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1. 发明授权

US5836976A Cardioversion energy reduction system 失效
标题翻译：心律转换能量减少系统
公开(公告)号：US5836976A
公开(公告)日：1998-11-17
申请号：US846747
申请日：1997-04-30
申请人： Xiaoyi Min , Li Wang , Rahul Mehra , Paul J. DeGroot , Walter H. Olson , Luc R. Mongeon , Michael R. S. Hill
发明人： Xiaoyi Min , Li Wang , Rahul Mehra , Paul J. DeGroot , Walter H. Olson , Luc R. Mongeon , Michael R. S. Hill
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61N1/3925 , A61N1/3987
摘要： In an implantable pacemaker/cardioverter/defibrillator, a system for correlating the delivery of a cardioversion therapy to an optimum point or phase of the respiratory cycle of the patient to effect delivery of the therapy when the impedance between the cardioversion electrodes is minimized. In a first application for use with cardioversion electrodes located substantially in contact with the heart chamber, the optimum point or phase is at the end of inspiration. In a second application for use with at least one cardioversion electrode located remotely from the heart chamber, the optimum point or phase is at end expiration or beginning of inspiration. The cardioversion therapy is delivered in synchrony with a ventricular sense event, if present. If the optimum point or phase of the respiratory cycle cannot be determined during a therapy time, a pre-shock may be delivered to elicit a respiration cycle through a stimulated contraction of the diaphragm.
摘要翻译：在植入式心脏起搏器/心律转复除颤器中，用于将心脏复律治疗的输送与患者呼吸周期的最佳点或阶段相关联的系统，以在心脏复律电极之间的阻抗最小化时实现治疗的传递。在与基本上与心脏腔室接触的心脏复律电极一起使用的第一个应用中，最佳点或阶段在吸气结束时。在与远离心脏室的位置的至少一个心脏复律电极一起使用的第二个应用中，最佳点或阶段是结束期满或开始吸气。复发疗法与心室感觉事件（如果存在）同步传递。如果在治疗时间内不能确定呼吸周期的最佳点或相位，则可以传送预休克以通过振膜的刺激收缩引起呼吸循环。

2. 发明授权

US5549642A Atrial defibrillator and method of use 失效
标题翻译：心房除颤器及使用方法
公开(公告)号：US5549642A
公开(公告)日：1996-08-27
申请号：US293769
申请日：1994-08-19
申请人： Xiaoyi Min , Luc R. Mongeon , Rahul Mehra , Kenneth M. Anderson , Paul J. DeGroot , Michael R. S. Hill
发明人： Xiaoyi Min , Luc R. Mongeon , Rahul Mehra , Kenneth M. Anderson , Paul J. DeGroot , Michael R. S. Hill
IPC分类号： A61N1/39
CPC分类号： A61N1/3918 , A61N1/3962 , A61N1/395
摘要： A method and apparatus for treating atrial tachyarrhythmias, particularly atrial fibrillation. High energy pulses are delivered between electrodes located in the right atrium/SVC, the right ventricle and the coronary sinus/great vein, with the right ventricular and coronary sinus/great vein electrodes connected in common. Optionally a subcutaneous electrode, preferably located in the left pectoral area may also be employed, coupled in common to the right atrial/SVC electrode.
摘要翻译：一种治疗房性快速性心律失常的方法和装置，特别是房颤。高能量脉冲在位于右心房/ SVC，右心室和冠状窦/大静脉的电极之间传递，右心室和冠状窦/大静脉电极共同连接。任选地，也可以使用优选位于左胸部区域的皮下电极，共同连接到右心房/ SVC电极。

3. 发明授权

US6091988A Apparatus for treating atrial tachyarrhythmias with synchronized shocks 失效
标题翻译：用同步冲击治疗房性快速性心律失常的装置
公开(公告)号：US6091988A
公开(公告)日：2000-07-18
申请号：US70690
申请日：1998-04-30
申请人： Eduardo N. Warman , Michael R. S. Hill , David K. L. Peterson , Rahul Mehra , Luc R. Mongeon
发明人： Eduardo N. Warman , Michael R. S. Hill , David K. L. Peterson , Rahul Mehra , Luc R. Mongeon
IPC分类号： A61N1/362 , A61N1/39
CPC分类号： A61N1/3956 , A61N1/3622 , A61N1/3987
摘要： An implantable anti-tachyarrhythmia device which delivers atrial cardioversion or defibrillation pulses heart in response to detection of atrial tachyarrhythmias. The pulses are synchronized to atrial and ventricular events in such a fashion as to assure they occur outside of the vulnerable periods associated with both chambers. The device is provided with a pulse synchronizer which defines a first synchronization interval initiated following a sensed atrial event and a second synchronization interval initiated responsive to a sensed ventricular event and a pulse triggerer which triggers delivery of a cardioversion or defibrillation pulse responsive to the first and second synchronization intervals simultaneously being underway. In particular, the pulse triggerer may be responsive to initiation of the first synchronization interval during the second synchronization interval. In addition, the synchronizer may also define minimum time intervals following ventricular events and the triggerer may additionally be responsive to expiration of a defined minimum time interval following a ventricular event preceding the sensed ventricular event which initiated the second synchronization interval currently underway.
摘要翻译：一种可植入的抗快速性心律失常装置，其响应于心房快速性心律失常的检测而传送心房心脏复律或除颤脉冲心脏。这些脉冲以这样的方式与心房和心室事件同步，以确保它们发生在与两个腔室相关联的脆弱周期之外。该装置设置有脉冲同步器，该脉冲同步器限定在感测的心房事件之后启动的第一同步间隔和响应于感测到的心室事件而发起的第二同步间隔和脉冲触发器，其响应于第一和第二同步间隔触发心脏复律或除颤脉冲的传递第二同步间隔同时进行。特别地，脉冲触发器可以响应于在第二同步间隔期间启动第一同步间隔。此外，同步器还可以定义心室事件之后的最小时间间隔，并且触发器可以另外响应于起始于当前正在进行的第二同步区间的感测的心室事件之前的心室事件之后的限定的最小时间间隔的到期。

4. 发明授权

US06272380B1 Apparatus for treating atrial tachy arrhythmias with synchronized shocks 失效
标题翻译：用同步冲击治疗心房速度性心律失常的装置
公开(公告)号：US06272380B1
公开(公告)日：2001-08-07
申请号：US09377514
申请日：1999-08-19
申请人： Eduardo N. Warman , Michael R. S. Hill , David K. L. Peterson , Rahul Mehra , Luc R. Mongeon
发明人： Eduardo N. Warman , Michael R. S. Hill , David K. L. Peterson , Rahul Mehra , Luc R. Mongeon
IPC分类号： A61N139
CPC分类号： A61N1/3987 , A61N1/3956
摘要： An implantable anti-tachyarrhythmia device which delivers atrial cardioversion or defibrillation pulses heart in response to detection of atrial tachyarrhythmias. The pulses are synchronized to atrial and ventricular events in such a fashion as to assure they occur outside of the vulnerable periods associated with both chambers.
摘要翻译：一种可植入的抗快速性心律失常装置，其响应于心房快速性心律失常的检测而传送心房心脏复律或除颤脉冲心脏。这些脉冲以这样的方式与心房和心室事件同步，以确保它们发生在与两个腔室相关联的脆弱周期之外。

5. 发明授权

US06185459B2 Method and apparatus for prevention of atrial tachyarrhythmias 有权
标题翻译：用于预防房性快速性心律失常的方法和装置
公开(公告)号：US06185459B2
公开(公告)日：2001-02-06
申请号：US09373699
申请日：1999-08-13
申请人： Rahul Mehra , Michael R. S. Hill , Stephanie M. Fitts , Luc R. Mongeon
发明人： Rahul Mehra , Michael R. S. Hill , Stephanie M. Fitts , Luc R. Mongeon
IPC分类号： A61N1362
CPC分类号： A61N1/3686 , A61N1/3622 , A61N1/3688 , A61N1/3706
摘要： A cardiac pacemaker and a method of its use. The pacemaker paces a patient's heart in a tachyarrhythmia prevention pacing mode for an extended time period, defines a metric of success of the tachyarrhythmia prevention pacing mode, monitors the metric over the extended time period and, responsive to the monitored metric, adjusts the tachyarrhythmia prevention pacing mode. Adjustment of the tachyarrhythmia prevention pacing mode may take the form of pacing the patient's heart with a different set of electrodes, pacing the patient's heart with a different tachyarrhythmia prevention pacing mode and/or terminating operation of the tachyarrhythmia prevention pacing mode.
摘要翻译：心脏起搏器及其使用方法。心脏起搏器在长时间的快速性心律失常预防起搏模式下对患者的心脏起搏，定义了快速心律失常预防起搏模式成功的指标，在延长的时间段内监测指标，并根据监测的指标调整心律失常预防起搏模式快速心律失常预防起搏模式的调整可以采取以不同的电极组起搏患者心脏的形式，使患者的心脏具有不同的快速性心律失常预防起搏模式和/或终止快速性心律失常预防起搏模式的操作。

6. 发明授权

US5620468A Method and apparatus for treatment of atrial fibrillation 失效
标题翻译：用于治疗房颤的方法和装置
公开(公告)号：US5620468A
公开(公告)日：1997-04-15
申请号：US627959
申请日：1996-04-02
申请人： Luc R. Mongeon , Michael R. S. Hill , Rahul Mehra
发明人： Luc R. Mongeon , Michael R. S. Hill , Rahul Mehra
IPC分类号： A61N1/38 , A61N1/39
CPC分类号： A61N1/385 , A61N1/3962 , A61N1/395
摘要： A method and apparatus for treating fibrillation, particularly atrial fibrillation. In response to detection of fibrillation, a series of low energy pulse bursts is delivered, separated by defined inter-burst intervals, and including bursts unsynchronized to heart depolarizations. Detection of termination of fibrillation during inter-burst intervals results in cancellation of further pulse bursts to prevent reinduction of fibrillation.
摘要翻译：一种用于治疗原纤维性颤动的方法和装置，特别是心房颤动。响应于原纤维化的检测，一系列低能量脉冲串被传送，通过限定的突发间隔隔开，并且包括与心脏去极化不同步的突发。在突发间隔期间检测到颤动的终止导致进一步的脉冲脉冲的消除，以防止纤维性颤动的再诱导。

7. 发明授权

US5690686A Atrial defibrillation method 失效
标题翻译：心房除颤方法
公开(公告)号：US5690686A
公开(公告)日：1997-11-25
申请号：US640380
申请日：1996-04-30
申请人： Xiaoyi Min , Luc R. Mongeon , Rahul Mehra , Kenneth M. Anderson
发明人： Xiaoyi Min , Luc R. Mongeon , Rahul Mehra , Kenneth M. Anderson
IPC分类号： A61N1/39
CPC分类号： A61N1/3962 , A61N1/3918 , A61N1/395
摘要： A method and apparatus for treating atrial tachyarrhythmias, particularly atrial fibrillation. High energy pulses are delivered between electrodes located in the right atrium/SVC, the left pectoral region and the coronary sinus/great vein, with the left pectoral and coronary sinus/great vein electrodes connected in common. Optionally a ventricular electrode may also be employed in conjunction with one or more of the other listed electrodes to accomplish ventricular cardioversion or defibrillation.
摘要翻译：一种治疗房性快速性心律失常的方法和装置，特别是房颤。在位于右心房/ SVC，左胸部区域和冠状窦/大静脉的电极之间传递高能量脉冲，左胸部和冠状窦/大静脉电极共同连接。任选地，心室电极还可以与一个或多个其它列出的电极结合使用以完成心室复律或除颤。

8. 发明授权

US07561913B2 Automatic adjusting R-wave synchronization algorithm for atrial cardioversion and defibrillation 有权
标题翻译：自动调整心律转复和除颤的R波同步算法
公开(公告)号：US07561913B2
公开(公告)日：2009-07-14
申请号：US10426284
申请日：2003-04-30
申请人： Luc R. Mongeon , Rahul Mehra
发明人： Luc R. Mongeon , Rahul Mehra
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61N1/3987
摘要： An implantable medical device system and method are provided for synchronizing atrial cardioversion shocks to the ventricular rhythm using an adjustable atrial cardioversion/defibrillation ventricular refractory period. Upon determining a need for an atrial shock therapy, the method determines if the ventricular rate meets synchronization criteria based on an upper ventricular refractory period limit. If synchronization criteria are not met, the refractory period is automatically adjusted in stepwise decrements until the synchronization criteria are met, or until a lower refractory period limit is exceeded. If synchronization criteria are met, an atrial shock is synchronized to the next ventricular depolarization occurring outside the current refractory period. If the lower refractory period limit is exceeded, the atrial therapy is aborted.
摘要翻译：提供了一种植入式医疗装置系统和方法，用于使用可调节心房复律/除颤心室不应期使心房心律转复冲击与心室节律同步。在确定需要心房休克治疗后，该方法确定心室率是否满足基于上心室不应期限的同步标准。如果不符合同步标准，则可以逐步递减地自动调整不应期，直到达到同步标准，或直到超过较低的不应期限为止。如果符合同步标准，心房休克与当前不应期以外发生的下一次心室去极化同步。如果超过较低的不应期限，则中止心房治疗。

9. 发明授权

US5653740A Method and apparatus for induction of fibrillation 失效
标题翻译：用于诱发原纤维化的方法和装置
公开(公告)号：US5653740A
公开(公告)日：1997-08-05
申请号：US587309
申请日：1996-01-16
申请人： Paul J. Degroot , Rahul Mehra
发明人： Paul J. Degroot , Rahul Mehra
IPC分类号： A61N1/38
CPC分类号： A61N1/385
摘要： A method and apparatus for inducing fibrillation in a patient, for example to verify the efficacy of a defibrillator system. In the disclosed embodiment, an implantable cardioverter-defibrillator has an output stage coupled via a plurality of leads to the patient's heart. When it is desired to induce fibrillation in the patient, the device's control circuitry initiates an output capacitor charging cycle and subsequent delivery of a multi-phase fibrillation inducing stimulus to the heart. The multiple phases of the stimulus reflect an incremental discharging of the output capacitor. In one embodiment, the stimulus has three phases, with the first two separated by a time interval equal to or slightly less than the patient's "vulnerability window," which is defined as the time period following a paced cardiac event during which repolarization of the cardiac muscle is occurring, rendering the heart susceptible to induced fibrillation. The final phase of the multi-phase waveform reflects an untruncated discharge of the remaining energy on the output capacitor.
摘要翻译：一种用于在患者中诱导纤维性颤动的方法和装置，例如以验证除颤器系统的功效。在所公开的实施例中，植入式心律转复除颤器具有通过多条引线耦合到患者心脏的输出级。当期望在患者体内引起原纤维化时，该装置的控制电路启动输出电容器充电循环，并随后向心脏递送诱导多相纤颤的刺激。刺激的多个相位反映输出电容器的增量放电。在一个实施例中，刺激具有三个阶段，前两个时间间隔等于或略小于患者的“脆弱性窗口”，该时间间隔被定义为心脏事件复位后的心跳事件之后的时间段肌肉正在发生，使心脏易受诱发纤颤。多相波形的最后阶段反映出输出电容器上剩余能量的未经截断的放电。

10. 发明授权

US07149577B2 Apparatus and method using ATP return cycle length for arrhythmia discrimination 有权
标题翻译：使用ATP返回周期长度进行心律失常辨别的装置和方法
公开(公告)号：US07149577B2
公开(公告)日：2006-12-12
申请号：US10307687
申请日：2002-12-02
申请人： Vinod Sharma , Paul J. Degroot , Rahul Mehra
发明人： Vinod Sharma , Paul J. Degroot , Rahul Mehra
IPC分类号： A61N1/362 , A61N1/38 , A61N1/39
CPC分类号： A61N1/3956 , A61N1/3622
摘要： An apparatus for discriminating between cardiac events that includes an input circuit receiving signals indicative of the cardiac events, a first output circuit generating pulses in response to the received signals, and a microprocessor determining whether a signal received by the input circuit subsequent to the generated pacing pulses corresponds to a predetermined cardiac event in response to an elapsed time period between the generated pulses and the subsequently received signal and a predetermined discrimination threshold.
摘要翻译：一种用于区分心脏事件的装置，包括接收指示心脏事件的信号的输入电路，响应于接收到的信号产生脉冲的第一输出电路和微处理器，确定在产生的起搏之后由输入电路接收到的信号响应于所产生的脉冲与随后接收的信号之间的经过时间段和预定的鉴别阈值，脉冲对应于预定的心脏事件。

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