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1. 发明授权

US06683300B2 Method and apparatus for mass spectrometry analysis of common analyte solutions 失效
标题翻译：普通分析物溶液质谱分析方法和装置
公开(公告)号：US06683300B2
公开(公告)日：2004-01-27
申请号：US09953403
申请日：2001-09-17
申请人： Vladimir M. Doroshenko , Victor V. Laiko , Mikhail Yakshin , Coorg R. Prasad , Hyo Sang Lee
发明人： Vladimir M. Doroshenko , Victor V. Laiko , Mikhail Yakshin , Coorg R. Prasad , Hyo Sang Lee
IPC分类号： H01J4916
CPC分类号： H01J49/04
摘要： A method, system, and apparatus for mass spectroscopic analysis of an analyte solution in which a liquid volume of the analyte solution is irradiated with a light source resulting in desorption of solution-specific ions into a surrounding gas to produce gas-phase ions, the gas-phase ions are transferred to an inlet port of a mass analyzer, and the gas-phase ions are mass analyzed. More specifically, the apparatus may include a laser configured to pulse irradiate a surface of the analyte solution, a mass spectrometer configured to mass-analyze the gas-phase ions according to the mass-to-charge ratio, and a transfer mechanism configured to transfer the gas-phase ions to an inlet port of the mass spectrometer.
摘要翻译：分析物溶液的质谱分析的方法，系统和装置，其中用光源照射分析物溶液的液体体积，导致溶液特异性离子解吸到周围气体中以产生气相离子，将气相离子转移到质量分析器的入口，并对气相离子进行质量分析。更具体地，该装置可以包括被配置为脉冲照射分析物溶液的表面的激光器，配置成根据质荷比对气相离子进行质量分析的质谱仪，以及被配置为转移气相离子到质谱仪的入口。

2. 发明授权

US07122789B2 Method and apparatus to increase ionization efficiency in an ion source 有权
标题翻译：提高离子源电离效率的方法和装置
公开(公告)号：US07122789B2
公开(公告)日：2006-10-17
申请号：US10842481
申请日：2004-05-11
申请人： Phillip V. Tan , Victor V. Laiko , Vadym Berkout , Vladimir M. Doroshenko
发明人： Phillip V. Tan , Victor V. Laiko , Vadym Berkout , Vladimir M. Doroshenko
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/164 , H01J49/0404
摘要： A method and an apparatus for collecting ions in which ions are produced from a sample in an ion source. An electric field is provided that is more uniform in an area adjacent the sample than in an area adjacent an inlet to the ion transfer device or that is larger in field strength at the sample than at a point removed from the sample towards the inlet of the ion transfer device. Ions are received into the electric field and transferred through the ion transfer device to a sampling orifice of the mass spectrometer. The apparatus includes an ion transfer device coupled to a sampling orifice of a mass spectrometer. The ion transfer device has an inlet with a surface that extends in a direction from an axis of the ion transfer device. The ion transfer device can extend a distance of at least 10 times an inner diameter of a sampling orifice of the mass spectrometer.
摘要翻译：用于收集离子的方法和装置，其中离子源中的样品产生离子。提供电场，其在靠近样品的区域中比邻近离子转移装置的入口的区域更均匀，或者在样品处的场强大于在从样品朝向所述样品的入口移除的点离子转移装置。离子被接收到电场中并通过离子传递装置传送到质谱仪的采样孔。该装置包括耦合到质谱仪的采样孔的离子传递装置。离子转移装置具有从离子转移装置的轴线方向延伸的表面的入口。离子转移装置可以延伸质谱仪的采样孔的内径的至少10倍的距离。

3. 发明授权

US06791080B2 Method and apparatus for efficient transfer of ions into a mass spectrometer 有权
标题翻译：将离子有效转移到质谱仪中的方法和装置
公开(公告)号：US06791080B2
公开(公告)日：2004-09-14
申请号：US10367917
申请日：2003-02-19
申请人： Vladimir M. Doroshenko , Victor V. Laiko , Phillip V. Tan
发明人： Vladimir M. Doroshenko , Victor V. Laiko , Phillip V. Tan
IPC分类号： H01J4904
CPC分类号： H01J49/403
摘要： An apparatus and a method which produce a pulse of ions, generate a transient electric field correlated in time with a duration of the pulse of ions, receive the pulse of ions into the transient electric field, and collect the ions from an ion drift region of the transient electric field into a gas dynamic flow region of the mass analyzer. As such, an apparatus for transferring ions into a mass analyzer includes an ion source configured to generate the pulse of ions, a transient electric field device configured to receive the pulse of ions and generate the transient electric field, and an ion collector configured to collect the ions from the ion drift region and transfer the ions into the mass analyzer.
摘要翻译：产生离子脉冲的装置和方法产生时间上与离子脉冲持续时间相关的瞬时电场，将离子脉冲接收到瞬态电场中，并从离子漂移区域瞬态电场进入质量分析仪的气体动态流动区域。因此，用于将离子转移到质量分析器中的装置包括被配置为产生离子脉冲的离子源，被配置为接收离子脉冲并产生瞬态电场的瞬态电场装置，以及被配置为收集离子的离子收集器来自离子漂移区域的离子并将离子转移到质谱仪中。

4. 发明授权

US08471199B1 Portable mass spectrometer with atmospheric pressure interface 有权
标题翻译：便携式质谱仪，带有大气压力界面
公开(公告)号：US08471199B1
公开(公告)日：2013-06-25
申请号：US13441532
申请日：2012-04-06
申请人： Vladimir M. Doroshenko , Victor V. Laiko , Alexander S. Misharin
发明人： Vladimir M. Doroshenko , Victor V. Laiko , Alexander S. Misharin
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/0013
摘要： A portable mass spectrometer having an atmospheric pressure interface for introducing ions generated at ambient pressure gas conditions into a vacuum of the mass spectrometer. The mass spectrometer has a vacuum chamber having at least one vacuum section and at least one gas inlet for directing the ambient pressure gas including the ions into the at least one vacuum section. The at least one gas inlet has a gas passage channel of a length L and a limiting cross section S with a ratio of L/S being less than 20,000 cm−1. The mass spectrometer has a radio frequency (RF) ion guide in the at least one vacuum section positioned for collecting the ions from the at least one gas inlet and transmitting the ions further to a mass analyzer for analyzing the ions transmitted from the ion guide.
摘要翻译：一种便携式质谱仪，具有用于将在环境压力气体条件下产生的离子引入质谱仪真空的大气压界面。质谱仪具有至少一个真空部分的真空室和至少一个气体入口，用于将包括离子的环境压力气体引导到至少一个真空部分中。至少一个气体入口具有长度为L的气体通道通道和L / S的比例小于20,000cm -1的限制横截面S. 所述质谱仪在所述至少一个真空部分中具有射频（RF）离子引导件，定位成用于从所述至少一个气体入口收集离子，并将所述离子进一步传输到质量分析器，以分析从所述离子导向器传输的离子。

5. 发明授权

US5965884A Atmospheric pressure matrix assisted laser desorption 失效
标题翻译：大气压矩阵辅助激光解吸
公开(公告)号：US5965884A
公开(公告)日：1999-10-12
申请号：US90764
申请日：1998-06-04
申请人： Victor V. Laiko , Alma L. Burlingame
发明人： Victor V. Laiko , Alma L. Burlingame
IPC分类号： H01J49/10 , H01J49/04 , H01J49/16
CPC分类号： H01J49/164
摘要： An Atmospheric Pressure Matrix-Assisted Laser Desorption Ionization (AP-MALDI) apparatus is for connecting to a mass spectrometer. This apparatus provides an ion source using matrix-assisted laser desorption and ionization at or near atmospheric pressure. The apparatus has non-destructive ion source having the characteristics of versatility, simplicity.
摘要翻译：大气压矩阵辅助激光解吸电离（AP-MALDI）装置用于连接质谱仪。该装置在大气压或接近大气压下提供使用基质辅助激光解吸和离子化的离子源。该设备具有无损离子源，具有通用性，简便性。

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