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1. 发明申请

US20070197510A1 Nitriles and medicinal compositions containing the same as the active ingredient 审中-公开
标题翻译：含有与活性成分相同的腈和药物组合物
公开(公告)号：US20070197510A1
公开(公告)日：2007-08-23
申请号：US10592117
申请日：2005-03-09
申请人： Kazuyuki Ohmoto , Katsuya Hisaichi , Motohiro Okuma , Makoto Tanaka , Naoki Kawada
发明人： Kazuyuki Ohmoto , Katsuya Hisaichi , Motohiro Okuma , Makoto Tanaka , Naoki Kawada
IPC分类号： A61K31/5513 , A61K31/5383 , A61K31/52 , A61K31/519 , A61K31/53 , C07D491/02 , C07D487/02 , C07D473/02 , A61K31/428 , A61K31/423
CPC分类号： C07D487/04
摘要： The present invention relates to a compound of formula (I) wherein Y and Z each is independently N or C; ring A is a carbocyclic group or a heterocyclic group; ring B is a heterocyclic group containing at least one nitrogen atom; R is a hydrogen atom, a substitutent, etc.; n is 0, or an integer of from 1 to 10, a salt thereof, a solvate thereof, or an N-oxide thereof, or a prodrug thereof. The compound of formula (I), a salt thereof, a solvate thereof, or an N-oxide thereof, or a prodrug thereof has an inhibitory activity against cysteine protease, and it is useful for the prophylaxis and/or treatment of a cysteine protease-related disease such as osteoporosis, etc.
摘要翻译：本发明涉及式（I）化合物，其中Y和Z各自独立地为N或C; 环A是碳环基或杂环基; 环B是含有至少一个氮原子的杂环基; R是氢原子，取代基等; n为0或1〜10的整数，其盐，其溶剂化物或其N-氧化物，或其前药。式（I）化合物，其盐，其溶剂合物或其N-氧化物或其前药对半胱氨酸蛋白酶具有抑制活性，可用于预防和/或治疗半胱氨酸蛋白酶相关疾病如骨质疏松症等

2. 发明申请

US20070232586A1 Hydrazino-Substituted Heterocyclic Nitrile Compounds and Use Thereof 审中-公开
标题翻译：肼基取代的杂环腈化合物及其用途
公开(公告)号：US20070232586A1
公开(公告)日：2007-10-04
申请号：US11587309
申请日：2005-04-20
申请人： Kazuyuki Ohmoto , Akira Hatayama , Katsuya Hisaichi , Makoto Tanaka , Hiroyuki Yamada
发明人： Kazuyuki Ohmoto , Akira Hatayama , Katsuya Hisaichi , Makoto Tanaka , Hiroyuki Yamada
IPC分类号： A61K31/421 , A61K31/426 , A61K31/505 , A61K31/506 , A61K31/53 , C07D239/48 , C07D263/48 , C07D277/20
CPC分类号： C07D487/04 , A61K31/421 , A61K31/426 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/53 , C07D239/42 , C07D239/48 , C07D239/70 , C07D491/048 , Y02A50/411
摘要： A compound having an inhibitory activity against cysteine protease, represented by formula (I): (wherein ring X is a heterocyclic group which may contain 1 to 4 hetero atoms selected from an nitrogen atom(s), a oxygen atom(s) and a sulfur atom(s) which may be oxidized, in addition to said nitrogen atom in the ring; J is a bond or a spacer having from 1 to 8 atoms; R, R1, R2 and R3 is each independently hydrogen atom or a substituent; n is 0 or an integer of 1 to 10), a salt thereof, a solvate thereof, or an N-oxide thereof, or a prodrug thereof; and an agent for prevention and/or treatment for a cysteine protease-related disease, such as osteoporosis, comprising it as an active ingredient are provided.
摘要翻译：由式（I）表示的具有对半胱氨酸蛋白酶的抑制活性的化合物：其中，环X是可以含有1〜4个选自氮原子，氧原子和除了环中的所述氮原子之外，可以被氧化的硫原子; J是具有1至8个原子的键或间隔基; R 1，R 1，R 2， 2和R 3各自独立地为氢原子或取代基; n为0或1〜10的整数），其盐，其溶剂合物或其N-氧化物，或其前药; 并提供了包含其作为活性成分的半胱氨酸蛋白酶相关疾病如骨质疏松症的预防和/或治疗药剂。

3. 发明授权

US5710153A Tetrazole compound 失效
标题翻译：四唑化合物
公开(公告)号：US5710153A
公开(公告)日：1998-01-20
申请号：US712393
申请日：1996-09-11
申请人： Kazuyuki Ohmoto , Makoto Tanaka , Tohru Miyazaki , Hiroyuki Ohno
发明人： Kazuyuki Ohmoto , Makoto Tanaka , Tohru Miyazaki , Hiroyuki Ohno
IPC分类号： C07D257/04 , C07D257/06 , C07D401/04 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D417/12 , C07K5/02 , C07K5/023 , C07K5/06 , A61K31/535 , C07D413/06
CPC分类号： C07D257/04 , C07D257/06 , C07D401/04 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D417/12 , C07K5/0202 , C07K5/06191
摘要： A tetrazole derivatives of formula (I) ##STR1## a non-toxic salt thereof, an acid addition salt thereof or a hydrate thereof which has an inhibitory effect on interleukin-1.beta. converting enzyme (ICE).
摘要翻译：式（I）的四唑衍生物（I）其无毒盐，其酸加成盐或其水合物对白细胞介素-1β转换酶（ICE）具有抑制作用。

4. 发明授权

US06376484B1 Tetrazole compounds and pharmaceutical agents containing such derivative as an active ingredient 失效
标题翻译：含有这种衍生物作为活性成分的四唑化合物和药剂
公开(公告)号：US06376484B1
公开(公告)日：2002-04-23
申请号：US09572569
申请日：2000-05-16
申请人： Kazuyuki Ohmoto , Makoto Tanaka , Tohru Miyazaki , Hiroyuki Ohno
发明人： Kazuyuki Ohmoto , Makoto Tanaka , Tohru Miyazaki , Hiroyuki Ohno
IPC分类号： A61K3155
CPC分类号： C07D257/04 , A61K38/00 , C07D401/06 , C07D403/06 , C07D403/12 , C07D403/14 , C07D413/06 , C07D413/12 , C07D417/06 , C07D417/12 , C07K5/0205 , C07K5/06052 , C07K5/06139
摘要： A tetrazole derivatives of formula (I) wherein R1 is H, alkyl, alkoxy, carbocyclic ring, hetero ring, alkyl or alkoxy substituted by carbocyclic ring or hetero ring, etc.; AA1 is bond or AA2 is bond or AA1 and AA2, together, may have the formula (a); Y is the formula (b) (in which Tet ring is tetrazole; Z is alkylene, alkenylene, O, S, SO, SO2, NR26, methylene in alkylene replaced by O, S, —SO—, —SO2— or —NR26—; E is H, alkyl, COOR27 or in which Cyc is carbocyclic ring or hetero ring); a non-toxic salt thereof, an acid addition salt thereof or a hydrate thereof which has a pharmaceutical agents as an active ingredient. The compound of the formula (I) has an inhibitory effect on interleukin-1&bgr; converting enzyme, therefore, they are useful for prevention and/or treatment of various kinds of inflammatory disease.
摘要翻译：式（I）的四唑衍生物，其中R 1为H，烷基，烷氧基，碳环，杂环，被碳环或杂环取代的烷基或烷氧基等; AA1是键或AA2是键或AA1和AA2，一起可以具有式（a）; Y是式（b）（其中Tet环是四唑; Z是亚烷基，亚烯基，O，S，SO，SO 2，NR 26，亚烷基被O，S，-SO-，-SO 2 - 或-NR 26 - ; E是H，烷基，COOR 27或其中Cyc是碳环或杂环）;其无毒盐，其酸加成盐或其水合物，其具有药剂作为活性成分。式（I）的化合物对白细胞介素-1β转换酶具有抑制作用，因此可用于预防和/或治疗各种炎性疾病。

5. 发明授权

US6136834A Tetrazole compounds and pharmaceutical agents containing such derivative 失效
标题翻译：四唑化合物和含有这种衍生物的药剂
公开(公告)号：US6136834A
公开(公告)日：2000-10-24
申请号：US101004
申请日：1998-06-29
申请人： Kazuyuki Ohmoto , Makoto Tanaka , Tohru Miyazaki , Hiroyuki Ohno
发明人： Kazuyuki Ohmoto , Makoto Tanaka , Tohru Miyazaki , Hiroyuki Ohno
IPC分类号： A61K38/00 , C07D257/04 , C07D401/06 , C07D403/06 , C07D403/12 , C07D403/14 , C07D413/06 , C07D413/12 , C07D417/06 , C07D417/12 , C07K5/02 , C07K5/06 , C07K5/078 , A61K31/41 , A61K47/22 , C07C229/28 , C07C229/34
CPC分类号： C07D257/04 , C07D401/06 , C07D403/06 , C07D403/12 , C07D403/14 , C07D413/06 , C07D413/12 , C07D417/06 , C07D417/12 , C07K5/0205 , C07K5/06052 , C07K5/06139 , A61K38/00
摘要： A tetrazole derivative of formula (I) ##STR1## wherein R is H, alkyl, alkoxy, carbocyclic ring, alkyl or alkoxy substituted by carbocyclic ring;AA.sup.1 and AA.sup.2 is a bond or ##STR2## and ##STR3## respectively, or AA.sup.1 and AA.sup.2, together, may have the formula (a); ##STR4## and Y is formula (b) ##STR5## wherein the Tet ring is tetrazole; Z is alkylene, alkenylene, O, S, SO, SO.sub.2, NR.sup.26, methylene in alkylene replaced by O, S, --SO--, --SO.sub.2 -- or --NR.sup.26 --; and E is H, alkyl, or COOR.sup.27.
摘要翻译： PCT No.PCT / JP96 / 03801 Sec。 371日期1998年6月29日第 102（e）日期1998年6月29日PCT 1996年12月26日PCT公布。公开号WO97 / 24339 日期：1997年10月7日一种式（I）的四唑衍生物，其中R为H，烷基，烷氧基，碳环，被碳环取代的烷基或烷氧基; AA1和AA2分别为或或AA1和AA2一起可以具有式（a）; Y是式（b），其中Tet环是四唑; Z是亚烷基，亚烯基，O，S，SO，SO 2，NR 26，亚烷基被O，S，-SO-，-SO 2 - 或-NR 26 - 取代; 并且E是H，烷基或COOR 27。

6. 发明授权

US07632813B2 Bone densifying agent characterized by use of cathepsin K inhibitor with PTH 失效
标题翻译：骨密集剂，其特征在于使用组织蛋白酶K抑制剂与PTH
公开(公告)号：US07632813B2
公开(公告)日：2009-12-15
申请号：US11587557
申请日：2005-04-25
申请人： Yasuo Ochi , Makoto Tanaka , Naoki Kawada , Hiroyuki Yamada , Hiroshi Mori , Ryouji Kayasuga
发明人： Yasuo Ochi , Makoto Tanaka , Naoki Kawada , Hiroyuki Yamada , Hiroshi Mori , Ryouji Kayasuga
IPC分类号： A61K31/70 , A61K31/425
CPC分类号： A61K45/06 , A61K31/4015 , A61K31/426 , A61K31/427 , A61K38/29 , A61K2300/00
摘要： The present invention relates to an agent for increasing BMD characterized by use of a cathepsin K inhibitor as a bone resorption inhibitor in combination with a type of PTH as a bone formation stimulator. This agent for increasing BMD is useful for the treatment of osteoporosis, bone fracture, arthritis, rheumatoid arthritis, osteoarthritis, hypercalcemia, osteometastasis of carcinoma, periodontal disease, bone Paget's disease and other bone metabolic diseases. For example, as the cathepsin K inhibitor, there can be mentioned a compound of formula (W) and a salt thereof, etc.
摘要翻译：本发明涉及用于增加BMD的试剂，其特征在于使用组织蛋白酶K抑制剂作为骨吸收抑制剂与一种PTH作为骨形成刺激剂的组合。用于增加BMD的该药物可用于治疗骨质疏松症，骨折，关节炎，类风湿性关节炎，骨关节炎，高钙血症，癌的骨转移，牙周病，骨佩吉特氏病和其他骨代谢疾病。例如，作为组织蛋白酶K抑制剂，可以举出式（W）的化合物及其盐等。

7. 发明申请

US20070238769A1 Bone Densifying Agent Characterized By Use Of Cathepsin K Inhibitor With Pth 失效
标题翻译：通过使用组织蛋白酶K抑制剂与Pth特征的骨密度剂
公开(公告)号：US20070238769A1
公开(公告)日：2007-10-11
申请号：US11587557
申请日：2005-04-25
申请人： Yasuo Ochi , Makoto Tanaka , Naoki Kawada , Hiroyuki Yamada , Hiroshi Mori , Ryouji Kayasuga
发明人： Yasuo Ochi , Makoto Tanaka , Naoki Kawada , Hiroyuki Yamada , Hiroshi Mori , Ryouji Kayasuga
IPC分类号： A61K31/426 , A61K31/27
CPC分类号： A61K45/06 , A61K31/4015 , A61K31/426 , A61K31/427 , A61K38/29 , A61K2300/00
摘要： The present invention relates to an agent for increasing BMD characterized by use of a cathepsin K inhibitor as a bone resorption inhibitor in combination with a type of PTH as a bone formation stimulator. This agent for increasing BMD is useful for the treatment of osteoporosis, bone fracture, arthritis, rheumatoid arthritis, osteoarthritis, hypercalcemia, osteometastasis of carcinoma, periodontal disease, bone Paget's disease and other bone metabolic diseases. For example, as the cathepsin K inhibitor, there can be mentioned a compound of formula (W) and a salt thereof, etc.
摘要翻译：本发明涉及用于增加BMD的试剂，其特征在于使用组织蛋白酶K抑制剂作为骨吸收抑制剂与一种PTH作为骨形成刺激剂的组合。用于增加BMD的该药物可用于治疗骨质疏松症，骨折，关节炎，类风湿性关节炎，骨关节炎，高钙血症，癌的骨转移，牙周病，骨佩吉特氏病和其他骨代谢疾病。例如，作为组织蛋白酶K抑制剂，可以举出式（W）的化合物及其盐等。

8. 发明申请

US20130342039A1 Switched Reluctance Motor and Switched Reluctance Motor Drive System 审中-公开
标题翻译：开关磁阻电机和开关磁阻电机驱动系统
公开(公告)号：US20130342039A1
公开(公告)日：2013-12-26
申请号：US13529620
申请日：2012-06-21
申请人： Takashi UMEMORI , Makoto Tanaka
发明人： Takashi UMEMORI , Makoto Tanaka
IPC分类号： H02K19/10
CPC分类号： H02K19/103 , H02K29/03
摘要： A regenerative switched reluctance motor and a motor drive system therefor are provided. The motor has a rotor 33 with stacked rotor units 33a-33d each comprising 2n salient poles and a stator 31 with stacked stator units 31a-31d surrounded by and corresponding to the rotor units and each comprising 4n magnetic poles to form a predetermined gap with the salient poles of the corresponding rotor unit. A first excitation coil 32(A) is wound on every other one of the 4n magnetic poles of each stator unit, while a second excitation coil 32(B) is wound on the remaining magnetic poles thereof. The rotor units are sequentially shifted by a predetermined angle in angular position relative to the stator units. The switched reluctance motor and the motor drive system can efficiently drive the motor and recover regenerative power with little torque ripple and noise.
摘要翻译：提供一种再生式开关磁阻电动机及其电动机驱动系统。电动机具有转子33，转子33具有堆叠的转子单元33a-33d，每个转子单元包括2n个凸极，定子31具有层叠的定子单元31a-31d，该转子单元由转子单元包围并对应于转子单元，每个包括4n个磁极，以形成与相应转子单元的极点。第一励磁线圈32（A）缠绕在每个定子单元的4n个磁极中的每一个上，而第二激励线圈32（B）缠绕在其剩余的磁极上。转子单元相对于定子单元在角度位置顺序地偏移预定的角度。开关磁阻电动机和电机驱动系统可以有效地驱动电机，并以较小的转矩脉动和噪声来恢复再生电力。

9. 发明授权

US08375206B2 Authentication and encryption utilizing command identifiers 失效
标题翻译：使用命令标识符进行认证和加密
公开(公告)号：US08375206B2
公开(公告)日：2013-02-12
申请号：US12709918
申请日：2010-02-22
申请人： Tomoyuki Asano , Yoshihito Ishibashi , Taizo Shirai , Toru Akishita , Masaharu Yoshimori , Makoto Tanaka
发明人： Tomoyuki Asano , Yoshihito Ishibashi , Taizo Shirai , Toru Akishita , Masaharu Yoshimori , Makoto Tanaka
IPC分类号： H04L29/06
CPC分类号： H04L9/3273 , G06F21/10 , G06F21/64 , G11B20/00086 , G11B20/00123 , G11B20/00173 , G11B20/0021 , G11B20/00224 , G11B20/00246 , G11B20/00492 , G11B20/00507 , G11B20/00536 , G11B20/00557 , G11B20/00739 , G11B20/00753 , G11B20/00775 , G11B2020/00057 , H04L9/0625 , H04L9/0637 , H04L9/0643 , H04L9/0897 , H04L9/14 , H04L9/3242 , H04L9/3247 , H04L2209/60
摘要： A data processing system, recording device, data processing method and program providing medium are provided to execute authentication processing and content storing processing between apparatuses. Program localization is employed to restrict access to program content. A plurality of key blocks store key data for authentication processing. Key block designation information is set in a recorder/reproducer, which is configured for executing authentication processing with the recording device by designating a key block. The recorder/reproducer can set a key block for each product, model or the like. In addition, data stored according to a selected key block cannot be utilized in a recorder/reproducer in which a different key block is set. Furthermore, an encryption processing controlling section of a recording device executes control in accordance with a pre-defined setting sequence. Furthermore, an illegal instrument that has not completed the authentication processing can be prevented from utilizing program content.
摘要翻译：提供数据处理系统，记录装置，数据处理方法和程序提供介质，以执行设备之间的认证处理和内容存储处理。使用程序本地化来限制对程序内容的访问。多个密钥块存储用于认证处理的密钥数据。键盘指定信息被设置在记录器/再现器中，其被配置为通过指定键块来执行与记录装置的认证处理。记录器/再现器可以为每个产品，型号等设置一个键块。此外，根据所选择的密钥块存储的数据不能用于设置不同密钥块的记录器/再现器中。此外，记录装置的加密处理控制部分根据预定义的设置顺序执行控制。此外，可以防止未完成认证处理的非法仪器利用程序内容。

10. 发明申请

US20110279977A1 DISPLAY DEVICE AND ELECTRONIC APPARATUS 有权
标题翻译：显示设备和电子设备
公开(公告)号：US20110279977A1
公开(公告)日：2011-11-17
申请号：US13079250
申请日：2011-04-04
申请人： Makoto Tanaka
发明人： Makoto Tanaka
IPC分类号： H05K7/20
CPC分类号： G06F1/203
摘要： According to one embodiment, an electronic apparatus includes a housing including an outlet, a cooling fan in the housing, a component in the housing configured to serve as a wall guiding air from the cooling fan to the outlet, and a wind shielding portion between the component and an inner surface of the housing.
摘要翻译：根据一个实施例，一种电子设备包括壳体，其包括出口，壳体中的冷却风扇，壳体中的部件，构造成用作将空气从冷却风扇引导到出口的壁，以及风屏蔽部分部件和壳体的内表面。

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