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1. 发明申请

US20130101616A1 COMPOSITIONS OF BOTANICAL EXTRACTS FOR CANCER THERAPY 审中-公开
标题翻译：用于癌症治疗的植物提取物的组合物
公开(公告)号：US20130101616A1
公开(公告)日：2013-04-25
申请号：US13445812
申请日：2012-04-12
申请人： James DAO , Tom C.S. DAO , David D. TONG , Leslie WILSON , Mary Ann JORDAN , William GERWICK
发明人： James DAO , Tom C.S. DAO , David D. TONG , Leslie WILSON , Mary Ann JORDAN , William GERWICK
IPC分类号： A61K36/539 , A61K36/537 , A61K31/704 , A61K31/519 , A61K31/337 , A61K31/437 , A61K36/074 , A61K31/7068
CPC分类号： A61K36/539 , A61K31/00 , A61K31/337 , A61K31/437 , A61K31/519 , A61K31/704 , A61K31/7068 , A61K36/074 , A61K36/185 , A61K36/537 , A61K36/82 , A61K41/00 , A61K45/06 , A61K2300/00
摘要： Methods and compositions for prevention and therapy of cancer are provided. Compositions comprising therapeutically effective amounts of two or more of an extract of Ganoderma lucidum, an extract of Salvia miltiorrhiza and an extract of Scutellaria barbata and optionally a therapeutically effective amount of an extract of Hippophae rhamnoides are provided. Novel synergistic effects of the use of these compounds in combination therapy are disclosed. Embodiments further comprising therapeutically effective amounts of at least one chemotherapeutic agent are also provided.
摘要翻译：提供了预防和治疗癌症的方法和组合物。提供包含治疗有效量的灵芝提取物，丹参提取物和黄芩提取物和任选的治疗有效量的沙棘提取物的两种或更多种的组合物。公开了在组合疗法中使用这些化合物的新的协同效应。还提供还包含治疗有效量的至少一种化学治疗剂的实施方案。

2. 发明申请

US20050214394A1 Hippophae rhamnoides compositions for cancer therapy 审中-公开
标题翻译：沙棘沙门氏菌组合物用于癌症治疗
公开(公告)号：US20050214394A1
公开(公告)日：2005-09-29
申请号：US10948580
申请日：2004-09-22
申请人： James Dao , Tom Dao , David Tong
发明人： James Dao , Tom Dao , David Tong
IPC分类号： A61K36/48 , A61K36/00 , A61K36/074 , A61K36/185 , A61K36/537 , A61K36/539 , A61K36/61 , A61K36/72 , A61P35/00 , A61K35/78
CPC分类号： A61K36/185 , A61K36/074 , A61K36/537 , A61K36/539 , A61K36/61 , A61K2300/00
摘要： Methods and compositions for prevention and therapy of cancer using a therapeutically effective amount of an extract of Hippophae rhamnoides (sea buckthorn) leaves, berries, and seeds are provided. Novel uses of these compositions in different stages of cancer therapy are disclosed. Novel compositions comprising Hippophae rhamnoides extracts that preferentially inhibit COX-2 over COX-1 are provided. Compositions comprising therapeutically effective amounts of at least one chemotherapeutic agent in addition to Hippophae rhamnoides are provided.
摘要翻译：提供了使用治疗有效量的沙棘（沙棘）叶，浆果和种子的提取物预防和治疗癌症的方法和组合物。公开了这些组合物在不同癌症治疗阶段的新用途。提供了包含优于COX-1优先抑制COX-2的沙棘沙门氏菌提取物的新型组合物。提供了包含治疗有效量的至少一种化学治疗剂的组合物，除了沙棘之外。

3. 发明授权

US08173177B2 Compositions of botanical extracts for cancer therapy 有权
标题翻译：用于癌症治疗的植物提取物的组合物
公开(公告)号：US08173177B2
公开(公告)日：2012-05-08
申请号：US10937707
申请日：2004-09-08
申请人： James Dao , Tom C. S. Dao , David D. Tong , Leslie Wilson , Mary Ann Jordan , William Gerwick
发明人： James Dao , Tom C. S. Dao , David D. Tong , Leslie Wilson , Mary Ann Jordan , William Gerwick
IPC分类号： A61K36/00
CPC分类号： A61K36/539 , A61K31/00 , A61K31/337 , A61K31/437 , A61K31/519 , A61K31/704 , A61K31/7068 , A61K36/074 , A61K36/185 , A61K36/537 , A61K36/82 , A61K41/00 , A61K45/06 , A61K2300/00
摘要： Methods and compositions for prevention and therapy of cancer are provided. Compositions comprising therapeutically effective amounts of two or more of an extract of Ganoderma lucidum, an extract of Salvia miltiorrhiza and an extract of Scutellaria barbata and optionally a therapeutically effective amount of an extract of Hippophae rhamnoides are provided. Novel synergistic effects of the use of these compounds in combination therapy are disclosed. Embodiments further comprising therapeutically effective amounts of at least one chemotherapeutic agent are also provided.
摘要翻译：提供了预防和治疗癌症的方法和组合物。提供包含治疗有效量的灵芝提取物，丹参提取物和黄芩提取物和任选的治疗有效量的沙棘提取物的两种或更多种的组合物。公开了在组合疗法中使用这些化合物的新的协同效应。还提供还包含治疗有效量的至少一种化学治疗剂的实施方案。

4. 发明申请

US20110117121A1 COMPOSITIONS FOR TREATMENT AND INHIBITION OF PAIN 审中-公开
标题翻译：用于治疗和抑制疼痛的组合物
公开(公告)号：US20110117121A1
公开(公告)日：2011-05-19
申请号：US12446561
申请日：2007-10-26
申请人： James Dao , Jeff Dao , Leslie Wilson , William Gerwick , Emin Oroudjev
发明人： James Dao , Jeff Dao , Leslie Wilson , William Gerwick , Emin Oroudjev
IPC分类号： A61K36/06 , A61P25/00
CPC分类号： A61K36/537 , A61K36/074 , A61K36/539 , Y02A50/422
摘要： Methods and compositions for therapy of pain are provided. Compositions comprising therapeutically effective amounts of two or more of an extract of Ganoderma lucidum, an extract of Salvia miltiorrhiza and an extract of Scutellaria barbata and optionally a therapeutically effective amount of an extract of Hippophae rhamnoides are provided. Novel synergistic effects of the use of these compounds in combination therapy are disclosed. Compositions exhibit multiple functions that are useful for the treatment of pain and inflammation. Compositions of the invention inhibit the activity of COX-2 to a greater extent than COX-1. Compositions of the invention also inhibit the nuclear accumulation of NF-kappaB and thus inhibit the expression of a number of proinflammatory molecules including COX-2.
摘要翻译：提供了治疗疼痛的方法和组合物。提供包含治疗有效量的灵芝提取物，丹参提取物和黄芩提取物和任选的治疗有效量的沙棘提取物的两种或更多种的组合物。公开了在组合疗法中使用这些化合物的新的协同效应。组合物表现出多种可用于治疗疼痛和炎症的功能。本发明的组合物比COX-1更大程度上抑制COX-2的活性。本发明的组合物还抑制NF-κB的核聚集，从而抑制许多促炎分子（包括COX-2）的表达。

5. 发明申请

US20050196409A1 Compositions of botanical extracts for treating malignancy-associated changes 审中-公开
标题翻译：用于治疗恶性肿瘤相关变化的植物提取物的组合物
公开(公告)号：US20050196409A1
公开(公告)日：2005-09-08
申请号：US10949178
申请日：2004-09-24
申请人： James Dao , Jeffrey Dao
发明人： James Dao , Jeffrey Dao
IPC分类号： A61K36/537 , A61K36/539 , C12Q1/68 , G01N33/48 , G01N33/50 , G01N33/574 , G06F19/00 , A61K35/84 , A61K35/78
CPC分类号： A61K36/539 , A61K36/074 , A61K36/537 , A61K36/61 , Y02A90/26 , A61K2300/00
摘要： Methods for diagnosis of malignancy associated changes (MAC) using Automated Quantitative Cytometry (AQC) and treatment using compositions, extracts and compounds comprising botanical extracts. Use of such compounds in the prevention and therapy of cancer diagnosed by the AQC MAC test are also provided as well as methods for treatment using the compositions of this invention. Compositions comprising therapeutically effective amounts of two or more of an extract of Ganoderma lucidum, an extract of Salvia miltiorrhiza and an extract of Scutellaria barbata and optionally a therapeutically effective amount of an extract of Hippophae rhamnoides are provided. Novel synergistic effects of the use of these compounds in combination therapy are disclosed. Compositions further comprising therapeutically effective amounts of at least one chemotherapeutic agent are also provided.
摘要翻译：使用自动定量细胞计数（AQC）诊断恶性肿瘤相关变化（MAC）的方法和使用包含植物提取物的组合物，提取物和化合物进行治疗。还提供了这些化合物在通过AQC MAC测试诊断的癌症的预防和治疗中的用途以及使用本发明组合物治疗的方法。提供包含治疗有效量的灵芝提取物，丹参提取物和黄芩提取物和任选的治疗有效量的沙棘提取物的两种或更多种的组合物。公开了在组合疗法中使用这些化合物的新的协同效应。还提供还包含治疗有效量的至少一种化学治疗剂的组合物。

6. 发明授权

US5049862A Keyless flat panel portable computer--computer aided notebook 失效
标题翻译：无钥匙平板手提电脑电脑辅助笔记本
公开(公告)号：US5049862A
公开(公告)日：1991-09-17
申请号：US418009
申请日：1989-10-06
申请人： James Dao , David C. Foyt , Jeffrey J. Dao , Kenneth R. Allen
发明人： James Dao , David C. Foyt , Jeffrey J. Dao , Kenneth R. Allen
IPC分类号： G06F1/16 , G06F3/033 , G06F3/041 , G06F3/048 , G06F15/02 , G06K9/62
CPC分类号： G06F1/1656 , G06F1/1626 , G06F1/1643 , G06F1/1647 , G06F1/1654 , G06F3/0488 , G06F2200/1614
摘要： A keyboardless portable computer simulates a foldable notepad and has a display which can be reoriented to the convenience of the user, carried in a self-protecting closed position and operated in any convenient open position. The computer has a first flat panel, a second flat panel and hinge means for joining the first panel to the second panel such that the first flat surface is juxtaposed to the second flat surface in a closed position and is disposed side by side in a common plane in one of a selection of open positions. The first flat surface comprises a first digitizer and the second flat surface comprises a second digitizer, and a stylus is provided which is connectable to at least one of the panels for interacting with at least one of the digitizers. One of the digitizers includes a flat panel display through which visual output is provided. Thus, registration of a written symbol on the surface of the panel produces a displayed symbol, preferably at the position of registration. The panels may be detachable at the hinge means, folded back to back to one another for compact usage and a second hinge on a digitizer panel permits a bound paper notebook to be interleaved with a thin digitizer.
摘要翻译：无键盘便携式计算机模拟可折叠记事本，并具有显示器，其可以重新定向以方便用户，携带在自保护关闭位置并且在任何方便的打开位置操作。计算机具有第一平板，第二平板和用于将第一面板接合到第二面板的铰链装置，使得第一平面在关闭位置并列到第二平面，并且并排设置在共同的飞机在一个选择的开放职位。第一平面包括第一数字转换器，第二平表面包括第二数字转换器，并且提供触针，其可与至少一个面板连接，用于与数字化仪中的至少一个进行交互。其中一个数字化仪包括一个平板显示器，通过该平板显示器提供视觉输出。因此，在面板的表面上注册书写符号产生显示的符号，优选地在注册位置。面板可以在铰链装置处可拆卸，彼此相对折叠以便紧凑地使用，并且数字转换器面板上的第二铰链允许装订纸笔记本电脑与薄型数字转换器交错。

7. 发明申请

US20050208070A1 Compositions of botanical extracts for cancer therapy 有权
标题翻译：用于癌症治疗的植物提取物的组合物
公开(公告)号：US20050208070A1
公开(公告)日：2005-09-22
申请号：US10937707
申请日：2004-09-08
申请人： James Dao , Tom Dao , David Tong , Leslie Wilson , Mary Jordan , William Gerwick
发明人： James Dao , Tom Dao , David Tong , Leslie Wilson , Mary Jordan , William Gerwick
IPC分类号： A61K20060101 , A61K31/00 , A61K36/537 , A61K36/539 , A61K36/82 , A61K41/00 , A61K45/06 , A61K35/84 , A61K35/78
CPC分类号： A61K36/539 , A61K31/00 , A61K31/337 , A61K31/437 , A61K31/519 , A61K31/704 , A61K31/7068 , A61K36/074 , A61K36/185 , A61K36/537 , A61K36/82 , A61K41/00 , A61K45/06 , A61K2300/00
摘要： Methods and compositions for prevention and therapy of cancer are provided. Compositions comprising therapeutically effective amounts of two or more of an extract of Ganoderma lucidum, an extract of Salvia miltiorrhiza and an extract of Scutellaria barbata and optionally a therapeutically effective amount of an extract of Hippophae rhamnoides are provided. Novel synergistic effects of the use of these compounds in combination therapy are disclosed. Embodiments further comprising therapeutically effective amounts of at least one chemotherapeutic agent are also provided.
摘要翻译：提供了预防和治疗癌症的方法和组合物。提供包含治疗有效量的灵芝提取物，丹参提取物和黄芩提取物和任选的治疗有效量的沙棘提取物的两种或更多种的组合物。公开了在组合疗法中使用这些化合物的新的协同效应。还提供还包含治疗有效量的至少一种化学治疗剂的实施方案。

8. 发明申请

US20050059894A1 Automated endoscopy device, diagnostic method, and uses 审中-公开
标题翻译：自动内窥镜装置，诊断方法和用途
公开(公告)号：US20050059894A1
公开(公告)日：2005-03-17
申请号：US10663998
申请日：2003-09-16
申请人： Haishan Zeng , Mirjan Petek , James Dao , Branko Palcic , Gary Ferguson
发明人： Haishan Zeng , Mirjan Petek , James Dao , Branko Palcic , Gary Ferguson
IPC分类号： A61B1/04 , A61B5/00 , A61B6/00
CPC分类号： A61B1/00055 , A61B1/043 , A61B5/0068 , A61B5/0071 , A61B5/0075 , A61B5/0084
摘要： The present invention is an automated endoscopic device and diagnostic method, which performs at least one other disease detection method simultaneously during a white light endoscopic procedure. In some embodiments fluorescence imaging or spectroscopy is performed during the white light examination. In other embodiments, multi-modal imaging and/or spectroscopy may be performed and combined in a variety of ways. Because diagnostic modes other than white light are performed transparently in the background, the procedure is not significantly more complex for the clinician than the familiar white light examination. In some embodiments the present invention automatically detects suspicious tissue and informs the clinician of its presence. In other embodiments the present invention helps determine if a biopsy is required, and may further assist the clinician, for example, by providing an outline or otherwise guide the clinician in identifying and/or taking a biopsy of a suspicious site. In yet other embodiments, the present invention includes refinements afforded by incorporating a priori information, for example, patient history, previous endoscopy data, the results of qualitative and/or quantitative sputum cytology etc.
摘要翻译：本发明是一种自动内窥镜装置和诊断方法，其在白光内窥镜手术中同时执行至少一种其它疾病检测方法。在一些实施例中，在白光检查期间进行荧光成像或光谱学。在其他实施例中，多模式成像和/或光谱可以以多种方式进行和组合。因为除了白光之外的诊断模式在背景中是透明的，所以对于临床医师来说，程序并不比熟悉的白光检查复杂得多。在一些实施例中，本发明自动检测可疑组织并通知临床医生其存在。在其他实施方案中，本发明有助于确定是否需要活组织检查，并且可以进一步辅助临床医生，例如通过提供临时医师来鉴定和/或进行可疑部位的活检。在其他实施方案中，本发明包括通过结合先验信息（例如患者病史，先前的内窥镜检查数据，定性和/或定量痰细胞学检查的结果等）而提供的改进。

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