外观设计

USD762253S1 Friction stir welding tool 有权
标题翻译：摩擦搅拌焊接工具
公开(公告)号：USD762253S1
公开(公告)日：2016-07-26
申请号：US29411890
申请日：2012-01-27
申请人： Takeshi Ishikawa , Ai Masuda , Naoki Kawada , Kenji Hashimoto , Shigeki Matsuoka
设计人： Takeshi Ishikawa , Ai Masuda , Naoki Kawada , Kenji Hashimoto , Shigeki Matsuoka
CPC分类号： H01T13/12 , H01T13/00

6. 发明授权

US06255092B1 Stereospecific alcohol dehydrogenase isolated from Candida parapsilosis, amino acid and DNA sequences therefor, and method of preparation thereof 失效
标题翻译：从念珠菌分离的立体特异性醇脱氢酶，氨基酸及其DNA序列及其制备方法
公开(公告)号：US06255092B1
公开(公告)日：2001-07-03
申请号：US08855767
申请日：1997-06-11
申请人： Tomoko Kojima , Hiroaki Yamamoto , Naoki Kawada , Akinobu Matsuyama
发明人： Tomoko Kojima , Hiroaki Yamamoto , Naoki Kawada , Akinobu Matsuyama
IPC分类号： C12N904
CPC分类号： C12N9/0006 , C12P7/04 , C12P7/24 , C12P41/002
摘要： The present invention provides a novel secondary alcohol dehydrogenase useful for the synthesis of optically active alcohol and DNA encoding said enzyme. A microorganism belonging to genus Candida was found to produce a novel secondary alcohol dehydrogenase with a high stereochemical specificity. Using said enzyme, optically active alcohols were prepared, and by cloning of DNA encoding said enzyme, the base sequence of said DNA was determined. By providing a novel secondary alcohol dehydrogenase with a high stereochemical specificity and the gene encoding said enzyme, an efficient production of optically active alcohols became possible.
摘要翻译：本发明提供了可用于合成光学活性醇和编码所述酶的DNA的新型仲醇脱氢酶。发现属于念珠菌属的微生物产生具有高立体化学特异性的新型仲醇脱氢酶。使用所述酶制备光学活性醇，通过克隆编码所述酶的DNA，测定所述DNA的碱基序列。通过提供具有高立体化学特异性的新型仲醇脱氢酶和编码所述酶的基因，可以有效地制备光学活性醇。

7. 发明授权

US6027926A Method of producing optically active 1,2,4-butanetriol 失效
标题翻译：光学活性1,2,4丁烷三醇的制备方法
公开(公告)号：US6027926A
公开(公告)日：2000-02-22
申请号：US78461
申请日：1998-05-14
申请人： Naoki Kawada , Rika Kinase
发明人： Naoki Kawada , Rika Kinase
IPC分类号： C12P7/18 , C12P41/00 , C12R1/01 , C12R1/07 , C12R1/685 , C12R1/72 , C12R1/78 , C12N1/14
CPC分类号： C12P7/18 , C12P41/00
摘要： Optically active 1,2,4-butanetriol of high optical purity can be produced economically and simply using a microorganism capable of increasing the content of (S)-1,2,4-butanetriol or (R)-1,2,4-butanetriol by acting on a mixture of enantiomers of 1,2,4-butanetriol.
摘要翻译：光学纯度高的1,2,4-丁三醇可以经济地和简单地使用能够增加（S）-1,2,4-丁三醇或（R）-1,2,4-丁二醇的含量的微生物，丁三醇通过作用于1,2,4-丁三醇的对映异构体的混合物。

8. 发明授权

US5874613A 3-(3-chlorophenyl) serine 失效
标题翻译： 3-（3-氯苯基）丝氨酸
公开(公告)号：US5874613A
公开(公告)日：1999-02-23
申请号：US839215
申请日：1997-04-22
申请人： Teruyuki Nikaido , Naoki Kawada , Takeshi Hamatani , Yoichiro Ueda
发明人： Teruyuki Nikaido , Naoki Kawada , Takeshi Hamatani , Yoichiro Ueda
IPC分类号： C12P13/00 , C12P41/00 , C07C229/00
CPC分类号： C12P13/001 , C12P13/06 , C12P41/00
摘要： Tyrosine decarboxylase, or microorganisms of the genuses Enterococcus, Lactobacillus, Providencia, Fusarium, and Gibberella were reacted with a mixture of the enantiomers of threo-3-phenylserine or its halogen substitution products to produce (R)-2-amino-1-phenylethanol or its halogen substitution products. At the same time, one of the enantiomers of threo-3-phenylserine or its halogen substitution products were selectively left, and optically active threo-3-phenylserine or its halogen substitution products were produced. In addition, a novel material of 3-(3-chlorophenyl)serine, which is a substrate of the reaction in the present invention, was produced. (R)-2-amino-1-phenylethanol or its halogen substitution products, and optically active threo-3-phenylserine or its halogen substitution products can economically be produced on an industrial scale.
摘要翻译：将酪氨酸脱羧酶或肠球菌属，乳杆菌属，普罗威登氏菌属，镰孢属和赤霉属的微生物与苏氨酸-3-苯基丝氨酸或其卤素取代产物的对映异构体的混合物反应以产生（R）-2-氨基-1-苯基乙醇或其卤素取代产物。同时，选择性地残留苏氨酸-3-苯基丝氨酸或其卤素取代产物的对映异构体之一，并制备光学活性的苏氨酸-3-苯基丝氨酸或其卤素取代产物。此外，制备作为本发明的反应的底物的3-（3-氯苯基）丝氨酸的新型材料。（R）-2-氨基-1-苯基乙醇或其卤素取代产物和光学活性的苏氨酸-3-苯基丝氨酸或其卤素取代产物可以经济上以工业规模生产。

9. 发明授权

US5846792A Method of producing (R)-2-amino-1-phenylethanol and opticaly active phenylserine and their halogen substituted products using tyrosine decarboxylase 失效
标题翻译：使用酪氨酸脱羧酶生产（R）-2-氨基-1-苯基乙醇和光学活性苯基丝氨酸及其卤素取代产物的方法
公开(公告)号：US5846792A
公开(公告)日：1998-12-08
申请号：US837887
申请日：1997-04-22
申请人： Teruyuki Nikaido , Naoki Kawada , Takeshi Hamatani , Yoichiro Ueda
发明人： Teruyuki Nikaido , Naoki Kawada , Takeshi Hamatani , Yoichiro Ueda
IPC分类号： C12P13/00 , C12P41/00 , C12P13/04 , C12P13/02
CPC分类号： C12P13/001 , C12P13/06 , C12P41/00
摘要： Tyrosine decarboxylase, or microorganisms of the genuses Enterococcus, Lactobacillus, Providencia, Fusarium, and Gibberella were reacted with a mixture of the enantiomers of threo-3-phenylserine or its halogen substitution products to produce (R)-2-amino-1-phenylethanol or its halogen substitution products. At the same time, one of the enantiomers of threo-3-phenylserine or its halogen substitution products were selectively left, and optically active threo-3-phenylserine or its halogen substitution products were produced. In addition, a novel material of 3-(3-chlorophenyl)serine, which is a substrate of the reaction in the present invention, was produced. (R)-2-amino-1-phenylethanol or its halogen substitution products, and optically active threo-3-phenylserine or its halogen substitution products can economically be produced on an industrial scale.
摘要翻译：将酪氨酸脱羧酶或肠球菌属，乳杆菌属，普罗威登氏菌属，镰孢属和赤霉属的微生物与苏氨酸-3-苯基丝氨酸或其卤素取代产物的对映异构体的混合物反应以产生（R）-2-氨基-1-苯基乙醇或其卤素取代产物。同时，选择性地残留苏氨酸-3-苯基丝氨酸或其卤素取代产物的对映异构体之一，并制备光学活性的苏氨酸-3-苯基丝氨酸或其卤素取代产物。此外，制备作为本发明的反应的底物的3-（3-氯苯基）丝氨酸的新型材料。（R）-2-氨基-1-苯基乙醇或其卤素取代产物和光学活性的苏氨酸-3-苯基丝氨酸或其卤素取代产物可以经济上以工业规模生产。

10. 发明授权

US5702928A Process for producing optically active triazole compounds and method of racemizing optically active triazole compounds 失效
标题翻译：光学活性三唑化合物的制造方法和光学活性三唑化合物的外消旋化方法
公开(公告)号：US5702928A
公开(公告)日：1997-12-30
申请号：US617747
申请日：1996-05-28
申请人： Naoki Kawada , Noritsugu Yamazaki , Takafumi Imoto , Kiyoshi Ikura
发明人： Naoki Kawada , Noritsugu Yamazaki , Takafumi Imoto , Kiyoshi Ikura
IPC分类号： C07D249/08 , C07D521/00 , C12P17/10 , C12P41/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C12P17/10 , C12P41/004
摘要： A process for the asymmetric synthesis of a compound represented by general formula (II-R) easily at a low cost by using a lipase, and a process for producing a compound to be utilized in the above synthesis. ##STR1##
摘要翻译： PCT No.PCT / JP95 / 01416 Sec。 371日期：1996年5月24日 102（e）日期1996年5月24日PCT提交1995年7月17日PCT公布。出版物WO96 / 02664 日期：1996年2月1日通过使用脂肪酶容易地以低成本不对称合成通式（II-R）表示的化合物的方法，以及用于制备上述合成中使用的化合物的方法。（II-R）

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式