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1. 发明授权

US06892094B2 Combined anti-tachycardia pacing (ATP) and high voltage therapy for treating ventricular arrhythmias 有权
标题翻译：联合抗心动过速起搏（ATP）和高压治疗治疗室性心律失常
公开(公告)号：US06892094B2
公开(公告)日：2005-05-10
申请号：US10137517
申请日：2002-04-30
申请人： Kevin T. Ousdigian , Vasant Padmanabhan , Paul J. DeGroot , Walter H. Olson , Vinod Sharma , Cameron J. Kaszas , Paul G. Krause
发明人： Kevin T. Ousdigian , Vasant Padmanabhan , Paul J. DeGroot , Walter H. Olson , Vinod Sharma , Cameron J. Kaszas , Paul G. Krause
IPC分类号： A61N1/365 , A61N1/39
CPC分类号： A61N1/3962 , A61N1/3987
摘要： A system and method for treating an arrhythmia of the heart, involves delivery of anti-tachy pacing (ATP) pulses to the heart, possibly followed by the delivery of a high-voltage shock. ATP delivery is controlled such that the time delivery of any high-voltage shock is not affected by the prior delivery of the ATP pulses. System control may be accomplished using one or more programmable parameters, which may include a user-specified shock energy.
摘要翻译：用于治疗心脏心律失常的系统和方法涉及向心脏递送抗起搏起搏（ATP）脉冲，可能之后传递高压休克。控制ATP递送，使得任何高压休克的时间传递不受ATP脉冲的先前递送的影响。系统控制可以使用一个或多个可编程参数来实现，其可以包括用户指定的冲击能量。

2. 发明授权

US06718204B2 Method and apparatus to control delivery of high-voltage and anti-tachy pacing therapy in an implantable medical device 有权
标题翻译：用于控制可植入医疗装置中的高电压和抗速度起搏治疗递送的方法和装置
公开(公告)号：US06718204B2
公开(公告)日：2004-04-06
申请号：US09918224
申请日：2001-07-30
申请人： Paul J. DeGroot , Kevin T. Ousdigian , Vasant Padmanabhan , Paul Krause , Vinod Sharma
发明人： Paul J. DeGroot , Kevin T. Ousdigian , Vasant Padmanabhan , Paul Krause , Vinod Sharma
IPC分类号： A61N108
CPC分类号： A61N1/3622 , A61N1/3688 , A61N1/3925 , A61N1/3956 , A61N1/3962 , A61N1/3987
摘要： A system and method for delivering both anti-tachy pacing (ATP) therapy and high-voltage shock therapy in response to detection of abnormal cardiac rhythms is disclosed. The system controls the time between delivering ATP therapy and the charging of high-voltage capacitors in preparation for shock delivery based on a predetermined set of criteria. In one embodiment, the inventive system operates in an ATP During Capacitor Charging (ATP-DCC) mode wherein all, or substantially all, of the ATP therapy is delivered during charging of the high-voltage capacitors. Based on evaluation of the predetermined set of criteria, the system may switch to an additional ATP Before Capacitor Charging (ATP-BCC) mode, wherein substantially all of the ATP therapy is delivered prior to charging of the high-voltage capacitor. According to one aspect of the invention, the predetermined set of criteria is based, at least in part, on the effectiveness of previously-delivered ATP therapy.
摘要翻译：公开了一种用于响应于异常心律的检测而提供抗起搏起搏（ATP）治疗和高压休克疗法的系统和方法。该系统基于预定的一组标准来控制ATP治疗与高压电容器的充电之间的时间，以准备冲击输送。在一个实施例中，本发明的系统在ATP电容器充电（ATP-DCC）模式下工作，其中在高压电容器充电期间全部或基本上全部ATP治疗被递送。基于对预定标准集合的评估，系统可以切换到在电容器充电（ATP-BCC）模式之外的另外的ATP，其中在高压电容器充电之前基本上全部ATP治疗被递送。根据本发明的一个方面，预定的一组标准至少部分地基于先前传递的ATP治疗的有效性。

3. 发明授权

US08170663B2 Method and apparatus to control delivery of high-voltage and anti-tachy pacing therapy in an implantable medical device 有权
标题翻译：用于控制可植入医疗装置中的高电压和抗速度起搏治疗递送的方法和装置
公开(公告)号：US08170663B2
公开(公告)日：2012-05-01
申请号：US11687282
申请日：2007-03-16
申请人： Paul J. DeGroot , Kevin T. Ousdigian , Vasant Padmanabhan , Paul Krause , Vinod Sharma
发明人： Paul J. DeGroot , Kevin T. Ousdigian , Vasant Padmanabhan , Paul Krause , Vinod Sharma
IPC分类号： A61N1/362 , A61N1/39
CPC分类号： A61N1/3622 , A61N1/3688 , A61N1/3925 , A61N1/3956 , A61N1/3962 , A61N1/3987
摘要： A system and method for delivering both anti-tachy pacing (ATP) therapy and high-voltage shock therapy in response to detection of abnormal cardiac rhythms is disclosed. The system controls the time between delivering ATP therapy and the charging of high-voltage capacitors in preparation for shock delivery based on a predetermined set of criteria. In one embodiment, the inventive system operates in an ATP During Capacitor Charging (ATP-DCC) mode wherein all, or substantially all, of the ATP therapy is delivered during charging of the high-voltage capacitors. Based on evaluation of the predetermined set of criteria, the system may switch to an additional ATP Before Capacitor Charging (ATP-BCC) mode, wherein substantially all of the ATP therapy is delivered prior to charging of the high-voltage capacitor. According to one aspect of the invention, the predetermined set of criteria is based, at least in part, on the effectiveness of previously-delivered ATP therapy.
摘要翻译：公开了一种用于响应于异常心律的检测而提供抗起搏起搏（ATP）治疗和高压休克疗法的系统和方法。该系统基于预定的一组标准来控制ATP治疗与高压电容器的充电之间的时间，以准备冲击输送。在一个实施例中，本发明的系统在ATP电容器充电（ATP-DCC）模式下工作，其中在高压电容器充电期间全部或基本上全部ATP治疗被递送。基于对预定标准集合的评估，系统可以切换到在电容器充电（ATP-BCC）模式之外的另外的ATP，其中在高压电容器充电之前基本上全部ATP治疗被递送。根据本发明的一个方面，预定的一组标准至少部分地基于先前传递的ATP治疗的有效性。

4. 发明授权

US06714811B1 Method and apparatus for monitoring heart rate 有权
标题翻译：监测心率的方法和装置
公开(公告)号：US06714811B1
公开(公告)日：2004-03-30
申请号：US09452659
申请日：1999-12-01
申请人： Vasant Padmanabhan , Karen A. Stone , Walter H. Olson , Kevin T. Ousdigian
发明人： Vasant Padmanabhan , Karen A. Stone , Walter H. Olson , Kevin T. Ousdigian
IPC分类号： A61B504
CPC分类号： A61B5/0031 , A61B5/0205 , A61B5/024 , A61B5/11 , A61B2560/0431
摘要： A monitoring device for implant in a patient's body. The device is provided with a physiologic sensor generating output signals, which signals are stored as numerical values. The device defines first monitoring periods limited to time periods during successive nights during which the patient is likely to be asleep, stores the numerical values generated during the first monitoring periods in a memory and calculates values reflecting general levels of the numerical values during the first monitoring periods. The device may also or alternatively define second monitoring periods limited to time periods during successive daytime and store numerical values generated during the second monitoring periods. The physiologic sensor may be an electrogram amplifier or other sensor indicative of metabolic demand for oxygenated blood, such as an activity sensor. The calculated values reflecting general levels of the numerical values generated during the monitoring periods may be average values, such as mean values or over-all total values, depending upon the sensor employed.
摘要翻译：一种用于植入患者体内的监测装置。该装置设置有生成输出信号的生理传感器，该信号被存储为数值。该装置定义了限制在患者可能睡着的连续夜晚的时间段的第一监测时段，将在第一监测周期期间产生的数值存储在存储器中，并且计算反映在第一监测期间的数值的一般水平的值时期。设备还可以或者替代地定义限制在连续白天期间的时间段的第二监视周期，并且存储在第二监视周期期间生成的数值。生理传感器可以是电描记放大器或指示氧合血液的代谢需求的其它传感器，例如活性传感器。反映在监测期间产生的数值的一般水平的计算值可以是平均值，例如平均值或全部总值，这取决于所使用的传感器。

5. 发明授权

US06931279B2 Method and apparatus for implementing task-oriented induction capabilities in an implantable cardioverter defibrillator and programmer 有权
标题翻译：用于在可植入式心律转复除颤器和编程器中实现面向任务的感应能力的方法和装置
公开(公告)号：US06931279B2
公开(公告)日：2005-08-16
申请号：US10131560
申请日：2002-04-22
申请人： Kevin T. Ousdigian , Seema Padmanabhan , James E. Willenbring , Paul G. Krause , James H. Ericksen , Paul J. Degroot
发明人： Kevin T. Ousdigian , Seema Padmanabhan , James E. Willenbring , Paul G. Krause , James H. Ericksen , Paul J. Degroot
IPC分类号： A61N1/372 , A61N1/39
CPC分类号： A61N1/3943 , A61N1/37247
摘要： The invention provides systems to prevent the delivery of anti-tachycardia pacing (ATP) following a defibrillation threshold (DFT) induction at implant. An algorithm that classifies episodes as induced or spontaneous is implemented, thereby enabling the ATP during charging feature to be operable only when spontaneous episodes are detected while temporarily suspending the ATP feature during the delivery of defibrillation shock after induction has been confirmed. Further, a user interface enables users to interact with an implantable medical device (IMD), particularly for setting a defibrillation threshold (DFT) or a 50 Hz burst from a single programmer screen. The user interface includes various functionalities to promote quick user access to parameters that govern diagnosis, therapy and other features of the IMD. A single screen enables the user to complete automatic and/or manual DFT inductions or a 50 Hz burst from a programmer interface while acquiring associated documentation from the same interface.
摘要翻译：本发明提供了防止在植入物中除颤阈值（DFT）诱导后递送抗心动过速起搏（ATP）的系统。实施了将发作分类为诱导或自发的算法，从而使得在充电特征期间的ATP仅在检测到自发发作时才可操作，同时在确认诱导后的除颤休克期间暂时停止ATP特征。此外，用户界面使得用户能够与可植入医疗装置（IMD）进行交互，特别是用于从单个编程器屏幕设置除颤阈值（DFT）或50Hz脉冲串。用户界面包括各种功能，以促进用户快速访问管理IMD诊断，治疗和其他功能的参数。单个屏幕使用户能够在从同一接口获取相关文档的同时，从编程器接口完成自动和/或手动DFT感应或50 Hz突发。

6. 发明授权

US06438407B1 Method and apparatus for monitoring physiologic parameters conjunction with a treatment 有权
标题翻译：用于监测与治疗结合的生理参数的方法和装置
公开(公告)号：US06438407B1
公开(公告)日：2002-08-20
申请号：US09528627
申请日：2000-03-20
申请人： Kevin T. Ousdigian , Karen A. Stone , Vasant Padmanabhan
发明人： Kevin T. Ousdigian , Karen A. Stone , Vasant Padmanabhan
IPC分类号： A61B504
CPC分类号： A61N1/37247
摘要： A system including an implantable medical device and an associated external device, in which the implantable device is adapted to monitor a physiologic parameter and includes a telemetry system for transmitting information to and receiving information from the external device, including information regarding the measured physiological parameter and in which wherein the external device includes a telemetry system for receiving information from the implanted device and for transmitting information to the implanted device and is provided with a mechanism for receiving information indicative of occurrences of significant therapeutic events and is further provided with a display system which combines information received from the implantable device related to the monitored physiologic parameter with the information of therapeutic significance and for displays the combined information in a time-scaled display in which the measured physiologic parameter is displayed along a common time scale with indications of occurrences of the significant therapy related events. The implantable device may also include a mechanism for delivering a therapy; and the mechanism in the external device for receiving information indicative of occurrences of significant therapeutic events may receive information regarding changes in the therapy delivered by the implantable device. The mechanism in the external device for receiving information indicative of occurrences of significant therapeutic events may also or in addition receive information indicative of changes in the therapy delivered by a physician, e.g. changes in a drug therapy.
摘要翻译：一种包括可植入医疗装置和相关联的外部装置的系统，其中所述可植入装置适于监测生理参数，并且包括用于向所述外部装置发送信息并从外部装置接收信息的遥测系统，所述遥测系统包括关于所测量的生理参数的信息，其中所述外部设备包括用于从所述植入设备接收信息并用于向所述植入设备发送信息的遥测系统，并且设置有用于接收指示重要治疗事件发生的信息的机构，并且还具有显示系统，所述显示系统将从与所监视的生理参数相关的可植入装置接收的信息与具有治疗意义的信息组合，并且以按照公共时间尺度显示测量的生理参数的时间尺度显示中的组合信息显示有明显的治疗相关事件的发生。可植入装置还可以包括用于递送治疗的机构; 并且用于接收指示重大治疗事件发生的信息的外部设备中的机制可以接收关于由可植入装置递送的治疗变化的信息。用于接收指示重大治疗事件发生的信息的外部设备中的机制还可以或另外接收指示由医师传递的治疗变化的信息，例如，药物治疗的变化。

7. 发明授权

US07110813B2 Activation of fibrillation and tachycardia functions 有权
标题翻译：激活原纤维性颤动和心动过速功能
公开(公告)号：US07110813B2
公开(公告)日：2006-09-19
申请号：US10413001
申请日：2003-04-15
申请人： Paul J. Degroot , Kevin T. Ousdigian
发明人： Paul J. Degroot , Kevin T. Ousdigian
IPC分类号： A61N1/38
CPC分类号： A61N1/3956 , A61N1/3622
摘要： An implantable medical device may be programmed by a programmer to apply a variety of ventricular fibrillation (VF) and ventricular tachycardia (VT) therapies, such as antitachycardia pacing (ATP) and cardioversion shocks. In general, the invention is directed to automatic activation of VF- and VT-related functions upon a single command. When a clinician interacts with the programmer to set VF therapies to active status, for example, VT therapies are automatically set to active status as well. Activation of several VF- and VT-related functions with a single command may save considerable time and may be beneficial to the patient. The invention further provides the freedom to customize the functions to the particular needs of a single patient or a group of patients.
摘要翻译：植入式医疗装置可以由程序员编程以应用各种心室颤动（VF）和室性心动过速（VT）疗法，例如抗心动过速起搏（ATP）和心律转复休克。通常，本发明涉及在单个命令上自动激活VF和VT相关功能。当临床医生与程序员进行交互以将VF治疗设置为活动状态时，例如，VT治疗也会自动设置为活动状态。通过单个命令激活几个VF和VT相关功能可以节省大量的时间并且可能对患者有益。本发明还提供了根据单个患者或一组患者的特定需要来定制功能的自由度。

8. 发明授权

US08744560B2 Electrogram summary 有权
标题翻译：电图概要
公开(公告)号：US08744560B2
公开(公告)日：2014-06-03
申请号：US13250676
申请日：2011-09-30
申请人： Bruce D. Gunderson , Karen J. Kleckner , Kevin T. Ousdigian , Amisha S. Patel , Julian Sanchez
发明人： Bruce D. Gunderson , Karen J. Kleckner , Kevin T. Ousdigian , Amisha S. Patel , Julian Sanchez
IPC分类号： A61B5/0456
CPC分类号： A61N1/37247 , A61B5/0031 , A61B5/044 , A61B5/0452 , A61B5/0464 , A61B5/0468 , A61B5/076 , A61B5/7217 , A61B5/7264
摘要： The present disclosure is directed to generating and displaying an electrogram (EGM) summary for use by physicians or other clinicians. An implantable medical device (IMD) transmits EGM signal data for a number of cardiac episodes to an external computing device. The external computing device selects a subset of the cardiac episodes for which information or images are displayed to the user. In various examples, cardiac episodes may be selected for display based at least in part on a retrospective analysis classification of the cardiac episode.
摘要翻译：本公开涉及生成和显示用于医生或其他临床医师使用的电描记图（EGM）摘要。可植入医疗装置（IMD）向多个心脏发作的EGM信号数据发送到外部计算装置。外部计算设备选择向用户显示信息或图像的心脏发作的子集。在各种示例中，可以至少部分地基于心脏发作的回顾性分析分类来选择心脏发作来进行显示。

9. 发明授权

US08229559B2 Evaluation of implantable medical device data 有权
标题翻译：可植入医疗器械数据的评估
公开(公告)号：US08229559B2
公开(公告)日：2012-07-24
申请号：US12837320
申请日：2010-07-15
申请人： Hendrikus A. Westendorp , Cygni Chan , Amisha S. Patel , Denise Dirnberger , Jean K. Ringold , Kevin T. Ousdigian , Robert B. Trojan , Nelson H. Soken , Karen J. Kleckner
发明人： Hendrikus A. Westendorp , Cygni Chan , Amisha S. Patel , Denise Dirnberger , Jean K. Ringold , Kevin T. Ousdigian , Robert B. Trojan , Nelson H. Soken , Karen J. Kleckner
IPC分类号： A61N1/00
CPC分类号： A61N1/37247 , A61B5/0031 , A61B5/0452 , A61B5/7217 , A61B5/7475 , A61N1/3962 , G06F19/00 , G06F19/3481 , G16H40/40
摘要： A system includes an episode classification module and a data retrieval module. The episode classification module receives electrograms (EGMs) from N implantable medical devices (IMDs) and determines whether the EGMs are associated with deliveries of therapy by the N IMDs. The episode classification module analyzes at least some of the EGMs and determines whether the deliveries or non-deliveries of therapy by the IMDs were appropriate. The data retrieval module receives a request from a computing device, via a network, that indicates at least two groups of the N IMDs. The data retrieval module provides to the computing device via the network, in response to the request, data for presentation to a user that indicates for each of the groups, at least one of how many of the one or more deliveries or non-deliveries were appropriate, or how many of the one or more deliveries or non-deliveries were inappropriate.
摘要翻译：系统包括剧集分类模块和数据检索模块。情节分类模块从N个植入式医疗设备（IMD）接收电描记图（EGM），并确定EGM是否与N IMD的治疗交付相关联。情节分类模块分析至少一些EGMs，并确定IMD的分娩或非递送治疗是否合适。数据检索模块经由网络从计算设备接收指示N个IMD的至少两组的请求。数据检索模块经由网络向计算设备提供响应于该请求的用于呈现给用户的用于指示每个组的数据的数据，所述一个或多个传送或非传送中的至少一个是适当的，或者一个或多个交付或不交付是不适当的。

10. 发明授权

US08862212B2 Aggregating cardiac resynchronization therapy data 有权
标题翻译：聚集心脏再同步治疗数据
公开(公告)号：US08862212B2
公开(公告)日：2014-10-14
申请号：US13316177
申请日：2011-12-09
申请人： Helen W. Otto , Kevin T. Ousdigian , Julian Sanchez , Sean R. Landman , Robert W. Stadler
发明人： Helen W. Otto , Kevin T. Ousdigian , Julian Sanchez , Sean R. Landman , Robert W. Stadler
IPC分类号： A61B5/0402 , G06F19/00
CPC分类号： G06F19/3443 , G06F19/00 , G16H50/70
摘要： Cardiac resynchronization therapy (CRT) performance data for a number of patients in which an implantable medical device (IMD) is implanted is aggregated and reports of the aggregated data are generated, e.g., for review by organizations or individual clinicians treating the patients. In one example, a method includes collecting CRT performance data correlated to cardiac rhythm event data for a first group of patients in which an IMD configured to deliver CRT is implanted, aggregating, with a computing device, the CRT performance data correlated to the cardiac rhythm event data for a second group of patients from among the first group of patients, and generating, with the computing device, a report comprising the aggregation of the CRT performance data correlated to the cardiac rhythm event data for the second group of patients.
摘要翻译：对植入了植入式医疗装置（IMD）的许多患者的心脏再同步治疗（CRT）性能数据进行聚合，并且生成聚合数据的报告，例如用于治疗患者的组织或个体临床医师的审查。在一个示例中，一种方法包括收集与其中植入用于递送CRT的IMD相关的第一组患者的与心律事件数据相关的CRT性能数据，与计算设备聚合与心律相关的CRT性能数据生成来自第一组患者的第二组患者的事件数据，并且与计算设备一起生成包括与第二组患者的心律事件数据相关的CRT性能数据的聚集的报告。

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