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1. 发明授权

US06892094B2 Combined anti-tachycardia pacing (ATP) and high voltage therapy for treating ventricular arrhythmias 有权
标题翻译：联合抗心动过速起搏（ATP）和高压治疗治疗室性心律失常
公开(公告)号：US06892094B2
公开(公告)日：2005-05-10
申请号：US10137517
申请日：2002-04-30
申请人： Kevin T. Ousdigian , Vasant Padmanabhan , Paul J. DeGroot , Walter H. Olson , Vinod Sharma , Cameron J. Kaszas , Paul G. Krause
发明人： Kevin T. Ousdigian , Vasant Padmanabhan , Paul J. DeGroot , Walter H. Olson , Vinod Sharma , Cameron J. Kaszas , Paul G. Krause
IPC分类号： A61N1/365 , A61N1/39
CPC分类号： A61N1/3962 , A61N1/3987
摘要： A system and method for treating an arrhythmia of the heart, involves delivery of anti-tachy pacing (ATP) pulses to the heart, possibly followed by the delivery of a high-voltage shock. ATP delivery is controlled such that the time delivery of any high-voltage shock is not affected by the prior delivery of the ATP pulses. System control may be accomplished using one or more programmable parameters, which may include a user-specified shock energy.
摘要翻译：用于治疗心脏心律失常的系统和方法涉及向心脏递送抗起搏起搏（ATP）脉冲，可能之后传递高压休克。控制ATP递送，使得任何高压休克的时间传递不受ATP脉冲的先前递送的影响。系统控制可以使用一个或多个可编程参数来实现，其可以包括用户指定的冲击能量。

2. 发明授权

US08170663B2 Method and apparatus to control delivery of high-voltage and anti-tachy pacing therapy in an implantable medical device 有权
标题翻译：用于控制可植入医疗装置中的高电压和抗速度起搏治疗递送的方法和装置
公开(公告)号：US08170663B2
公开(公告)日：2012-05-01
申请号：US11687282
申请日：2007-03-16
申请人： Paul J. DeGroot , Kevin T. Ousdigian , Vasant Padmanabhan , Paul Krause , Vinod Sharma
发明人： Paul J. DeGroot , Kevin T. Ousdigian , Vasant Padmanabhan , Paul Krause , Vinod Sharma
IPC分类号： A61N1/362 , A61N1/39
CPC分类号： A61N1/3622 , A61N1/3688 , A61N1/3925 , A61N1/3956 , A61N1/3962 , A61N1/3987
摘要： A system and method for delivering both anti-tachy pacing (ATP) therapy and high-voltage shock therapy in response to detection of abnormal cardiac rhythms is disclosed. The system controls the time between delivering ATP therapy and the charging of high-voltage capacitors in preparation for shock delivery based on a predetermined set of criteria. In one embodiment, the inventive system operates in an ATP During Capacitor Charging (ATP-DCC) mode wherein all, or substantially all, of the ATP therapy is delivered during charging of the high-voltage capacitors. Based on evaluation of the predetermined set of criteria, the system may switch to an additional ATP Before Capacitor Charging (ATP-BCC) mode, wherein substantially all of the ATP therapy is delivered prior to charging of the high-voltage capacitor. According to one aspect of the invention, the predetermined set of criteria is based, at least in part, on the effectiveness of previously-delivered ATP therapy.
摘要翻译：公开了一种用于响应于异常心律的检测而提供抗起搏起搏（ATP）治疗和高压休克疗法的系统和方法。该系统基于预定的一组标准来控制ATP治疗与高压电容器的充电之间的时间，以准备冲击输送。在一个实施例中，本发明的系统在ATP电容器充电（ATP-DCC）模式下工作，其中在高压电容器充电期间全部或基本上全部ATP治疗被递送。基于对预定标准集合的评估，系统可以切换到在电容器充电（ATP-BCC）模式之外的另外的ATP，其中在高压电容器充电之前基本上全部ATP治疗被递送。根据本发明的一个方面，预定的一组标准至少部分地基于先前传递的ATP治疗的有效性。

3. 发明授权

US06718204B2 Method and apparatus to control delivery of high-voltage and anti-tachy pacing therapy in an implantable medical device 有权
标题翻译：用于控制可植入医疗装置中的高电压和抗速度起搏治疗递送的方法和装置
公开(公告)号：US06718204B2
公开(公告)日：2004-04-06
申请号：US09918224
申请日：2001-07-30
申请人： Paul J. DeGroot , Kevin T. Ousdigian , Vasant Padmanabhan , Paul Krause , Vinod Sharma
发明人： Paul J. DeGroot , Kevin T. Ousdigian , Vasant Padmanabhan , Paul Krause , Vinod Sharma
IPC分类号： A61N108
CPC分类号： A61N1/3622 , A61N1/3688 , A61N1/3925 , A61N1/3956 , A61N1/3962 , A61N1/3987
摘要： A system and method for delivering both anti-tachy pacing (ATP) therapy and high-voltage shock therapy in response to detection of abnormal cardiac rhythms is disclosed. The system controls the time between delivering ATP therapy and the charging of high-voltage capacitors in preparation for shock delivery based on a predetermined set of criteria. In one embodiment, the inventive system operates in an ATP During Capacitor Charging (ATP-DCC) mode wherein all, or substantially all, of the ATP therapy is delivered during charging of the high-voltage capacitors. Based on evaluation of the predetermined set of criteria, the system may switch to an additional ATP Before Capacitor Charging (ATP-BCC) mode, wherein substantially all of the ATP therapy is delivered prior to charging of the high-voltage capacitor. According to one aspect of the invention, the predetermined set of criteria is based, at least in part, on the effectiveness of previously-delivered ATP therapy.
摘要翻译：公开了一种用于响应于异常心律的检测而提供抗起搏起搏（ATP）治疗和高压休克疗法的系统和方法。该系统基于预定的一组标准来控制ATP治疗与高压电容器的充电之间的时间，以准备冲击输送。在一个实施例中，本发明的系统在ATP电容器充电（ATP-DCC）模式下工作，其中在高压电容器充电期间全部或基本上全部ATP治疗被递送。基于对预定标准集合的评估，系统可以切换到在电容器充电（ATP-BCC）模式之外的另外的ATP，其中在高压电容器充电之前基本上全部ATP治疗被递送。根据本发明的一个方面，预定的一组标准至少部分地基于先前传递的ATP治疗的有效性。

4. 发明授权

US5836976A Cardioversion energy reduction system 失效
标题翻译：心律转换能量减少系统
公开(公告)号：US5836976A
公开(公告)日：1998-11-17
申请号：US846747
申请日：1997-04-30
申请人： Xiaoyi Min , Li Wang , Rahul Mehra , Paul J. DeGroot , Walter H. Olson , Luc R. Mongeon , Michael R. S. Hill
发明人： Xiaoyi Min , Li Wang , Rahul Mehra , Paul J. DeGroot , Walter H. Olson , Luc R. Mongeon , Michael R. S. Hill
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61N1/3925 , A61N1/3987
摘要： In an implantable pacemaker/cardioverter/defibrillator, a system for correlating the delivery of a cardioversion therapy to an optimum point or phase of the respiratory cycle of the patient to effect delivery of the therapy when the impedance between the cardioversion electrodes is minimized. In a first application for use with cardioversion electrodes located substantially in contact with the heart chamber, the optimum point or phase is at the end of inspiration. In a second application for use with at least one cardioversion electrode located remotely from the heart chamber, the optimum point or phase is at end expiration or beginning of inspiration. The cardioversion therapy is delivered in synchrony with a ventricular sense event, if present. If the optimum point or phase of the respiratory cycle cannot be determined during a therapy time, a pre-shock may be delivered to elicit a respiration cycle through a stimulated contraction of the diaphragm.
摘要翻译：在植入式心脏起搏器/心律转复除颤器中，用于将心脏复律治疗的输送与患者呼吸周期的最佳点或阶段相关联的系统，以在心脏复律电极之间的阻抗最小化时实现治疗的传递。在与基本上与心脏腔室接触的心脏复律电极一起使用的第一个应用中，最佳点或阶段在吸气结束时。在与远离心脏室的位置的至少一个心脏复律电极一起使用的第二个应用中，最佳点或阶段是结束期满或开始吸气。复发疗法与心室感觉事件（如果存在）同步传递。如果在治疗时间内不能确定呼吸周期的最佳点或相位，则可以传送预休克以通过振膜的刺激收缩引起呼吸循环。

5. 发明授权

US09144685B2 Using focal myocardial stimulation to distinguish supraventricular tachycardia from ventricular tachycardia 有权
标题翻译：使用局灶性心肌刺激来区分室上性心动过速与室性心动过速
公开(公告)号：US09144685B2
公开(公告)日：2015-09-29
申请号：US13357646
申请日：2012-01-25
申请人： Yong-Fu Xiao , Jeffrey M. Gillberg , Paul J. DeGroot , Eduardo N. Warman , Scott J. Brabec , John L. Sommer , Jon F. Urban , Lepeng Zeng
发明人： Yong-Fu Xiao , Jeffrey M. Gillberg , Paul J. DeGroot , Eduardo N. Warman , Scott J. Brabec , John L. Sommer , Jon F. Urban , Lepeng Zeng
IPC分类号： A61N1/00 , A61N1/365 , A61N1/362
CPC分类号： A61N1/365 , A61N1/3622 , A61N1/36585
摘要： An apparatus and method to discriminate cardiac events by sensing atrial and ventricular depolarizations having associated refractory periods thereafter. A fast ventricular rate is detected in response to the sensed ventricular depolarizations. Responsive to detecting the fast ventricular rate, at least one stimulus pulse is delivered to atrial tissue within the associated refractory period of the ventricle but outside of an associated refractory period of the stimulated atrial tissue. A ventricular response to the atrial tissue stimulus pulse is determined, and the cardiac event is discriminated based on the ventricular response to the atrial tissue stimulus pulse.
摘要翻译：通过感应心房和心室去极化来区分心脏事件的装置和方法，其后具有相关联的不良期。响应于感测到的心室去极化，检测到快速心室率。响应于检测快速心室率，至少一个刺激脉冲被输送到心室的相关不应期内但在受刺激的心房组织的相关不应期内之外的心房组织。确定对心房组织刺激脉冲的心室反应，并且基于对心房组织刺激脉冲的心室响应来区分心脏事件。

6. 发明授权

US08876727B2 Phrenic nerve stimulation detection using heart sounds 有权
标题翻译：使用心脏声音进行膈神经刺激检测
公开(公告)号：US08876727B2
公开(公告)日：2014-11-04
申请号：US13474041
申请日：2012-05-17
申请人： Xusheng Zhang , Jeffrey M. Gillberg , Thomas J. Mullen , Paul J. DeGroot
发明人： Xusheng Zhang , Jeffrey M. Gillberg , Thomas J. Mullen , Paul J. DeGroot
IPC分类号： A61B5/04 , A61B5/08 , A61N1/36 , A61B7/04 , A61B5/00 , A61B7/00 , A61B5/0205 , A61N1/365 , A61B5/024
CPC分类号： A61N1/3611 , A61B5/0031 , A61B5/0205 , A61B5/024 , A61B5/0826 , A61B5/4029 , A61B5/7217 , A61B7/005 , A61B7/006 , A61B7/04 , A61N1/36114 , A61N1/36135 , A61N1/36535 , A61N1/36578
摘要： A method and system of detecting phrenic nerve stimulation in a patient that includes detecting an activation event, obtaining a heart sound signal of a patient from an implanted heart sound sensor, determining that an electrical stimulation has been applied to the patient, in response to detecting the activation event, monitoring a portion of the heart sound signal, the portion defined by a predetermined window after the application of the electrical stimulation, and determining whether phrenic nerve stimulation occurred based on the portion of the heart sound signal.
摘要翻译：一种检测患者膈神经刺激的方法和系统，包括检测激活事件，响应于检测，从植入的心音传感器获得患者的心音信号，确定电刺激已经施加到患者激活事件，监测心音信号的一部分，在施加电刺激之后由预定窗口定义的部分，以及基于心音信号的部分来确定是否发生膈神经刺激。

7. 发明授权

US5836975A Method and apparatus for diagnosis and treatment of arrhythmias 失效
公开(公告)号：US5836975A
公开(公告)日：1998-11-17
申请号：US816822
申请日：1997-06-05
申请人： Paul J. DeGroot
发明人： Paul J. DeGroot
IPC分类号： A61N1/05 , A61N1/362 , A61N1/372 , A61N1/39
CPC分类号： A61N1/3962 , A61N1/056 , A61N1/3622 , A61N1/37258 , A61N1/3925 , A61N1/3987
摘要： An implantable anti-arrhythmia device such as a defibrillator or anti-tachycardia pacemaker with an associated patient activator. In response to the patient activation signal, the implanted device notifies the activator whether an atrial rhythm requiring treatment is present and whether a therapy is available for delivery in response to the patient's request. After the patient is notified that a therapy is pending, the implanted device charges its output capacitors and thereafter determines whether opportunities for prompt synchronization are present with a desired frequency, over a preceding series of depolarizations. If both conditions are met, the likelihood that a defibrillation or cardioversion pulse can be delivered quickly following a patient initiated retrigger signal is high, and the device notifies the patient's activator that it will await receipt of a patient retrigger signal, as a prerequisite for a delivery of the cardioversion or defibrillation pulse. The patient retrigger signal may take the form of a second downlink from the activator to the implanted device, or may take the form of a defined patient action, detected by the implanted device. For example, the implanted device may be provided with an impedance sensor of the sort typically employed in rate responsive implantable pacemakers to measure respiration rate and minute volume. This sensor may be used to detect the action of the patient holding his or her breath, in preparation to receiving the shock. In this embodiment, the patient's own action of bracing to receive the shock may be used as the mechanism for triggering delivery of the shock. An alternative patient trigger might be accomplished by providing the implanted device with a piezoelectric crystal, located on an interior surface of the pacemaker housing, of the sort typically employed to sense physical activity in the rate responsive cardiac pacemakers. This sensor may be employed in the context of the present invention to detect the patient tapping on an implanted device, as a signal to trigger delivery of therapy.

8. 发明授权

US08374686B2 Continuous monitoring of risk burden for sudden cardiac death risk stratification 有权
标题翻译：持续监测心源性猝死危险分层的风险负担
公开(公告)号：US08374686B2
公开(公告)日：2013-02-12
申请号：US12793526
申请日：2010-06-03
申请人： Raja N. Ghanem , Paul J. DeGroot
发明人： Raja N. Ghanem , Paul J. DeGroot
IPC分类号： A61B5/04
CPC分类号： A61B5/0452 , A61B5/02405 , A61B5/7275 , G06F19/00
摘要： System and method for assessing a likelihood of a patient to experience a cardiac arrhythmia. A biological sensor is configured to sense biological parameters of the patient. A processor is coupled to the biological sensor and is configured to determine the likelihood of the patient experiencing a cardiac arrhythmia based, at least in part, on a combination of the biological parameters, the combination dynamically weighting each of the plurality of biological parameters based on another one of the plurality of biological parameters.
摘要翻译：用于评估患者经历心律失常的可能性的系统和方法。生物传感器被配置为感测患者的生物学参数。处理器耦合到生物传感器并且被配置为至少部分地基于生物参数的组合来确定患者经历心律失常的可能性，所述组合基于动态加权多个生物参数中的每一个，基于多个生物参数中的另一个。

9. 发明申请

US20120296388A1 PHRENIC NERVE STIMULATION DETECTION USING HEART SOUNDS 有权
标题翻译：使用心脏声波的神经根神经刺激检测
公开(公告)号：US20120296388A1
公开(公告)日：2012-11-22
申请号：US13474041
申请日：2012-05-17
申请人： Xusheng Zhang , Jeffrey M. Gillberg , Thomas J. Mullen , Paul J. DeGroot
发明人： Xusheng Zhang , Jeffrey M. Gillberg , Thomas J. Mullen , Paul J. DeGroot
IPC分类号： A61N1/37 , A61N1/365
CPC分类号： A61N1/3611 , A61B5/0031 , A61B5/0205 , A61B5/024 , A61B5/0826 , A61B5/4029 , A61B5/7217 , A61B7/005 , A61B7/006 , A61B7/04 , A61N1/36114 , A61N1/36135 , A61N1/36535 , A61N1/36578
摘要： A method and system of detecting phrenic nerve stimulation in a patient that includes detecting an activation event, obtaining a heart sound signal of a patient from an implanted heart sound sensor, determining that an electrical stimulation has been applied to the patient, in response to detecting the activation event, monitoring a portion of the heart sound signal, the portion defined by a predetermined window after the application of the electrical stimulation, and determining whether phrenic nerve stimulation occurred based on the portion of the heart sound signal.
摘要翻译：一种检测患者膈神经刺激的方法和系统，包括检测激活事件，响应于检测，从植入的心音传感器获得患者的心音信号，确定电刺激已经施加到患者激活事件，监测心音信号的一部分，在施加电刺激之后由预定窗口定义的部分，以及基于心音信号的部分来确定是否发生膈神经刺激。

10. 发明申请

US20120232605A1 USING FOCAL MYOCARDIAL STIMULATION TO DISTINGUISH SUPRAVENTRICULAR TACHYCARDIA FROM VENTRICULAR TACHYCARDIA 有权
标题翻译：使用焦虑性心肌梗塞对来自心脏TACHYCARDIA的非致病性TACHYCARDIA
公开(公告)号：US20120232605A1
公开(公告)日：2012-09-13
申请号：US13357646
申请日：2012-01-25
申请人： Yong-Fu Xiao , Jeffrey M. Gillberg , Paul J. DeGroot , Eduardo N. Warman , Scott J. Brabec , John L. Sommer , Jon F. Urban , Lepeng Zeng
发明人： Yong-Fu Xiao , Jeffrey M. Gillberg , Paul J. DeGroot , Eduardo N. Warman , Scott J. Brabec , John L. Sommer , Jon F. Urban , Lepeng Zeng
IPC分类号： A61N1/365
CPC分类号： A61N1/365 , A61N1/3622 , A61N1/36585
摘要： An apparatus and method to discriminate cardiac events by sensing atrial and ventricular depolarizations having associated refractory periods thereafter. A fast ventricular rate is detected in response to the sensed ventricular depolarizations. Responsive to detecting the fast ventricular rate, at least one stimulus pulse is delivered to atrial tissue within the associated refractory period of the ventricle but outside of an associated refractory period of the stimulated atrial tissue. A ventricular response to the atrial tissue stimulus pulse is determined, and the cardiac event is discriminated based on the ventricular response to the atrial tissue stimulus pulse.
摘要翻译：通过感应心房和心室去极化来区分心脏事件的装置和方法，其后具有相关联的不良期。响应于感测到的心室去极化，检测到快速心室率。响应于检测快速心室率，至少一个刺激脉冲被输送到心室的相关不应期内但在受刺激的心房组织的相关不应期内之外的心房组织。确定对心房组织刺激脉冲的心室反应，并且基于对心房组织刺激脉冲的心室响应来区分心脏事件。

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