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1. 发明授权

US5836976A Cardioversion energy reduction system 失效
标题翻译：心律转换能量减少系统
公开(公告)号：US5836976A
公开(公告)日：1998-11-17
申请号：US846747
申请日：1997-04-30
申请人： Xiaoyi Min , Li Wang , Rahul Mehra , Paul J. DeGroot , Walter H. Olson , Luc R. Mongeon , Michael R. S. Hill
发明人： Xiaoyi Min , Li Wang , Rahul Mehra , Paul J. DeGroot , Walter H. Olson , Luc R. Mongeon , Michael R. S. Hill
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61N1/3925 , A61N1/3987
摘要： In an implantable pacemaker/cardioverter/defibrillator, a system for correlating the delivery of a cardioversion therapy to an optimum point or phase of the respiratory cycle of the patient to effect delivery of the therapy when the impedance between the cardioversion electrodes is minimized. In a first application for use with cardioversion electrodes located substantially in contact with the heart chamber, the optimum point or phase is at the end of inspiration. In a second application for use with at least one cardioversion electrode located remotely from the heart chamber, the optimum point or phase is at end expiration or beginning of inspiration. The cardioversion therapy is delivered in synchrony with a ventricular sense event, if present. If the optimum point or phase of the respiratory cycle cannot be determined during a therapy time, a pre-shock may be delivered to elicit a respiration cycle through a stimulated contraction of the diaphragm.
摘要翻译：在植入式心脏起搏器/心律转复除颤器中，用于将心脏复律治疗的输送与患者呼吸周期的最佳点或阶段相关联的系统，以在心脏复律电极之间的阻抗最小化时实现治疗的传递。在与基本上与心脏腔室接触的心脏复律电极一起使用的第一个应用中，最佳点或阶段在吸气结束时。在与远离心脏室的位置的至少一个心脏复律电极一起使用的第二个应用中，最佳点或阶段是结束期满或开始吸气。复发疗法与心室感觉事件（如果存在）同步传递。如果在治疗时间内不能确定呼吸周期的最佳点或相位，则可以传送预休克以通过振膜的刺激收缩引起呼吸循环。

2. 发明授权

US07076298B2 Method and apparatus for prevention of arrhythmia clusters using overdrive pacing 有权
公开(公告)号：US07076298B2
公开(公告)日：2006-07-11
申请号：US10171231
申请日：2002-06-14
申请人： Vasant Padmanabhan , Walter H. Olson , Rahul Mehra , Xiaohong Zhou , Thomas J. Mullen , William J. George
发明人： Vasant Padmanabhan , Walter H. Olson , Rahul Mehra , Xiaohong Zhou , Thomas J. Mullen , William J. George
IPC分类号： A61N1/36
CPC分类号： A61N1/3622
摘要： An implantable medical device that includes a microprocessor that characterizes cardiac activity of a patient to enable the implantable medical device to deliver therapy in response to an identified arrhythmia event. A monitor/controller monitors the characterized cardiac activity and the delivered therapy, and controls activation of triggered overdrive pacing subsequent to the delivered therapy.

3. 发明授权

US06892094B2 Combined anti-tachycardia pacing (ATP) and high voltage therapy for treating ventricular arrhythmias 有权
标题翻译：联合抗心动过速起搏（ATP）和高压治疗治疗室性心律失常
公开(公告)号：US06892094B2
公开(公告)日：2005-05-10
申请号：US10137517
申请日：2002-04-30
申请人： Kevin T. Ousdigian , Vasant Padmanabhan , Paul J. DeGroot , Walter H. Olson , Vinod Sharma , Cameron J. Kaszas , Paul G. Krause
发明人： Kevin T. Ousdigian , Vasant Padmanabhan , Paul J. DeGroot , Walter H. Olson , Vinod Sharma , Cameron J. Kaszas , Paul G. Krause
IPC分类号： A61N1/365 , A61N1/39
CPC分类号： A61N1/3962 , A61N1/3987
摘要： A system and method for treating an arrhythmia of the heart, involves delivery of anti-tachy pacing (ATP) pulses to the heart, possibly followed by the delivery of a high-voltage shock. ATP delivery is controlled such that the time delivery of any high-voltage shock is not affected by the prior delivery of the ATP pulses. System control may be accomplished using one or more programmable parameters, which may include a user-specified shock energy.
摘要翻译：用于治疗心脏心律失常的系统和方法涉及向心脏递送抗起搏起搏（ATP）脉冲，可能之后传递高压休克。控制ATP递送，使得任何高压休克的时间传递不受ATP脉冲的先前递送的影响。系统控制可以使用一个或多个可编程参数来实现，其可以包括用户指定的冲击能量。

4. 发明授权

US08013133B2 Genetic modification of targeted regions of the cardiac conduction system 有权
标题翻译：心脏传导系统目标区域的遗传修饰
公开(公告)号：US08013133B2
公开(公告)日：2011-09-06
申请号：US10423595
申请日：2003-04-25
申请人： Vinod Sharma , Walter H. Olson
发明人： Vinod Sharma , Walter H. Olson
IPC分类号： A61K48/00 , C12N15/00 , C07H21/02
CPC分类号： C12N15/86 , A61K38/177 , A61K48/00 , A61K48/005 , C12N2750/14143
摘要： Disclosed are methods and systems for preventing or treating cardiac dysfunction, particularly cardiac pacing dysfunction by genetic modification of the conduction system of the heart. In one embodiment, the invention provides a method of genetically modifying the cells by delivering to the cells one or more coding sequence in a genetic construct capable of modifying the expression of ion channels of the cells.
摘要翻译：公开了通过心脏传导系统的遗传修饰来预防或治疗心脏功能障碍，特别是心脏起搏功能障碍的方法和系统。在一个实施方案中，本发明提供了通过向细胞递送能够修饰细胞的离子通道的表达的遗传构建体中的一个或多个编码序列来遗传修饰细胞的方法。

5. 发明授权

US06178350B1 Prioritized rule based method and apparatus for diagnosis and treatment of arrhythmias 有权
标题翻译：用于诊断和治疗心律失常的优先规则方法和装置
公开(公告)号：US06178350B1
公开(公告)日：2001-01-23
申请号：US09487189
申请日：2000-01-19
申请人： Walter H. Olson , Jeffrey M. Gillberg
发明人： Walter H. Olson , Jeffrey M. Gillberg
IPC分类号： A61N1362
CPC分类号： A61N1/3622 , A61B5/042 , A61B5/046 , A61B5/0464 , A61B5/7264
摘要： An implantable anti-tachyarrhythmia device which delivers anti-tachyarrhythmia therapies to a patient's heart in response to detection of tachyarrhythmias. The device defines first criteria indicating the presence of atrial tachycardia and second criteria indicating the presence of atrial fibrillation, and compares the time elapsed since the either the first or second criteria were initially met to a defined time duration. In response to the defined duration having passed and either of the first or second criteria being met, the device triggers delivery of an appropriate anti-tachyarrhythmia therapy. The timer is reset on detection of termination of atrial tachyarrhythmia, but not on failure of the first and second criteria to be met. The first and second criteria are defined such that they can not be concurrently met.
摘要翻译：一种可植入的抗快速性心律失常装置，其响应于快速性心律失常的检测而向患者的心脏递送抗快速性心律失常疗法。该装置定义了指示心房心动过速存在的第一标准和指示心房纤维性颤动的存在的第二标准，并且比较了从第一或第二标准开始满足到限定的持续时间之后经过的时间。响应于已经通过的限定的持续时间并满足第一或第二标准中的任一个，该装置触发适当的抗快速性心律失常治疗的递送。在检测到心房性心律失常终止时，定时器复位，但不符合第一和第二标准的失败。第一和第二个标准被定义为不能同时满足。

6. 发明授权

US6141581A Prioritized rule based method and apparatus for diagnosis and treatment of arrhythmias 有权
公开(公告)号：US6141581A
公开(公告)日：2000-10-31
申请号：US160064
申请日：1998-09-24
申请人： Walter H. Olson , William F. Kaemmerer , Mark L. Brown
发明人： Walter H. Olson , William F. Kaemmerer , Mark L. Brown
IPC分类号： A61N1/365 , A61N1/362 , A61B5/0452
CPC分类号： A61N1/3622 , A61B5/042 , A61B5/046 , A61B5/0464 , A61B5/7264
摘要： An implantable antiarrhythmia device which detects and classifies arrhythmias of the human heart, and delivers appropriate therapy. The device employs a method of arrhythmia classification based on a set of prioritized rules, each of the rules defining a plurality of criteria based upon characteristics of sensed depolarizations of heart tissue, each rule being met when the criteria associated with the rule are met. Some rules, when met, trigger delivery of antiarrhythmia therapy. Other rules, when met, inhibit delivery of antiarrhythmia therapy. The rules may be met simultaneously, and if so, the highest priority rule governs the behavior of the device.

7. 发明授权

US5545186A Prioritized rule based method and apparatus for diagnosis and treatment of arrhythmias 失效
标题翻译：用于诊断和治疗心律失常的优先规则方法和装置
公开(公告)号：US5545186A
公开(公告)日：1996-08-13
申请号：US413570
申请日：1995-03-30
申请人： Walter H. Olson , William F. Kaemmerer
发明人： Walter H. Olson , William F. Kaemmerer
IPC分类号： A61N1/365 , A61N1/362 , A61N1/368
CPC分类号： A61N1/3622 , A61B5/042 , A61B5/046 , A61B5/0464 , A61B5/7264
摘要： An implantable antiarrhythmia device which detects and classifies arrhythmias of the human heart, and delivers appropriate therapy. The device employs a method of arrhythmia classification based on a set of prioritized rules, each of the rules defining a plurality of criteria based upon characteristics of sensed depolarizations of heart tissue, each role being met when the criteria associated with the role are met. Some rules, when met, trigger delivery of antiarrhythmia therapy. Other rules, when met, inhibit delivery of antiarrhythmia therapy. The rules may be met simultaneously, and if so, the highest priority rule governs the behavior of the device.
摘要翻译：一种可植入的抗心律失常装置，用于检测和分类人心脏的心律失常，并提供适当的治疗。该装置采用基于一组优先规则的心律失常分类方法，每个规则基于感测到的心脏组织的去极化的特征来定义多个标准，当满足与角色相关联的标准时，满足每个作用。一些规则，当遇到时，触发了抗心律失常治疗的传递。遇到其他规则时，抑制抗心律失常治疗。可以同时满足规则，如果是，则最高优先级规则控制设备的行为。

8. 发明授权

US4535774A Stroke volume controlled pacer 失效
标题翻译：中风量控制起搏器
公开(公告)号：US4535774A
公开(公告)日：1985-08-20
申请号：US509573
申请日：1983-06-30
申请人： Walter H. Olson
发明人： Walter H. Olson
IPC分类号： A61N1/362 , A61N1/365 , A61N1/36
CPC分类号： A61N1/36521
摘要： A rate responsive pacer which paces the heart at a rate dependent on detected variations in the stroke volume of the heart.
摘要翻译：速率响应起搏器，其速度取决于检测到的心脏搏动体积变化的速率。

9. 发明申请

US20120109240A1 AUTOMATIC ADJUSTMENT OF ARRHYTHMIA DETECTION PARAMETERS 审中-公开
标题翻译：自动调整ARRHYTHMIA检测参数
公开(公告)号：US20120109240A1
公开(公告)日：2012-05-03
申请号：US12915877
申请日：2010-10-29
申请人： Xiaohong Zhou , Robert Stadler , Bruce D. Gunderson , Walter H. Olson
发明人： Xiaohong Zhou , Robert Stadler , Bruce D. Gunderson , Walter H. Olson
IPC分类号： A61N1/39 , A61N1/365
CPC分类号： A61N1/3706 , A61B5/046 , A61B5/0464 , A61B5/4836 , A61N1/3621
摘要： Methods and/or devices for initiating an automatic adjustment of arrhythmia detection parameters (e.g., upon delivery of cardiac therapy after detection of VT/VF).
摘要翻译：用于启动心律失常检测参数的自动调整的方法和/或装置（例如，在检测到VT / VF之后递送心脏治疗）。

10. 发明授权

US06922585B2 Method and apparatus for predicting recurring ventricular arrhythmias 有权
标题翻译：用于预测复发性室性心律失常的方法和装置
公开(公告)号：US06922585B2
公开(公告)日：2005-07-26
申请号：US10117465
申请日：2002-04-05
申请人： Xiaohong Zhou , Vinod Sharma , Walter H. Olson
发明人： Xiaohong Zhou , Vinod Sharma , Walter H. Olson
IPC分类号： A61B5/0452 , A61B5/0402 , A61B5/046 , A61B5/0464 , A61N1/362 , A61N1/37 , A61N1/39
CPC分类号： A61B5/4035 , A61B5/046 , A61B5/0464 , A61N1/3622 , A61N1/3962
摘要： An implantable medical device and method are provided for assessing autonomic tone and risk factors associated with arrhythmias and, based on this assessment, an early recurrence of ventricular tachycardia or ventricular fibrillation is predicted. Specifically, changes in R—R interval, heart rate variability, patient activity, and myocardial ischemia are measured prior to and after a detected an arrhythmia episode. A recurrence score is calculated as a weighted sum of measured parameters and compared to a prediction criterion. The prediction criterion may be a preset threshold score or an individualized episode template based on previously calculated recurrence scores associated with recurring episodes. Stored parameters and episode-related data may be downloaded for offline analyses for optimizing prediction criteria and monitoring patient status.
摘要翻译：提供了一种用于评估与心律失常相关的自主神经和风险因素的可植入医疗装置和方法，并且基于该评估，预测了室性心动过速或心室颤动的早期复发。具体地，在检测到心律失常发作之前和之后测量R-R间期，心率变异性，患者活动和心肌缺血的变化。计算复发得分作为测量参数的加权和并与预测标准进行比较。预测标准可以是基于先前计算的与重复发作相关联的复发评分的预设阈值评分或个体化发作模板。可以下载存储的参数和与剧集相关的数据用于离线分析，以优化预测标准和监测患者状态。

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