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1. 发明授权

US5731175A Method of producing (R)-2-amino-1-phenylethanol and optically active phenylserine and their halogen substituted products using microbes 失效
标题翻译：使用微生物制备（R）-2-氨基-1-苯基乙醇和光学活性苯基丝氨酸及其卤素取代产物的方法
公开(公告)号：US5731175A
公开(公告)日：1998-03-24
申请号：US696844
申请日：1996-08-29
申请人： Teruyuki Nikaido , Naoki Kawada , Takeshi Hamatani , Yoichiro Ueda
发明人： Teruyuki Nikaido , Naoki Kawada , Takeshi Hamatani , Yoichiro Ueda
IPC分类号： C12P13/00 , C12P41/00 , C12P13/04
CPC分类号： C12P13/001 , C12P13/06 , C12P41/00
摘要： Tyrosine decarboxylase, or microorganisms of the genuses Enterococcus, Lactobacillus, Providencia, Fusarium, and Gibberella were reacted with a mixture of the enantiomers of threo-3-phenylserine or its halogen substitution products to produce (R)-2-amino-1-phenylethanol or its halogen substitution products. At the same time, one of the enantiomers of threo-3-phenylserine or its halogen substitution products were selectively left, and optically active threo-3-phenylserine or its halogen substitution products were produced. In addition, a novel material of 3-(3-chlorophenyl)serine, which is a substrate of the reaction in the present invention, was produced. (R)-2-amino-1-phenylethanol or its halogen substitution products, and optically active threo-3-phenylserine or its halogen substitution products can economically be produced on an industrial scale.
摘要翻译： PCT No.PCT / JP95 / 00337 Sec。 371日期：1996年8月29日 102（e）日期1996年8月29日PCT 1995年3月2日PCT公布。 WO95 / 23869 PCT公开号日期1995年9月8日将酪氨酸脱羧酶或肠球菌属，乳杆菌属，普罗威登氏菌属，镰刀菌属和赤霉菌属的微生物与苏氨酸-3-苯基丝氨酸或其卤素取代产物的对映异构体的混合物反应以产生（R）-2- 氨基-1-苯基乙醇或其卤素取代产物。同时，选择性地残留苏氨酸-3-苯基丝氨酸或其卤素取代产物的对映异构体之一，并制备光学活性的苏氨酸-3-苯基丝氨酸或其卤素取代产物。此外，制备作为本发明的反应的底物的3-（3-氯苯基）丝氨酸的新型材料。（R）-2-氨基-1-苯基乙醇或其卤素取代产物和光学活性的苏氨酸-3-苯基丝氨酸或其卤素取代产物可以经济上以工业规模生产。

2. 发明授权

US5874613A 3-(3-chlorophenyl) serine 失效
标题翻译： 3-（3-氯苯基）丝氨酸
公开(公告)号：US5874613A
公开(公告)日：1999-02-23
申请号：US839215
申请日：1997-04-22
申请人： Teruyuki Nikaido , Naoki Kawada , Takeshi Hamatani , Yoichiro Ueda
发明人： Teruyuki Nikaido , Naoki Kawada , Takeshi Hamatani , Yoichiro Ueda
IPC分类号： C12P13/00 , C12P41/00 , C07C229/00
CPC分类号： C12P13/001 , C12P13/06 , C12P41/00
摘要： Tyrosine decarboxylase, or microorganisms of the genuses Enterococcus, Lactobacillus, Providencia, Fusarium, and Gibberella were reacted with a mixture of the enantiomers of threo-3-phenylserine or its halogen substitution products to produce (R)-2-amino-1-phenylethanol or its halogen substitution products. At the same time, one of the enantiomers of threo-3-phenylserine or its halogen substitution products were selectively left, and optically active threo-3-phenylserine or its halogen substitution products were produced. In addition, a novel material of 3-(3-chlorophenyl)serine, which is a substrate of the reaction in the present invention, was produced. (R)-2-amino-1-phenylethanol or its halogen substitution products, and optically active threo-3-phenylserine or its halogen substitution products can economically be produced on an industrial scale.
摘要翻译：将酪氨酸脱羧酶或肠球菌属，乳杆菌属，普罗威登氏菌属，镰孢属和赤霉属的微生物与苏氨酸-3-苯基丝氨酸或其卤素取代产物的对映异构体的混合物反应以产生（R）-2-氨基-1-苯基乙醇或其卤素取代产物。同时，选择性地残留苏氨酸-3-苯基丝氨酸或其卤素取代产物的对映异构体之一，并制备光学活性的苏氨酸-3-苯基丝氨酸或其卤素取代产物。此外，制备作为本发明的反应的底物的3-（3-氯苯基）丝氨酸的新型材料。（R）-2-氨基-1-苯基乙醇或其卤素取代产物和光学活性的苏氨酸-3-苯基丝氨酸或其卤素取代产物可以经济上以工业规模生产。

3. 发明授权

US5846792A Method of producing (R)-2-amino-1-phenylethanol and opticaly active phenylserine and their halogen substituted products using tyrosine decarboxylase 失效
标题翻译：使用酪氨酸脱羧酶生产（R）-2-氨基-1-苯基乙醇和光学活性苯基丝氨酸及其卤素取代产物的方法
公开(公告)号：US5846792A
公开(公告)日：1998-12-08
申请号：US837887
申请日：1997-04-22
申请人： Teruyuki Nikaido , Naoki Kawada , Takeshi Hamatani , Yoichiro Ueda
发明人： Teruyuki Nikaido , Naoki Kawada , Takeshi Hamatani , Yoichiro Ueda
IPC分类号： C12P13/00 , C12P41/00 , C12P13/04 , C12P13/02
CPC分类号： C12P13/001 , C12P13/06 , C12P41/00
摘要： Tyrosine decarboxylase, or microorganisms of the genuses Enterococcus, Lactobacillus, Providencia, Fusarium, and Gibberella were reacted with a mixture of the enantiomers of threo-3-phenylserine or its halogen substitution products to produce (R)-2-amino-1-phenylethanol or its halogen substitution products. At the same time, one of the enantiomers of threo-3-phenylserine or its halogen substitution products were selectively left, and optically active threo-3-phenylserine or its halogen substitution products were produced. In addition, a novel material of 3-(3-chlorophenyl)serine, which is a substrate of the reaction in the present invention, was produced. (R)-2-amino-1-phenylethanol or its halogen substitution products, and optically active threo-3-phenylserine or its halogen substitution products can economically be produced on an industrial scale.
摘要翻译：将酪氨酸脱羧酶或肠球菌属，乳杆菌属，普罗威登氏菌属，镰孢属和赤霉属的微生物与苏氨酸-3-苯基丝氨酸或其卤素取代产物的对映异构体的混合物反应以产生（R）-2-氨基-1-苯基乙醇或其卤素取代产物。同时，选择性地残留苏氨酸-3-苯基丝氨酸或其卤素取代产物的对映异构体之一，并制备光学活性的苏氨酸-3-苯基丝氨酸或其卤素取代产物。此外，制备作为本发明的反应的底物的3-（3-氯苯基）丝氨酸的新型材料。（R）-2-氨基-1-苯基乙醇或其卤素取代产物和光学活性的苏氨酸-3-苯基丝氨酸或其卤素取代产物可以经济上以工业规模生产。

4. 发明申请

US20090203096A1 Process for Production of Optically Active Alcohol 审中-公开
标题翻译：光活性醇生产工艺
公开(公告)号：US20090203096A1
公开(公告)日：2009-08-13
申请号：US12227981
申请日：2007-06-05
申请人： Motoko Hayashi , Teruyuki Nikaido , Hiroaki Yamamoto
发明人： Motoko Hayashi , Teruyuki Nikaido , Hiroaki Yamamoto
IPC分类号： C12P7/04
CPC分类号： C12P7/04 , C12N9/0006 , C12N9/0008
摘要： The present invention provides methods for producing (S)-1,1,1-trifluoro-2-propanol, which include the step of reacting an enzyme of any one of alcohol dehydrogenase CpSADH, alcohol dehydrogenase ReSADH, carbonyl reductase ScoPAR, (2S,3S)-butanediol dehydrogenase ZraSBDH, carbonyl reductase ScGCY1, tropinone reductase HnTR1, tropinone reductase DsTR1, or alcohol dehydrogenase BstADHT, a microorganism or a transformant strain that functionally expresses the enzyme, or a processed material thereof, with 1,1,1-trifluoroacetone. The present invention also provides methods for producing (R)-1,1,1-trifluoro-2-propanol, which include the step of reacting alcohol dehydrogenase PfODH, a microorganism or a transformant strain that functionally expresses the enzyme, or a processed material thereof, with 1,1,1-trifluoroacetone.
摘要翻译：本发明提供了制备（S）-1,1,1-三氟-2-丙醇的方法，其包括使任何一种醇脱氢酶CpSADH，醇脱氢酶ReSADH，羰基还原酶ScoPAR，（2S， 3S） - 丁二醇脱氢酶ZraSBDH，羰基还原酶ScGCY1，托品酮还原酶HnTR1，托替罗还原酶DsTR1或醇脱氢酶BstADHT，一种功能性表达该酶的微生物或转化体菌株或其加工物与1,1,1-三氟丙酮。本发明还提供了制备（R）-1,1,1-三氟-2-丙醇的方法，其包括使醇脱氢酶PfODH，功能性表达酶的微生物或转化体菌株或加工物质与1,1,1-三氟丙酮反应。

5. 发明授权

US6015698A Method of producing D-amino acid and method of producing amine 失效
标题翻译： D-氨基酸的制备方法和制备胺的方法
公开(公告)号：US6015698A
公开(公告)日：2000-01-18
申请号：US23884
申请日：1998-02-13
申请人： Teruyuki Nikaido
发明人： Teruyuki Nikaido
IPC分类号： C12P13/22 , C12P41/00 , C12R1/645 , C12R1/66 , C12R1/69 , C12R1/77 , C12P13/04
CPC分类号： C12P41/001 , C12P13/22
摘要： D-amino acid with high optical purity represented by formula (1-A) and/or formula (1-B), ##STR1## wherein R represents H or OH, ##STR2## wherein R.sub.1, R.sub.2 each represents H or OH, and amine represented by formula (2-A) and/or formula (2-B) ##STR3## wherein R represents H or OH, ##STR4## wherein R.sub.1 and R.sub.2 each represents H or OH, can be produced economically in an industrial scale by contacting a mixture of enantiomers of amino acid represented by the above formula (1-A) and/or formula (1-B) with a microorganism capable of selectively degrading L-amino acid or with at least one of the treated products of the microorganism.
摘要翻译：由式（1-A）和/或式（1-B）表示的具有高光学纯度的D-氨基酸，其中R表示H或OH，其中R1，R2各自表示H或OH，和由式（2）表示的胺 -A）和/或其中R表示H或OH的式（2-B），其中R 1和R 2各自表示H或OH，可以在工业规模上通过将由上述表示的氨基酸的对映异构体的混合物式（1-A）和/或式（1-B）与能够选择性降解L-氨基酸的微生物或微生物的至少一种处理产物。

6. 发明授权

US5371014A Process for the production of optically active 2-hydroxy acid esters using microbes to reduce the 2-oxo precursor 失效
标题翻译：使用微生物生产光学活性的2-羟基酸酯以还原2-氧代前体的方法
公开(公告)号：US5371014A
公开(公告)日：1994-12-06
申请号：US139878
申请日：1993-10-22
申请人： Akinobu Matsuyama , Teruyuki Nikaido , Yoshinori Kobayashi
发明人： Akinobu Matsuyama , Teruyuki Nikaido , Yoshinori Kobayashi
IPC分类号： C12P7/62 , C12P41/00
CPC分类号： C12P7/62 , Y10S435/822 , Y10S435/911
摘要： An optically active 2-hydroxy acid derivative is produced by treating a 2-oxo acid derivative with a microorganism, which has been optionally treated, capable of asymmetrically reducing said 2-oxo acid derivative into an optically active (R)- or (S)-2-hydroxy acid derivative represented by the formula (II) and recovering the optically active (R)- or (S)-hydroxy acid derivative thus formed. Optically active 2-hydroxy acid derivatives are important intermediates in the synthesis of various drugs such as a remedy for hypertension.
摘要翻译：通过用任选处理的能够将所述2-氧代酸衍生物不对称还原成光学活性（R） - 或（S）的微生物的2-氧代酸衍生物来制备光学活性的2-羟基酸衍生物，（II）表示的2-羟基酸衍生物，并回收由此形成的光学活性（R） - 或（S） - 羟基酸衍生物。光学活性的2-羟基酸衍生物是合成各种药物的重要中间体，例如高血压药物。

7. 发明授权

US5256552A Process for the production of optically active 2-hydroxy-4-phenylbutyric acid 失效
标题翻译：光学活性2-羟基-4-苯基丁酸的制备方法
公开(公告)号：US5256552A
公开(公告)日：1993-10-26
申请号：US913990
申请日：1992-07-17
申请人： Akinobu Matsuyama , Teruyuki Nikaido , Yoshinori Kobayashi
发明人： Akinobu Matsuyama , Teruyuki Nikaido , Yoshinori Kobayashi
IPC分类号： C12P7/42 , C12P41/00 , C12R1/245 , C12R1/465
CPC分类号： C12P7/42 , Y10S435/822 , Y10S435/824 , Y10S435/83 , Y10S435/836 , Y10S435/852 , Y10S435/853 , Y10S435/854 , Y10S435/856 , Y10S435/857 , Y10S435/873 , Y10S435/874 , Y10S435/885 , Y10S435/911 , Y10S435/921 , Y10S435/93
摘要： 2-Oxo-4-phenylbutyric acid is treated with a microorganism, which has been optionally treated, capable of asymmetrically reducing 2-oxo-4-phenylbutyric acid into either (R)-2-hydroxy-4-phenylbutyric acid or (S)-2-hydroxy-4-phenylbutyric acid, and the (R)-2-hydroxy-4-phenylbutyric acid or (S)-2-hydroxy-4-phenylbutyric acid thus produced is recovered to thereby give optically active 2-hydroxy-4-phenylbutyric acid.The optically active 2-hydroxy-4-phenylbutyric acid is an important intermediate in the synthesis of various drugs such as a remedy for hypertension.
摘要翻译： 2-氧代-4-苯基丁酸用任选处理的能够将2-氧代-4-苯基丁酸不对称还原成（R）-2-羟基-4-苯基丁酸或（S）-2-羟基-4-苯基丁酸的微生物处理， -2-羟基-4-苯基丁酸和（R）-2-羟基-4-苯基丁酸或（S）-2-羟基-4-苯基丁酸，由此得到光学活性的2-羟基-4-苯基丁酸， 4-苯基丁酸。光学活性的2-羟基-4-苯基丁酸是合成各种药物的重要中间体，例如高血压药物。

8. 发明授权

US5219757A Production of optically active 1,3-butanediol by asymmetric assimilation or reduction of 4-hydroxy-2-butanone 失效
标题翻译：通过不对称或降低4-羟基-2-丁酮生产光学活性的1,3-丁二醇
公开(公告)号：US5219757A
公开(公告)日：1993-06-15
申请号：US449929
申请日：1989-12-07
申请人： Akinobu Matsuyama , Teruyuki Nikaido , Yoshinori Kobayashi
发明人： Akinobu Matsuyama , Teruyuki Nikaido , Yoshinori Kobayashi
IPC分类号： C12P7/18 , C12P41/00
CPC分类号： C12P41/001 , C12P7/18 , Y10S435/822 , Y10S435/911 , Y10S435/921 , Y10S435/938
摘要： An optically active 1,3-butanediol can be produced by either (1) treating a mixture of 1,3-butanediol enantiomers with a microorganism, which has been optionally treated, capable of asymmetrically assimilating said mixture, or (2) preparing a microorganism, which has been optionally treated, capable of asymmetrically reducing 4-hydroxy-2-butanone, and collecting optically active 1,3-butanediol.
摘要翻译： PCT No.PCT / JP89 / 00447 Sec。 371日期：1989年12月7日 102（e）日期1989年12月7日PCT 1989年4月27日PCT PCT。出版物WO89 / 10410 日本1991年11月2日。光学活性1,3-丁二醇可以通过（1）将1,3-丁二醇对映异构体与已经任选处理的能够不对称地同化所述混合物的微生物进行处理来制备，或（2）制备可任意处理的能够不对称还原4-羟基-2-丁酮的微生物，并收集光学活性1,3-丁二醇。

9. 发明授权

US5413922A Process for producing optically active 1,3-butanediol by reduction of 4-hydroxy-2-butanone 失效
标题翻译：通过还原4-羟基-2-丁酮制备光学活性1,3-丁二醇的方法
公开(公告)号：US5413922A
公开(公告)日：1995-05-09
申请号：US54276
申请日：1993-04-30
申请人： Akinobu Matsuyama , Teruyuki Nikaido , Yoshinori Kobayashi
发明人： Akinobu Matsuyama , Teruyuki Nikaido , Yoshinori Kobayashi
IPC分类号： C12P7/18 , C12P41/00
CPC分类号： C12P41/001 , C12P7/18 , Y10S435/822 , Y10S435/911 , Y10S435/921 , Y10S435/938
摘要： An optically active 1,3-butanediol can be produced by either (1) treating a mixture of 1,3-butanediol enantiomers with a microorganism, which has been optionally treated, capable of asymmetrically assimilating said mixture, or (2) preparing a microorganism, which has been optionally treated, capable of asymmetrically reducing 4-hydroxy-2-butanone, and collecting optically active 1,3-butanediol.
摘要翻译：光学活性1,3-丁二醇可以通过（1）将1,3-丁二醇对映异构体与已经任意处理的能够不对称地同化所述混合物的微生物处理，或（2）制备微生物，其可任选地处理，能够不对称地还原4-羟基-2-丁酮，并收集光学活性的1,3-丁二醇。

10. 发明授权

US5401660A Process for producing optically active 1,3-butanediol by asymmetric assimilation 失效
标题翻译：通过不对称同化制备光学活性1,3-丁二醇的方法
公开(公告)号：US5401660A
公开(公告)日：1995-03-28
申请号：US964264
申请日：1992-10-21
申请人： Akinobu Matsuyama , Teruyuki Nikaido , Yoshinori Kobayashi
发明人： Akinobu Matsuyama , Teruyuki Nikaido , Yoshinori Kobayashi
IPC分类号： C12P7/18 , C12P41/00
CPC分类号： C12P41/001 , C12P7/18 , Y10S435/822 , Y10S435/911 , Y10S435/921 , Y10S435/938
摘要： An optically active 1,3-butanediol can be produced by either (1) treating a mixture of 1,3-butanediol enantiomers with a microorganism, which has been optionally treated, capable of asymmetrically assimilating said mixture, or (2) preparing a microorganism, which has been optionally treated, capable of asymmetrically reducing 4-hydroxy-2-butanone, and collecting optically active 1,3-butanediol.
摘要翻译：光学活性1,3-丁二醇可以通过（1）将1,3-丁二醇对映异构体与已经任意处理的能够不对称地同化所述混合物的微生物处理，或（2）制备微生物，其可任选地处理，能够不对称地还原4-羟基-2-丁酮，并收集光学活性的1,3-丁二醇。

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