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1. 发明申请

US20100266675A1 LIPOPROTEINS, LIPOPEPTIDES AND ANALOGS, AND METHODS FOR MAKING AND USING THEM 有权
标题翻译：脂蛋白，脂蛋白和类似物，以及制备和使用它们的方法
公开(公告)号：US20100266675A1
公开(公告)日：2010-10-21
申请号：US12600930
申请日：2008-05-21
申请人： William Gerwick , Wolfgang Wrasidlo , Dennis Carson , Dwayne Stupack , Takashi Suyama
发明人： William Gerwick , Wolfgang Wrasidlo , Dennis Carson , Dwayne Stupack , Takashi Suyama
IPC分类号： A61K9/127 , C07K2/00 , A61K38/00 , A61P35/00
CPC分类号： C07C323/60 , C07C233/47
摘要： The invention provides novel compositions—lipopeptides and analogs, including somocystinamide A, and somocystinamide A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment, these lipopeptides and analogs are used to induce apoptosis in a cell, which can be a normal cell, a dysfunctional cell and/or a cancer (tumor) cell. In alternative embodiments, the compositions of the invention, including the lipopeptides and analogs of the invention, and the pharmaceutical compositions comprising them, are used to treat or ameliorate (including slowing the progression of) normal, dysfunctional (e.g., abnormally proliferating) and/or tumor associated blood vessels, including endothelial and/or capillary cell growth; including neovasculature related to (within, providing a blood supply to) a tumor.
摘要翻译：本发明提供了新颖的组合物 - 脂肽和类似物，包括胞质酰胺A和胞囊酰胺A变体和类似物，以及包含它们的药物组合物，脂质体和纳米颗粒，以及制备和使用它们的方法。在一个实施方案中，这些脂肽和类似物用于诱导细胞凋亡，细胞可以是正常细胞，功能障碍细胞和/或癌症（肿瘤）细胞。在替代实施方案中，本发明的组合物，包括本发明的脂肽和类似物以及包含它们的药物组合物用于治疗或改善（包括减缓正常，功能障碍（例如异常增殖）和/ 或肿瘤相关血管，包括内皮细胞和/或毛细胞生长; 包括与肿瘤相关的新血管生成（内部，提供血液供应）。

2. 发明授权

US09045401B2 Methods for treating or ameliorating a melanoma and killing melanoma cells 有权
标题翻译：用于治疗或改善黑素瘤并杀死黑素瘤细胞的方法
公开(公告)号：US09045401B2
公开(公告)日：2015-06-02
申请号：US12600930
申请日：2008-05-21
申请人： William Gerwick , Wolfgang Wrasidlo , Dennis Carson , Dwayne Stupack , Takashi Suyama
发明人： William Gerwick , Wolfgang Wrasidlo , Dennis Carson , Dwayne Stupack , Takashi Suyama
IPC分类号： A61K9/127 , C07C323/60 , C07C233/47
CPC分类号： C07C323/60 , C07C233/47
摘要： The invention provides novel compositions—lipopeptides and analogs, including somocystinamide A, and somocystinamide A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment, these lipopeptides and analogs are used to induce apoptosis in a cell, which can be a normal cell, a dysfunctional cell and/or a cancer (tumor) cell. In alternative embodiments, the compositions of the invention, including the lipopeptides and analogs of the invention, and the pharmaceutical compositions comprising them, are used to treat or ameliorate (including slowing the progression of) normal, dysfunctional (e.g., abnormally proliferating) and/or tumor associated blood vessels, including endothelial and/or capillary cell growth; including neovasculature related to (within, providing a blood supply to) a tumor.
摘要翻译：本发明提供了新颖的组合物 - 脂肽和类似物，包括胞质酰胺A和胞囊酰胺A变体和类似物，以及包含它们的药物组合物，脂质体和纳米颗粒，以及制备和使用它们的方法。在一个实施方案中，这些脂肽和类似物用于诱导细胞凋亡，细胞可以是正常细胞，功能障碍细胞和/或癌症（肿瘤）细胞。在替代实施方案中，本发明的组合物，包括本发明的脂肽和类似物以及包含它们的药物组合物用于治疗或改善（包括减缓正常，功能障碍（例如异常增殖）和/ 或肿瘤相关血管，包括内皮细胞和/或毛细胞生长; 包括与肿瘤相关的新血管生成（内部，提供血液供应）。

3. 发明申请

US20140147481A1 ANTI-INFLAMMATORY AND QUORUM SENSING INHIBITION COMPOUNDS AND METHODS OF MAKING AND USING THEM 有权
标题翻译：抗炎和感应抑制化合物及其制备和使用方法
公开(公告)号：US20140147481A1
公开(公告)日：2014-05-29
申请号：US13696583
申请日：2011-06-03
申请人： William Gerwick , Lena Gerwick , Huykjae Choi , Francisco Villa , Jennifer Smith , David C Rowley
发明人： William Gerwick , Lena Gerwick , Huykjae Choi , Francisco Villa , Jennifer Smith , David C Rowley
IPC分类号： C07D307/33 , C07C69/732 , C07C57/52 , C07C233/15 , A61Q11/00 , A61K8/49 , A61K8/37 , A61K8/42 , A61K8/14 , A61K9/127 , A61K8/69
CPC分类号： C07D307/33 , A61F2310/0097 , A61K8/14 , A61K8/37 , A61K8/42 , A61K8/4973 , A61K8/69 , A61K9/0019 , A61K9/127 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/202 , A61L2300/404 , A61L2300/41 , A61Q11/00 , C07C57/52 , C07C57/54 , C07C69/732 , C07C233/15
摘要： The invention provides novel compositions based on a structure designated as “Honaucin A”, including Honaucin A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used as bacterial quorumsensing inhibitors. Accordingly, in alternative embodiments the compositions of the invention are used as anti-bacterial agents.
摘要翻译：本发明提供了基于称为“Honaucin A”的结构的新型组合物，包括Honaucin A变体和类似物，以及包含它们的药物组合物，脂质体和纳米颗粒，以及制备和使用它们的方法。在一个实施方案中，这些Honaucin A化合物及其变体和类似物用于改善（包括治疗或预防）炎症。在一个实施方案中，这些Honaucin A化合物及其变体和类似物用于改善（包括治疗或预防）炎症。在一个实施方案中，这些Honaucin A化合物及其变体和类似物用作细菌麻醉抑制剂。因此，在替代实施方案中，本发明的组合物用作抗细菌剂。

4. 发明申请

US20050208070A1 Compositions of botanical extracts for cancer therapy 有权
标题翻译：用于癌症治疗的植物提取物的组合物
公开(公告)号：US20050208070A1
公开(公告)日：2005-09-22
申请号：US10937707
申请日：2004-09-08
申请人： James Dao , Tom Dao , David Tong , Leslie Wilson , Mary Jordan , William Gerwick
发明人： James Dao , Tom Dao , David Tong , Leslie Wilson , Mary Jordan , William Gerwick
IPC分类号： A61K20060101 , A61K31/00 , A61K36/537 , A61K36/539 , A61K36/82 , A61K41/00 , A61K45/06 , A61K35/84 , A61K35/78
CPC分类号： A61K36/539 , A61K31/00 , A61K31/337 , A61K31/437 , A61K31/519 , A61K31/704 , A61K31/7068 , A61K36/074 , A61K36/185 , A61K36/537 , A61K36/82 , A61K41/00 , A61K45/06 , A61K2300/00
摘要： Methods and compositions for prevention and therapy of cancer are provided. Compositions comprising therapeutically effective amounts of two or more of an extract of Ganoderma lucidum, an extract of Salvia miltiorrhiza and an extract of Scutellaria barbata and optionally a therapeutically effective amount of an extract of Hippophae rhamnoides are provided. Novel synergistic effects of the use of these compounds in combination therapy are disclosed. Embodiments further comprising therapeutically effective amounts of at least one chemotherapeutic agent are also provided.
摘要翻译：提供了预防和治疗癌症的方法和组合物。提供包含治疗有效量的灵芝提取物，丹参提取物和黄芩提取物和任选的治疗有效量的沙棘提取物的两种或更多种的组合物。公开了在组合疗法中使用这些化合物的新的协同效应。还提供还包含治疗有效量的至少一种化学治疗剂的实施方案。

5. 发明授权

US09073884B2 Anti-inflammatory and quorum sensing inhibition compounds and methods of making and using them 有权
标题翻译：抗炎和法定感应抑制化合物及其制备及使用方法
公开(公告)号：US09073884B2
公开(公告)日：2015-07-07
申请号：US13696583
申请日：2011-06-03
申请人： William Gerwick , Lena Gerwick , Hyuakjae Choi , Francisco Villa , Jennifer Smith , David C Rowley
发明人： William Gerwick , Lena Gerwick , Hyuakjae Choi , Francisco Villa , Jennifer Smith , David C Rowley
IPC分类号： C07D307/33 , A61K8/14 , A61K8/37 , A61K8/42 , A61K8/49 , A61K9/00 , A61K9/127 , A61Q11/00 , C07C57/54 , A61L27/54 , A61L29/16 , A61L31/16 , A61K8/69 , C07C57/52 , C07C69/732 , C07C233/15
CPC分类号： C07D307/33 , A61F2310/0097 , A61K8/14 , A61K8/37 , A61K8/42 , A61K8/4973 , A61K8/69 , A61K9/0019 , A61K9/127 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/202 , A61L2300/404 , A61L2300/41 , A61Q11/00 , C07C57/52 , C07C57/54 , C07C69/732 , C07C233/15
摘要： The invention provides novel compositions based on a structure designated as “Honaucin A”, including Honaucin A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used as bacterial quorumsensing inhibitors. Accordingly, in alternative embodiments the compositions of the invention are used as anti-bacterial agents.
摘要翻译：本发明提供了基于称为“Honaucin A”的结构的新型组合物，包括Honaucin A变体和类似物，以及包含它们的药物组合物，脂质体和纳米颗粒，以及制备和使用它们的方法。在一个实施方案中，这些Honaucin A化合物及其变体和类似物用于改善（包括治疗或预防）炎症。在一个实施方案中，这些Honaucin A化合物及其变体和类似物用于改善（包括治疗或预防）炎症。在一个实施方案中，这些Honaucin A化合物及其变体和类似物用作细菌麻醉抑制剂。因此，在替代实施方案中，本发明的组合物用作抗细菌剂。

6. 发明授权

US08173177B2 Compositions of botanical extracts for cancer therapy 有权
标题翻译：用于癌症治疗的植物提取物的组合物
公开(公告)号：US08173177B2
公开(公告)日：2012-05-08
申请号：US10937707
申请日：2004-09-08
申请人： James Dao , Tom C. S. Dao , David D. Tong , Leslie Wilson , Mary Ann Jordan , William Gerwick
发明人： James Dao , Tom C. S. Dao , David D. Tong , Leslie Wilson , Mary Ann Jordan , William Gerwick
IPC分类号： A61K36/00
CPC分类号： A61K36/539 , A61K31/00 , A61K31/337 , A61K31/437 , A61K31/519 , A61K31/704 , A61K31/7068 , A61K36/074 , A61K36/185 , A61K36/537 , A61K36/82 , A61K41/00 , A61K45/06 , A61K2300/00
摘要： Methods and compositions for prevention and therapy of cancer are provided. Compositions comprising therapeutically effective amounts of two or more of an extract of Ganoderma lucidum, an extract of Salvia miltiorrhiza and an extract of Scutellaria barbata and optionally a therapeutically effective amount of an extract of Hippophae rhamnoides are provided. Novel synergistic effects of the use of these compounds in combination therapy are disclosed. Embodiments further comprising therapeutically effective amounts of at least one chemotherapeutic agent are also provided.
摘要翻译：提供了预防和治疗癌症的方法和组合物。提供包含治疗有效量的灵芝提取物，丹参提取物和黄芩提取物和任选的治疗有效量的沙棘提取物的两种或更多种的组合物。公开了在组合疗法中使用这些化合物的新的协同效应。还提供还包含治疗有效量的至少一种化学治疗剂的实施方案。

7. 发明申请

US20110117121A1 COMPOSITIONS FOR TREATMENT AND INHIBITION OF PAIN 审中-公开
标题翻译：用于治疗和抑制疼痛的组合物
公开(公告)号：US20110117121A1
公开(公告)日：2011-05-19
申请号：US12446561
申请日：2007-10-26
申请人： James Dao , Jeff Dao , Leslie Wilson , William Gerwick , Emin Oroudjev
发明人： James Dao , Jeff Dao , Leslie Wilson , William Gerwick , Emin Oroudjev
IPC分类号： A61K36/06 , A61P25/00
CPC分类号： A61K36/537 , A61K36/074 , A61K36/539 , Y02A50/422
摘要： Methods and compositions for therapy of pain are provided. Compositions comprising therapeutically effective amounts of two or more of an extract of Ganoderma lucidum, an extract of Salvia miltiorrhiza and an extract of Scutellaria barbata and optionally a therapeutically effective amount of an extract of Hippophae rhamnoides are provided. Novel synergistic effects of the use of these compounds in combination therapy are disclosed. Compositions exhibit multiple functions that are useful for the treatment of pain and inflammation. Compositions of the invention inhibit the activity of COX-2 to a greater extent than COX-1. Compositions of the invention also inhibit the nuclear accumulation of NF-kappaB and thus inhibit the expression of a number of proinflammatory molecules including COX-2.
摘要翻译：提供了治疗疼痛的方法和组合物。提供包含治疗有效量的灵芝提取物，丹参提取物和黄芩提取物和任选的治疗有效量的沙棘提取物的两种或更多种的组合物。公开了在组合疗法中使用这些化合物的新的协同效应。组合物表现出多种可用于治疗疼痛和炎症的功能。本发明的组合物比COX-1更大程度上抑制COX-2的活性。本发明的组合物还抑制NF-κB的核聚集，从而抑制许多促炎分子（包括COX-2）的表达。

8. 发明申请

US20050074834A1 Method and system for classifying a scenario 审中-公开
标题翻译：分类场景的方法和系统
公开(公告)号：US20050074834A1
公开(公告)日：2005-04-07
申请号：US10801389
申请日：2004-03-12
申请人： Frank Chaplen , William Gerwick , Goran Jovanovic , Wojtek Kolodziej , Jim Liburdy , Phil McFadden , Brian Paul , Thomas Plant , Janine Trempy , Nicolas Roussel , Corwin Willard , Rosalyn Upson , Andrzej Pacut
发明人： Frank Chaplen , William Gerwick , Goran Jovanovic , Wojtek Kolodziej , Jim Liburdy , Phil McFadden , Brian Paul , Thomas Plant , Janine Trempy , Nicolas Roussel , Corwin Willard , Rosalyn Upson , Andrzej Pacut
IPC分类号： C12Q1/04 , G01N15/14 , G01N33/48 , G01N33/50 , G06F19/00 , G06K9/00 , G06K9/62 , G06K9/68
CPC分类号： G06K9/6292 , G01N15/1475 , G01N2015/1472 , G06K9/00127
摘要： Living cells can be used to identify or quantify bioactive conditions, including without limitation, chemicals, biological pathogens, and environmental conditions, such as pH, in samples based on changes in, for example, cell color, morphology and/or physiology. Such changes can be directly detected or detected with the aid of instrumentation. One embodiment of the method comprises exposing a system to a bioactive condition, such as a chemical agent, a biological pathogen, an environmental condition, such as pH, etc., and combinations of such conditions. The system then exhibits a response to the bioactive condition. The response of the system, or a portion thereof, to the bioactive condition is then represented, such as by digital images. The method then involves attempting to classify a scenario by database comparison. Classification can be in terms of numeric or non-numerical classifiers. Typically, the system comprises living cells. Living cells useful for practicing the method experience a detectable change in response to an interaction with a bioactive condition. A likely living cell for use with the method and apparatus of the present invention is a chromatophore. The present method has a number of uses, including classifying unknown drug candidates, classifying unknown toxins, classifying chemical warfare agents, etc. The method a can be implemented using a computer program encoding the method. Moreover, a computer-readable medium is described on which is stored a computer program having instructions for executing the method. A cytosensor apparatus also is described.
摘要翻译：活体细胞可以用于基于例如细胞颜色，形态和/或生理学的变化来鉴定或定量生物活性条件，包括但不限于化学品，生物病原体和样品中的环境条件，例如pH。可以借助于仪器直接检测或检测到这种变化。该方法的一个实施方案包括将系统暴露于生物活性状况，例如化学试剂，生物病原体，环境条件如pH等，以及这些条件的组合。然后，该系统对生物活性状况作出响应。然后，例如通过数字图像来表示系统或其一部分对生物活性状况的响应。该方法然后涉及尝试通过数据库比较对场景进行分类。分类可以是数字或非数字分类器。通常，该系统包括活细胞。可用于实践该方法的活细胞经历对与生物活性条件相互作用的响应的可检测变化。与本发明的方法和装置一起使用的可能的活细胞是染色质。本方法具有多种用途，包括分类未知药物候选物，分类未知毒素，分类化学战剂等。方法a可以使用编码该方法的计算机程序来实现。此外，描述了一种计算机可读介质，其上存储有具有用于执行该方法的指令的计算机程序。还描述了细胞传感器装置。

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